Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

BibTeX

@article{allodium:10.1016/j.immuni.2017.03.013,
  title = {Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors},
  author = {Frederick Arce Vargas and Andrew J.S. Furness and Isabelle Solomon and Kroopa Joshi and Leila Mekkaoui and Marta H. Lesko and Enrique Miranda Rota and Rony Dahan and Andrew Georgiou and Anna Sledzinska and Assma Ben Aissa and Dafne Franz and Mariana Werner Sunderland and Yien Ning Sophia Wong and Jake Y. Henry and Tim O’Brien and David Nicol and Ben Challacombe and Stephen A. Beers and Lavinia Spain and Andrew Wotherspoon and Nicholas Francis and Myles Smith and Dirk Strauss and Andrew Hayes and Aspasia Soultati and Mark Stares and Lavinia Spain and Joanna Lynch and Nicos Fotiadis and Archana Fernando and Steve Hazell and Ashish Chandra and Lisa Pickering and Sarah Rudman and Simon Chowdhury and Charles Swanton and Mariam Jamal-Hanjani and Selvaraju Veeriah and Seema Shafi and Justyna Czyzewska-Khan and Diana Johnson and Joanne Laycock and Leticia Bosshard-Carter and Gerald Goh and Rachel Rosenthal and Pat Gorman and Nirupa Murugaesu and Robert E. Hynds and Gareth Wilson and Nicolai J. Birkbak and Thomas B.K. Watkins and Nicholas McGranahan and Stuart Horswell and Richard Mitter and Mickael Escudero and Aengus Stewart and Peter Van Loo and Andrew Rowan and Hang Xu and Samra Turajlic and Crispin Hiley and Christopher Abbosh and Jacki Goldman and Richard Kevin Stone and Tamara Denner and Nik Matthews and Greg Elgar and Sophia Ward and Jennifer Biggs and Marta Costa and Sharmin Begum and Ben Phillimore and Tim Chambers and Emma Nye and Sofia Graca and Maise Al Bakir and John A. Hartley and Helen L. Lowe and Javier Herrero and David Lawrence and Martin Hayward and Nikolaos Panagiotopoulos and Shyam Kolvekar and Mary Falzon and Elaine Borg and Celia Simeon and Gemma Hector and Amy Smith and Marie Aranda and Marco Novelli and Dahmane Oukrif and Sam M. Janes and Ricky Thakrar and Martin Forster and Tanya Ahmad and Siow Ming Lee and Dionysis Papadatos-Pastos and Dawn Carnell and Ruheena Mendes and Jeremy George and Neal Navani and Asia Ahmed and Magali Taylor and Junaid Choudhary and Yvonne Summers and Raffaele Califano and Paul Taylor and Rajesh Shah and Piotr Krysiak and Kendadai Rammohan and Eustace Fontaine and Richard Booton and Matthew Evison and Phil Crosbie and Stuart Moss and Faiza Idries and Leena Joseph and Paul Bishop and Anshuman Chaturved and Anne Marie Quinn and Helen Doran and Angela Leek and Phil Harrison and Katrina Moore and Rachael Waddington and Juliette Novasio and Fiona Blackhall and Jane Rogan and Elaine Smith and Caroline Dive and Jonathan Tugwood and Ged Brady and Dominic G. Rothwell and Francesca Chemi and Jackie Pierce and Sakshi Gulati and Babu Naidu and Gerald Langman and Simon Trotter and Mary Bellamy and Hollie Bancroft and Amy Kerr and Salma Kadiri and Joanne Webb and Gary Middleton and Madava Djearaman and Dean Fennell and Jacqui A. Shaw and John Le Quesne and David Moore and Apostolos Nakas and Sridhar Rathinam and William Monteiro and Hilary Marshall and Louise Nelson and Jonathan Bennett and Joan Riley and Lindsay Primrose and Luke Martinson and Girija Anand and Sajid Khan and Anita Amadi and Marianne Nicolson and Keith Kerr and Shirley Palmer and Hardy Remmen and Joy Miller and Keith Buchan and Mahendran Chetty and Lesley Gomersall and Jason Lester and Alison Edwards and Fiona Morgan and Haydn Adams and Helen Davies and Malgorzata Kornaszewska and Richard Attanoos and Sara Lock and Azmina Verjee and Mairead MacKenzie and Maggie Wilcox and Harriet Bell and Natasha Iles and Allan Hackshaw and Yenting Ngai and Sean Smith and Nicole Gower and Christian Ottensmeier and Serena Chee and Benjamin Johnson and Aiman Alzetani and Emily Shaw and Eric Lim and Paulo De Sousa and Monica Tavares Barbosa and Alex Bowman and Simon Jorda and Alexandra Rice and Hilgardt Raubenheimer and Chiara Proli and Maria Elena Cufari and John Carlo Ronquillo and Angela Kwayie and Harshil Bhayani and Morag Hamilton and Yusura Bakar and Natalie Mensah and Lyn Ambrose and Anand Devaraj and Silviu Buderi and Jonathan Finch and Leire Azcarate and Hema Chavan and Sophie Green and Hillaria Mashinga and Andrew G. Nicholson and Kelvin Lau and Michael Sheaff and Peter Schmid and John Conibear and Veni Ezhil and Babikir Ismail and Melanie Irvin-sellers and Vineet Prakash and Peter Russell and Teresa Light and Tracey Horey and Sarah Danson and Jonathan Bury and John Edwards and Jennifer Hill and Sue Matthews and Yota Kitsanta and Kim Suvarna and Patricia Fisher and Allah Dino Keerio and Michael Shackcloth and John Gosney and Pieter Postmus and Sarah Feeney and Julius Asante-Siaw and Samra Turajlic and Martin Gore and James Larkin and Charles Swanton and Kerry A. Chester and Martin Pule and Jeffrey V. Ravetch and Teresa Marafioti and Karl S. Peggs and Sergio A. Quezada},
  year = {2017},
  journal = {Immunity},
  doi = {10.1016/j.immuni.2017.03.013},
  url = {https://doi.org/10.1016/j.immuni.2017.03.013}
}

RIS

TY  - JOUR
TI  - Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors
AU  - Frederick Arce Vargas
AU  - Andrew J.S. Furness
AU  - Isabelle Solomon
AU  - Kroopa Joshi
AU  - Leila Mekkaoui
AU  - Marta H. Lesko
AU  - Enrique Miranda Rota
AU  - Rony Dahan
AU  - Andrew Georgiou
AU  - Anna Sledzinska
AU  - Assma Ben Aissa
AU  - Dafne Franz
AU  - Mariana Werner Sunderland
AU  - Yien Ning Sophia Wong
AU  - Jake Y. Henry
AU  - Tim O’Brien
AU  - David Nicol
AU  - Ben Challacombe
AU  - Stephen A. Beers
AU  - Lavinia Spain
AU  - Andrew Wotherspoon
AU  - Nicholas Francis
AU  - Myles Smith
AU  - Dirk Strauss
AU  - Andrew Hayes
AU  - Aspasia Soultati
AU  - Mark Stares
AU  - Lavinia Spain
AU  - Joanna Lynch
AU  - Nicos Fotiadis
AU  - Archana Fernando
AU  - Steve Hazell
AU  - Ashish Chandra
AU  - Lisa Pickering
AU  - Sarah Rudman
AU  - Simon Chowdhury
AU  - Charles Swanton
AU  - Mariam Jamal-Hanjani
AU  - Selvaraju Veeriah
AU  - Seema Shafi
AU  - Justyna Czyzewska-Khan
AU  - Diana Johnson
AU  - Joanne Laycock
AU  - Leticia Bosshard-Carter
AU  - Gerald Goh
AU  - Rachel Rosenthal
AU  - Pat Gorman
AU  - Nirupa Murugaesu
AU  - Robert E. Hynds
AU  - Gareth Wilson
AU  - Nicolai J. Birkbak
AU  - Thomas B.K. Watkins
AU  - Nicholas McGranahan
AU  - Stuart Horswell
AU  - Richard Mitter
AU  - Mickael Escudero
AU  - Aengus Stewart
AU  - Peter Van Loo
AU  - Andrew Rowan
AU  - Hang Xu
AU  - Samra Turajlic
AU  - Crispin Hiley
AU  - Christopher Abbosh
AU  - Jacki Goldman
AU  - Richard Kevin Stone
AU  - Tamara Denner
AU  - Nik Matthews
AU  - Greg Elgar
AU  - Sophia Ward
AU  - Jennifer Biggs
AU  - Marta Costa
AU  - Sharmin Begum
AU  - Ben Phillimore
AU  - Tim Chambers
AU  - Emma Nye
AU  - Sofia Graca
AU  - Maise Al Bakir
AU  - John A. Hartley
AU  - Helen L. Lowe
AU  - Javier Herrero
AU  - David Lawrence
AU  - Martin Hayward
AU  - Nikolaos Panagiotopoulos
AU  - Shyam Kolvekar
AU  - Mary Falzon
AU  - Elaine Borg
AU  - Celia Simeon
AU  - Gemma Hector
AU  - Amy Smith
AU  - Marie Aranda
AU  - Marco Novelli
AU  - Dahmane Oukrif
AU  - Sam M. Janes
AU  - Ricky Thakrar
AU  - Martin Forster
AU  - Tanya Ahmad
AU  - Siow Ming Lee
AU  - Dionysis Papadatos-Pastos
AU  - Dawn Carnell
AU  - Ruheena Mendes
AU  - Jeremy George
AU  - Neal Navani
AU  - Asia Ahmed
AU  - Magali Taylor
AU  - Junaid Choudhary
AU  - Yvonne Summers
AU  - Raffaele Califano
AU  - Paul Taylor
AU  - Rajesh Shah
AU  - Piotr Krysiak
AU  - Kendadai Rammohan
AU  - Eustace Fontaine
AU  - Richard Booton
AU  - Matthew Evison
AU  - Phil Crosbie
AU  - Stuart Moss
AU  - Faiza Idries
AU  - Leena Joseph
AU  - Paul Bishop
AU  - Anshuman Chaturved
AU  - Anne Marie Quinn
AU  - Helen Doran
AU  - Angela Leek
AU  - Phil Harrison
AU  - Katrina Moore
AU  - Rachael Waddington
AU  - Juliette Novasio
AU  - Fiona Blackhall
AU  - Jane Rogan
AU  - Elaine Smith
AU  - Caroline Dive
AU  - Jonathan Tugwood
AU  - Ged Brady
AU  - Dominic G. Rothwell
AU  - Francesca Chemi
AU  - Jackie Pierce
AU  - Sakshi Gulati
AU  - Babu Naidu
AU  - Gerald Langman
AU  - Simon Trotter
AU  - Mary Bellamy
AU  - Hollie Bancroft
AU  - Amy Kerr
AU  - Salma Kadiri
AU  - Joanne Webb
AU  - Gary Middleton
AU  - Madava Djearaman
AU  - Dean Fennell
AU  - Jacqui A. Shaw
AU  - John Le Quesne
AU  - David Moore
AU  - Apostolos Nakas
AU  - Sridhar Rathinam
AU  - William Monteiro
AU  - Hilary Marshall
AU  - Louise Nelson
AU  - Jonathan Bennett
AU  - Joan Riley
AU  - Lindsay Primrose
AU  - Luke Martinson
AU  - Girija Anand
AU  - Sajid Khan
AU  - Anita Amadi
AU  - Marianne Nicolson
AU  - Keith Kerr
AU  - Shirley Palmer
AU  - Hardy Remmen
AU  - Joy Miller
AU  - Keith Buchan
AU  - Mahendran Chetty
AU  - Lesley Gomersall
AU  - Jason Lester
AU  - Alison Edwards
AU  - Fiona Morgan
AU  - Haydn Adams
AU  - Helen Davies
AU  - Malgorzata Kornaszewska
AU  - Richard Attanoos
AU  - Sara Lock
AU  - Azmina Verjee
AU  - Mairead MacKenzie
AU  - Maggie Wilcox
AU  - Harriet Bell
AU  - Natasha Iles
AU  - Allan Hackshaw
AU  - Yenting Ngai
AU  - Sean Smith
AU  - Nicole Gower
AU  - Christian Ottensmeier
AU  - Serena Chee
AU  - Benjamin Johnson
AU  - Aiman Alzetani
AU  - Emily Shaw
AU  - Eric Lim
AU  - Paulo De Sousa
AU  - Monica Tavares Barbosa
AU  - Alex Bowman
AU  - Simon Jorda
AU  - Alexandra Rice
AU  - Hilgardt Raubenheimer
AU  - Chiara Proli
AU  - Maria Elena Cufari
AU  - John Carlo Ronquillo
AU  - Angela Kwayie
AU  - Harshil Bhayani
AU  - Morag Hamilton
AU  - Yusura Bakar
AU  - Natalie Mensah
AU  - Lyn Ambrose
AU  - Anand Devaraj
AU  - Silviu Buderi
AU  - Jonathan Finch
AU  - Leire Azcarate
AU  - Hema Chavan
AU  - Sophie Green
AU  - Hillaria Mashinga
AU  - Andrew G. Nicholson
AU  - Kelvin Lau
AU  - Michael Sheaff
AU  - Peter Schmid
AU  - John Conibear
AU  - Veni Ezhil
AU  - Babikir Ismail
AU  - Melanie Irvin-sellers
AU  - Vineet Prakash
AU  - Peter Russell
AU  - Teresa Light
AU  - Tracey Horey
AU  - Sarah Danson
AU  - Jonathan Bury
AU  - John Edwards
AU  - Jennifer Hill
AU  - Sue Matthews
AU  - Yota Kitsanta
AU  - Kim Suvarna
AU  - Patricia Fisher
AU  - Allah Dino Keerio
AU  - Michael Shackcloth
AU  - John Gosney
AU  - Pieter Postmus
AU  - Sarah Feeney
AU  - Julius Asante-Siaw
AU  - Samra Turajlic
AU  - Martin Gore
AU  - James Larkin
AU  - Charles Swanton
AU  - Kerry A. Chester
AU  - Martin Pule
AU  - Jeffrey V. Ravetch
AU  - Teresa Marafioti
AU  - Karl S. Peggs
AU  - Sergio A. Quezada
PY  - 2017
JO  - Immunity
DO  - 10.1016/j.immuni.2017.03.013
UR  - https://doi.org/10.1016/j.immuni.2017.03.013
ER  - 

APA

Vargas, F. A., Furness, A. J., Solomon, I., Joshi, K., Mekkaoui, L., Lesko, M. H., Rota, E. M., Dahan, R., Georgiou, A., Sledzinska, A., Aissa, A. B., Franz, D., Sunderland, M. W., Wong, Y. N. S., Henry, J. Y., O’Brien, T., Nicol, D., Challacombe, B., Beers, S. A., Spain, L., Wotherspoon, A., Francis, N., Smith, M., Strauss, D., Hayes, A., Soultati, A., Stares, M., Spain, L., Lynch, J., Fotiadis, N., Fernando, A., Hazell, S., Chandra, A., Pickering, L., Rudman, S., Chowdhury, S., Swanton, C., Jamal-Hanjani, M., Veeriah, S., Shafi, S., Czyzewska-Khan, J., Johnson, D., Laycock, J., Bosshard-Carter, L., Goh, G., Rosenthal, R., Gorman, P., Murugaesu, N., Hynds, R. E., Wilson, G., Birkbak, N. J., Watkins, T. B., McGranahan, N., Horswell, S., Mitter, R., Escudero, M., Stewart, A., Loo, P. V., Rowan, A., Xu, H., Turajlic, S., Hiley, C., Abbosh, C., Goldman, J., Stone, R. K., Denner, T., Matthews, N., Elgar, G., Ward, S., Biggs, J., Costa, M., Begum, S., Phillimore, B., Chambers, T., Nye, E., Graca, S., Bakir, M. A., Hartley, J. A., Lowe, H. L., Herrero, J., Lawrence, D., Hayward, M., Panagiotopoulos, N., Kolvekar, S., Falzon, M., Borg, E., Simeon, C., Hector, G., Smith, A., Aranda, M., Novelli, M., Oukrif, D., Janes, S. M., Thakrar, R., Forster, M., Ahmad, T., Lee, S. M., Papadatos-Pastos, D., Carnell, D., Mendes, R., George, J., Navani, N., Ahmed, A., Taylor, M., Choudhary, J., Summers, Y., Califano, R., Taylor, P., Shah, R., Krysiak, P., Rammohan, K., Fontaine, E., Booton, R., Evison, M., Crosbie, P., Moss, S., Idries, F., Joseph, L., Bishop, P., Chaturved, A., Quinn, A. M., Doran, H., Leek, A., Harrison, P., Moore, K., Waddington, R., Novasio, J., Blackhall, F., Rogan, J., Smith, E., Dive, C., Tugwood, J., Brady, G., Rothwell, D. G., Chemi, F., Pierce, J., Gulati, S., Naidu, B., Langman, G., Trotter, S., Bellamy, M., Bancroft, H., Kerr, A., Kadiri, S., Webb, J., Middleton, G., Djearaman, M., Fennell, D., Shaw, J. A., Quesne, J. L., Moore, D., Nakas, A., Rathinam, S., Monteiro, W., Marshall, H., Nelson, L., Bennett, J., Riley, J., Primrose, L., Martinson, L., Anand, G., Khan, S., Amadi, A., Nicolson, M., Kerr, K., Palmer, S., Remmen, H., Miller, J., Buchan, K., Chetty, M., Gomersall, L., Lester, J., Edwards, A., Morgan, F., Adams, H., Davies, H., Kornaszewska, M., Attanoos, R., Lock, S., Verjee, A., MacKenzie, M., Wilcox, M., Bell, H., Iles, N., Hackshaw, A., Ngai, Y., Smith, S., Gower, N., Ottensmeier, C., Chee, S., Johnson, B., Alzetani, A., Shaw, E., Lim, E., Sousa, P. D., Barbosa, M. T., Bowman, A., Jorda, S., Rice, A., Raubenheimer, H., Proli, C., Cufari, M. E., Ronquillo, J. C., Kwayie, A., Bhayani, H., Hamilton, M., Bakar, Y., Mensah, N., Ambrose, L., Devaraj, A., Buderi, S., Finch, J., Azcarate, L., Chavan, H., Green, S., Mashinga, H., Nicholson, A. G., Lau, K., Sheaff, M., Schmid, P., Conibear, J., Ezhil, V., Ismail, B., Irvin-sellers, M., Prakash, V., Russell, P., Light, T., Horey, T., Danson, S., Bury, J., Edwards, J., Hill, J., Matthews, S., Kitsanta, Y., Suvarna, K., Fisher, P., Keerio, A. D., Shackcloth, M., Gosney, J., Postmus, P., Feeney, S., Asante-Siaw, J., Turajlic, S., Gore, M., Larkin, J., Swanton, C., Chester, K. A., Pule, M., Ravetch, J. V., Marafioti, T., Peggs, K. S., & Quezada, S. A. (2017). Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors. Immunity. https://doi.org/10.1016/j.immuni.2017.03.013