Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy.

Zink A, Dai DF, Wittich A, Henke MT, Pedrotti G, Heiduschka S, Santamaria G, Pentimalli TM, Brueser C, Notopoulou S, Umar AR, Zhaivoron A, Petersilie L, Jerred C, Bergmans J, Neu LA, Schumacher F, Keller-Findeisen J, Rybak-Wolf A, Stach D, Reinshagen J, Haferkamp U, Krieg K, Zaliani A, Euro L, Di Donfrancesco A, Santanatoglia C, Cappellozza E, Suarez Cubero M, Pavez-Giani M, Bakumenko O, Meierhofer D, Foley A, Morales-Gonzalez S, Tolle I, Herebian D, Bonesso D, Cecchetto G, Wong SN, Moresco M, Maresca A, Decimo I, De Sanctis F, Adamo A, Adjobo-Hermans MJW, Duchi R, Barandalla M, Scaglia M, Perota A, Galli C, Kleuser B, Cyganek L, Mühlhausen C, Schlotawa L, Tiranti V, Mayatepek E, Szabo I, La Morgia C, Klopstock T, Carelli V, Distelmaier F, Rossi A, Rajewsky N, Ullah G, Jakobs S, Rose CR, Petrakis S, Edenhofer F, Koopman WJH, Lisowski P, Suomalainen A, Brunetti D, Del Sol A, Bottani E, Pless O, Schuelke M, Prigione A

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DOI: 10.1016/j.cell.2026.02.008
Published: 2026 Mar 19
Container: Cell
Publisher: Not recorded
Open access: yes

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BibTeX

@article{allodium:10.1016/j.cell.2026.02.008,
  title = {Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy.},
  author = {Zink A and Dai DF and Wittich A and Henke MT and Pedrotti G and Heiduschka S and Santamaria G and Pentimalli TM and Brueser C and Notopoulou S and Umar AR and Zhaivoron A and Petersilie L and Jerred C and Bergmans J and Neu LA and Schumacher F and Keller-Findeisen J and Rybak-Wolf A and Stach D and Reinshagen J and Haferkamp U and Krieg K and Zaliani A and Euro L and Di Donfrancesco A and Santanatoglia C and Cappellozza E and Suarez Cubero M and Pavez-Giani M and Bakumenko O and Meierhofer D and Foley A and Morales-Gonzalez S and Tolle I and Herebian D and Bonesso D and Cecchetto G and Wong SN and Moresco M and Maresca A and Decimo I and De Sanctis F and Adamo A and Adjobo-Hermans MJW and Duchi R and Barandalla M and Scaglia M and Perota A and Galli C and Kleuser B and Cyganek L and Mühlhausen C and Schlotawa L and Tiranti V and Mayatepek E and Szabo I and La Morgia C and Klopstock T and Carelli V and Distelmaier F and Rossi A and Rajewsky N and Ullah G and Jakobs S and Rose CR and Petrakis S and Edenhofer F and Koopman WJH and Lisowski P and Suomalainen A and Brunetti D and Del Sol A and Bottani E and Pless O and Schuelke M and Prigione A},
  year = {2026},
  journal = {Cell},
  doi = {10.1016/j.cell.2026.02.008},
  url = {https://doi.org/10.1016/j.cell.2026.02.008}
}

RIS

TY  - JOUR
TI  - Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy.
AU  - Zink A
AU  - Dai DF
AU  - Wittich A
AU  - Henke MT
AU  - Pedrotti G
AU  - Heiduschka S
AU  - Santamaria G
AU  - Pentimalli TM
AU  - Brueser C
AU  - Notopoulou S
AU  - Umar AR
AU  - Zhaivoron A
AU  - Petersilie L
AU  - Jerred C
AU  - Bergmans J
AU  - Neu LA
AU  - Schumacher F
AU  - Keller-Findeisen J
AU  - Rybak-Wolf A
AU  - Stach D
AU  - Reinshagen J
AU  - Haferkamp U
AU  - Krieg K
AU  - Zaliani A
AU  - Euro L
AU  - Di Donfrancesco A
AU  - Santanatoglia C
AU  - Cappellozza E
AU  - Suarez Cubero M
AU  - Pavez-Giani M
AU  - Bakumenko O
AU  - Meierhofer D
AU  - Foley A
AU  - Morales-Gonzalez S
AU  - Tolle I
AU  - Herebian D
AU  - Bonesso D
AU  - Cecchetto G
AU  - Wong SN
AU  - Moresco M
AU  - Maresca A
AU  - Decimo I
AU  - De Sanctis F
AU  - Adamo A
AU  - Adjobo-Hermans MJW
AU  - Duchi R
AU  - Barandalla M
AU  - Scaglia M
AU  - Perota A
AU  - Galli C
AU  - Kleuser B
AU  - Cyganek L
AU  - Mühlhausen C
AU  - Schlotawa L
AU  - Tiranti V
AU  - Mayatepek E
AU  - Szabo I
AU  - La Morgia C
AU  - Klopstock T
AU  - Carelli V
AU  - Distelmaier F
AU  - Rossi A
AU  - Rajewsky N
AU  - Ullah G
AU  - Jakobs S
AU  - Rose CR
AU  - Petrakis S
AU  - Edenhofer F
AU  - Koopman WJH
AU  - Lisowski P
AU  - Suomalainen A
AU  - Brunetti D
AU  - Del Sol A
AU  - Bottani E
AU  - Pless O
AU  - Schuelke M
AU  - Prigione A
PY  - 2026
JO  - Cell
DO  - 10.1016/j.cell.2026.02.008
UR  - https://doi.org/10.1016/j.cell.2026.02.008
ER  -

APA

A, Z., DF, D., A, W., MT, H., G, P., S, H., G, S., TM, P., C, B., S, N., AR, U., A, Z., L, P., C, J., J, B., LA, N., F, S., J, K., A, R., D, S., J, R., U, H., K, K., A, Z., L, E., A, D. D., C, S., E, C., M, S. C., M, P., O, B., D, M., A, F., S, M., I, T., D, H., D, B., G, C., SN, W., M, M., A, M., I, D., F, D. S., A, A., MJW, A., R, D., M, B., M, S., A, P., C, G., B, K., L, C., C, M., L, S., V, T., E, M., I, S., C, L. M., T, K., V, C., F, D., A, R., N, R., G, U., S, J., CR, R., S, P., F, E., WJH, K., P, L., A, S., D, B., A, D. S., E, B., O, P., M, S., & A, P. (2026). Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy.. Cell. https://doi.org/10.1016/j.cell.2026.02.008

Source records

pubmed · retrieved 2026-09-25T00:13:07.492Z