Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeutics

Florine Roussange, Jacqueline Gide, Johana Tournois, Michel Cailleret, Anne Boland, Christophe Battail, Jean-François Deleuze, Hélène Polvèche, Didier Auboeuf, Knut Brockmann, Edor Kabashi, Anca Marian, Lina El Kassar, Sophie Blondel, François Salachas, Gaëlle Bruneteau, Marc Peschanski, Cécile Martinat, Sandrine Baghdoyan

Open source

DOI: 10.1016/j.stemcr.2026.102977
Published: 2026-07
Container: Stem Cell Reports
Publisher: Elsevier BV
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1016/j.stemcr.2026.102977,
  title = {Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeutics},
  author = {Florine Roussange and Jacqueline Gide and Johana Tournois and Michel Cailleret and Anne Boland and Christophe Battail and Jean-François Deleuze and Hélène Polvèche and Didier Auboeuf and Knut Brockmann and Edor Kabashi and Anca Marian and Lina El Kassar and Sophie Blondel and François Salachas and Gaëlle Bruneteau and Marc Peschanski and Cécile Martinat and Sandrine Baghdoyan},
  year = {2026},
  journal = {Stem Cell Reports},
  doi = {10.1016/j.stemcr.2026.102977},
  url = {https://doi.org/10.1016/j.stemcr.2026.102977}
}

RIS

TY  - JOUR
TI  - Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeutics
AU  - Florine Roussange
AU  - Jacqueline Gide
AU  - Johana Tournois
AU  - Michel Cailleret
AU  - Anne Boland
AU  - Christophe Battail
AU  - Jean-François Deleuze
AU  - Hélène Polvèche
AU  - Didier Auboeuf
AU  - Knut Brockmann
AU  - Edor Kabashi
AU  - Anca Marian
AU  - Lina El Kassar
AU  - Sophie Blondel
AU  - François Salachas
AU  - Gaëlle Bruneteau
AU  - Marc Peschanski
AU  - Cécile Martinat
AU  - Sandrine Baghdoyan
PY  - 2026
JO  - Stem Cell Reports
DO  - 10.1016/j.stemcr.2026.102977
UR  - https://doi.org/10.1016/j.stemcr.2026.102977
ER  -

APA

Roussange, F., Gide, J., Tournois, J., Cailleret, M., Boland, A., Battail, C., Deleuze, J., Polvèche, H., Auboeuf, D., Brockmann, K., Kabashi, E., Marian, A., Kassar, L. E., Blondel, S., Salachas, F., Bruneteau, G., Peschanski, M., Martinat, C., & Baghdoyan, S. (2026). Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeutics. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2026.102977

Source records

crossref · retrieved 2026-11-09T00:56:59.873Z