The clinical effectiveness of clarithromycin versus endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps (MACRO): a pragmatic, multicentre, three-arm, randomised, placebo-controlled phase 4 trial.

Philpott C, Beard DJ, Saeedi E, Cook JA, Jones S, Clarke CS, Teoh L, Thomas M, Little P, Vennik J, Lund V, Schilder AGM, Long F, Durham S, Boardman J, Hopkins C, MACRO Collaborative, MACRO Programme Team

Open source

DOI: 10.1016/s0140-6736(25)01248-6
Published: 2025 Aug 30
Container: Lancet (London, England)
Publisher: Not recorded
Open access: unknown

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1016/s0140-6736-25-01248-6,
  title = {The clinical effectiveness of clarithromycin versus endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps (MACRO): a pragmatic, multicentre, three-arm, randomised, placebo-controlled phase 4 trial.},
  author = {Philpott C and Beard DJ and Saeedi E and Cook JA and Jones S and Clarke CS and Teoh L and Thomas M and Little P and Vennik J and Lund V and Schilder AGM and Long F and Durham S and Boardman J and Hopkins C and MACRO Collaborative and MACRO Programme Team},
  year = {2025},
  journal = {Lancet (London, England)},
  doi = {10.1016/s0140-6736(25)01248-6},
  url = {https://doi.org/10.1016/s0140-6736(25)01248-6}
}

RIS

TY  - JOUR
TI  - The clinical effectiveness of clarithromycin versus endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps (MACRO): a pragmatic, multicentre, three-arm, randomised, placebo-controlled phase 4 trial.
AU  - Philpott C
AU  - Beard DJ
AU  - Saeedi E
AU  - Cook JA
AU  - Jones S
AU  - Clarke CS
AU  - Teoh L
AU  - Thomas M
AU  - Little P
AU  - Vennik J
AU  - Lund V
AU  - Schilder AGM
AU  - Long F
AU  - Durham S
AU  - Boardman J
AU  - Hopkins C
AU  - MACRO Collaborative
AU  - MACRO Programme Team
PY  - 2025
JO  - Lancet (London, England)
DO  - 10.1016/s0140-6736(25)01248-6
UR  - https://doi.org/10.1016/s0140-6736(25)01248-6
ER  -

APA

C, P., DJ, B., E, S., JA, C., S, J., CS, C., L, T., M, T., P, L., J, V., V, L., AGM, S., F, L., S, D., J, B., C, H., Collaborative, M., & Team, M. P. (2025). The clinical effectiveness of clarithromycin versus endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps (MACRO): a pragmatic, multicentre, three-arm, randomised, placebo-controlled phase 4 trial.. Lancet (London, England). https://doi.org/10.1016/s0140-6736(25)01248-6

Source records

pubmed · retrieved 2026-09-25T20:08:19.814Z