Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.

Heinrich N, de Jager V, Dreisbach J, Gross-Demel P, Schultz S, Gerbach S, Kloss F, Dawson R, Narunsky K, Matt L, Wildner L, McHugh TD, Fuhr U, Aldana BH, Mouhdad C, Brake LT, Boeree MJ, Aarnoutse RE, Svensson EM, Gong X, P J Phillips P, Diacon AH, Hoelscher M, PanACEA-TB consortium

Open source

DOI: 10.1016/j.lanmic.2024.07.015
Published: 2025 Feb
Container: The Lancet. Microbe
Publisher: Not recorded
Open access: unknown

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1016/j.lanmic.2024.07.015,
  title = {Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.},
  author = {Heinrich N and de Jager V and Dreisbach J and Gross-Demel P and Schultz S and Gerbach S and Kloss F and Dawson R and Narunsky K and Matt L and Wildner L and McHugh TD and Fuhr U and Aldana BH and Mouhdad C and Brake LT and Boeree MJ and Aarnoutse RE and Svensson EM and Gong X and P J Phillips P and Diacon AH and Hoelscher M and PanACEA-TB consortium},
  year = {2025},
  journal = {The Lancet. Microbe},
  doi = {10.1016/j.lanmic.2024.07.015},
  url = {https://doi.org/10.1016/j.lanmic.2024.07.015}
}

RIS

TY  - JOUR
TI  - Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.
AU  - Heinrich N
AU  - de Jager V
AU  - Dreisbach J
AU  - Gross-Demel P
AU  - Schultz S
AU  - Gerbach S
AU  - Kloss F
AU  - Dawson R
AU  - Narunsky K
AU  - Matt L
AU  - Wildner L
AU  - McHugh TD
AU  - Fuhr U
AU  - Aldana BH
AU  - Mouhdad C
AU  - Brake LT
AU  - Boeree MJ
AU  - Aarnoutse RE
AU  - Svensson EM
AU  - Gong X
AU  - P J Phillips P
AU  - Diacon AH
AU  - Hoelscher M
AU  - PanACEA-TB consortium
PY  - 2025
JO  - The Lancet. Microbe
DO  - 10.1016/j.lanmic.2024.07.015
UR  - https://doi.org/10.1016/j.lanmic.2024.07.015
ER  -

APA

N, H., V, D. J., J, D., P, G., S, S., S, G., F, K., R, D., K, N., L, M., L, W., TD, M., U, F., BH, A., C, M., LT, B., MJ, B., RE, A., EM, S., X, G., P, P. J. P., AH, D., M, H., & consortium, P. (2025). Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.. The Lancet. Microbe. https://doi.org/10.1016/j.lanmic.2024.07.015

Source records

pubmed · retrieved 2026-09-25T05:22:23.147Z