Impact of Concomitant Methotrexate Use and Prior Biologic Disease-Modifying Antirheumatic Drug Exposure on Tofacitinib Efficacy and Safety in Patients with Polyarticular Course Juvenile Idiopathic Arthritis: Post Hoc Analysis of a Phase 3 Randomized Withdrawal Trial.

Ruperto N, Lovell DJ, Synoverska O, Abud-Mendoza C, Spindler A, Vyzhga Y, Reyhan I, Grebenkina L, Tirosh I, Imundo L, Chiraseveenuprapund P, Kingsbury DJ, Sozeri B, Vora SS, Prahalad S, Zholobova E, Roberts KD, Sawyerr G, Blum A, Shapiro A, Diehl A, Ebrahim A, Klaus P, Martini A, Brunner HI, Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)

Open source

DOI: 10.1002/acr2.70097
Published: 2025 Oct
Container: ACR open rheumatology
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1002/acr2.70097,
  title = {Impact of Concomitant Methotrexate Use and Prior Biologic Disease-Modifying Antirheumatic Drug Exposure on Tofacitinib Efficacy and Safety in Patients with Polyarticular Course Juvenile Idiopathic Arthritis: Post Hoc Analysis of a Phase 3 Randomized Withdrawal Trial.},
  author = {Ruperto N and Lovell DJ and Synoverska O and Abud-Mendoza C and Spindler A and Vyzhga Y and Reyhan I and Grebenkina L and Tirosh I and Imundo L and Chiraseveenuprapund P and Kingsbury DJ and Sozeri B and Vora SS and Prahalad S and Zholobova E and Roberts KD and Sawyerr G and Blum A and Shapiro A and Diehl A and Ebrahim A and Klaus P and Martini A and Brunner HI and Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)},
  year = {2025},
  journal = {ACR open rheumatology},
  doi = {10.1002/acr2.70097},
  url = {https://doi.org/10.1002/acr2.70097}
}

RIS

TY  - JOUR
TI  - Impact of Concomitant Methotrexate Use and Prior Biologic Disease-Modifying Antirheumatic Drug Exposure on Tofacitinib Efficacy and Safety in Patients with Polyarticular Course Juvenile Idiopathic Arthritis: Post Hoc Analysis of a Phase 3 Randomized Withdrawal Trial.
AU  - Ruperto N
AU  - Lovell DJ
AU  - Synoverska O
AU  - Abud-Mendoza C
AU  - Spindler A
AU  - Vyzhga Y
AU  - Reyhan I
AU  - Grebenkina L
AU  - Tirosh I
AU  - Imundo L
AU  - Chiraseveenuprapund P
AU  - Kingsbury DJ
AU  - Sozeri B
AU  - Vora SS
AU  - Prahalad S
AU  - Zholobova E
AU  - Roberts KD
AU  - Sawyerr G
AU  - Blum A
AU  - Shapiro A
AU  - Diehl A
AU  - Ebrahim A
AU  - Klaus P
AU  - Martini A
AU  - Brunner HI
AU  - Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)
PY  - 2025
JO  - ACR open rheumatology
DO  - 10.1002/acr2.70097
UR  - https://doi.org/10.1002/acr2.70097
ER  -

APA

N, R., DJ, L., O, S., C, A., A, S., Y, V., I, R., L, G., I, T., L, I., P, C., DJ, K., B, S., SS, V., S, P., E, Z., KD, R., G, S., A, B., A, S., A, D., A, E., P, K., A, M., HI, B., & (PRCSG), P. R. I. T. O. (. A. T. P. R. C. S. G. (2025). Impact of Concomitant Methotrexate Use and Prior Biologic Disease-Modifying Antirheumatic Drug Exposure on Tofacitinib Efficacy and Safety in Patients with Polyarticular Course Juvenile Idiopathic Arthritis: Post Hoc Analysis of a Phase 3 Randomized Withdrawal Trial.. ACR open rheumatology. https://doi.org/10.1002/acr2.70097

Source records

pubmed · retrieved 2026-09-27T01:06:18.624Z