Reasoning-driven large language models in medicine: opportunities, challenges, and the road ahead

Xiaofei Wang, Zhuxin Xiong, Ke Zou, Sahana Srinivasan, Thaddaeus Wai Soon Lo, Yilan Wu, Minjie Zou, Nan Liu, Fares Antaki, Weizhi Ma, Atanas G Atanasov, Julian Savulescu, Josip Car, David C Klonoff, Bin Sheng, Tien Yin Wong, Qingyu Chen, Yih Chung Tham

Open source

DOI
10.1016/j.landig.2025.100931
Published
2026-01
Container
The Lancet Digital Health
Publisher
Elsevier BV
Open access
unknown

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BibTeX

@article{allodium:10.1016/j.landig.2025.100931,
  title = {Reasoning-driven large language models in medicine: opportunities, challenges, and the road ahead},
  author = {Xiaofei Wang and Zhuxin Xiong and Ke Zou and Sahana Srinivasan and Thaddaeus Wai Soon Lo and Yilan Wu and Minjie Zou and Nan Liu and Fares Antaki and Weizhi Ma and Atanas G Atanasov and Julian Savulescu and Josip Car and David C Klonoff and Bin Sheng and Tien Yin Wong and Qingyu Chen and Yih Chung Tham},
  year = {2026},
  journal = {The Lancet Digital Health},
  doi = {10.1016/j.landig.2025.100931},
  url = {https://doi.org/10.1016/j.landig.2025.100931}
}

RIS

TY  - JOUR
TI  - Reasoning-driven large language models in medicine: opportunities, challenges, and the road ahead
AU  - Xiaofei Wang
AU  - Zhuxin Xiong
AU  - Ke Zou
AU  - Sahana Srinivasan
AU  - Thaddaeus Wai Soon Lo
AU  - Yilan Wu
AU  - Minjie Zou
AU  - Nan Liu
AU  - Fares Antaki
AU  - Weizhi Ma
AU  - Atanas G Atanasov
AU  - Julian Savulescu
AU  - Josip Car
AU  - David C Klonoff
AU  - Bin Sheng
AU  - Tien Yin Wong
AU  - Qingyu Chen
AU  - Yih Chung Tham
PY  - 2026
JO  - The Lancet Digital Health
DO  - 10.1016/j.landig.2025.100931
UR  - https://doi.org/10.1016/j.landig.2025.100931
ER  - 

APA

Wang, X., Xiong, Z., Zou, K., Srinivasan, S., Lo, T. W. S., Wu, Y., Zou, M., Liu, N., Antaki, F., Ma, W., Atanasov, A. G., Savulescu, J., Car, J., Klonoff, D. C., Sheng, B., Wong, T. Y., Chen, Q., & Tham, Y. C. (2026). Reasoning-driven large language models in medicine: opportunities, challenges, and the road ahead. The Lancet Digital Health. https://doi.org/10.1016/j.landig.2025.100931

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