Design and development of 1,5-diarylpyrazole-based multitarget-directed ligands as dual COX-2/HDAC6 inhibitors for Alzheimer's disease therapy: Molecular dynamics and experimental insights

Kamal S. Abdelrahman, Osama M. Soltan, Hend E. Abo Mansour, Amany E. Nofal, Eman A. Eissa, Heba Rady Salem, Marwa M. Mahfouz, Samar A. El-Adawy, Ghada S.A. Ewies, Abdelrahman Hamdi, Mostafa M. Elbadawi, Ahmed H.A. Abusabaa, Ahmed A. El-Rashedy, Hiroyuki Konno, Amr K.A. Bass

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DOI: 10.1016/j.ejmech.2026.118738
Published: 2026-05
Container: European Journal of Medicinal Chemistry
Publisher: Elsevier BV
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1016/j.ejmech.2026.118738,
  title = {Design and development of 1,5-diarylpyrazole-based multitarget-directed ligands as dual COX-2/HDAC6 inhibitors for Alzheimer's disease therapy: Molecular dynamics and experimental insights},
  author = {Kamal S. Abdelrahman and Osama M. Soltan and Hend E. Abo Mansour and Amany E. Nofal and Eman A. Eissa and Heba Rady Salem and Marwa M. Mahfouz and Samar A. El-Adawy and Ghada S.A. Ewies and Abdelrahman Hamdi and Mostafa M. Elbadawi and Ahmed H.A. Abusabaa and Ahmed A. El-Rashedy and Hiroyuki Konno and Amr K.A. Bass},
  year = {2026},
  journal = {European Journal of Medicinal Chemistry},
  doi = {10.1016/j.ejmech.2026.118738},
  url = {https://doi.org/10.1016/j.ejmech.2026.118738}
}

RIS

TY  - JOUR
TI  - Design and development of 1,5-diarylpyrazole-based multitarget-directed ligands as dual COX-2/HDAC6 inhibitors for Alzheimer's disease therapy: Molecular dynamics and experimental insights
AU  - Kamal S. Abdelrahman
AU  - Osama M. Soltan
AU  - Hend E. Abo Mansour
AU  - Amany E. Nofal
AU  - Eman A. Eissa
AU  - Heba Rady Salem
AU  - Marwa M. Mahfouz
AU  - Samar A. El-Adawy
AU  - Ghada S.A. Ewies
AU  - Abdelrahman Hamdi
AU  - Mostafa M. Elbadawi
AU  - Ahmed H.A. Abusabaa
AU  - Ahmed A. El-Rashedy
AU  - Hiroyuki Konno
AU  - Amr K.A. Bass
PY  - 2026
JO  - European Journal of Medicinal Chemistry
DO  - 10.1016/j.ejmech.2026.118738
UR  - https://doi.org/10.1016/j.ejmech.2026.118738
ER  -

APA

Abdelrahman, K. S., Soltan, O. M., Mansour, H. E. A., Nofal, A. E., Eissa, E. A., Salem, H. R., Mahfouz, M. M., El-Adawy, S. A., Ewies, G. S., Hamdi, A., Elbadawi, M. M., Abusabaa, A. H., El-Rashedy, A. A., Konno, H., & Bass, A. K. (2026). Design and development of 1,5-diarylpyrazole-based multitarget-directed ligands as dual COX-2/HDAC6 inhibitors for Alzheimer's disease therapy: Molecular dynamics and experimental insights. European Journal of Medicinal Chemistry. https://doi.org/10.1016/j.ejmech.2026.118738

Source records

crossref · retrieved 2026-09-27T02:30:59.068Z