Myosin Modulator Aficamten Inhibits Force by Altering Myosin’s Biochemical Activity Without Changing Thick Filament Structure

Saffie Mohran, Kristina B. Kooiker, Ateeqa Naim, Matvey Pilagov, Anthony Asencio, Kyrah L. Turner, Weikang Ma, Galina Flint, Siyao Jiang, Jing Zhao, Timothy S. McMillen, Christian Mandrycky, Max Mahoney-Schaefer, Thomas C. Irving, Bertrand C.W. Tanner, Neil M. Kad, Michael Regnier, Farid Moussavi-Harami

Open source

DOI: 10.1016/j.jacbts.2025.101449
Published: 2026-01
Container: JACC: Basic to Translational Science
Publisher: Elsevier BV
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1016/j.jacbts.2025.101449,
  title = {Myosin Modulator Aficamten Inhibits Force by Altering Myosin’s Biochemical Activity Without Changing Thick Filament Structure},
  author = {Saffie Mohran and Kristina B. Kooiker and Ateeqa Naim and Matvey Pilagov and Anthony Asencio and Kyrah L. Turner and Weikang Ma and Galina Flint and Siyao Jiang and Jing Zhao and Timothy S. McMillen and Christian Mandrycky and Max Mahoney-Schaefer and Thomas C. Irving and Bertrand C.W. Tanner and Neil M. Kad and Michael Regnier and Farid Moussavi-Harami},
  year = {2026},
  journal = {JACC: Basic to Translational Science},
  doi = {10.1016/j.jacbts.2025.101449},
  url = {https://doi.org/10.1016/j.jacbts.2025.101449}
}

RIS

TY  - JOUR
TI  - Myosin Modulator Aficamten Inhibits Force by Altering Myosin’s Biochemical Activity Without Changing Thick Filament Structure
AU  - Saffie Mohran
AU  - Kristina B. Kooiker
AU  - Ateeqa Naim
AU  - Matvey Pilagov
AU  - Anthony Asencio
AU  - Kyrah L. Turner
AU  - Weikang Ma
AU  - Galina Flint
AU  - Siyao Jiang
AU  - Jing Zhao
AU  - Timothy S. McMillen
AU  - Christian Mandrycky
AU  - Max Mahoney-Schaefer
AU  - Thomas C. Irving
AU  - Bertrand C.W. Tanner
AU  - Neil M. Kad
AU  - Michael Regnier
AU  - Farid Moussavi-Harami
PY  - 2026
JO  - JACC: Basic to Translational Science
DO  - 10.1016/j.jacbts.2025.101449
UR  - https://doi.org/10.1016/j.jacbts.2025.101449
ER  -

APA

Mohran, S., Kooiker, K. B., Naim, A., Pilagov, M., Asencio, A., Turner, K. L., Ma, W., Flint, G., Jiang, S., Zhao, J., McMillen, T. S., Mandrycky, C., Mahoney-Schaefer, M., Irving, T. C., Tanner, B. C., Kad, N. M., Regnier, M., & Moussavi-Harami, F. (2026). Myosin Modulator Aficamten Inhibits Force by Altering Myosin’s Biochemical Activity Without Changing Thick Filament Structure. JACC: Basic to Translational Science. https://doi.org/10.1016/j.jacbts.2025.101449

Source records

crossref · retrieved 2026-09-26T04:58:20.086Z