Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial

BibTeX

@article{allodium:10.1016/s0140-6736-25-00549-5,
  title = {Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial},
  author = {Craig S Anderson and Debbie Summers and Menglu Ouyang and Yi Sui and Brenda Johnson and Laurent Billot and Alejandra Malavera and Roland Faigle and Paula Muñoz-Venturelli and Diana Day and Xiaoqiu Liu and Qiang Li and Lili Song and Thompson G Robinson and Francisca González and Francisca Urrutia-Goldsack and Michael Iacobelli and Michelle Montalbano and April Pruski and Candice Delcourt and Alice C Durham and Ahtasam Ebraimo and Ha Hong Van Ta and Pratiti Ghosh and Ann Leonhardt-Caprio and Huy Thang Nguyen and Mai Duy Ton and Stephen Jan and Hueiming Liu and Richard I Lindley and Antonio Arauz and Andrés Mercado and Wan Asyraf Wan Zaidi and Pooja Khatri and Xia Wang and Victor C Urrutia and Sheila Jala and Susan Day and Ying Hu and Aneeta Lal and Elizabeth O'Brien and Michael Devlin and Carol Bendall and Christianna Nebauer and Duncan Maddox and Melissa Brooks and Timothy Kleinig and Jennifer Cranefield and Samantha McMahon and Roy Drew and Patrick McMullan and Joschka Straha and Donna Rowley and Helen Rodgers and Jessica Pyman and Rohan Grimley and Kylie Tastula and Xiaowen (Erin) Li and Stephen Walker and Alanah Bailey and Julia R Hennessey and Ken S Butcher and Darshan Ghia and Gillian Edmonds and Erin Casey and Lydia Ting and Jane Prosser and Krystle Franklin and Henry Ma and Thanh Phan and Jason Vuong and Berzenn Urbi and Rebecca Phair and Nino Jose and Andrew Shine and Susan Lane and Juliette Mai and F O'Rourke and Christine Fuller and Ravindra Urkude and Nerida Myers and Nicole Bradford and Yi Sui and Wei Bian and Xinze Guo and Yang Zhao and Yang Zhang and Xuchen Qi and Yanxing Zhang and Huan Tang and Xuan Fang and Min Zheng and Mingzong Yan and Yanyan Yin and Penglai Shi and Junmei Li and Junming Luo and Fuqiang Fan and Xueting Guo and Huaxiang Zhou and Xueqing Ba and Yongxia Nie and Chenguang Song and Hong'an Gao and Lili Sun and Chunnan Jia and Mingyue Wang and Lihong Zhang and Jing Yang and Aijie Song and Yanli Zhang and Shuang Yu and Ying Guan and Ruyu Bai and Changqing Li and Tong Bai and Xin Li and Dongyu Wang and Haiyan Yu and Wei Zhao and Nan Li and Hongjun L and Tao Yan and Jinnan Zhang and Shumin Jiang and Yi Shen and Xiaowei Hu and Runhui Li and Li Cui and Yan Kong and Hong Zhang and Shuang Yang and Guiying Guo and Xiaochen Zhao and Haishan Zhao and Fan Zhang and Siheng Li and Yan Yang and Ying Wang and Haiyan Jin and Zijia Liu and Ping Jiang and Hongquan Jiang and Yao Shai and Ying Tang and Jing Xue and Xinyu Dong and Jinchun Wang and Jingyu Guo and Xiuying Wang and Yihe Bao and Hongyan Li and Xiangna Yang and Longna Xie and Shanshan Zhang and Xinxin Yang and Minglei Qu and Dan Deng and Jianghua Liu and Zhonglei Bao and Tieyan Wang and Li Lin and Cheng Bi and Ying Pan and Xinli Chen and Na Gao and Bo Peng and Guozhi Lu and Zidian Jiang and Yongmei Pan and Lianjing Kang and Chunxue Zhu and Lei Zhang and Yan Liang and Huiping Peng and Baiyan Song and Lilan Xiao and Jingyun Kuang and Xuejiao Lu and Xueying Liao and Zefeng Tan and Weiqi Zeng and Wanyi Lin and Enyang Zhou and Jun Wu and Yiqiao Chen and Yajun Liu and Li Meng and Zuo Wang and Yang Liu and Xuefeng Xu and Wei Xu and Yongyi Dai and Yong'e Dong and Yi'nan Zhang and Xiaodi Wang and Ying Hai and Zhi Li and Ying Pei and Guosheng Zheng and Chenyao Li and Zhifei Wang and Yundong Shi and Shanshan Li and Zhichen Liu and Jiaxin Zhang and Liying Cui and Xiaowei Zhao and Yu Qiao and Li Liu and Jingyu Zhang and Changhao Jiang and Cheng Fang and Rui Su and Chenwen Zhang and Yi Ren and Liyang Zhang and Yan Liu and Mingming Dong and Ting Yang and Sirui Gao and Rong Yin and Zhongxia Fu and Yuanming Li and Yaqin Ke and Xiaoxiao Liu and Hongguang Gao and Ying Liu and Chao Wang and Yang Liu and Bo Zhang and Zhenli Guo and Qian Tan and Wanhua Zhong and Ke Ling and Shi'e Ma and Yi Cheng and Ying Bi and Fei Jiang and Yuying Hao and Xiaoxi Yao and Zhiying Wang and Mengju Lei and Liya Lei and Dongyou Yue and Hanyan Xiao and Shuhua Chen and Yiqun Chao and Guangzhao He and Yan Li and Muhui Lin and Jiao Lv and Caixia Liu and Juan Feng and Xuedong Zhao and Xue Yang and Haiyang Yu and Ning Ma and Xuerong Lu and Runzhe Jiang and Xuemei Sun and Na Liu and Yan Zhuang and Andrés Silva-Pozo and Philippe Grandjean Silva and Nataly Cisterna Carrera and Enrico Mazzon and Alejandro Brunser and Pablo Brinck and Andrés Gallardo and Pablo Gonzalez Valdivieso and Juan Almeida and Olivia Sanhueza Neira and Astrid Haleby and Aldo Letelier Durán and Denisse Wenger and Pedro Canales and Keren Zambrano and Camila Rojas and Diego Rocha Jiménez and Mario Rivera and María Jose Orellana and Juan Polanco and Tomás Esparza and Wan Asyraf and Tan Hui Jan Tan and Rabani Remli and Wan Nur Nafisah Wan Yahya and Khoo Ching Soong and Law Zhe Kang and Siti Zaleha Sahibulddin and Dayang Anis Binti Awang Baki and Hamidah Hassan and Nur Liyana Rahmat and Nur Arifah Mohd Khaili and Rathika Rajah and Tan Juen Kiem and Abdul Hanif Khan Yusof Khan and Adnan Lutfi A. Rauf and Shi Hajjar Zakaria and Sanihah Abdul Halim and Jafri Malin Abdullah and Zamzuri Idris and Kamarul Aryffin Bin Baharuddin and Muhammad Ihfaz Ismail and Law Wan Chung and Tay Jiann Shyang and Anderson Steven and Wong Siaw Cheng and Sim Chun Yang and Sheila Ong and Judith James and Irene Looi and Antonio Arauz and Andrés Mercado-Pompa and Vanessa Cano-Nigenda and Ricardo Romero-Vucovich and Pablo Nava-Sánchez and Alejandro López-Pizano and Ranferi E. Herrera-Calderón and Fernando Góngora-Rivera and Adrian Infante-Valenzuela and Ricardo López-Soto and Raymundo Chávez-Gamboa and Luis Daniel Arreola-Sánchez and Gustavo Gonzalez Gonzalez and Sebastián León Vallejo and José Luis Galvez Romero and María Del Rocio Marquez Estudillo and Daniel Reyes Ortega and Amado Jiménez-Ruiz and José Luis Ruiz-Sandoval and Victor Aguilar-Fuentes and Juan Antonio Sotelo-Ramirez and Ricardo Gabriel Ascencio-Tene and Eric De la Cruz Estrada and Victor Mateo Perez and Duy Ton Mai and Viet Phuong Dao and Tien Dung Nguyen and Tuan Anh Le and Quoc Viet Bui and Thi Phuong Nga Nguyen and Thi Thuy Uyen Le and Thi Ngoc Nhung Tran and Thai Hoang Nguyen and Quoc Huy Nguyen and Duc Chien Vo and Trung Thanh Tran and Thai My Phuong Nguyen and Hao Nhien Cao and Linh Tuyen Nguyen and Huy Thang Nguyen and Nguyen Binh Pham and Thanh Thai An Nguyen and Quang Huy Dang and Thi Kim Anh Nguyen and Tri Thanh Vu and Tran Vinh Le and Cong Tri Le and Nguyen Mai Thao Dang and Thi Thu Trang Nguyen and Rachel Teal and Jeethu Joseph and Phil Mathieson and James Kennedy and Tim Comont and Gillian Cumberbatch and Ana Margarida Castanheira and Cai Hua Sim and Rita Ghatala and Kate Kennedy and Beatrix Sari and Jatinder Minhas and Kashif Musarrat and Shagufta Khan and Tracy Harris and Jennifer Mitchell-Douglas and Smriti Agarwal and Arshi Iqbal and Karolina Kowalska and Alex McGovern and Joel Stanton and Marilena Marinescu and Shez Feerick and Sabaa Obarey and Georgia Raingold and Katie Flanagan and Gemenelie Ann Revilla and Roberto Avila and Rose Kennedy and Yee Chin Lee and James Lyon and Alexandra Lewis and Riham El Sayed and Jannine and Bianca Bandiola and Lance Vincent Sese and Kevin Babia and Zubeda Nungu and Joice Timotec and Stephanie Drysdale and Maria Consuelo Tibasia and Caroline Domingos Belo and Samantha Bayhonan Rubern and Beatrix Sari and Aaizza Naqvi and Emma Richards and Jo Howe and Chris Kamara and Sadaf Younis and Saul Sundayi and Lakshmanan Sekaran and Lisa Reid and Jimy David and Lincy Poolon and Mair A Carpenter and Balasubramanian Venkatesh and Charity W Kimaru and Courtney Greaves and Sarah E Watson and Daniel Ryan and Nichola Kearsley and Natalie Temple and Kirsty Allen and Dan Arcoria and Zoey Horne and Emelda Veraque and Junyao Zhao and Susan Evans and Alix Baird and Tomas Hannam-Penfold and Simon Smith and Camille Hutchinson and Amanda Hedstorm and Lucy Gray and Rachael Jones and Tegan Taylor and Blessing Oduh and Nasar Ahmad and Rachel Evans and Esther Erumere and Brittany Sanders and Edward Kinsella-Perks and Kevin Villa and Samantha Keenan and Sharon Finch and Rebecca Page and Lucy Topliss and Thirukumaran Duraisami and Tamsyn Pattenden and Katie Morgan and Emilie Williams and Nicola Yeo and Sonia Mariampillai and Ruth Penn and Marjorie Castillo and Nicola Cook and Susan Campbell and Shumita Palit and Helen Tench and Ronda Loosley and Tanya Sims and Rebecca Wolf-Roberts and Cerrys Parker and Senthil Kumar Subbarayan and Linda O'Brien and Victoria Riddell and Anna Smith and Cristopher Price and Mark Garside and Nina Jensen and Yaw Duodu and Cheryl Padilla-Harris and Patricia Avila Del Puerto and Bernard Esisi and Emma Clarkson and Mike Murrey and Vivek Rai and Megan Heckathorn and Heather Bartelt and Michelle Hill and Dalida Akhmedova and Brian Silver and Christina Manxhari and Tatiana Thompson and Michelle Manxhari and Ann Leonhardt-Caprio and Emily Prentiss and Curtis Benesch and Paige Hepple and Raymond Reichwein and Cesar Velasco and Andrea Singer and Erin Cekovich and Alicia Richardson and Olivia Christman and Leonard Kishel and Iftekhar Ahmed and Jana Braklow and Richard Smith and Jennifer McMahon and Carly Rossi and Alex Graves and Julie Schafer and Jamie Lynch and Sheryl Giambartolomei and Maria Aguilar and Melissa Ortiona and Elizabeth Dienst and Karin Olds and Debbie Summers and Christine Kennish and Claranne Mathiesen and Erin Conahan and Vivek Rai and Megan Heckathorn and Heather Bartelt and Michelle Hill and Dalida Akhmedova and Pramod Sethi and Sharon Biby and Amber Carter and Jessica Buckner and McNeill Kirkpatrick and Jindong Xu and Tammy Blackburn and Hannah Bell and Karen Newnam and Hannah Mack and Sarah Hocutt and Laith Altaweel and Saqib Chaudhry and Laura Madarász and Karlie Smith and Stefannie Belardo and Tugce Karageyer and Mihaela Alexander and Danielle Hagedorn and Nicole Westensee and Lisa Cohen and Teresa Wiegand and John (Hughes) Barghols and Russell Wheeler and Keri Smith and Kathy Stilwell and Victor Urrutia and Brenda Johnson and Jaime Butler and Roland Faigle and Amer AlShekhlee and Chizoba Ezepue and Bridget Gatscher and Richard King and Mike Ke and Gloria Dow and Michael Seamon and Travis Smith and Burton Tabaac and Kristen Gurnea and Jeffery Webb and Michael Phipps and Chad Schrier and Ann Leonhardt-Caprio and Emily Prentiss and Bruce Silverman and Nicole Green and Jean Kelly and Lynne Froehlich and Craig Anderson and Victor Urrutia and Brenda Johnson and Debbie Summers and Roland Faigle and Diana Day and Thompson Robinson and Paula Muñoz Venturelli and Pooja Khatri and Richard Lindley and Xia Wang and Yi Sui and Lili Song and Wan Asyraf and Huy Thang Nguyen and Robert Herbert and Andrew Barreto and Karen S. Rapp and Laurent Billot and Qiang Li and Xiaoqiu Liu and Yinyan Wang and Qiao Han and Menglu Ouyang and Hueiming Liu and Lizheng Xu and Stephen Jan and Rachel Tang and Michelle Montalbano and April Pruski and Francisca González and Diana Day and Alejandra Del Rio Weldt and Alejandro Jesus López Pizano and Siti Zaleha Sahibulddin and Nur Liyana Rahmat and Nur Afrifah Mohd Khaili and Dayang Anis and Hamidah Hassan and Ahtasam Ebraimo and Ranjit J. Injety and Alejandra Malavera and Ha Hong Van (Melanie) Ta and Pratiti Ghosh and Natalie Espinosa and Lauren Clancy and Aisling Byrne and Luke Hatchwell and Alexandra Hurden and Antonio Michell and Manuela Armenis and Ravikumar Tummapudi and Ullas Arabhavi and Menglu Ouyang and Jipeng Cheng and Zhuo Meng and Alice Durham and Ahtasam Ebraimo and Uyen Hong and Linh Le Thi My and Nguyen Nhat Ha and Thi Thao Van and Thi Kim Nhung and Tuyet Mai and Nhat Phuong Ha and Thi Huong Giang and Nhat Linh and Thi Kim Chi and Thi Nhi and Hai Ngo Thanh and Paula Muñoz Venturelli and Francisca González and Francisca Urrutia Goldsack and Alejandra Del Rio Weldt},
  year = {2025},
  journal = {The Lancet},
  doi = {10.1016/s0140-6736(25)00549-5},
  url = {https://doi.org/10.1016/s0140-6736(25)00549-5}
}

RIS

TY  - JOUR
TI  - Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial
AU  - Craig S Anderson
AU  - Debbie Summers
AU  - Menglu Ouyang
AU  - Yi Sui
AU  - Brenda Johnson
AU  - Laurent Billot
AU  - Alejandra Malavera
AU  - Roland Faigle
AU  - Paula Muñoz-Venturelli
AU  - Diana Day
AU  - Xiaoqiu Liu
AU  - Qiang Li
AU  - Lili Song
AU  - Thompson G Robinson
AU  - Francisca González
AU  - Francisca Urrutia-Goldsack
AU  - Michael Iacobelli
AU  - Michelle Montalbano
AU  - April Pruski
AU  - Candice Delcourt
AU  - Alice C Durham
AU  - Ahtasam Ebraimo
AU  - Ha Hong Van Ta
AU  - Pratiti Ghosh
AU  - Ann Leonhardt-Caprio
AU  - Huy Thang Nguyen
AU  - Mai Duy Ton
AU  - Stephen Jan
AU  - Hueiming Liu
AU  - Richard I Lindley
AU  - Antonio Arauz
AU  - Andrés Mercado
AU  - Wan Asyraf Wan Zaidi
AU  - Pooja Khatri
AU  - Xia Wang
AU  - Victor C Urrutia
AU  - Sheila Jala
AU  - Susan Day
AU  - Ying Hu
AU  - Aneeta Lal
AU  - Elizabeth O'Brien
AU  - Michael Devlin
AU  - Carol Bendall
AU  - Christianna Nebauer
AU  - Duncan Maddox
AU  - Melissa Brooks
AU  - Timothy Kleinig
AU  - Jennifer Cranefield
AU  - Samantha McMahon
AU  - Roy Drew
AU  - Patrick McMullan
AU  - Joschka Straha
AU  - Donna Rowley
AU  - Helen Rodgers
AU  - Jessica Pyman
AU  - Rohan Grimley
AU  - Kylie Tastula
AU  - Xiaowen (Erin) Li
AU  - Stephen Walker
AU  - Alanah Bailey
AU  - Julia R Hennessey
AU  - Ken S Butcher
AU  - Darshan Ghia
AU  - Gillian Edmonds
AU  - Erin Casey
AU  - Lydia Ting
AU  - Jane Prosser
AU  - Krystle Franklin
AU  - Henry Ma
AU  - Thanh Phan
AU  - Jason Vuong
AU  - Berzenn Urbi
AU  - Rebecca Phair
AU  - Nino Jose
AU  - Andrew Shine
AU  - Susan Lane
AU  - Juliette Mai
AU  - F O'Rourke
AU  - Christine Fuller
AU  - Ravindra Urkude
AU  - Nerida Myers
AU  - Nicole Bradford
AU  - Yi Sui
AU  - Wei Bian
AU  - Xinze Guo
AU  - Yang Zhao
AU  - Yang Zhang
AU  - Xuchen Qi
AU  - Yanxing Zhang
AU  - Huan Tang
AU  - Xuan Fang
AU  - Min Zheng
AU  - Mingzong Yan
AU  - Yanyan Yin
AU  - Penglai Shi
AU  - Junmei Li
AU  - Junming Luo
AU  - Fuqiang Fan
AU  - Xueting Guo
AU  - Huaxiang Zhou
AU  - Xueqing Ba
AU  - Yongxia Nie
AU  - Chenguang Song
AU  - Hong'an Gao
AU  - Lili Sun
AU  - Chunnan Jia
AU  - Mingyue Wang
AU  - Lihong Zhang
AU  - Jing Yang
AU  - Aijie Song
AU  - Yanli Zhang
AU  - Shuang Yu
AU  - Ying Guan
AU  - Ruyu Bai
AU  - Changqing Li
AU  - Tong Bai
AU  - Xin Li
AU  - Dongyu Wang
AU  - Haiyan Yu
AU  - Wei Zhao
AU  - Nan Li
AU  - Hongjun L
AU  - Tao Yan
AU  - Jinnan Zhang
AU  - Shumin Jiang
AU  - Yi Shen
AU  - Xiaowei Hu
AU  - Runhui Li
AU  - Li Cui
AU  - Yan Kong
AU  - Hong Zhang
AU  - Shuang Yang
AU  - Guiying Guo
AU  - Xiaochen Zhao
AU  - Haishan Zhao
AU  - Fan Zhang
AU  - Siheng Li
AU  - Yan Yang
AU  - Ying Wang
AU  - Haiyan Jin
AU  - Zijia Liu
AU  - Ping Jiang
AU  - Hongquan Jiang
AU  - Yao Shai
AU  - Ying Tang
AU  - Jing Xue
AU  - Xinyu Dong
AU  - Jinchun Wang
AU  - Jingyu Guo
AU  - Xiuying Wang
AU  - Yihe Bao
AU  - Hongyan Li
AU  - Xiangna Yang
AU  - Longna Xie
AU  - Shanshan Zhang
AU  - Xinxin Yang
AU  - Minglei Qu
AU  - Dan Deng
AU  - Jianghua Liu
AU  - Zhonglei Bao
AU  - Tieyan Wang
AU  - Li Lin
AU  - Cheng Bi
AU  - Ying Pan
AU  - Xinli Chen
AU  - Na Gao
AU  - Bo Peng
AU  - Guozhi Lu
AU  - Zidian Jiang
AU  - Yongmei Pan
AU  - Lianjing Kang
AU  - Chunxue Zhu
AU  - Lei Zhang
AU  - Yan Liang
AU  - Huiping Peng
AU  - Baiyan Song
AU  - Lilan Xiao
AU  - Jingyun Kuang
AU  - Xuejiao Lu
AU  - Xueying Liao
AU  - Zefeng Tan
AU  - Weiqi Zeng
AU  - Wanyi Lin
AU  - Enyang Zhou
AU  - Jun Wu
AU  - Yiqiao Chen
AU  - Yajun Liu
AU  - Li Meng
AU  - Zuo Wang
AU  - Yang Liu
AU  - Xuefeng Xu
AU  - Wei Xu
AU  - Yongyi Dai
AU  - Yong'e Dong
AU  - Yi'nan Zhang
AU  - Xiaodi Wang
AU  - Ying Hai
AU  - Zhi Li
AU  - Ying Pei
AU  - Guosheng Zheng
AU  - Chenyao Li
AU  - Zhifei Wang
AU  - Yundong Shi
AU  - Shanshan Li
AU  - Zhichen Liu
AU  - Jiaxin Zhang
AU  - Liying Cui
AU  - Xiaowei Zhao
AU  - Yu Qiao
AU  - Li Liu
AU  - Jingyu Zhang
AU  - Changhao Jiang
AU  - Cheng Fang
AU  - Rui Su
AU  - Chenwen Zhang
AU  - Yi Ren
AU  - Liyang Zhang
AU  - Yan Liu
AU  - Mingming Dong
AU  - Ting Yang
AU  - Sirui Gao
AU  - Rong Yin
AU  - Zhongxia Fu
AU  - Yuanming Li
AU  - Yaqin Ke
AU  - Xiaoxiao Liu
AU  - Hongguang Gao
AU  - Ying Liu
AU  - Chao Wang
AU  - Yang Liu
AU  - Bo Zhang
AU  - Zhenli Guo
AU  - Qian Tan
AU  - Wanhua Zhong
AU  - Ke Ling
AU  - Shi'e Ma
AU  - Yi Cheng
AU  - Ying Bi
AU  - Fei Jiang
AU  - Yuying Hao
AU  - Xiaoxi Yao
AU  - Zhiying Wang
AU  - Mengju Lei
AU  - Liya Lei
AU  - Dongyou Yue
AU  - Hanyan Xiao
AU  - Shuhua Chen
AU  - Yiqun Chao
AU  - Guangzhao He
AU  - Yan Li
AU  - Muhui Lin
AU  - Jiao Lv
AU  - Caixia Liu
AU  - Juan Feng
AU  - Xuedong Zhao
AU  - Xue Yang
AU  - Haiyang Yu
AU  - Ning Ma
AU  - Xuerong Lu
AU  - Runzhe Jiang
AU  - Xuemei Sun
AU  - Na Liu
AU  - Yan Zhuang
AU  - Andrés Silva-Pozo
AU  - Philippe Grandjean Silva
AU  - Nataly Cisterna Carrera
AU  - Enrico Mazzon
AU  - Alejandro Brunser
AU  - Pablo Brinck
AU  - Andrés Gallardo
AU  - Pablo Gonzalez Valdivieso
AU  - Juan Almeida
AU  - Olivia Sanhueza Neira
AU  - Astrid Haleby
AU  - Aldo Letelier Durán
AU  - Denisse Wenger
AU  - Pedro Canales
AU  - Keren Zambrano
AU  - Camila Rojas
AU  - Diego Rocha Jiménez
AU  - Mario Rivera
AU  - María Jose Orellana
AU  - Juan Polanco
AU  - Tomás Esparza
AU  - Wan Asyraf
AU  - Tan Hui Jan Tan
AU  - Rabani Remli
AU  - Wan Nur Nafisah Wan Yahya
AU  - Khoo Ching Soong
AU  - Law Zhe Kang
AU  - Siti Zaleha Sahibulddin
AU  - Dayang Anis Binti Awang Baki
AU  - Hamidah Hassan
AU  - Nur Liyana Rahmat
AU  - Nur Arifah Mohd Khaili
AU  - Rathika Rajah
AU  - Tan Juen Kiem
AU  - Abdul Hanif Khan Yusof Khan
AU  - Adnan Lutfi A. Rauf
AU  - Shi Hajjar Zakaria
AU  - Sanihah Abdul Halim
AU  - Jafri Malin Abdullah
AU  - Zamzuri Idris
AU  - Kamarul Aryffin Bin Baharuddin
AU  - Muhammad Ihfaz Ismail
AU  - Law Wan Chung
AU  - Tay Jiann Shyang
AU  - Anderson Steven
AU  - Wong Siaw Cheng
AU  - Sim Chun Yang
AU  - Sheila Ong
AU  - Judith James
AU  - Irene Looi
AU  - Antonio Arauz
AU  - Andrés Mercado-Pompa
AU  - Vanessa Cano-Nigenda
AU  - Ricardo Romero-Vucovich
AU  - Pablo Nava-Sánchez
AU  - Alejandro López-Pizano
AU  - Ranferi E. Herrera-Calderón
AU  - Fernando Góngora-Rivera
AU  - Adrian Infante-Valenzuela
AU  - Ricardo López-Soto
AU  - Raymundo Chávez-Gamboa
AU  - Luis Daniel Arreola-Sánchez
AU  - Gustavo Gonzalez Gonzalez
AU  - Sebastián León Vallejo
AU  - José Luis Galvez Romero
AU  - María Del Rocio Marquez Estudillo
AU  - Daniel Reyes Ortega
AU  - Amado Jiménez-Ruiz
AU  - José Luis Ruiz-Sandoval
AU  - Victor Aguilar-Fuentes
AU  - Juan Antonio Sotelo-Ramirez
AU  - Ricardo Gabriel Ascencio-Tene
AU  - Eric De la Cruz Estrada
AU  - Victor Mateo Perez
AU  - Duy Ton Mai
AU  - Viet Phuong Dao
AU  - Tien Dung Nguyen
AU  - Tuan Anh Le
AU  - Quoc Viet Bui
AU  - Thi Phuong Nga Nguyen
AU  - Thi Thuy Uyen Le
AU  - Thi Ngoc Nhung Tran
AU  - Thai Hoang Nguyen
AU  - Quoc Huy Nguyen
AU  - Duc Chien Vo
AU  - Trung Thanh Tran
AU  - Thai My Phuong Nguyen
AU  - Hao Nhien Cao
AU  - Linh Tuyen Nguyen
AU  - Huy Thang Nguyen
AU  - Nguyen Binh Pham
AU  - Thanh Thai An Nguyen
AU  - Quang Huy Dang
AU  - Thi Kim Anh Nguyen
AU  - Tri Thanh Vu
AU  - Tran Vinh Le
AU  - Cong Tri Le
AU  - Nguyen Mai Thao Dang
AU  - Thi Thu Trang Nguyen
AU  - Rachel Teal
AU  - Jeethu Joseph
AU  - Phil Mathieson
AU  - James Kennedy
AU  - Tim Comont
AU  - Gillian Cumberbatch
AU  - Ana Margarida Castanheira
AU  - Cai Hua Sim
AU  - Rita Ghatala
AU  - Kate Kennedy
AU  - Beatrix Sari
AU  - Jatinder Minhas
AU  - Kashif Musarrat
AU  - Shagufta Khan
AU  - Tracy Harris
AU  - Jennifer Mitchell-Douglas
AU  - Smriti Agarwal
AU  - Arshi Iqbal
AU  - Karolina Kowalska
AU  - Alex McGovern
AU  - Joel Stanton
AU  - Marilena Marinescu
AU  - Shez Feerick
AU  - Sabaa Obarey
AU  - Georgia Raingold
AU  - Katie Flanagan
AU  - Gemenelie Ann Revilla
AU  - Roberto Avila
AU  - Rose Kennedy
AU  - Yee Chin Lee
AU  - James Lyon
AU  - Alexandra Lewis
AU  - Riham El Sayed
AU  - Jannine
AU  - Bianca Bandiola
AU  - Lance Vincent Sese
AU  - Kevin Babia
AU  - Zubeda Nungu
AU  - Joice Timotec
AU  - Stephanie Drysdale
AU  - Maria Consuelo Tibasia
AU  - Caroline Domingos Belo
AU  - Samantha Bayhonan Rubern
AU  - Beatrix Sari
AU  - Aaizza Naqvi
AU  - Emma Richards
AU  - Jo Howe
AU  - Chris Kamara
AU  - Sadaf Younis
AU  - Saul Sundayi
AU  - Lakshmanan Sekaran
AU  - Lisa Reid
AU  - Jimy David
AU  - Lincy Poolon
AU  - Mair A Carpenter
AU  - Balasubramanian Venkatesh
AU  - Charity W Kimaru
AU  - Courtney Greaves
AU  - Sarah E Watson
AU  - Daniel Ryan
AU  - Nichola Kearsley
AU  - Natalie Temple
AU  - Kirsty Allen
AU  - Dan Arcoria
AU  - Zoey Horne
AU  - Emelda Veraque
AU  - Junyao Zhao
AU  - Susan Evans
AU  - Alix Baird
AU  - Tomas Hannam-Penfold
AU  - Simon Smith
AU  - Camille Hutchinson
AU  - Amanda Hedstorm
AU  - Lucy Gray
AU  - Rachael Jones
AU  - Tegan Taylor
AU  - Blessing Oduh
AU  - Nasar Ahmad
AU  - Rachel Evans
AU  - Esther Erumere
AU  - Brittany Sanders
AU  - Edward Kinsella-Perks
AU  - Kevin Villa
AU  - Samantha Keenan
AU  - Sharon Finch
AU  - Rebecca Page
AU  - Lucy Topliss
AU  - Thirukumaran Duraisami
AU  - Tamsyn Pattenden
AU  - Katie Morgan
AU  - Emilie Williams
AU  - Nicola Yeo
AU  - Sonia Mariampillai
AU  - Ruth Penn
AU  - Marjorie Castillo
AU  - Nicola Cook
AU  - Susan Campbell
AU  - Shumita Palit
AU  - Helen Tench
AU  - Ronda Loosley
AU  - Tanya Sims
AU  - Rebecca Wolf-Roberts
AU  - Cerrys Parker
AU  - Senthil Kumar Subbarayan
AU  - Linda O'Brien
AU  - Victoria Riddell
AU  - Anna Smith
AU  - Cristopher Price
AU  - Mark Garside
AU  - Nina Jensen
AU  - Yaw Duodu
AU  - Cheryl Padilla-Harris
AU  - Patricia Avila Del Puerto
AU  - Bernard Esisi
AU  - Emma Clarkson
AU  - Mike Murrey
AU  - Vivek Rai
AU  - Megan Heckathorn
AU  - Heather Bartelt
AU  - Michelle Hill
AU  - Dalida Akhmedova
AU  - Brian Silver
AU  - Christina Manxhari
AU  - Tatiana Thompson
AU  - Michelle Manxhari
AU  - Ann Leonhardt-Caprio
AU  - Emily Prentiss
AU  - Curtis Benesch
AU  - Paige Hepple
AU  - Raymond Reichwein
AU  - Cesar Velasco
AU  - Andrea Singer
AU  - Erin Cekovich
AU  - Alicia Richardson
AU  - Olivia Christman
AU  - Leonard Kishel
AU  - Iftekhar Ahmed
AU  - Jana Braklow
AU  - Richard Smith
AU  - Jennifer McMahon
AU  - Carly Rossi
AU  - Alex Graves
AU  - Julie Schafer
AU  - Jamie Lynch
AU  - Sheryl Giambartolomei
AU  - Maria Aguilar
AU  - Melissa Ortiona
AU  - Elizabeth Dienst
AU  - Karin Olds
AU  - Debbie Summers
AU  - Christine Kennish
AU  - Claranne Mathiesen
AU  - Erin Conahan
AU  - Vivek Rai
AU  - Megan Heckathorn
AU  - Heather Bartelt
AU  - Michelle Hill
AU  - Dalida Akhmedova
AU  - Pramod Sethi
AU  - Sharon Biby
AU  - Amber Carter
AU  - Jessica Buckner
AU  - McNeill Kirkpatrick
AU  - Jindong Xu
AU  - Tammy Blackburn
AU  - Hannah Bell
AU  - Karen Newnam
AU  - Hannah Mack
AU  - Sarah Hocutt
AU  - Laith Altaweel
AU  - Saqib Chaudhry
AU  - Laura Madarász
AU  - Karlie Smith
AU  - Stefannie Belardo
AU  - Tugce Karageyer
AU  - Mihaela Alexander
AU  - Danielle Hagedorn
AU  - Nicole Westensee
AU  - Lisa Cohen
AU  - Teresa Wiegand
AU  - John (Hughes) Barghols
AU  - Russell Wheeler
AU  - Keri Smith
AU  - Kathy Stilwell
AU  - Victor Urrutia
AU  - Brenda Johnson
AU  - Jaime Butler
AU  - Roland Faigle
AU  - Amer AlShekhlee
AU  - Chizoba Ezepue
AU  - Bridget Gatscher
AU  - Richard King
AU  - Mike Ke
AU  - Gloria Dow
AU  - Michael Seamon
AU  - Travis Smith
AU  - Burton Tabaac
AU  - Kristen Gurnea
AU  - Jeffery Webb
AU  - Michael Phipps
AU  - Chad Schrier
AU  - Ann Leonhardt-Caprio
AU  - Emily Prentiss
AU  - Bruce Silverman
AU  - Nicole Green
AU  - Jean Kelly
AU  - Lynne Froehlich
AU  - Craig Anderson
AU  - Victor Urrutia
AU  - Brenda Johnson
AU  - Debbie Summers
AU  - Roland Faigle
AU  - Diana Day
AU  - Thompson Robinson
AU  - Paula Muñoz Venturelli
AU  - Pooja Khatri
AU  - Richard Lindley
AU  - Xia Wang
AU  - Yi Sui
AU  - Lili Song
AU  - Wan Asyraf
AU  - Huy Thang Nguyen
AU  - Robert Herbert
AU  - Andrew Barreto
AU  - Karen S. Rapp
AU  - Laurent Billot
AU  - Qiang Li
AU  - Xiaoqiu Liu
AU  - Yinyan Wang
AU  - Qiao Han
AU  - Menglu Ouyang
AU  - Hueiming Liu
AU  - Lizheng Xu
AU  - Stephen Jan
AU  - Rachel Tang
AU  - Michelle Montalbano
AU  - April Pruski
AU  - Francisca González
AU  - Diana Day
AU  - Alejandra Del Rio Weldt
AU  - Alejandro Jesus López Pizano
AU  - Siti Zaleha Sahibulddin
AU  - Nur Liyana Rahmat
AU  - Nur Afrifah Mohd Khaili
AU  - Dayang Anis
AU  - Hamidah Hassan
AU  - Ahtasam Ebraimo
AU  - Ranjit J. Injety
AU  - Alejandra Malavera
AU  - Ha Hong Van (Melanie) Ta
AU  - Pratiti Ghosh
AU  - Natalie Espinosa
AU  - Lauren Clancy
AU  - Aisling Byrne
AU  - Luke Hatchwell
AU  - Alexandra Hurden
AU  - Antonio Michell
AU  - Manuela Armenis
AU  - Ravikumar Tummapudi
AU  - Ullas Arabhavi
AU  - Menglu Ouyang
AU  - Jipeng Cheng
AU  - Zhuo Meng
AU  - Alice Durham
AU  - Ahtasam Ebraimo
AU  - Uyen Hong
AU  - Linh Le Thi My
AU  - Nguyen Nhat Ha
AU  - Thi Thao Van
AU  - Thi Kim Nhung
AU  - Tuyet Mai
AU  - Nhat Phuong Ha
AU  - Thi Huong Giang
AU  - Nhat Linh
AU  - Thi Kim Chi
AU  - Thi Nhi
AU  - Hai Ngo Thanh
AU  - Paula Muñoz Venturelli
AU  - Francisca González
AU  - Francisca Urrutia Goldsack
AU  - Alejandra Del Rio Weldt
PY  - 2025
JO  - The Lancet
DO  - 10.1016/s0140-6736(25)00549-5
UR  - https://doi.org/10.1016/s0140-6736(25)00549-5
ER  - 

APA

Anderson, C. S., Summers, D., Ouyang, M., Sui, Y., Johnson, B., Billot, L., Malavera, A., Faigle, R., Muñoz-Venturelli, P., Day, D., Liu, X., Li, Q., Song, L., Robinson, T. G., González, F., Urrutia-Goldsack, F., Iacobelli, M., Montalbano, M., Pruski, A., Delcourt, C., Durham, A. C., Ebraimo, A., Ta, H. H. V., Ghosh, P., Leonhardt-Caprio, A., Nguyen, H. T., Ton, M. D., Jan, S., Liu, H., Lindley, R. I., Arauz, A., Mercado, A., Zaidi, W. A. W., Khatri, P., Wang, X., Urrutia, V. C., Jala, S., Day, S., Hu, Y., Lal, A., O'Brien, E., Devlin, M., Bendall, C., Nebauer, C., Maddox, D., Brooks, M., Kleinig, T., Cranefield, J., McMahon, S., Drew, R., McMullan, P., Straha, J., Rowley, D., Rodgers, H., Pyman, J., Grimley, R., Tastula, K., Li, X. (., Walker, S., Bailey, A., Hennessey, J. R., Butcher, K. S., Ghia, D., Edmonds, G., Casey, E., Ting, L., Prosser, J., Franklin, K., Ma, H., Phan, T., Vuong, J., Urbi, B., Phair, R., Jose, N., Shine, A., Lane, S., Mai, J., O'Rourke, F., Fuller, C., Urkude, R., Myers, N., Bradford, N., Sui, Y., Bian, W., Guo, X., Zhao, Y., Zhang, Y., Qi, X., Zhang, Y., Tang, H., Fang, X., Zheng, M., Yan, M., Yin, Y., Shi, P., Li, J., Luo, J., Fan, F., Guo, X., Zhou, H., Ba, X., Nie, Y., Song, C., Gao, H., Sun, L., Jia, C., Wang, M., Zhang, L., Yang, J., Song, A., Zhang, Y., Yu, S., Guan, Y., Bai, R., Li, C., Bai, T., Li, X., Wang, D., Yu, H., Zhao, W., Li, N., L, H., Yan, T., Zhang, J., Jiang, S., Shen, Y., Hu, X., Li, R., Cui, L., Kong, Y., Zhang, H., Yang, S., Guo, G., Zhao, X., Zhao, H., Zhang, F., Li, S., Yang, Y., Wang, Y., Jin, H., Liu, Z., Jiang, P., Jiang, H., Shai, Y., Tang, Y., Xue, J., Dong, X., Wang, J., Guo, J., Wang, X., Bao, Y., Li, H., Yang, X., Xie, L., Zhang, S., Yang, X., Qu, M., Deng, D., Liu, J., Bao, Z., Wang, T., Lin, L., Bi, C., Pan, Y., Chen, X., Gao, N., Peng, B., Lu, G., Jiang, Z., Pan, Y., Kang, L., Zhu, C., Zhang, L., Liang, Y., Peng, H., Song, B., Xiao, L., Kuang, J., Lu, X., Liao, X., Tan, Z., Zeng, W., Lin, W., Zhou, E., Wu, J., Chen, Y., Liu, Y., Meng, L., Wang, Z., Liu, Y., Xu, X., Xu, W., Dai, Y., Dong, Y., Zhang, Y., Wang, X., Hai, Y., Li, Z., Pei, Y., Zheng, G., Li, C., Wang, Z., Shi, Y., Li, S., Liu, Z., Zhang, J., Cui, L., Zhao, X., Qiao, Y., Liu, L., Zhang, J., Jiang, C., Fang, C., Su, R., Zhang, C., Ren, Y., Zhang, L., Liu, Y., Dong, M., Yang, T., Gao, S., Yin, R., Fu, Z., Li, Y., Ke, Y., Liu, X., Gao, H., Liu, Y., Wang, C., Liu, Y., Zhang, B., Guo, Z., Tan, Q., Zhong, W., Ling, K., Ma, S., Cheng, Y., Bi, Y., Jiang, F., Hao, Y., Yao, X., Wang, Z., Lei, M., Lei, L., Yue, D., Xiao, H., Chen, S., Chao, Y., He, G., Li, Y., Lin, M., Lv, J., Liu, C., Feng, J., Zhao, X., Yang, X., Yu, H., Ma, N., Lu, X., Jiang, R., Sun, X., Liu, N., Zhuang, Y., Silva-Pozo, A., Silva, P. G., Carrera, N. C., Mazzon, E., Brunser, A., Brinck, P., Gallardo, A., Valdivieso, P. G., Almeida, J., Neira, O. S., Haleby, A., Durán, A. L., Wenger, D., Canales, P., Zambrano, K., Rojas, C., Jiménez, D. R., Rivera, M., Orellana, M. J., Polanco, J., Esparza, T., Asyraf, W., Tan, T. H. J., Remli, R., Yahya, W. N. N. W., Soong, K. C., Kang, L. Z., Sahibulddin, S. Z., Baki, D. A. B. A., Hassan, H., Rahmat, N. L., Khaili, N. A. M., Rajah, R., Kiem, T. J., Khan, A. H. K. Y., Rauf, A. L. A., Zakaria, S. H., Halim, S. A., Abdullah, J. M., Idris, Z., Baharuddin, K. A. B., Ismail, M. I., Chung, L. W., Shyang, T. J., Steven, A., Cheng, W. S., Yang, S. C., Ong, S., James, J., Looi, I., Arauz, A., Mercado-Pompa, A., Cano-Nigenda, V., Romero-Vucovich, R., Nava-Sánchez, P., López-Pizano, A., Herrera-Calderón, R. E., Góngora-Rivera, F., Infante-Valenzuela, A., López-Soto, R., Chávez-Gamboa, R., Arreola-Sánchez, L. D., Gonzalez, G. G., Vallejo, S. L., Romero, J. L. G., Estudillo, M. D. R. M., Ortega, D. R., Jiménez-Ruiz, A., Ruiz-Sandoval, J. L., Aguilar-Fuentes, V., Sotelo-Ramirez, J. A., Ascencio-Tene, R. G., Estrada, E. D. L. C., Perez, V. M., Mai, D. T., Dao, V. P., Nguyen, T. D., Le, T. A., Bui, Q. V., Nguyen, T. P. N., Le, T. T. U., Tran, T. N. N., Nguyen, T. H., Nguyen, Q. H., Vo, D. C., Tran, T. T., Nguyen, T. M. P., Cao, H. N., Nguyen, L. T., Nguyen, H. T., Pham, N. B., Nguyen, T. T. A., Dang, Q. H., Nguyen, T. K. A., Vu, T. T., Le, T. V., Le, C. T., Dang, N. M. T., Nguyen, T. T. T., Teal, R., Joseph, J., Mathieson, P., Kennedy, J., Comont, T., Cumberbatch, G., Castanheira, A. M., Sim, C. H., Ghatala, R., Kennedy, K., Sari, B., Minhas, J., Musarrat, K., Khan, S., Harris, T., Mitchell-Douglas, J., Agarwal, S., Iqbal, A., Kowalska, K., McGovern, A., Stanton, J., Marinescu, M., Feerick, S., Obarey, S., Raingold, G., Flanagan, K., Revilla, G. A., Avila, R., Kennedy, R., Lee, Y. C., Lyon, J., Lewis, A., Sayed, R. E., Jannine, Bandiola, B., Sese, L. V., Babia, K., Nungu, Z., Timotec, J., Drysdale, S., Tibasia, M. C., Belo, C. D., Rubern, S. B., Sari, B., Naqvi, A., Richards, E., Howe, J., Kamara, C., Younis, S., Sundayi, S., Sekaran, L., Reid, L., David, J., Poolon, L., Carpenter, M. A., Venkatesh, B., Kimaru, C. W., Greaves, C., Watson, S. E., Ryan, D., Kearsley, N., Temple, N., Allen, K., Arcoria, D., Horne, Z., Veraque, E., Zhao, J., Evans, S., Baird, A., Hannam-Penfold, T., Smith, S., Hutchinson, C., Hedstorm, A., Gray, L., Jones, R., Taylor, T., Oduh, B., Ahmad, N., Evans, R., Erumere, E., Sanders, B., Kinsella-Perks, E., Villa, K., Keenan, S., Finch, S., Page, R., Topliss, L., Duraisami, T., Pattenden, T., Morgan, K., Williams, E., Yeo, N., Mariampillai, S., Penn, R., Castillo, M., Cook, N., Campbell, S., Palit, S., Tench, H., Loosley, R., Sims, T., Wolf-Roberts, R., Parker, C., Subbarayan, S. K., O'Brien, L., Riddell, V., Smith, A., Price, C., Garside, M., Jensen, N., Duodu, Y., Padilla-Harris, C., Puerto, P. A. D., Esisi, B., Clarkson, E., Murrey, M., Rai, V., Heckathorn, M., Bartelt, H., Hill, M., Akhmedova, D., Silver, B., Manxhari, C., Thompson, T., Manxhari, M., Leonhardt-Caprio, A., Prentiss, E., Benesch, C., Hepple, P., Reichwein, R., Velasco, C., Singer, A., Cekovich, E., Richardson, A., Christman, O., Kishel, L., Ahmed, I., Braklow, J., Smith, R., McMahon, J., Rossi, C., Graves, A., Schafer, J., Lynch, J., Giambartolomei, S., Aguilar, M., Ortiona, M., Dienst, E., Olds, K., Summers, D., Kennish, C., Mathiesen, C., Conahan, E., Rai, V., Heckathorn, M., Bartelt, H., Hill, M., Akhmedova, D., Sethi, P., Biby, S., Carter, A., Buckner, J., Kirkpatrick, M., Xu, J., Blackburn, T., Bell, H., Newnam, K., Mack, H., Hocutt, S., Altaweel, L., Chaudhry, S., Madarász, L., Smith, K., Belardo, S., Karageyer, T., Alexander, M., Hagedorn, D., Westensee, N., Cohen, L., Wiegand, T., Barghols, J. (., Wheeler, R., Smith, K., Stilwell, K., Urrutia, V., Johnson, B., Butler, J., Faigle, R., AlShekhlee, A., Ezepue, C., Gatscher, B., King, R., Ke, M., Dow, G., Seamon, M., Smith, T., Tabaac, B., Gurnea, K., Webb, J., Phipps, M., Schrier, C., Leonhardt-Caprio, A., Prentiss, E., Silverman, B., Green, N., Kelly, J., Froehlich, L., Anderson, C., Urrutia, V., Johnson, B., Summers, D., Faigle, R., Day, D., Robinson, T., Venturelli, P. M., Khatri, P., Lindley, R., Wang, X., Sui, Y., Song, L., Asyraf, W., Nguyen, H. T., Herbert, R., Barreto, A., Rapp, K. S., Billot, L., Li, Q., Liu, X., Wang, Y., Han, Q., Ouyang, M., Liu, H., Xu, L., Jan, S., Tang, R., Montalbano, M., Pruski, A., González, F., Day, D., Weldt, A. D. R., Pizano, A. J. L., Sahibulddin, S. Z., Rahmat, N. L., Khaili, N. A. M., Anis, D., Hassan, H., Ebraimo, A., Injety, R. J., Malavera, A., Ta, H. H. V. (., Ghosh, P., Espinosa, N., Clancy, L., Byrne, A., Hatchwell, L., Hurden, A., Michell, A., Armenis, M., Tummapudi, R., Arabhavi, U., Ouyang, M., Cheng, J., Meng, Z., Durham, A., Ebraimo, A., Hong, U., My, L. L. T., Ha, N. N., Van, T. T., Nhung, T. K., Mai, T., Ha, N. P., Giang, T. H., Linh, N., Chi, T. K., Nhi, T., Thanh, H. N., Venturelli, P. M., González, F., Goldsack, F. U., & Weldt, A. D. R. (2025). Safety and efficacy of low-intensity versus standard monitoring following intravenous thrombolytic treatment in patients with acute ischaemic stroke (OPTIMISTmain): an international, pragmatic, stepped-wedge, cluster-randomised, controlled non-inferiority trial. The Lancet. https://doi.org/10.1016/s0140-6736(25)00549-5