The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D <sub>2</sub> receptor occupancy in humans

Mengxu Zhang, Thomas I. F. H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange

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DOI: 10.1002/bcp.70788
Published: 2026-09-09
Container: British Journal of Clinical Pharmacology
Publisher: Wiley
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1002/bcp.70788,
  title = {The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D
                    <sub>2</sub>
                    receptor occupancy in humans},
  author = {Mengxu Zhang and Thomas I. F. H. Cremers and Vivi Rottschäfer and Elizabeth C. M. de Lange},
  year = {2026},
  journal = {British Journal of Clinical Pharmacology},
  doi = {10.1002/bcp.70788},
  url = {https://doi.org/10.1002/bcp.70788}
}

RIS

TY  - JOUR
TI  - The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D
                    <sub>2</sub>
                    receptor occupancy in humans
AU  - Mengxu Zhang
AU  - Thomas I. F. H. Cremers
AU  - Vivi Rottschäfer
AU  - Elizabeth C. M. de Lange
PY  - 2026
JO  - British Journal of Clinical Pharmacology
DO  - 10.1002/bcp.70788
UR  - https://doi.org/10.1002/bcp.70788
ER  -

APA

Zhang, M., Cremers, T. I. F. H., Rottschäfer, V., & Lange, E. C. M. D. (2026). The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D <sub>2</sub> receptor occupancy in humans. British Journal of Clinical Pharmacology. https://doi.org/10.1002/bcp.70788

Source records

crossref · retrieved 2026-09-27T04:23:59.400Z