Liver biopsy confirms precise and efficient correction of SERPINA1 after in vivo Base Editing in a Patient with Alpha-1 Antitrypsin Deficiency

Simon Alexander Krooss, Taihua Yang, Qinggong Yuan, Nora Drick, Malte Sgodda, Julia Held, Patrick Behrendt, Bjoern Hartleben, Rembert Koczulla, Xiaoying Ma, Ying Liu, Heiner Wedemeyer, Sabina Janciauskiene, Nataliya Di Donato, Tobias Cantz, ZiJun Wang, Yuxuan Wu, Marius Hoeper, Qiang Xia, Michael Ott

Open source

DOI: 10.1016/j.jhep.2026.09.028
Published: 2026-11
Container: Journal of Hepatology
Publisher: Elsevier BV
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1016/j.jhep.2026.09.028,
  title = {Liver biopsy confirms precise and efficient correction of SERPINA1 after in vivo Base Editing in a Patient with Alpha-1 Antitrypsin Deficiency},
  author = {Simon Alexander Krooss and Taihua Yang and Qinggong Yuan and Nora Drick and Malte Sgodda and Julia Held and Patrick Behrendt and Bjoern Hartleben and Rembert Koczulla and Xiaoying Ma and Ying Liu and Heiner Wedemeyer and Sabina Janciauskiene and Nataliya Di Donato and Tobias Cantz and ZiJun Wang and Yuxuan Wu and Marius Hoeper and Qiang Xia and Michael Ott},
  year = {2026},
  journal = {Journal of Hepatology},
  doi = {10.1016/j.jhep.2026.09.028},
  url = {https://doi.org/10.1016/j.jhep.2026.09.028}
}

RIS

TY  - JOUR
TI  - Liver biopsy confirms precise and efficient correction of SERPINA1 after in vivo Base Editing in a Patient with Alpha-1 Antitrypsin Deficiency
AU  - Simon Alexander Krooss
AU  - Taihua Yang
AU  - Qinggong Yuan
AU  - Nora Drick
AU  - Malte Sgodda
AU  - Julia Held
AU  - Patrick Behrendt
AU  - Bjoern Hartleben
AU  - Rembert Koczulla
AU  - Xiaoying Ma
AU  - Ying Liu
AU  - Heiner Wedemeyer
AU  - Sabina Janciauskiene
AU  - Nataliya Di Donato
AU  - Tobias Cantz
AU  - ZiJun Wang
AU  - Yuxuan Wu
AU  - Marius Hoeper
AU  - Qiang Xia
AU  - Michael Ott
PY  - 2026
JO  - Journal of Hepatology
DO  - 10.1016/j.jhep.2026.09.028
UR  - https://doi.org/10.1016/j.jhep.2026.09.028
ER  -

APA

Krooss, S. A., Yang, T., Yuan, Q., Drick, N., Sgodda, M., Held, J., Behrendt, P., Hartleben, B., Koczulla, R., Ma, X., Liu, Y., Wedemeyer, H., Janciauskiene, S., Donato, N. D., Cantz, T., Wang, Z., Wu, Y., Hoeper, M., Xia, Q., & Ott, M. (2026). Liver biopsy confirms precise and efficient correction of SERPINA1 after in vivo Base Editing in a Patient with Alpha-1 Antitrypsin Deficiency. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2026.09.028

Source records

crossref · retrieved 2026-11-04T11:16:39.850Z