Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve

Ling-Jie Gao, Mathy Froeyen, Chieh-Wen Lo, Do Hoang Nhu Tran, Tom Van Loy, Dominique Schols, Jef Rozenski, Wim Dehaen, Shirit Einav, Steven De Jonghe

Open source

DOI
10.1016/j.bioorg.2026.110337
Published
2026-10
Container
Bioorganic Chemistry
Publisher
Elsevier BV
Open access
unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

Cite this work

BibTeX

@article{allodium:10.1016/j.bioorg.2026.110337,
  title = {Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve},
  author = {Ling-Jie Gao and Mathy Froeyen and Chieh-Wen Lo and Do Hoang Nhu Tran and Tom Van Loy and Dominique Schols and Jef Rozenski and Wim Dehaen and Shirit Einav and Steven De Jonghe},
  year = {2026},
  journal = {Bioorganic Chemistry},
  doi = {10.1016/j.bioorg.2026.110337},
  url = {https://doi.org/10.1016/j.bioorg.2026.110337}
}

RIS

TY  - JOUR
TI  - Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve
AU  - Ling-Jie Gao
AU  - Mathy Froeyen
AU  - Chieh-Wen Lo
AU  - Do Hoang Nhu Tran
AU  - Tom Van Loy
AU  - Dominique Schols
AU  - Jef Rozenski
AU  - Wim Dehaen
AU  - Shirit Einav
AU  - Steven De Jonghe
PY  - 2026
JO  - Bioorganic Chemistry
DO  - 10.1016/j.bioorg.2026.110337
UR  - https://doi.org/10.1016/j.bioorg.2026.110337
ER  - 

APA

Gao, L., Froeyen, M., Lo, C., Tran, D. H. N., Loy, T. V., Schols, D., Rozenski, J., Dehaen, W., Einav, S., & Jonghe, S. D. (2026). Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve. Bioorganic Chemistry. https://doi.org/10.1016/j.bioorg.2026.110337

Source records