A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

BibTeX

@article{allodium:10.1002/1521-3773-20020118-41:2-265::aid-anie265-3.0.co-2-q,
  title = {A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).},
  author = {Anton Bom and Mark Bradley and Ken Cameron and John K. Clark and Jan van Egmond and Helen Feilden and Elizabeth J. MacLean and Alan W. Muir and Ronald Palin and David C. Rees and Ming-Qiang Zhang},
  year = {2002},
  journal = {Angewandte Chemie International Edition},
  doi = {10.1002/1521-3773(20020118)41:2<265::aid-anie265>3.0.co;2-q},
  url = {https://doi.org/10.1002/1521-3773(20020118)41:2<265::aid-anie265>3.0.co;2-q}
}

RIS

TY  - JOUR
TI  - A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).
AU  - Anton Bom
AU  - Mark Bradley
AU  - Ken Cameron
AU  - John K. Clark
AU  - Jan van Egmond
AU  - Helen Feilden
AU  - Elizabeth J. MacLean
AU  - Alan W. Muir
AU  - Ronald Palin
AU  - David C. Rees
AU  - Ming-Qiang Zhang
PY  - 2002
JO  - Angewandte Chemie International Edition
DO  - 10.1002/1521-3773(20020118)41:2<265::aid-anie265>3.0.co;2-q
UR  - https://doi.org/10.1002/1521-3773(20020118)41:2<265::aid-anie265>3.0.co;2-q
ER  - 

APA

Bom, A., Bradley, M., Cameron, K., Clark, J. K., Egmond, J. V., Feilden, H., MacLean, E. J., Muir, A. W., Palin, R., Rees, D. C., & Zhang, M. (2002). A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).. Angewandte Chemie International Edition. https://doi.org/10.1002/1521-3773(20020118)41:2<265::aid-anie265>3.0.co;2-q