Epilepsy-associated SCN2A-L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids.

Olivero-Acosta MI, Robinson M, Que Z, Zhang Z, Salazar-Salazar KV, Harlow HE, Shankar V, Hong S, Wang M, Otterbacher CM, Kadono H, Halurkar M, Kothandaraman H, Lanman NA, Nguyen T, Wettschurack K, Zirkle B, Yunis L, Cui N, Chen X, Zhang J, Wu J, Skarnes WC, Yuan C, Guo F, Abbott M, Yang Y

Open source

DOI: 10.1002/epi.70392
Published: 2026 Jul 30
Container: Epilepsia
Publisher: Not recorded
Open access: unknown

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1002/epi.70392,
  title = {Epilepsy-associated SCN2A-L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids.},
  author = {Olivero-Acosta MI and Robinson M and Que Z and Zhang Z and Salazar-Salazar KV and Harlow HE and Shankar V and Hong S and Wang M and Otterbacher CM and Kadono H and Halurkar M and Kothandaraman H and Lanman NA and Nguyen T and Wettschurack K and Zirkle B and Yunis L and Cui N and Chen X and Zhang J and Wu J and Skarnes WC and Yuan C and Guo F and Abbott M and Yang Y},
  year = {2026},
  journal = {Epilepsia},
  doi = {10.1002/epi.70392},
  url = {https://doi.org/10.1002/epi.70392}
}

RIS

TY  - JOUR
TI  - Epilepsy-associated SCN2A-L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids.
AU  - Olivero-Acosta MI
AU  - Robinson M
AU  - Que Z
AU  - Zhang Z
AU  - Salazar-Salazar KV
AU  - Harlow HE
AU  - Shankar V
AU  - Hong S
AU  - Wang M
AU  - Otterbacher CM
AU  - Kadono H
AU  - Halurkar M
AU  - Kothandaraman H
AU  - Lanman NA
AU  - Nguyen T
AU  - Wettschurack K
AU  - Zirkle B
AU  - Yunis L
AU  - Cui N
AU  - Chen X
AU  - Zhang J
AU  - Wu J
AU  - Skarnes WC
AU  - Yuan C
AU  - Guo F
AU  - Abbott M
AU  - Yang Y
PY  - 2026
JO  - Epilepsia
DO  - 10.1002/epi.70392
UR  - https://doi.org/10.1002/epi.70392
ER  -

APA

MI, O., M, R., Z, Q., Z, Z., KV, S., HE, H., V, S., S, H., M, W., CM, O., H, K., M, H., H, K., NA, L., T, N., K, W., B, Z., L, Y., N, C., X, C., J, Z., J, W., WC, S., C, Y., F, G., M, A., & Y, Y. (2026). Epilepsy-associated SCN2A-L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids.. Epilepsia. https://doi.org/10.1002/epi.70392

Source records

pubmed · retrieved 2026-09-25T10:36:33.993Z