Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in France

Slim Fourati, Alawiya Reslan, Jérôme Bourret, Jean-Sébastien Casalegno, Yannis Rahou, Laurent Softic, Lionel Chollet, Pauline Trémeaux, Berthe-Marie Imbert-Marcille, Sylvie Pillet, Nicolas Veyrenche, Agathe Boudet, Luc Deroche, Sonia Burrel, Lina Mouna, Theophile Cocherie, Aurélie Schnuriger, Charlotte Pronier, Lynda Handala, Véronique Brodard, Floriane Gallais, Sylvie Larrat, Alexandre Regueme, Nefert Candace Dossou, Amandine Henry, Elyanne Gault, Cédric Hartard, Ségolène Brichler, Alice Moisan, Véronique Avettand-Fenoel, Caroline Lefeuvre, Ilka Engelmann, Sandrine Castelain, Audrey Mirand, Maud Salmona, Marie-Christine Jaffar-Bandjee, Mohamed Ader, Sarah Seng, Pierre Cappy, Christophe Rodriguez, Arnaud Ly, Georges Dos Santos, Olivier Schwartz, Chloé Petiot, Delphine Planas, Samar Berreira Ibraim, Kévin Da Silva, Amélie Recoing, Jean-Michel Pawlotsky, Frédéric Lemoine, Etienne Audureau, Marie-Anne Rameix-Welti, Naël Zemali, Sonia Burrel, Pantxika Bellecave, Alice Moisan, Zakasoa-Mbololona Zavaoarisaina, Romain Legros, Boris Derman, Vincent Pargny, Hortense Petat, Jean-Christophe Plantier, Véronique Avettand-Fenoel, Salim Ferrani, Jérome Guinard, Clémence Guillaume, Gilbert Mchantaf, Victoria Marie, Laurent Bret, Fabien Lesne, Anthony de Oliveira, Alexandre Regueme, Kazali Alidjinou, Lionel Chollet, Vincent Gardan, Ségolène Brichler, Loic de Pontual, Camille Aupiais, Stéphane Marot, Aurélie Schnuriger, Marine Perrier, Pierre Jatteau, Djeneba Fofana, Théophile Cocherie, Elisa Teyssou, Cathia Soulié, Vincent Calvez, Sylvie Larrat, Anne Faisant, Guillaume Mortamet, Caroline Tournegros, Mohamed Habib, Sylvie Pillet, Aymeric Cantais, Franck Zekre, Thomas Bourlet, Oulfa Boussetta-Charfi, Sara Chenafi-Adham, Eva Gleizes, Cédric Hartard, Caroline Lefeuvre, Elise Bouthry, Lina Mouna, Fairly Warnakulasuriya, Quentin Le Hingrat, Marie-Christine Jaffar-Bandjee, Diana Heaugwane, Benjamin Azemar, Nicolas Mnemosyme, Laurent Souply, Catherine François, Sandrine Castelain, Cinthia Rames, Arnaud Bécourt, Ilka Engelmann, Eric Jeziorski, Vincent Foulongne, Lynda Handala, Catherine Gaudy-Graffin, Agathe Crémadés, Amandine Henry, Alessandra Pennisi, Maud Salmona, Jérôme Le Goff, Audrey Gabassi, Marie-Laure Néré, Marine Minier, Audrey Baron, Stéphane Bonacorsi, Naim Ouldali, Abdeljalil Senhaji Rachik, Marie-Anne Rameix-Welti, Alawyia Reslan, Yannis Rahou, Banujaa Jeyarajah, Anne Huard de Verneuil, Jérome Bourret, Frédéric Lemoine, Kévin Da Silva, Samar Berreira Ibraim, Vincent Enouf, Danielle Perez-Bercoff, Lucy Mosscrop, Etienne Simon-Loriere, Nefert Candace Dossou, Astrid Vabret, Slim Fourati, Christophe Rodriguez, Jean-Michel Pawlotsky, Pierre Cappy, Alexandre Soulier, Mohamed Ader, Sarah Seng, Arnaud Ly, Amandine Caillault, Pierre-André Natella, Etienne Audureau, Georges Dos Santos, Laurence Fagour, Anne-Julie Schapira, Olivier Flechelles, Luc Deroche, Nicolas Lévêque, Claire Morton Fauche, Sarah Borel, Erwan Ripley, Juliette Aubin, Berthe-Marie Imbert, Louise Castain, Audreay Rodallec, Justine Sourice, Christele Gras-Le Guen, Anne Chauvire-Drouard, Elyanne Gault, Frédérique Moreau, Claire Deback, Floriane Gallais, Morgane Solis, Valentin Stephan, Léa Pilorgé, Sophie Vallet, Léa Gaitan, Sylvie Rogez, Audrey Mirand, Cecile Henquell, Charlotte Pronier, Claire Grolhier, Vincent Thibault, Pauline Trémeaux, Isabelle Claudet, Mélanie Pucelle, Laetitia Staes, Camille Vellas, Sofia Demmou, Romain Carcenac, Nicolas Veyrenche, Jean-sébastien Casalegno, Alexandre Gaymard, Jose Kombou, Antonin Bal, Stanislas Ogoudjobi, Agathe Boudet, Amélie Recoing

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DOI: 10.1016/j.lanmic.2026.101353
Published: 2026-07
Container: The Lancet Microbe
Publisher: Elsevier BV
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BibTeX

@article{allodium:10.1016/j.lanmic.2026.101353,
  title = {Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in France},
  author = {Slim Fourati and Alawiya Reslan and Jérôme Bourret and Jean-Sébastien Casalegno and Yannis Rahou and Laurent Softic and Lionel Chollet and Pauline Trémeaux and Berthe-Marie Imbert-Marcille and Sylvie Pillet and Nicolas Veyrenche and Agathe Boudet and Luc Deroche and Sonia Burrel and Lina Mouna and Theophile Cocherie and Aurélie Schnuriger and Charlotte Pronier and Lynda Handala and Véronique Brodard and Floriane Gallais and Sylvie Larrat and Alexandre Regueme and Nefert Candace Dossou and Amandine Henry and Elyanne Gault and Cédric Hartard and Ségolène Brichler and Alice Moisan and Véronique Avettand-Fenoel and Caroline Lefeuvre and Ilka Engelmann and Sandrine Castelain and Audrey Mirand and Maud Salmona and Marie-Christine Jaffar-Bandjee and Mohamed Ader and Sarah Seng and Pierre Cappy and Christophe Rodriguez and Arnaud Ly and Georges Dos Santos and Olivier Schwartz and Chloé Petiot and Delphine Planas and Samar Berreira Ibraim and Kévin Da Silva and Amélie Recoing and Jean-Michel Pawlotsky and Frédéric Lemoine and Etienne Audureau and Marie-Anne Rameix-Welti and Naël Zemali and Sonia Burrel and Pantxika Bellecave and Alice Moisan and Zakasoa-Mbololona Zavaoarisaina and Romain Legros and Boris Derman and Vincent Pargny and Hortense Petat and Jean-Christophe Plantier and Véronique Avettand-Fenoel and Salim Ferrani and Jérome Guinard and Clémence Guillaume and Gilbert Mchantaf and Victoria Marie and Laurent Bret and Fabien Lesne and Anthony de Oliveira and Alexandre Regueme and Kazali Alidjinou and Lionel Chollet and Vincent Gardan and Ségolène Brichler and Loic de Pontual and Camille Aupiais and Stéphane Marot and Aurélie Schnuriger and Marine Perrier and Pierre Jatteau and Djeneba Fofana and Théophile Cocherie and Elisa Teyssou and Cathia Soulié and Vincent Calvez and Sylvie Larrat and Anne Faisant and Guillaume Mortamet and Caroline Tournegros and Mohamed Habib and Sylvie Pillet and Aymeric Cantais and Franck Zekre and Thomas Bourlet and Oulfa Boussetta-Charfi and Sara Chenafi-Adham and Eva Gleizes and Cédric Hartard and Caroline Lefeuvre and Elise Bouthry and Lina Mouna and Fairly Warnakulasuriya and Quentin Le Hingrat and Marie-Christine Jaffar-Bandjee and Diana Heaugwane and Benjamin Azemar and Nicolas Mnemosyme and Laurent Souply and Catherine François and Sandrine Castelain and Cinthia Rames and Arnaud Bécourt and Ilka Engelmann and Eric Jeziorski and Vincent Foulongne and Lynda Handala and Catherine Gaudy-Graffin and Agathe Crémadés and Amandine Henry and Alessandra Pennisi and Maud Salmona and Jérôme Le Goff and Audrey Gabassi and Marie-Laure Néré and Marine Minier and Audrey Baron and Stéphane Bonacorsi and Naim Ouldali and Abdeljalil Senhaji Rachik and Marie-Anne Rameix-Welti and Alawyia Reslan and Yannis Rahou and Banujaa Jeyarajah and Anne Huard de Verneuil and Jérome Bourret and Frédéric Lemoine and Kévin Da Silva and Samar Berreira Ibraim and Vincent Enouf and Danielle Perez-Bercoff and Lucy Mosscrop and Etienne Simon-Loriere and Nefert Candace Dossou and Astrid Vabret and Slim Fourati and Christophe Rodriguez and Jean-Michel Pawlotsky and Pierre Cappy and Alexandre Soulier and Mohamed Ader and Sarah Seng and Arnaud Ly and Amandine Caillault and Pierre-André Natella and Etienne Audureau and Georges Dos Santos and Laurence Fagour and Anne-Julie Schapira and Olivier Flechelles and Luc Deroche and Nicolas Lévêque and Claire Morton Fauche and Sarah Borel and Erwan Ripley and Juliette Aubin and Berthe-Marie Imbert and Louise Castain and Audreay Rodallec and Justine Sourice and Christele Gras-Le Guen and Anne Chauvire-Drouard and Elyanne Gault and Frédérique Moreau and Claire Deback and Floriane Gallais and Morgane Solis and Valentin Stephan and Léa Pilorgé and Sophie Vallet and Léa Gaitan and Sylvie Rogez and Audrey Mirand and Cecile Henquell and Charlotte Pronier and Claire Grolhier and Vincent Thibault and Pauline Trémeaux and Isabelle Claudet and Mélanie Pucelle and Laetitia Staes and Camille Vellas and Sofia Demmou and Romain Carcenac and Nicolas Veyrenche and Jean-sébastien Casalegno and Alexandre Gaymard and Jose Kombou and Antonin Bal and Stanislas Ogoudjobi and Agathe Boudet and Amélie Recoing},
  year = {2026},
  journal = {The Lancet Microbe},
  doi = {10.1016/j.lanmic.2026.101353},
  url = {https://doi.org/10.1016/j.lanmic.2026.101353}
}

RIS

TY  - JOUR
TI  - Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in France
AU  - Slim Fourati
AU  - Alawiya Reslan
AU  - Jérôme Bourret
AU  - Jean-Sébastien Casalegno
AU  - Yannis Rahou
AU  - Laurent Softic
AU  - Lionel Chollet
AU  - Pauline Trémeaux
AU  - Berthe-Marie Imbert-Marcille
AU  - Sylvie Pillet
AU  - Nicolas Veyrenche
AU  - Agathe Boudet
AU  - Luc Deroche
AU  - Sonia Burrel
AU  - Lina Mouna
AU  - Theophile Cocherie
AU  - Aurélie Schnuriger
AU  - Charlotte Pronier
AU  - Lynda Handala
AU  - Véronique Brodard
AU  - Floriane Gallais
AU  - Sylvie Larrat
AU  - Alexandre Regueme
AU  - Nefert Candace Dossou
AU  - Amandine Henry
AU  - Elyanne Gault
AU  - Cédric Hartard
AU  - Ségolène Brichler
AU  - Alice Moisan
AU  - Véronique Avettand-Fenoel
AU  - Caroline Lefeuvre
AU  - Ilka Engelmann
AU  - Sandrine Castelain
AU  - Audrey Mirand
AU  - Maud Salmona
AU  - Marie-Christine Jaffar-Bandjee
AU  - Mohamed Ader
AU  - Sarah Seng
AU  - Pierre Cappy
AU  - Christophe Rodriguez
AU  - Arnaud Ly
AU  - Georges Dos Santos
AU  - Olivier Schwartz
AU  - Chloé Petiot
AU  - Delphine Planas
AU  - Samar Berreira Ibraim
AU  - Kévin Da Silva
AU  - Amélie Recoing
AU  - Jean-Michel Pawlotsky
AU  - Frédéric Lemoine
AU  - Etienne Audureau
AU  - Marie-Anne Rameix-Welti
AU  - Naël Zemali
AU  - Sonia Burrel
AU  - Pantxika Bellecave
AU  - Alice Moisan
AU  - Zakasoa-Mbololona Zavaoarisaina
AU  - Romain Legros
AU  - Boris Derman
AU  - Vincent Pargny
AU  - Hortense Petat
AU  - Jean-Christophe Plantier
AU  - Véronique Avettand-Fenoel
AU  - Salim Ferrani
AU  - Jérome Guinard
AU  - Clémence Guillaume
AU  - Gilbert Mchantaf
AU  - Victoria Marie
AU  - Laurent Bret
AU  - Fabien Lesne
AU  - Anthony de Oliveira
AU  - Alexandre Regueme
AU  - Kazali Alidjinou
AU  - Lionel Chollet
AU  - Vincent Gardan
AU  - Ségolène Brichler
AU  - Loic de Pontual
AU  - Camille Aupiais
AU  - Stéphane Marot
AU  - Aurélie Schnuriger
AU  - Marine Perrier
AU  - Pierre Jatteau
AU  - Djeneba Fofana
AU  - Théophile Cocherie
AU  - Elisa Teyssou
AU  - Cathia Soulié
AU  - Vincent Calvez
AU  - Sylvie Larrat
AU  - Anne Faisant
AU  - Guillaume Mortamet
AU  - Caroline Tournegros
AU  - Mohamed Habib
AU  - Sylvie Pillet
AU  - Aymeric Cantais
AU  - Franck Zekre
AU  - Thomas Bourlet
AU  - Oulfa Boussetta-Charfi
AU  - Sara Chenafi-Adham
AU  - Eva Gleizes
AU  - Cédric Hartard
AU  - Caroline Lefeuvre
AU  - Elise Bouthry
AU  - Lina Mouna
AU  - Fairly Warnakulasuriya
AU  - Quentin Le Hingrat
AU  - Marie-Christine Jaffar-Bandjee
AU  - Diana Heaugwane
AU  - Benjamin Azemar
AU  - Nicolas Mnemosyme
AU  - Laurent Souply
AU  - Catherine François
AU  - Sandrine Castelain
AU  - Cinthia Rames
AU  - Arnaud Bécourt
AU  - Ilka Engelmann
AU  - Eric Jeziorski
AU  - Vincent Foulongne
AU  - Lynda Handala
AU  - Catherine Gaudy-Graffin
AU  - Agathe Crémadés
AU  - Amandine Henry
AU  - Alessandra Pennisi
AU  - Maud Salmona
AU  - Jérôme Le Goff
AU  - Audrey Gabassi
AU  - Marie-Laure Néré
AU  - Marine Minier
AU  - Audrey Baron
AU  - Stéphane Bonacorsi
AU  - Naim Ouldali
AU  - Abdeljalil Senhaji Rachik
AU  - Marie-Anne Rameix-Welti
AU  - Alawyia Reslan
AU  - Yannis Rahou
AU  - Banujaa Jeyarajah
AU  - Anne Huard de Verneuil
AU  - Jérome Bourret
AU  - Frédéric Lemoine
AU  - Kévin Da Silva
AU  - Samar Berreira Ibraim
AU  - Vincent Enouf
AU  - Danielle Perez-Bercoff
AU  - Lucy Mosscrop
AU  - Etienne Simon-Loriere
AU  - Nefert Candace Dossou
AU  - Astrid Vabret
AU  - Slim Fourati
AU  - Christophe Rodriguez
AU  - Jean-Michel Pawlotsky
AU  - Pierre Cappy
AU  - Alexandre Soulier
AU  - Mohamed Ader
AU  - Sarah Seng
AU  - Arnaud Ly
AU  - Amandine Caillault
AU  - Pierre-André Natella
AU  - Etienne Audureau
AU  - Georges Dos Santos
AU  - Laurence Fagour
AU  - Anne-Julie Schapira
AU  - Olivier Flechelles
AU  - Luc Deroche
AU  - Nicolas Lévêque
AU  - Claire Morton Fauche
AU  - Sarah Borel
AU  - Erwan Ripley
AU  - Juliette Aubin
AU  - Berthe-Marie Imbert
AU  - Louise Castain
AU  - Audreay Rodallec
AU  - Justine Sourice
AU  - Christele Gras-Le Guen
AU  - Anne Chauvire-Drouard
AU  - Elyanne Gault
AU  - Frédérique Moreau
AU  - Claire Deback
AU  - Floriane Gallais
AU  - Morgane Solis
AU  - Valentin Stephan
AU  - Léa Pilorgé
AU  - Sophie Vallet
AU  - Léa Gaitan
AU  - Sylvie Rogez
AU  - Audrey Mirand
AU  - Cecile Henquell
AU  - Charlotte Pronier
AU  - Claire Grolhier
AU  - Vincent Thibault
AU  - Pauline Trémeaux
AU  - Isabelle Claudet
AU  - Mélanie Pucelle
AU  - Laetitia Staes
AU  - Camille Vellas
AU  - Sofia Demmou
AU  - Romain Carcenac
AU  - Nicolas Veyrenche
AU  - Jean-sébastien Casalegno
AU  - Alexandre Gaymard
AU  - Jose Kombou
AU  - Antonin Bal
AU  - Stanislas Ogoudjobi
AU  - Agathe Boudet
AU  - Amélie Recoing
PY  - 2026
JO  - The Lancet Microbe
DO  - 10.1016/j.lanmic.2026.101353
UR  - https://doi.org/10.1016/j.lanmic.2026.101353
ER  -

APA

Fourati, S., Reslan, A., Bourret, J., Casalegno, J., Rahou, Y., Softic, L., Chollet, L., Trémeaux, P., Imbert-Marcille, B., Pillet, S., Veyrenche, N., Boudet, A., Deroche, L., Burrel, S., Mouna, L., Cocherie, T., Schnuriger, A., Pronier, C., Handala, L., Brodard, V., Gallais, F., Larrat, S., Regueme, A., Dossou, N. C., Henry, A., Gault, E., Hartard, C., Brichler, S., Moisan, A., Avettand-Fenoel, V., Lefeuvre, C., Engelmann, I., Castelain, S., Mirand, A., Salmona, M., Jaffar-Bandjee, M., Ader, M., Seng, S., Cappy, P., Rodriguez, C., Ly, A., Santos, G. D., Schwartz, O., Petiot, C., Planas, D., Ibraim, S. B., Silva, K. D., Recoing, A., Pawlotsky, J., Lemoine, F., Audureau, E., Rameix-Welti, M., Zemali, N., Burrel, S., Bellecave, P., Moisan, A., Zavaoarisaina, Z., Legros, R., Derman, B., Pargny, V., Petat, H., Plantier, J., Avettand-Fenoel, V., Ferrani, S., Guinard, J., Guillaume, C., Mchantaf, G., Marie, V., Bret, L., Lesne, F., Oliveira, A. D., Regueme, A., Alidjinou, K., Chollet, L., Gardan, V., Brichler, S., Pontual, L. D., Aupiais, C., Marot, S., Schnuriger, A., Perrier, M., Jatteau, P., Fofana, D., Cocherie, T., Teyssou, E., Soulié, C., Calvez, V., Larrat, S., Faisant, A., Mortamet, G., Tournegros, C., Habib, M., Pillet, S., Cantais, A., Zekre, F., Bourlet, T., Boussetta-Charfi, O., Chenafi-Adham, S., Gleizes, E., Hartard, C., Lefeuvre, C., Bouthry, E., Mouna, L., Warnakulasuriya, F., Hingrat, Q. L., Jaffar-Bandjee, M., Heaugwane, D., Azemar, B., Mnemosyme, N., Souply, L., François, C., Castelain, S., Rames, C., Bécourt, A., Engelmann, I., Jeziorski, E., Foulongne, V., Handala, L., Gaudy-Graffin, C., Crémadés, A., Henry, A., Pennisi, A., Salmona, M., Goff, J. L., Gabassi, A., Néré, M., Minier, M., Baron, A., Bonacorsi, S., Ouldali, N., Rachik, A. S., Rameix-Welti, M., Reslan, A., Rahou, Y., Jeyarajah, B., Verneuil, A. H. D., Bourret, J., Lemoine, F., Silva, K. D., Ibraim, S. B., Enouf, V., Perez-Bercoff, D., Mosscrop, L., Simon-Loriere, E., Dossou, N. C., Vabret, A., Fourati, S., Rodriguez, C., Pawlotsky, J., Cappy, P., Soulier, A., Ader, M., Seng, S., Ly, A., Caillault, A., Natella, P., Audureau, E., Santos, G. D., Fagour, L., Schapira, A., Flechelles, O., Deroche, L., Lévêque, N., Fauche, C. M., Borel, S., Ripley, E., Aubin, J., Imbert, B., Castain, L., Rodallec, A., Sourice, J., Guen, C. G., Chauvire-Drouard, A., Gault, E., Moreau, F., Deback, C., Gallais, F., Solis, M., Stephan, V., Pilorgé, L., Vallet, S., Gaitan, L., Rogez, S., Mirand, A., Henquell, C., Pronier, C., Grolhier, C., Thibault, V., Trémeaux, P., Claudet, I., Pucelle, M., Staes, L., Vellas, C., Demmou, S., Carcenac, R., Veyrenche, N., Casalegno, J., Gaymard, A., Kombou, J., Bal, A., Ogoudjobi, S., Boudet, A., & Recoing, A. (2026). Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in France. The Lancet Microbe. https://doi.org/10.1016/j.lanmic.2026.101353

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crossref · retrieved 2026-09-27T04:43:24.361Z