Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability.

Federico S, Khan T, Fontana A, Brogi S, Benedetti R, Sarno F, Carullo G, Pezzotta A, Saraswati AP, Passaro E, Pozzetti L, Papa A, Relitti N, Gemma S, Butini S, Pistocchi A, Ramunno A, Vincenzi F, Varani K, Tatangelo V, Patrussi L, Baldari CT, Saponara S, Gorelli B, Lamponi S, Valoti M, Saccoccia F, Giannaccari M, Ruberti G, Herp D, Jung M, Altucci L, Campiani G

Open source

DOI: 10.1016/j.ejmech.2022.114409
Published: 2022 Aug 5
Container: European journal of medicinal chemistry
Publisher: Not recorded
Open access: unknown

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1016/j.ejmech.2022.114409,
  title = {Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability.},
  author = {Federico S and Khan T and Fontana A and Brogi S and Benedetti R and Sarno F and Carullo G and Pezzotta A and Saraswati AP and Passaro E and Pozzetti L and Papa A and Relitti N and Gemma S and Butini S and Pistocchi A and Ramunno A and Vincenzi F and Varani K and Tatangelo V and Patrussi L and Baldari CT and Saponara S and Gorelli B and Lamponi S and Valoti M and Saccoccia F and Giannaccari M and Ruberti G and Herp D and Jung M and Altucci L and Campiani G},
  year = {2022},
  journal = {European journal of medicinal chemistry},
  doi = {10.1016/j.ejmech.2022.114409},
  url = {https://doi.org/10.1016/j.ejmech.2022.114409}
}

RIS

TY  - JOUR
TI  - Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability.
AU  - Federico S
AU  - Khan T
AU  - Fontana A
AU  - Brogi S
AU  - Benedetti R
AU  - Sarno F
AU  - Carullo G
AU  - Pezzotta A
AU  - Saraswati AP
AU  - Passaro E
AU  - Pozzetti L
AU  - Papa A
AU  - Relitti N
AU  - Gemma S
AU  - Butini S
AU  - Pistocchi A
AU  - Ramunno A
AU  - Vincenzi F
AU  - Varani K
AU  - Tatangelo V
AU  - Patrussi L
AU  - Baldari CT
AU  - Saponara S
AU  - Gorelli B
AU  - Lamponi S
AU  - Valoti M
AU  - Saccoccia F
AU  - Giannaccari M
AU  - Ruberti G
AU  - Herp D
AU  - Jung M
AU  - Altucci L
AU  - Campiani G
PY  - 2022
JO  - European journal of medicinal chemistry
DO  - 10.1016/j.ejmech.2022.114409
UR  - https://doi.org/10.1016/j.ejmech.2022.114409
ER  -

APA

S, F., T, K., A, F., S, B., R, B., F, S., G, C., A, P., AP, S., E, P., L, P., A, P., N, R., S, G., S, B., A, P., A, R., F, V., K, V., V, T., L, P., CT, B., S, S., B, G., S, L., M, V., F, S., M, G., G, R., D, H., M, J., L, A., & G, C. (2022). Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability.. European journal of medicinal chemistry. https://doi.org/10.1016/j.ejmech.2022.114409

Source records

pubmed · retrieved 2026-09-25T15:14:55.877Z