Verification of novel CFD-based scale-down devices against 5 L bottles for freezing and thawing of protein drug substance: Thermal histories, concentration shifts, ice-liquid interfacial area, and stability prediction
- DOI
- 10.1016/j.xphs.2026.104511
- Published
- 2026-09
- Container
- Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Open access
- unknown
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Cite this work
BibTeX
@article{allodium:10.1016/j.xphs.2026.104511,
title = {Verification of novel CFD-based scale-down devices against 5 L bottles for freezing and thawing of protein drug substance: Thermal histories, concentration shifts, ice-liquid interfacial area, and stability prediction},
author = {Ricarda Nagel and Astrid Hauptmann and Reinhard Tober and Rafaela Neves and Miguel Â. Rodrigues and Karoline Bechtold-Peters and Wolfgang Frieß},
year = {2026},
journal = {Journal of Pharmaceutical Sciences},
doi = {10.1016/j.xphs.2026.104511},
url = {https://doi.org/10.1016/j.xphs.2026.104511}
}RIS
TY - JOUR TI - Verification of novel CFD-based scale-down devices against 5 L bottles for freezing and thawing of protein drug substance: Thermal histories, concentration shifts, ice-liquid interfacial area, and stability prediction AU - Ricarda Nagel AU - Astrid Hauptmann AU - Reinhard Tober AU - Rafaela Neves AU - Miguel Â. Rodrigues AU - Karoline Bechtold-Peters AU - Wolfgang Frieß PY - 2026 JO - Journal of Pharmaceutical Sciences DO - 10.1016/j.xphs.2026.104511 UR - https://doi.org/10.1016/j.xphs.2026.104511 ER -
APA
Nagel, R., Hauptmann, A., Tober, R., Neves, R., Rodrigues, M. Â., Bechtold-Peters, K., & Frieß, W. (2026). Verification of novel CFD-based scale-down devices against 5 L bottles for freezing and thawing of protein drug substance: Thermal histories, concentration shifts, ice-liquid interfacial area, and stability prediction. Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.xphs.2026.104511
Source records
- crossref · retrieved 2026-09-25T13:51:57.922Z