Rational discovery of therapeutic PAK1 allosteric activators

Yu He, James S.H. Bae, Elżbieta Nowak, Carlos Outeiral, Daniel A. Nissley, Anthony Tumber, Georgina Berridge, Eidarus Salah, Yi Wang, Wenqi He, Hongyuan Zhang, Tangting Chen, Samuel Tusk, Sebastian Mathea, Ying-Jie Wang, Alexander Grassam-Rowe, Philipp Kukura, Christopher J. Schofield, Darragh P. O’Brien, Andrea Pierangelini, Grant C. Churchill, Thomas Lanyon-Hogg, Yunbo Ke, Chao Xu, Tao Ye, Hugh Watkins, Liming Ying, Andreas Koschinski, R. John Solaro, Xiaoqiu Tan, Jani R. Bolla, Xin Wang, Stefan Knapp, Charlotte M. Deane, Manuela Zaccolo, Marcin Nowotny, Ming Lei

Open source

DOI: 10.1016/j.cell.2026.03.008
Published: 2026-05
Container: Cell
Publisher: Elsevier BV
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1016/j.cell.2026.03.008,
  title = {Rational discovery of therapeutic PAK1 allosteric activators},
  author = {Yu He and James S.H. Bae and Elżbieta Nowak and Carlos Outeiral and Daniel A. Nissley and Anthony Tumber and Georgina Berridge and Eidarus Salah and Yi Wang and Wenqi He and Hongyuan Zhang and Tangting Chen and Samuel Tusk and Sebastian Mathea and Ying-Jie Wang and Alexander Grassam-Rowe and Philipp Kukura and Christopher J. Schofield and Darragh P. O’Brien and Andrea Pierangelini and Grant C. Churchill and Thomas Lanyon-Hogg and Yunbo Ke and Chao Xu and Tao Ye and Hugh Watkins and Liming Ying and Andreas Koschinski and R. John Solaro and Xiaoqiu Tan and Jani R. Bolla and Xin Wang and Stefan Knapp and Charlotte M. Deane and Manuela Zaccolo and Marcin Nowotny and Ming Lei},
  year = {2026},
  journal = {Cell},
  doi = {10.1016/j.cell.2026.03.008},
  url = {https://doi.org/10.1016/j.cell.2026.03.008}
}

RIS

TY  - JOUR
TI  - Rational discovery of therapeutic PAK1 allosteric activators
AU  - Yu He
AU  - James S.H. Bae
AU  - Elżbieta Nowak
AU  - Carlos Outeiral
AU  - Daniel A. Nissley
AU  - Anthony Tumber
AU  - Georgina Berridge
AU  - Eidarus Salah
AU  - Yi Wang
AU  - Wenqi He
AU  - Hongyuan Zhang
AU  - Tangting Chen
AU  - Samuel Tusk
AU  - Sebastian Mathea
AU  - Ying-Jie Wang
AU  - Alexander Grassam-Rowe
AU  - Philipp Kukura
AU  - Christopher J. Schofield
AU  - Darragh P. O’Brien
AU  - Andrea Pierangelini
AU  - Grant C. Churchill
AU  - Thomas Lanyon-Hogg
AU  - Yunbo Ke
AU  - Chao Xu
AU  - Tao Ye
AU  - Hugh Watkins
AU  - Liming Ying
AU  - Andreas Koschinski
AU  - R. John Solaro
AU  - Xiaoqiu Tan
AU  - Jani R. Bolla
AU  - Xin Wang
AU  - Stefan Knapp
AU  - Charlotte M. Deane
AU  - Manuela Zaccolo
AU  - Marcin Nowotny
AU  - Ming Lei
PY  - 2026
JO  - Cell
DO  - 10.1016/j.cell.2026.03.008
UR  - https://doi.org/10.1016/j.cell.2026.03.008
ER  -

APA

He, Y., Bae, J. S., Nowak, E., Outeiral, C., Nissley, D. A., Tumber, A., Berridge, G., Salah, E., Wang, Y., He, W., Zhang, H., Chen, T., Tusk, S., Mathea, S., Wang, Y., Grassam-Rowe, A., Kukura, P., Schofield, C. J., O’Brien, D. P., Pierangelini, A., Churchill, G. C., Lanyon-Hogg, T., Ke, Y., Xu, C., Ye, T., Watkins, H., Ying, L., Koschinski, A., Solaro, R. J., Tan, X., Bolla, J. R., Wang, X., Knapp, S., Deane, C. M., Zaccolo, M., Nowotny, M., & Lei, M. (2026). Rational discovery of therapeutic PAK1 allosteric activators. Cell. https://doi.org/10.1016/j.cell.2026.03.008

Source records

crossref · retrieved 2026-09-25T13:02:18.849Z