Sub-stoichiometric 5-methoxyuridine modification enables tunable immune evasion and protein expression from synthetic mRNAs

Jonathan R. Miles, Sarah Masterson, Eleanor Bellows, Fabio Fisher, Ritu Rani, Sara Marelli, Colin Hardman, Luigi Grassi, Luis Santos, Victoria James, Nigel P. Mongan, Christopher J. Hayes, Matthew Loose, Janet M. Daly, James Button, George Thom, Rupert G. Fray, Nathan Archer

Open source

DOI
10.1016/j.omtn.2026.103058
Published
2026-09
Container
Molecular Therapy Nucleic Acids
Publisher
Elsevier BV
Open access
unknown

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BibTeX

@article{allodium:10.1016/j.omtn.2026.103058,
  title = {Sub-stoichiometric 5-methoxyuridine modification enables tunable immune evasion and protein expression from synthetic mRNAs},
  author = {Jonathan R. Miles and Sarah Masterson and Eleanor Bellows and Fabio Fisher and Ritu Rani and Sara Marelli and Colin Hardman and Luigi Grassi and Luis Santos and Victoria James and Nigel P. Mongan and Christopher J. Hayes and Matthew Loose and Janet M. Daly and James Button and George Thom and Rupert G. Fray and Nathan Archer},
  year = {2026},
  journal = {Molecular Therapy Nucleic Acids},
  doi = {10.1016/j.omtn.2026.103058},
  url = {https://doi.org/10.1016/j.omtn.2026.103058}
}

RIS

TY  - JOUR
TI  - Sub-stoichiometric 5-methoxyuridine modification enables tunable immune evasion and protein expression from synthetic mRNAs
AU  - Jonathan R. Miles
AU  - Sarah Masterson
AU  - Eleanor Bellows
AU  - Fabio Fisher
AU  - Ritu Rani
AU  - Sara Marelli
AU  - Colin Hardman
AU  - Luigi Grassi
AU  - Luis Santos
AU  - Victoria James
AU  - Nigel P. Mongan
AU  - Christopher J. Hayes
AU  - Matthew Loose
AU  - Janet M. Daly
AU  - James Button
AU  - George Thom
AU  - Rupert G. Fray
AU  - Nathan Archer
PY  - 2026
JO  - Molecular Therapy Nucleic Acids
DO  - 10.1016/j.omtn.2026.103058
UR  - https://doi.org/10.1016/j.omtn.2026.103058
ER  - 

APA

Miles, J. R., Masterson, S., Bellows, E., Fisher, F., Rani, R., Marelli, S., Hardman, C., Grassi, L., Santos, L., James, V., Mongan, N. P., Hayes, C. J., Loose, M., Daly, J. M., Button, J., Thom, G., Fray, R. G., & Archer, N. (2026). Sub-stoichiometric 5-methoxyuridine modification enables tunable immune evasion and protein expression from synthetic mRNAs. Molecular Therapy Nucleic Acids. https://doi.org/10.1016/j.omtn.2026.103058

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