Discovery of chalcone-quinazolinone hybrids as BRAF kinase inhibitors with potential anticancer activity: Design, synthesis, biological evaluation, and molecular modeling studies

Randa Atef Ibrahim Abdelaziz, Iman Ahmed Youssef Ghannam, Heba Abdelrasheed Allam, Ahmed Mahmoud El Kerdawy, Rasha Mousa Allam, Mahmoud Taha Abo-Elfadl, Safinaz El-Sayed Abbas

Open source

DOI
10.1016/j.bioorg.2026.110709
Published
2026-11
Container
Bioorganic Chemistry
Publisher
Elsevier BV
Open access
unknown

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Cite this work

BibTeX

@article{allodium:10.1016/j.bioorg.2026.110709,
  title = {Discovery of chalcone-quinazolinone hybrids as BRAF kinase inhibitors with potential anticancer activity: Design, synthesis, biological evaluation, and molecular modeling studies},
  author = {Randa Atef Ibrahim Abdelaziz and Iman Ahmed Youssef Ghannam and Heba Abdelrasheed Allam and Ahmed Mahmoud El Kerdawy and Rasha Mousa Allam and Mahmoud Taha Abo-Elfadl and Safinaz El-Sayed Abbas},
  year = {2026},
  journal = {Bioorganic Chemistry},
  doi = {10.1016/j.bioorg.2026.110709},
  url = {https://doi.org/10.1016/j.bioorg.2026.110709}
}

RIS

TY  - JOUR
TI  - Discovery of chalcone-quinazolinone hybrids as BRAF kinase inhibitors with potential anticancer activity: Design, synthesis, biological evaluation, and molecular modeling studies
AU  - Randa Atef Ibrahim Abdelaziz
AU  - Iman Ahmed Youssef Ghannam
AU  - Heba Abdelrasheed Allam
AU  - Ahmed Mahmoud El Kerdawy
AU  - Rasha Mousa Allam
AU  - Mahmoud Taha Abo-Elfadl
AU  - Safinaz El-Sayed Abbas
PY  - 2026
JO  - Bioorganic Chemistry
DO  - 10.1016/j.bioorg.2026.110709
UR  - https://doi.org/10.1016/j.bioorg.2026.110709
ER  - 

APA

Abdelaziz, R. A. I., Ghannam, I. A. Y., Allam, H. A., Kerdawy, A. M. E., Allam, R. M., Abo-Elfadl, M. T., & Abbas, S. E. (2026). Discovery of chalcone-quinazolinone hybrids as BRAF kinase inhibitors with potential anticancer activity: Design, synthesis, biological evaluation, and molecular modeling studies. Bioorganic Chemistry. https://doi.org/10.1016/j.bioorg.2026.110709

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