Discovery of potent, selective, and orally bioavailable monocyclic pyridine-based PKMYT1 inhibitors that synergize with CHK1 inhibition in replication-stressed cancer cells

Ying Sun, Hongzhu Chu, Yonggang Wei, Xinying Qian, Fei Ye, Hongchuan Zhao, Xinying Zhu, Jing Zhang, Song Huang, Mingyou Hu

Open source

DOI
10.1016/j.bmcl.2026.130779
Published
2027-01
Container
Bioorganic & Medicinal Chemistry Letters
Publisher
Elsevier BV
Open access
unknown

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BibTeX

@article{allodium:10.1016/j.bmcl.2026.130779,
  title = {Discovery of potent, selective, and orally bioavailable monocyclic pyridine-based PKMYT1 inhibitors that synergize with CHK1 inhibition in replication-stressed cancer cells},
  author = {Ying Sun and Hongzhu Chu and Yonggang Wei and Xinying Qian and Fei Ye and Hongchuan Zhao and Xinying Zhu and Jing Zhang and Song Huang and Mingyou Hu},
  year = {2027},
  journal = {Bioorganic \& Medicinal Chemistry Letters},
  doi = {10.1016/j.bmcl.2026.130779},
  url = {https://doi.org/10.1016/j.bmcl.2026.130779}
}

RIS

TY  - JOUR
TI  - Discovery of potent, selective, and orally bioavailable monocyclic pyridine-based PKMYT1 inhibitors that synergize with CHK1 inhibition in replication-stressed cancer cells
AU  - Ying Sun
AU  - Hongzhu Chu
AU  - Yonggang Wei
AU  - Xinying Qian
AU  - Fei Ye
AU  - Hongchuan Zhao
AU  - Xinying Zhu
AU  - Jing Zhang
AU  - Song Huang
AU  - Mingyou Hu
PY  - 2027
JO  - Bioorganic & Medicinal Chemistry Letters
DO  - 10.1016/j.bmcl.2026.130779
UR  - https://doi.org/10.1016/j.bmcl.2026.130779
ER  - 

APA

Sun, Y., Chu, H., Wei, Y., Qian, X., Ye, F., Zhao, H., Zhu, X., Zhang, J., Huang, S., & Hu, M. (2027). Discovery of potent, selective, and orally bioavailable monocyclic pyridine-based PKMYT1 inhibitors that synergize with CHK1 inhibition in replication-stressed cancer cells. Bioorganic & Medicinal Chemistry Letters. https://doi.org/10.1016/j.bmcl.2026.130779

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