Hepatotoxicity in AAV Gene Therapy: Clinical Challenges and Strategic Solutions

Akihiro Asai, Amal Aqul, Anna M. Banc-Husu, Tamir Diamond, Scott A. Elisofon, A. Jay. Freeman, Kathleen M. Loomes, Saeed Mohammad, Shikha S. Sundaram, Catherine A. Chapin

Open source

DOI: 10.1016/j.jpeds.2026.115317
Published: 2026-09
Container: The Journal of Pediatrics
Publisher: Elsevier BV
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1016/j.jpeds.2026.115317,
  title = {Hepatotoxicity in AAV Gene Therapy: Clinical Challenges and Strategic Solutions},
  author = {Akihiro Asai and Amal Aqul and Anna M. Banc-Husu and Tamir Diamond and Scott A. Elisofon and A. Jay. Freeman and Kathleen M. Loomes and Saeed Mohammad and Shikha S. Sundaram and Catherine A. Chapin},
  year = {2026},
  journal = {The Journal of Pediatrics},
  doi = {10.1016/j.jpeds.2026.115317},
  url = {https://doi.org/10.1016/j.jpeds.2026.115317}
}

RIS

TY  - JOUR
TI  - Hepatotoxicity in AAV Gene Therapy: Clinical Challenges and Strategic Solutions
AU  - Akihiro Asai
AU  - Amal Aqul
AU  - Anna M. Banc-Husu
AU  - Tamir Diamond
AU  - Scott A. Elisofon
AU  - A. Jay. Freeman
AU  - Kathleen M. Loomes
AU  - Saeed Mohammad
AU  - Shikha S. Sundaram
AU  - Catherine A. Chapin
PY  - 2026
JO  - The Journal of Pediatrics
DO  - 10.1016/j.jpeds.2026.115317
UR  - https://doi.org/10.1016/j.jpeds.2026.115317
ER  -

APA

Asai, A., Aqul, A., Banc-Husu, A. M., Diamond, T., Elisofon, S. A., Freeman, A. J., Loomes, K. M., Mohammad, S., Sundaram, S. S., & Chapin, C. A. (2026). Hepatotoxicity in AAV Gene Therapy: Clinical Challenges and Strategic Solutions. The Journal of Pediatrics. https://doi.org/10.1016/j.jpeds.2026.115317

Source records

crossref · retrieved 2026-09-25T22:23:05.891Z