Single-Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis.

Xu H, He T, Qian Y, Li J, Ni B, Xu X, Wang H, Wang P, Cao G, Ying S, Ding G, Wang R, Gu Z, Li W, Man Z, Zheng H, Zhu Z, Li Z, Meng Q, Zheng C, Yang L

Open source

DOI: 10.1002/advs.202516720
Published: 2026 May
Container: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1002/advs.202516720,
  title = {Single-Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis.},
  author = {Xu H and He T and Qian Y and Li J and Ni B and Xu X and Wang H and Wang P and Cao G and Ying S and Ding G and Wang R and Gu Z and Li W and Man Z and Zheng H and Zhu Z and Li Z and Meng Q and Zheng C and Yang L},
  year = {2026},
  journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
  doi = {10.1002/advs.202516720},
  url = {https://doi.org/10.1002/advs.202516720}
}

RIS

TY  - JOUR
TI  - Single-Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis.
AU  - Xu H
AU  - He T
AU  - Qian Y
AU  - Li J
AU  - Ni B
AU  - Xu X
AU  - Wang H
AU  - Wang P
AU  - Cao G
AU  - Ying S
AU  - Ding G
AU  - Wang R
AU  - Gu Z
AU  - Li W
AU  - Man Z
AU  - Zheng H
AU  - Zhu Z
AU  - Li Z
AU  - Meng Q
AU  - Zheng C
AU  - Yang L
PY  - 2026
JO  - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
DO  - 10.1002/advs.202516720
UR  - https://doi.org/10.1002/advs.202516720
ER  -

APA

H, X., T, H., Y, Q., J, L., B, N., X, X., H, W., P, W., G, C., S, Y., G, D., R, W., Z, G., W, L., Z, M., H, Z., Z, Z., Z, L., Q, M., C, Z., & L, Y. (2026). Single-Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis.. Advanced science (Weinheim, Baden-Wurttemberg, Germany). https://doi.org/10.1002/advs.202516720

Source records

pubmed · retrieved 2026-09-26T17:48:24.522Z