Conformational flexibility governs phosphate-induced solubility enhancement: a comparative study of cimetidine and famotidine by pH-dependent dissolution, NMR titration, DOSY, and DFT analysis.

Tsunoda C, Goto S, Hiroshige R, Hasegawa K, Kasai T, Kataoka H, Tsuchida T, Terada H

DOI: 10.1016/j.ejpb.2026.115235
Published: 2026 Sep 16
Container: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Publisher: Not recorded
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1016/j.ejpb.2026.115235,
  title = {Conformational flexibility governs phosphate-induced solubility enhancement: a comparative study of cimetidine and famotidine by pH-dependent dissolution, NMR titration, DOSY, and DFT analysis.},
  author = {Tsunoda C and Goto S and Hiroshige R and Hasegawa K and Kasai T and Kataoka H and Tsuchida T and Terada H},
  year = {2026},
  journal = {European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  doi = {10.1016/j.ejpb.2026.115235},
  url = {https://doi.org/10.1016/j.ejpb.2026.115235}
}

RIS

TY  - JOUR
TI  - Conformational flexibility governs phosphate-induced solubility enhancement: a comparative study of cimetidine and famotidine by pH-dependent dissolution, NMR titration, DOSY, and DFT analysis.
AU  - Tsunoda C
AU  - Goto S
AU  - Hiroshige R
AU  - Hasegawa K
AU  - Kasai T
AU  - Kataoka H
AU  - Tsuchida T
AU  - Terada H
PY  - 2026
JO  - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
DO  - 10.1016/j.ejpb.2026.115235
UR  - https://doi.org/10.1016/j.ejpb.2026.115235
ER  -

APA

C, T., S, G., R, H., K, H., T, K., H, K., T, T., & H, T. (2026). Conformational flexibility governs phosphate-induced solubility enhancement: a comparative study of cimetidine and famotidine by pH-dependent dissolution, NMR titration, DOSY, and DFT analysis.. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. https://doi.org/10.1016/j.ejpb.2026.115235

Source records

pubmed · retrieved 2026-09-25T00:23:54.528Z