Breaking the 1% unbound threshold: an IQ consortium whitepaper on the evaluation of plasma protein binding of highly bound compounds

Faraz Kazmi, Ulrike Gradhand, Eric T. Gangl, Robert Fricke, Tanya Aldinger, Rob Chambers, Massimiliano Donzelli, Douglas Ferguson, Bernard G. Francq, Paul J. Harradine, Rémi Kazma, Saro Mardirosian, Jean-Marie Nicolas, Raku Shinkyo, Sandrine Simon, Michael Sinz, Patricia Stuart, Kanaka Tatikola, Matthias Beat Wittwer, Gloria Vendrell-Navarro, Zhengyin Yan, John C. Kalvass

Open source

DOI: 10.1016/j.dmd.2026.100358
Published: 2026-09
Container: Drug Metabolism and Disposition
Publisher: Elsevier BV
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1016/j.dmd.2026.100358,
  title = {Breaking the 1\% unbound threshold: an IQ consortium whitepaper on the evaluation of plasma protein binding of highly bound compounds},
  author = {Faraz Kazmi and Ulrike Gradhand and Eric T. Gangl and Robert Fricke and Tanya Aldinger and Rob Chambers and Massimiliano Donzelli and Douglas Ferguson and Bernard G. Francq and Paul J. Harradine and Rémi Kazma and Saro Mardirosian and Jean-Marie Nicolas and Raku Shinkyo and Sandrine Simon and Michael Sinz and Patricia Stuart and Kanaka Tatikola and Matthias Beat Wittwer and Gloria Vendrell-Navarro and Zhengyin Yan and John C. Kalvass},
  year = {2026},
  journal = {Drug Metabolism and Disposition},
  doi = {10.1016/j.dmd.2026.100358},
  url = {https://doi.org/10.1016/j.dmd.2026.100358}
}

RIS

TY  - JOUR
TI  - Breaking the 1% unbound threshold: an IQ consortium whitepaper on the evaluation of plasma protein binding of highly bound compounds
AU  - Faraz Kazmi
AU  - Ulrike Gradhand
AU  - Eric T. Gangl
AU  - Robert Fricke
AU  - Tanya Aldinger
AU  - Rob Chambers
AU  - Massimiliano Donzelli
AU  - Douglas Ferguson
AU  - Bernard G. Francq
AU  - Paul J. Harradine
AU  - Rémi Kazma
AU  - Saro Mardirosian
AU  - Jean-Marie Nicolas
AU  - Raku Shinkyo
AU  - Sandrine Simon
AU  - Michael Sinz
AU  - Patricia Stuart
AU  - Kanaka Tatikola
AU  - Matthias Beat Wittwer
AU  - Gloria Vendrell-Navarro
AU  - Zhengyin Yan
AU  - John C. Kalvass
PY  - 2026
JO  - Drug Metabolism and Disposition
DO  - 10.1016/j.dmd.2026.100358
UR  - https://doi.org/10.1016/j.dmd.2026.100358
ER  -

APA

Kazmi, F., Gradhand, U., Gangl, E. T., Fricke, R., Aldinger, T., Chambers, R., Donzelli, M., Ferguson, D., Francq, B. G., Harradine, P. J., Kazma, R., Mardirosian, S., Nicolas, J., Shinkyo, R., Simon, S., Sinz, M., Stuart, P., Tatikola, K., Wittwer, M. B., Vendrell-Navarro, G., Yan, Z., & Kalvass, J. C. (2026). Breaking the 1% unbound threshold: an IQ consortium whitepaper on the evaluation of plasma protein binding of highly bound compounds. Drug Metabolism and Disposition. https://doi.org/10.1016/j.dmd.2026.100358

Source records

crossref · retrieved 2026-09-27T00:17:30.338Z