Discovery of a novel 10-hydroxy-12-methyl-substituted evodiamine derivative with anti-hepatocellular carcinoma activity through multi-pathway modulation involving suppression of PKA/AKT signaling cascades and moderate Topo I inhibition
- DOI
- 10.1016/j.ejmech.2026.119226
- Published
- 2026-12
- Container
- European Journal of Medicinal Chemistry
- Publisher
- Elsevier BV
- Open access
- unknown
Credibility signals
uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.
Show all credibility signals
- supportingDOI registered: A matching record was returned by Crossref.
- supportingDOI resolves: A matching record was returned by Crossref.
- not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility.
- not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made.
- not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made.
- not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made.
- not scoredROR affiliation: Not checked or no result supplied; no credibility inference made.
- not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete.
- not scoredOpen access status: Not checked or no result supplied; no credibility inference made.
- not scoredPublication license: Not checked or no result supplied; no credibility inference made.
- not scoredPublication version: A publication version was supplied but is not scored.
- supportingMetadata completeness: All 6 scored descriptive metadata groups are present.
Cite this work
BibTeX
@article{allodium:10.1016/j.ejmech.2026.119226,
title = {Discovery of a novel 10-hydroxy-12-methyl-substituted evodiamine derivative with anti-hepatocellular carcinoma activity through multi-pathway modulation involving suppression of PKA/AKT signaling cascades and moderate Topo I inhibition},
author = {Yan Peng and Zixuan Li and Hanxuan Mo and Xinyu Deng and Xinjue Ping and Lele Zhou and Chaofeng Feng and Keting Wu and Yongxia Xiong and Lin Long and Huihong Wang and Linsheng Zhuo and Zhen Wang and Xuelin Li},
year = {2026},
journal = {European Journal of Medicinal Chemistry},
doi = {10.1016/j.ejmech.2026.119226},
url = {https://doi.org/10.1016/j.ejmech.2026.119226}
}RIS
TY - JOUR TI - Discovery of a novel 10-hydroxy-12-methyl-substituted evodiamine derivative with anti-hepatocellular carcinoma activity through multi-pathway modulation involving suppression of PKA/AKT signaling cascades and moderate Topo I inhibition AU - Yan Peng AU - Zixuan Li AU - Hanxuan Mo AU - Xinyu Deng AU - Xinjue Ping AU - Lele Zhou AU - Chaofeng Feng AU - Keting Wu AU - Yongxia Xiong AU - Lin Long AU - Huihong Wang AU - Linsheng Zhuo AU - Zhen Wang AU - Xuelin Li PY - 2026 JO - European Journal of Medicinal Chemistry DO - 10.1016/j.ejmech.2026.119226 UR - https://doi.org/10.1016/j.ejmech.2026.119226 ER -
APA
Peng, Y., Li, Z., Mo, H., Deng, X., Ping, X., Zhou, L., Feng, C., Wu, K., Xiong, Y., Long, L., Wang, H., Zhuo, L., Wang, Z., & Li, X. (2026). Discovery of a novel 10-hydroxy-12-methyl-substituted evodiamine derivative with anti-hepatocellular carcinoma activity through multi-pathway modulation involving suppression of PKA/AKT signaling cascades and moderate Topo I inhibition. European Journal of Medicinal Chemistry. https://doi.org/10.1016/j.ejmech.2026.119226
Source records
- crossref · retrieved 2026-09-26T20:51:00.452Z