Exercise Performance With Aficamten vs Metoprolol in Obstructive Hypertrophic Cardiomyopathy: The MAPLE-HCM Randomized Clinical Trial.

Lewis GD, Garcia-Pavia P, Masri A, Merkely B, Nassif ME, Peña-Peña ML, Barriales-Villa R, Bilen O, Burroughs M, Claggett B, Costabel JP, de Barros Correia E, Dybro AM, Kulac IJ, Lakdawala NK, Mann A, Maron MS, McGinnis S, Nair A, Newlands C, Poulsen SH, Reant P, Schulze PC, Solomon SD, Wang A, Sohn R, Berhane I, Heitner SB, Jacoby DL, Kupfer S, Malik FI, Wohltman A, Fifer MA, Elliott PM, MAPLE-HCM Investigators.

Open source

DOI: 10.1001/jamacardio.2026.1730
Published: 2026-08-01
Container: JAMA Cardiol
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1001/jamacardio.2026.1730,
  title = {Exercise Performance With Aficamten vs Metoprolol in Obstructive Hypertrophic Cardiomyopathy: The MAPLE-HCM Randomized Clinical Trial.},
  author = {Lewis GD and  Garcia-Pavia P and  Masri A and  Merkely B and  Nassif ME and  Peña-Peña ML and  Barriales-Villa R and  Bilen O and  Burroughs M and  Claggett B and  Costabel JP and  de Barros Correia E and  Dybro AM and  Kulac IJ and  Lakdawala NK and  Mann A and  Maron MS and  McGinnis S and  Nair A and  Newlands C and  Poulsen SH and  Reant P and  Schulze PC and  Solomon SD and  Wang A and  Sohn R and  Berhane I and  Heitner SB and  Jacoby DL and  Kupfer S and  Malik FI and  Wohltman A and  Fifer MA and  Elliott PM and  MAPLE-HCM Investigators.},
  year = {2026},
  journal = {JAMA Cardiol},
  doi = {10.1001/jamacardio.2026.1730},
  url = {https://doi.org/10.1001/jamacardio.2026.1730}
}

RIS

TY  - JOUR
TI  - Exercise Performance With Aficamten vs Metoprolol in Obstructive Hypertrophic Cardiomyopathy: The MAPLE-HCM Randomized Clinical Trial.
AU  - Lewis GD
AU  -  Garcia-Pavia P
AU  -  Masri A
AU  -  Merkely B
AU  -  Nassif ME
AU  -  Peña-Peña ML
AU  -  Barriales-Villa R
AU  -  Bilen O
AU  -  Burroughs M
AU  -  Claggett B
AU  -  Costabel JP
AU  -  de Barros Correia E
AU  -  Dybro AM
AU  -  Kulac IJ
AU  -  Lakdawala NK
AU  -  Mann A
AU  -  Maron MS
AU  -  McGinnis S
AU  -  Nair A
AU  -  Newlands C
AU  -  Poulsen SH
AU  -  Reant P
AU  -  Schulze PC
AU  -  Solomon SD
AU  -  Wang A
AU  -  Sohn R
AU  -  Berhane I
AU  -  Heitner SB
AU  -  Jacoby DL
AU  -  Kupfer S
AU  -  Malik FI
AU  -  Wohltman A
AU  -  Fifer MA
AU  -  Elliott PM
AU  -  MAPLE-HCM Investigators.
PY  - 2026
JO  - JAMA Cardiol
DO  - 10.1001/jamacardio.2026.1730
UR  - https://doi.org/10.1001/jamacardio.2026.1730
ER  -

APA

GD, L., P, G., A, M., B, M., ME, N., ML, P., R, B., O, B., M, B., B, C., JP, C., E, D. B. C., AM, D., IJ, K., NK, L., A, M., MS, M., S, M., A, N., C, N., SH, P., P, R., PC, S., SD, S., A, W., R, S., I, B., SB, H., DL, J., S, K., FI, M., A, W., MA, F., PM, E., & Investigators., M. (2026). Exercise Performance With Aficamten vs Metoprolol in Obstructive Hypertrophic Cardiomyopathy: The MAPLE-HCM Randomized Clinical Trial.. JAMA Cardiol. https://doi.org/10.1001/jamacardio.2026.1730

Source records

europe-pmc · retrieved 2026-09-25T18:37:38.319Z