A small molecule ACT004 targets four-and-a-half LIM domain protein 1 to disrupt TGF-β/Smad signaling and promote FHL1 degradation in renal fibrosis.

He X, Peng F, Wang H, Yang J, Long Y, Lu D, Zhao L, Huang Q, Li Q, Ma N, Chen X, Long H

Open source

DOI
10.1016/j.phrs.2026.109640
Published
2026 Sep 24
Container
Pharmacological research
Publisher
Not recorded
Open access
unknown

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BibTeX

@article{allodium:10.1016/j.phrs.2026.109640,
  title = {A small molecule ACT004 targets four-and-a-half LIM domain protein 1 to disrupt TGF-β/Smad signaling and promote FHL1 degradation in renal fibrosis.},
  author = {He X and Peng F and Wang H and Yang J and Long Y and Lu D and Zhao L and Huang Q and Li Q and Ma N and Chen X and Long H},
  year = {2026},
  journal = {Pharmacological research},
  doi = {10.1016/j.phrs.2026.109640},
  url = {https://doi.org/10.1016/j.phrs.2026.109640}
}

RIS

TY  - JOUR
TI  - A small molecule ACT004 targets four-and-a-half LIM domain protein 1 to disrupt TGF-β/Smad signaling and promote FHL1 degradation in renal fibrosis.
AU  - He X
AU  - Peng F
AU  - Wang H
AU  - Yang J
AU  - Long Y
AU  - Lu D
AU  - Zhao L
AU  - Huang Q
AU  - Li Q
AU  - Ma N
AU  - Chen X
AU  - Long H
PY  - 2026
JO  - Pharmacological research
DO  - 10.1016/j.phrs.2026.109640
UR  - https://doi.org/10.1016/j.phrs.2026.109640
ER  - 

APA

X, H., F, P., H, W., J, Y., Y, L., D, L., L, Z., Q, H., Q, L., N, M., X, C., & H, L. (2026). A small molecule ACT004 targets four-and-a-half LIM domain protein 1 to disrupt TGF-β/Smad signaling and promote FHL1 degradation in renal fibrosis.. Pharmacological research. https://doi.org/10.1016/j.phrs.2026.109640

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