Early best available antibiotic therapy for multidrug-resistant gram-negative bloodstream infections: a target trial emulation

Luca Mezzadri, Wei Cong Tan, Xinxin Hao, Joan Quah, Abi Manesh, Ya-Ting Chang, Anh T.K. Nguyen, Ying Ding, Suwatthiya Kitsaran, Hock Hin Chua, Sotharith Bory, Sasheela Ponnampalavanar, Siriluck Anunnatsiri, Mohd Zulfakar Mazlan, Azizullah Khan Dhiloo, Rongpong Plongla, Andrea Lay-Hoon Kwa, Syed Faisal Mahmood, Arthur Dessi Roman, C Louise Thwaites, Phan Vinh Tho, Sheng Wu, Darunee Chotiprasitsakul, Ke Juin Wong, Hendri Wijaya, Cybele L. Abad, Muhammad Osama Rehman Khalid, Gazi Md. Salahuddin Mamun, Giri Shan Rajahram, Helio Gutierres, Huynh Ngoc Hon, Tran Van Giang, Ngoc Thach Pham, Abhilasha Karkey, Samanmalee Gunasekara, Raph L. Hamers, Robert Sinto, Inke N.D. Lubis, Minggui Wang, Merlin Moni, Po-Yu Liu, Yonghong Xiao, Basudha Khanal, N. Lakshmi Priya, Yohei Doi, Hitoshi Honda, Bayaraa Baljin, Ulziijargal Gurav, Rosmonaliza Asli, Lowell Ling, Ashesh Dhungana, Li-Yang Hsu, David L. Paterson, Yin Mo, Jie Su, May Gee Ong, Kee Mee Tan, Amanda Wei Ping Ling, Shweta Rajkumar Singh, Siew Pei Ong, Jia Rhou Lai, Shiau Hui Diong, Suchart Booraphun, Ratiporn Bansong, Xun Ting Tiong, Alisa Hanum Arba'eni, Sophany Koy, Seanghuoy Ho, Helmi Bin Sulaiman, Soo Nee Tang, Pope Kosalaraksa, Zeti Norfidiyati Salmuna, Gabriel Zherong Yan, Ambreen Fatima, Suvaporn Anugulruengkitt, Sadia Shakoor, Cecilia C. Maramba Lazarte, Thi Kim Anh Nguyen, Jinlan Lin, Pitak Santanirand, Ruth Tsin En Cheng, Rina Yunita, Nicole Bernadette Terre, Madiha Hashmi, Md. Ali Amin Nabin, Mohd Zaki Bin Mohd Zaili, Joshua Francis, H. Rogier van Doorn, Bidhya Sharma Sharma, Sumudu Withanage, Yulia R. Saharman, R. Lia Kusumawati Kusumawati, Xiaohua Qin, Chithra Tomy, Chien-Hao Tseng, Ping Shen, Shyam Prasad Kafle, T. Palaniappan, Shogo Hanai, Damdindorj Boldbaatar, Mohamed Ibrahim Ali Alsaman, Khurelbaatar Nyamdavaa, Damdindorj Boldbaatar, Christopher Lai, Santosh Poudel

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DOI: 10.1016/j.eclinm.2026.104302
Published: 2026-11
Container: eClinicalMedicine
Publisher: Elsevier BV
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1016/j.eclinm.2026.104302,
title = {Early best available antibiotic therapy for multidrug-resistant gram-negative bloodstream infections: a target trial emulation},
author = {Luca Mezzadri and Wei Cong Tan and Xinxin Hao and Joan Quah and Abi Manesh and Ya-Ting Chang and Anh T.K. Nguyen and Ying Ding and Suwatthiya Kitsaran and Hock Hin Chua and Sotharith Bory and Sasheela Ponnampalavanar and Siriluck Anunnatsiri and Mohd Zulfakar Mazlan and Azizullah Khan Dhiloo and Rongpong Plongla and Andrea Lay-Hoon Kwa and Syed Faisal Mahmood and Arthur Dessi Roman and C Louise Thwaites and Phan Vinh Tho and Sheng Wu and Darunee Chotiprasitsakul and Ke Juin Wong and Hendri Wijaya and Cybele L. Abad and Muhammad Osama Rehman Khalid and Gazi Md. Salahuddin Mamun and Giri Shan Rajahram and Helio Gutierres and Huynh Ngoc Hon and Tran Van Giang and Ngoc Thach Pham and Abhilasha Karkey and Samanmalee Gunasekara and Raph L. Hamers and Robert Sinto and Inke N.D. Lubis and Minggui Wang and Merlin Moni and Po-Yu Liu and Yonghong Xiao and Basudha Khanal and N. Lakshmi Priya and Yohei Doi and Hitoshi Honda and Bayaraa Baljin and Ulziijargal Gurav and Rosmonaliza Asli and Lowell Ling and Ashesh Dhungana and Li-Yang Hsu and David L. Paterson and Yin Mo and Jie Su and May Gee Ong and Kee Mee Tan and Amanda Wei Ping Ling and Shweta Rajkumar Singh and Siew Pei Ong and Jia Rhou Lai and Shiau Hui Diong and Suchart Booraphun and Ratiporn Bansong and Xun Ting Tiong and Alisa Hanum Arba'eni and Sophany Koy and Seanghuoy Ho and Helmi Bin Sulaiman and Soo Nee Tang and Pope Kosalaraksa and Zeti Norfidiyati Salmuna and Gabriel Zherong Yan and Ambreen Fatima and Suvaporn Anugulruengkitt and Sadia Shakoor and Cecilia C. Maramba Lazarte and Thi Kim Anh Nguyen and Jinlan Lin and Pitak Santanirand and Ruth Tsin En Cheng and Rina Yunita and Nicole Bernadette Terre and Madiha Hashmi and Md. Ali Amin Nabin and Mohd Zaki Bin Mohd Zaili and Joshua Francis and H. Rogier van Doorn and Bidhya Sharma Sharma and Sumudu Withanage and Yulia R. Saharman and R. Lia Kusumawati Kusumawati and Xiaohua Qin and Chithra Tomy and Chien-Hao Tseng and Ping Shen and Shyam Prasad Kafle and T. Palaniappan and Shogo Hanai and Damdindorj Boldbaatar and Mohamed Ibrahim Ali Alsaman and Khurelbaatar Nyamdavaa and Damdindorj Boldbaatar and Christopher Lai and Santosh Poudel},
year = {2026},
journal = {eClinicalMedicine},
doi = {10.1016/j.eclinm.2026.104302},
url = {https://doi.org/10.1016/j.eclinm.2026.104302}
}

RIS

TY  - JOUR
TI  - Early best available antibiotic therapy for multidrug-resistant gram-negative bloodstream infections: a target trial emulation
AU  - Luca Mezzadri
AU  - Wei Cong Tan
AU  - Xinxin Hao
AU  - Joan Quah
AU  - Abi Manesh
AU  - Ya-Ting Chang
AU  - Anh T.K. Nguyen
AU  - Ying Ding
AU  - Suwatthiya Kitsaran
AU  - Hock Hin Chua
AU  - Sotharith Bory
AU  - Sasheela Ponnampalavanar
AU  - Siriluck Anunnatsiri
AU  - Mohd Zulfakar Mazlan
AU  - Azizullah Khan Dhiloo
AU  - Rongpong Plongla
AU  - Andrea Lay-Hoon Kwa
AU  - Syed Faisal Mahmood
AU  - Arthur Dessi Roman
AU  - C Louise Thwaites
AU  - Phan Vinh Tho
AU  - Sheng Wu
AU  - Darunee Chotiprasitsakul
AU  - Ke Juin Wong
AU  - Hendri Wijaya
AU  - Cybele L. Abad
AU  - Muhammad Osama Rehman Khalid
AU  - Gazi Md. Salahuddin Mamun
AU  - Giri Shan Rajahram
AU  - Helio Gutierres
AU  - Huynh Ngoc Hon
AU  - Tran Van Giang
AU  - Ngoc Thach Pham
AU  - Abhilasha Karkey
AU  - Samanmalee Gunasekara
AU  - Raph L. Hamers
AU  - Robert Sinto
AU  - Inke N.D. Lubis
AU  - Minggui Wang
AU  - Merlin Moni
AU  - Po-Yu Liu
AU  - Yonghong Xiao
AU  - Basudha Khanal
AU  - N. Lakshmi Priya
AU  - Yohei Doi
AU  - Hitoshi Honda
AU  - Bayaraa Baljin
AU  - Ulziijargal Gurav
AU  - Rosmonaliza Asli
AU  - Lowell Ling
AU  - Ashesh Dhungana
AU  - Li-Yang Hsu
AU  - David L. Paterson
AU  - Yin Mo
AU  - Jie Su
AU  - May Gee Ong
AU  - Kee Mee Tan
AU  - Amanda Wei Ping Ling
AU  - Shweta Rajkumar Singh
AU  - Siew Pei Ong
AU  - Jia Rhou Lai
AU  - Shiau Hui Diong
AU  - Suchart Booraphun
AU  - Ratiporn Bansong
AU  - Xun Ting Tiong
AU  - Alisa Hanum Arba'eni
AU  - Sophany Koy
AU  - Seanghuoy Ho
AU  - Helmi Bin Sulaiman
AU  - Soo Nee Tang
AU  - Pope Kosalaraksa
AU  - Zeti Norfidiyati Salmuna
AU  - Gabriel Zherong Yan
AU  - Ambreen Fatima
AU  - Suvaporn Anugulruengkitt
AU  - Sadia Shakoor
AU  - Cecilia C. Maramba Lazarte
AU  - Thi Kim Anh Nguyen
AU  - Jinlan Lin
AU  - Pitak Santanirand
AU  - Ruth Tsin En Cheng
AU  - Rina Yunita
AU  - Nicole Bernadette Terre
AU  - Madiha Hashmi
AU  - Md. Ali Amin Nabin
AU  - Mohd Zaki Bin Mohd Zaili
AU  - Joshua Francis
AU  - H. Rogier van Doorn
AU  - Bidhya Sharma Sharma
AU  - Sumudu Withanage
AU  - Yulia R. Saharman
AU  - R. Lia Kusumawati Kusumawati
AU  - Xiaohua Qin
AU  - Chithra Tomy
AU  - Chien-Hao Tseng
AU  - Ping Shen
AU  - Shyam Prasad Kafle
AU  - T. Palaniappan
AU  - Shogo Hanai
AU  - Damdindorj Boldbaatar
AU  - Mohamed Ibrahim Ali Alsaman
AU  - Khurelbaatar Nyamdavaa
AU  - Damdindorj Boldbaatar
AU  - Christopher Lai
AU  - Santosh Poudel
PY  - 2026
JO  - eClinicalMedicine
DO  - 10.1016/j.eclinm.2026.104302
UR  - https://doi.org/10.1016/j.eclinm.2026.104302
ER  -

APA

Mezzadri, L., Tan, W. C., Hao, X., Quah, J., Manesh, A., Chang, Y., Nguyen, A. T., Ding, Y., Kitsaran, S., Chua, H. H., Bory, S., Ponnampalavanar, S., Anunnatsiri, S., Mazlan, M. Z., Dhiloo, A. K., Plongla, R., Kwa, A. L., Mahmood, S. F., Roman, A. D., Thwaites, C. L., Tho, P. V., Wu, S., Chotiprasitsakul, D., Wong, K. J., Wijaya, H., Abad, C. L., Khalid, M. O. R., Mamun, G. M. S., Rajahram, G. S., Gutierres, H., Hon, H. N., Giang, T. V., Pham, N. T., Karkey, A., Gunasekara, S., Hamers, R. L., Sinto, R., Lubis, I. N., Wang, M., Moni, M., Liu, P., Xiao, Y., Khanal, B., Priya, N. L., Doi, Y., Honda, H., Baljin, B., Gurav, U., Asli, R., Ling, L., Dhungana, A., Hsu, L., Paterson, D. L., Mo, Y., Su, J., Ong, M. G., Tan, K. M., Ling, A. W. P., Singh, S. R., Ong, S. P., Lai, J. R., Diong, S. H., Booraphun, S., Bansong, R., Tiong, X. T., Arba'eni, A. H., Koy, S., Ho, S., Sulaiman, H. B., Tang, S. N., Kosalaraksa, P., Salmuna, Z. N., Yan, G. Z., Fatima, A., Anugulruengkitt, S., Shakoor, S., Lazarte, C. C. M., Nguyen, T. K. A., Lin, J., Santanirand, P., Cheng, R. T. E., Yunita, R., Terre, N. B., Hashmi, M., Nabin, M. A. A., Zaili, M. Z. B. M., Francis, J., Doorn, H. R. V., Sharma, B. S., Withanage, S., Saharman, Y. R., Kusumawati, R. L. K., Qin, X., Tomy, C., Tseng, C., Shen, P., Kafle, S. P., Palaniappan, T., Hanai, S., Boldbaatar, D., Alsaman, M. I. A., Nyamdavaa, K., Boldbaatar, D., Lai, C., & Poudel, S. (2026). Early best available antibiotic therapy for multidrug-resistant gram-negative bloodstream infections: a target trial emulation. eClinicalMedicine. https://doi.org/10.1016/j.eclinm.2026.104302

Source records

crossref · retrieved 2026-11-10T00:06:09.927Z