A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.

Virolainen SJ, Creighton K, Dashtiahangar M, Krishnamurthy D, Parks L, Forney C, Ampadu B, Rudrapatna AN, Dunn KA, Parameswaran S, Hesse HK, Chen X, VonHandorf A, Edsall LE, Yin C, Lynch A, Gittens O, Diouf AA, Jones SH, Hass M, Javier E, Donmez O, Keddari Y, Danzinger O, Seelamneni H, Namjou-Khales B, Ainsworth HC, Comeau ME, Marion MC, Glenn SB, Nath SK, Freedman BI, Tsao BP, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Reveille JD, James JA, Criswell LA, Vilá LM, Alarcón-Riquelme ME, Petri M, Scofield RH, Kimberly RP, Ramsey-Goldman R, Bae SC, Graham DC, Vyse TJ, Guthridge JM, Gaffney PM, Langefeld CD, Kelly JA, Kaufman KM, Sivils KL, Harley JB, Shen N, Lawson LP, Baglaenko Y, Miraldi ER, Rosenberg BR, Siggers T, Waggoner SN, Weirauch MT, Kottyan LC

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DOI
10.1016/j.ajhg.2026.08.016
Published
2026 Sep 11
Container
American journal of human genetics
Publisher
Not recorded
Open access
yes

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BibTeX

@article{allodium:10.1016/j.ajhg.2026.08.016,
  title = {A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.},
  author = {Virolainen SJ and Creighton K and Dashtiahangar M and Krishnamurthy D and Parks L and Forney C and Ampadu B and Rudrapatna AN and Dunn KA and Parameswaran S and Hesse HK and Chen X and VonHandorf A and Edsall LE and Yin C and Lynch A and Gittens O and Diouf AA and Jones SH and Hass M and Javier E and Donmez O and Keddari Y and Danzinger O and Seelamneni H and Namjou-Khales B and Ainsworth HC and Comeau ME and Marion MC and Glenn SB and Nath SK and Freedman BI and Tsao BP and Kamen DL and Brown EE and Gilkeson GS and Alarcón GS and Reveille JD and James JA and Criswell LA and Vilá LM and Alarcón-Riquelme ME and Petri M and Scofield RH and Kimberly RP and Ramsey-Goldman R and Bae SC and Graham DC and Vyse TJ and Guthridge JM and Gaffney PM and Langefeld CD and Kelly JA and Kaufman KM and Sivils KL and Harley JB and Shen N and Lawson LP and Baglaenko Y and Miraldi ER and Rosenberg BR and Siggers T and Waggoner SN and Weirauch MT and Kottyan LC},
  year = {2026},
  journal = {American journal of human genetics},
  doi = {10.1016/j.ajhg.2026.08.016},
  url = {https://doi.org/10.1016/j.ajhg.2026.08.016}
}

RIS

TY  - JOUR
TI  - A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.
AU  - Virolainen SJ
AU  - Creighton K
AU  - Dashtiahangar M
AU  - Krishnamurthy D
AU  - Parks L
AU  - Forney C
AU  - Ampadu B
AU  - Rudrapatna AN
AU  - Dunn KA
AU  - Parameswaran S
AU  - Hesse HK
AU  - Chen X
AU  - VonHandorf A
AU  - Edsall LE
AU  - Yin C
AU  - Lynch A
AU  - Gittens O
AU  - Diouf AA
AU  - Jones SH
AU  - Hass M
AU  - Javier E
AU  - Donmez O
AU  - Keddari Y
AU  - Danzinger O
AU  - Seelamneni H
AU  - Namjou-Khales B
AU  - Ainsworth HC
AU  - Comeau ME
AU  - Marion MC
AU  - Glenn SB
AU  - Nath SK
AU  - Freedman BI
AU  - Tsao BP
AU  - Kamen DL
AU  - Brown EE
AU  - Gilkeson GS
AU  - Alarcón GS
AU  - Reveille JD
AU  - James JA
AU  - Criswell LA
AU  - Vilá LM
AU  - Alarcón-Riquelme ME
AU  - Petri M
AU  - Scofield RH
AU  - Kimberly RP
AU  - Ramsey-Goldman R
AU  - Bae SC
AU  - Graham DC
AU  - Vyse TJ
AU  - Guthridge JM
AU  - Gaffney PM
AU  - Langefeld CD
AU  - Kelly JA
AU  - Kaufman KM
AU  - Sivils KL
AU  - Harley JB
AU  - Shen N
AU  - Lawson LP
AU  - Baglaenko Y
AU  - Miraldi ER
AU  - Rosenberg BR
AU  - Siggers T
AU  - Waggoner SN
AU  - Weirauch MT
AU  - Kottyan LC
PY  - 2026
JO  - American journal of human genetics
DO  - 10.1016/j.ajhg.2026.08.016
UR  - https://doi.org/10.1016/j.ajhg.2026.08.016
ER  -

APA

SJ, V., K, C., M, D., D, K., L, P., C, F., B, A., AN, R., KA, D., S, P., HK, H., X, C., A, V., LE, E., C, Y., A, L., O, G., AA, D., SH, J., M, H., E, J., O, D., Y, K., O, D., H, S., B, N., HC, A., ME, C., MC, M., SB, G., SK, N., BI, F., BP, T., DL, K., EE, B., GS, G., GS, A., JD, R., JA, J., LA, C., LM, V., ME, A., M, P., RH, S., RP, K., R, R., SC, B., DC, G., TJ, V., JM, G., PM, G., CD, L., JA, K., KM, K., KL, S., JB, H., N, S., LP, L., Y, B., ER, M., BR, R., T, S., SN, W., MT, W., & LC, K. (2026). A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.. American journal of human genetics. https://doi.org/10.1016/j.ajhg.2026.08.016

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