Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA: a multicentre, randomised, open-label, non-inferiority phase 3 trial

Steven J Frank, Paul M Busse, J Jack Lee, David I Rosenthal, Mike Hernandez, David M Swanson, Adam S Garden, G Brandon Gunn, Samir H Patel, James W Snider, Daniel J Ma, Jason K Molitoris, Nancy Y Lee, Upendra Parvathaneni, Mark W McDonald, Noah S Kalman, Alexander Lin, Nasiruddin Mohammed, Christina Henson, Christian Hyde, Gopal K Bajaj, Sanford R Katz, Roi Dagan, William H Morrison, Jay P Reddy, C David Fuller, Shalin J Shah, Jack Phan, Gregory M Chronowski, Lauren Mayo, Erich M Sturgis, Renata Ferrarotto, Xiaorong R Zhu, Xiaodong Zhang, Li Wang, Katherine A Hutcheson, Adel K El-Naggar, Amy C Moreno, Anna Lee, Michael T Spiotto, Neil D Gross, Stephen Y Lai, Jay J Liao, Jonathan Paly, Zhongxing Liao, Robert L Foote, James Bates, Mark Chambers, Stephen Chun, Adeel Kaiser, Scott Lester, John N. Lukens, Lisa McGee, Michelle Neben-Wittich, Quynh-Nhu Nguyen, David M. Routman, Pamela Schlembach, Heath Skinner, Michael Soike, Jean-Claude Rwigema, Lee Wiederhold, Pierre Blanchard, Isabelle Choi, Albert Koong, Hans Langendijk, Radhe Mohan, Barbara J Carlson, Aileen Mapps, Jeffery G Sarmiento, Menna Y Teferra, Walter Bosch, David S Followill, Paige A Taylor, Sasha Y Fuentes, Matthew S Ning, Iakovos Toumazis, Christine F Wogan, Beth De Gracia, Kathryn Fink, Adam Grippin, Jacquelin Ma, Elizabeth A. Pettersen, Rasha M Sareyeldin, Catherine Cronin, Stacey Muise, Mary Johnson, Kevin Pyfferoen, Briana Tranby, June Leonard, Shelby Watkin, Caitlin Eggleston, Briana Barrow, Janette Wolcott, Jordan Antonio, Jeffery Brand, Amy Cleverdon, Melissa Drake, Erica Peters, Christopher Small, Kelly Clark, Ryan Holder

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DOI: 10.1016/s0140-6736(25)01962-2
Published: 2026-01
Container: The Lancet
Publisher: Elsevier BV
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1016/s0140-6736-25-01962-2,
  title = {Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA: a multicentre, randomised, open-label, non-inferiority phase 3 trial},
  author = {Steven J Frank and Paul M Busse and J Jack Lee and David I Rosenthal and Mike Hernandez and David M Swanson and Adam S Garden and G Brandon Gunn and Samir H Patel and James W Snider and Daniel J Ma and Jason K Molitoris and Nancy Y Lee and Upendra Parvathaneni and Mark W McDonald and Noah S Kalman and Alexander Lin and Nasiruddin Mohammed and Christina Henson and Christian Hyde and Gopal K Bajaj and Sanford R Katz and Roi Dagan and William H Morrison and Jay P Reddy and C David Fuller and Shalin J Shah and Jack Phan and Gregory M Chronowski and Lauren Mayo and Erich M Sturgis and Renata Ferrarotto and Xiaorong R Zhu and Xiaodong Zhang and Li Wang and Katherine A Hutcheson and Adel K El-Naggar and Amy C Moreno and Anna Lee and Michael T Spiotto and Neil D Gross and Stephen Y Lai and Jay J Liao and Jonathan Paly and Zhongxing Liao and Robert L Foote and James Bates and Mark Chambers and Stephen Chun and Adeel Kaiser and Scott Lester and John N. Lukens and Lisa McGee and Michelle Neben-Wittich and Quynh-Nhu Nguyen and David M. Routman and Pamela Schlembach and Heath Skinner and Michael Soike and Jean-Claude Rwigema and Lee Wiederhold and Pierre Blanchard and Isabelle Choi and Albert Koong and Hans Langendijk and Radhe Mohan and Barbara J Carlson and Aileen Mapps and Jeffery G Sarmiento and Menna Y Teferra and Walter Bosch and David S Followill and Paige A Taylor and Sasha Y Fuentes and Matthew S Ning and Iakovos Toumazis and Christine F Wogan and Beth De Gracia and Kathryn Fink and Adam Grippin and Jacquelin Ma and Elizabeth A. Pettersen and Rasha M Sareyeldin and Catherine Cronin and Stacey Muise and Mary Johnson and Kevin Pyfferoen and Briana Tranby and June Leonard and Shelby Watkin and Caitlin Eggleston and Briana Barrow and Janette Wolcott and Jordan Antonio and Jeffery Brand and Amy Cleverdon and Melissa Drake and Erica Peters and Christopher Small and Kelly Clark and Ryan Holder},
  year = {2026},
  journal = {The Lancet},
  doi = {10.1016/s0140-6736(25)01962-2},
  url = {https://doi.org/10.1016/s0140-6736(25)01962-2}
}

RIS

TY  - JOUR
TI  - Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA: a multicentre, randomised, open-label, non-inferiority phase 3 trial
AU  - Steven J Frank
AU  - Paul M Busse
AU  - J Jack Lee
AU  - David I Rosenthal
AU  - Mike Hernandez
AU  - David M Swanson
AU  - Adam S Garden
AU  - G Brandon Gunn
AU  - Samir H Patel
AU  - James W Snider
AU  - Daniel J Ma
AU  - Jason K Molitoris
AU  - Nancy Y Lee
AU  - Upendra Parvathaneni
AU  - Mark W McDonald
AU  - Noah S Kalman
AU  - Alexander Lin
AU  - Nasiruddin Mohammed
AU  - Christina Henson
AU  - Christian Hyde
AU  - Gopal K Bajaj
AU  - Sanford R Katz
AU  - Roi Dagan
AU  - William H Morrison
AU  - Jay P Reddy
AU  - C David Fuller
AU  - Shalin J Shah
AU  - Jack Phan
AU  - Gregory M Chronowski
AU  - Lauren Mayo
AU  - Erich M Sturgis
AU  - Renata Ferrarotto
AU  - Xiaorong R Zhu
AU  - Xiaodong Zhang
AU  - Li Wang
AU  - Katherine A Hutcheson
AU  - Adel K El-Naggar
AU  - Amy C Moreno
AU  - Anna Lee
AU  - Michael T Spiotto
AU  - Neil D Gross
AU  - Stephen Y Lai
AU  - Jay J Liao
AU  - Jonathan Paly
AU  - Zhongxing Liao
AU  - Robert L Foote
AU  - James Bates
AU  - Mark Chambers
AU  - Stephen Chun
AU  - Adeel Kaiser
AU  - Scott Lester
AU  - John N. Lukens
AU  - Lisa McGee
AU  - Michelle Neben-Wittich
AU  - Quynh-Nhu Nguyen
AU  - David M. Routman
AU  - Pamela Schlembach
AU  - Heath Skinner
AU  - Michael Soike
AU  - Jean-Claude Rwigema
AU  - Lee Wiederhold
AU  - Pierre Blanchard
AU  - Isabelle Choi
AU  - Albert Koong
AU  - Hans Langendijk
AU  - Radhe Mohan
AU  - Barbara J Carlson
AU  - Aileen Mapps
AU  - Jeffery G Sarmiento
AU  - Menna Y Teferra
AU  - Walter Bosch
AU  - David S Followill
AU  - Paige A Taylor
AU  - Sasha Y Fuentes
AU  - Matthew S Ning
AU  - Iakovos Toumazis
AU  - Christine F Wogan
AU  - Beth De Gracia
AU  - Kathryn Fink
AU  - Adam Grippin
AU  - Jacquelin Ma
AU  - Elizabeth A. Pettersen
AU  - Rasha M Sareyeldin
AU  - Catherine Cronin
AU  - Stacey Muise
AU  - Mary Johnson
AU  - Kevin Pyfferoen
AU  - Briana Tranby
AU  - June Leonard
AU  - Shelby Watkin
AU  - Caitlin Eggleston
AU  - Briana Barrow
AU  - Janette Wolcott
AU  - Jordan Antonio
AU  - Jeffery Brand
AU  - Amy Cleverdon
AU  - Melissa Drake
AU  - Erica Peters
AU  - Christopher Small
AU  - Kelly Clark
AU  - Ryan Holder
PY  - 2026
JO  - The Lancet
DO  - 10.1016/s0140-6736(25)01962-2
UR  - https://doi.org/10.1016/s0140-6736(25)01962-2
ER  -

APA

Frank, S. J., Busse, P. M., Lee, J. J., Rosenthal, D. I., Hernandez, M., Swanson, D. M., Garden, A. S., Gunn, G. B., Patel, S. H., Snider, J. W., Ma, D. J., Molitoris, J. K., Lee, N. Y., Parvathaneni, U., McDonald, M. W., Kalman, N. S., Lin, A., Mohammed, N., Henson, C., Hyde, C., Bajaj, G. K., Katz, S. R., Dagan, R., Morrison, W. H., Reddy, J. P., Fuller, C. D., Shah, S. J., Phan, J., Chronowski, G. M., Mayo, L., Sturgis, E. M., Ferrarotto, R., Zhu, X. R., Zhang, X., Wang, L., Hutcheson, K. A., El-Naggar, A. K., Moreno, A. C., Lee, A., Spiotto, M. T., Gross, N. D., Lai, S. Y., Liao, J. J., Paly, J., Liao, Z., Foote, R. L., Bates, J., Chambers, M., Chun, S., Kaiser, A., Lester, S., Lukens, J. N., McGee, L., Neben-Wittich, M., Nguyen, Q., Routman, D. M., Schlembach, P., Skinner, H., Soike, M., Rwigema, J., Wiederhold, L., Blanchard, P., Choi, I., Koong, A., Langendijk, H., Mohan, R., Carlson, B. J., Mapps, A., Sarmiento, J. G., Teferra, M. Y., Bosch, W., Followill, D. S., Taylor, P. A., Fuentes, S. Y., Ning, M. S., Toumazis, I., Wogan, C. F., Gracia, B. D., Fink, K., Grippin, A., Ma, J., Pettersen, E. A., Sareyeldin, R. M., Cronin, C., Muise, S., Johnson, M., Pyfferoen, K., Tranby, B., Leonard, J., Watkin, S., Eggleston, C., Barrow, B., Wolcott, J., Antonio, J., Brand, J., Cleverdon, A., Drake, M., Peters, E., Small, C., Clark, K., & Holder, R. (2026). Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA: a multicentre, randomised, open-label, non-inferiority phase 3 trial. The Lancet. https://doi.org/10.1016/s0140-6736(25)01962-2

Source records

crossref · retrieved 2026-09-25T14:19:12.047Z