Efficacy and safety of tiotropium in partial and uncontrolled preschool asthma (TIPP): a phase III, multicentre, randomised, double-blind, placebo-controlled trial

Stefan Zielen, Nadine Wollscheid, Tanja Nickolay, Caroline Grimmel, David Scheele, Franziska Sattler, Freerk Prenzel, Michael Lorenz, Bianca Schaub, Christiane Lex, Franziska Stieglitz, Jordis Trischler, Helena Donath, Susanne Lau, Eckard Hamelmann, Christian Vogelberg, Michael Gerstlauer, Ruth Grychtol, Ralf Schubert, Monika Gappa, Lukas Schollenberger, Julia Wosniok

Open source

DOI: 10.1016/j.eclinm.2026.104172
Published: 2026-09
Container: eClinicalMedicine
Publisher: Elsevier BV
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1016/j.eclinm.2026.104172,
  title = {Efficacy and safety of tiotropium in partial and uncontrolled preschool asthma (TIPP): a phase III, multicentre, randomised, double-blind, placebo-controlled trial},
  author = {Stefan Zielen and Nadine Wollscheid and Tanja Nickolay and Caroline Grimmel and David Scheele and Franziska Sattler and Freerk Prenzel and Michael Lorenz and Bianca Schaub and Christiane Lex and Franziska Stieglitz and Jordis Trischler and Helena Donath and Susanne Lau and Eckard Hamelmann and Christian Vogelberg and Michael Gerstlauer and Ruth Grychtol and Ralf Schubert and Monika Gappa and Lukas Schollenberger and Julia Wosniok},
  year = {2026},
  journal = {eClinicalMedicine},
  doi = {10.1016/j.eclinm.2026.104172},
  url = {https://doi.org/10.1016/j.eclinm.2026.104172}
}

RIS

TY  - JOUR
TI  - Efficacy and safety of tiotropium in partial and uncontrolled preschool asthma (TIPP): a phase III, multicentre, randomised, double-blind, placebo-controlled trial
AU  - Stefan Zielen
AU  - Nadine Wollscheid
AU  - Tanja Nickolay
AU  - Caroline Grimmel
AU  - David Scheele
AU  - Franziska Sattler
AU  - Freerk Prenzel
AU  - Michael Lorenz
AU  - Bianca Schaub
AU  - Christiane Lex
AU  - Franziska Stieglitz
AU  - Jordis Trischler
AU  - Helena Donath
AU  - Susanne Lau
AU  - Eckard Hamelmann
AU  - Christian Vogelberg
AU  - Michael Gerstlauer
AU  - Ruth Grychtol
AU  - Ralf Schubert
AU  - Monika Gappa
AU  - Lukas Schollenberger
AU  - Julia Wosniok
PY  - 2026
JO  - eClinicalMedicine
DO  - 10.1016/j.eclinm.2026.104172
UR  - https://doi.org/10.1016/j.eclinm.2026.104172
ER  -

APA

Zielen, S., Wollscheid, N., Nickolay, T., Grimmel, C., Scheele, D., Sattler, F., Prenzel, F., Lorenz, M., Schaub, B., Lex, C., Stieglitz, F., Trischler, J., Donath, H., Lau, S., Hamelmann, E., Vogelberg, C., Gerstlauer, M., Grychtol, R., Schubert, R., Gappa, M., Schollenberger, L., & Wosniok, J. (2026). Efficacy and safety of tiotropium in partial and uncontrolled preschool asthma (TIPP): a phase III, multicentre, randomised, double-blind, placebo-controlled trial. eClinicalMedicine. https://doi.org/10.1016/j.eclinm.2026.104172

Source records

crossref · retrieved 2026-09-25T10:06:28.713Z