Epcoritamab, lenalidomide, and rituximab versus lenalidomide and rituximab for relapsed or refractory follicular lymphoma (EPCORE FL-1): a global, open-label, randomised, phase 3 trial

Lorenzo Falchi, Marcel Nijland, Huiqiang Huang, Kim M Linton, John F Seymour, Rong Tao, Michal Kwiatek, Abel Costa, Theodoros P Vassilakopoulos, Richard Greil, Ana Jiménez-Ubieto, Shane A Gangatharan, Ohad Benjamini, Catherine Thieblemont, Alessandra Tucci, Anna Elinder-Camburn, Arpad Illes, Jan Novak, Miguel A Pavlovsky, Andrew McDonald, Dok Hyun Yoon, Dai Maruyama, Gauri Sunkersett, Jian P Mei, Nabanita Mukherjee, Feng Zhu, Abualbishr Alshreef, Elena Favaro, Franck Morschhauser, Panagiotis Tsirigotis, Juliana Pereira, Sonia Gonzalez de Villambrosia, Jayr Schmidt Filho, Irit Avivi, Wojciech Jurczak, Olivier Casasnovas, Juan Miguel Bergua Burgues, Jianzhen Shen, Neta Goldschmidt, Maria Bouzani, Zsolt Nagy, Loic Ysebaert, Roch Houot, Benoit Tessoulin, Gandhi Laurent Damaj, Umberto Vitolo, Juan Manuel Sancho, Vinay Vanguru, Su-Peng Yeh, Xiaojing Yan, Ashley Freeman, Jean-Francois Larouche, Szabolcs Modok, Caterina Patti, Joaquin Sanchez Garcia, Ederson Roberto de Mattos, Patricia Walker, Jeong Ok Lee, Suguru Fukuhara, Yuko Mishima, Jie Jin, Zhengzi Qian, Russell Sterrett, Ronit Gurion, Natalia Rotter, David Belada, Katerina Kopeckova, Marek Trneny, Kamal Bouabdallah, Laure LeBras, Agathe Waultier, Stephanie Guidez, Pierre Feugier, Enrico Derenzini, Gloria Margiotta Casaluci, Blanca Sanchez Gonzalez, Javier Lopez Jiménez, Norma Gutierrez Gutierrez, Guillermo Rodriguez, Ana Carolina Caballero Gonzalez, Eva de Jongh, Wim Terpstra, Joost Vermaat, Tsai-Yun Chen, Hung-Lin Liu, Takayuki Ikezoe, Huijing Wu, Wenyu Li, Hongmei Jing, Adam Kittai, Catherine Diefenbach, Brad Hunter, Netanel Horowitz, Petra Pichler, Gabor Mikala, Andras Masszi, Lubos Drgona, Marie-Christine Ngirabacu, Ann Janssens, Romain Guieze, Eric Durot, Corinne Haioun, Johannes Duell, Enrico Schalk, Monica Tani, Ana Carla Oliveira Ramos, Raul Cordoba Mascunano, Carlos Grande Garcia, Adolfo de la Fuente, Michael Roost Clausen, Troels Thomsen, Ingemar Lagerlof, Inger Nijhof, Roderick Johnson, Danielle Leao Cordeiro de, Ricardo Bigni, Hock Choong Lai, Samar Issa, Dong-Yeop Shin, Cheng-Wei Chou, Hideki Goto, Takafumi Nakao, Caixia Li, Xiaolei Wei, Xudong Wei, Wenbin Qian, Shuo Ma, Vijayalakshmi Donthireddy, Catherine Diefenbach, Mark Fesler, Francisco Hernandez-Ilizaliturri, Moshe Levy, Abhijeet Kumar, Habte Yimer, David Berz, Fernando Cabanillas, Maya Koren Michowitz, Muhit Ozcan, Ozan Salim, Guray Saydam, Mehmet Turgut, Ozgur Mehtap, Mehmet Orhan Ayyildiz, Eirini Katodritou, Meletios-Athanasios Dimopoulos, Peter Rajnics, Vanessa Van Hende, Renaud Roufosse, Inge Vrelust, Nadine Morineau, Sylvain Choquet, Emmanuel Bachy, Julie Abraham, Frank Kroschinsky, Carmen Herling, Marco Ladetto, Potito Scalzulli, Andres Ferreri, Simone Ferrero, Stefan Hohaus, Stefan Kallert, Berit Johansson, Rinske Boersma, Eduard Libourel, Clara Klerk, Matthew Wilson, Rebecca Auer, Shankaranarayana Paneesha, Toby Eyre, David Lewis, Robert Ayto, Wendy Osborne, Luciana Andrea Guanchiale, Hun Chuah, Anita Shetty, Chan Cheah, Allanah Kilfoyle, Won Seog Kim, Ho-Jin Shin, Tomoaki Fujisaki, Takahiro Kumode, Kenji Ishitsuka, Junichiro Yuda, Hisayuki Yokoyama, Koji Kato, Toshio Kitawaki, Tadakazu Kondo, Youko Suehiro, Yoshiaki Ogawa, Hideyuki Nakazawa, Akihiro Tomita, Hirotoshi Kamata, Xun Lai, Yuerong Shuang, Guangxun Gao, Lihong Liu, Haiyan Yang, XiNan Cen

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DOI: 10.1016/s0140-6736(25)02360-8
Published: 2026-01
Container: The Lancet
Publisher: Elsevier BV
Open access: unknown

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BibTeX

@article{allodium:10.1016/s0140-6736-25-02360-8,
  title = {Epcoritamab, lenalidomide, and rituximab versus lenalidomide and rituximab for relapsed or refractory follicular lymphoma (EPCORE FL-1): a global, open-label, randomised, phase 3 trial},
  author = {Lorenzo Falchi and Marcel Nijland and Huiqiang Huang and Kim M Linton and John F Seymour and Rong Tao and Michal Kwiatek and Abel Costa and Theodoros P Vassilakopoulos and Richard Greil and Ana Jiménez-Ubieto and Shane A Gangatharan and Ohad Benjamini and Catherine Thieblemont and Alessandra Tucci and Anna Elinder-Camburn and Arpad Illes and Jan Novak and Miguel A Pavlovsky and Andrew McDonald and Dok Hyun Yoon and Dai Maruyama and Gauri Sunkersett and Jian P Mei and Nabanita Mukherjee and Feng Zhu and Abualbishr Alshreef and Elena Favaro and Franck Morschhauser and Panagiotis Tsirigotis and Juliana Pereira and Sonia Gonzalez de Villambrosia and Jayr Schmidt Filho and Irit Avivi and Wojciech Jurczak and Olivier Casasnovas and Juan Miguel Bergua Burgues and Jianzhen Shen and Neta Goldschmidt and Maria Bouzani and Zsolt Nagy and Loic Ysebaert and Roch Houot and Benoit Tessoulin and Gandhi Laurent Damaj and Umberto Vitolo and Juan Manuel Sancho and Vinay Vanguru and Su-Peng Yeh and Xiaojing Yan and Ashley Freeman and Jean-Francois Larouche and Szabolcs Modok and Caterina Patti and Joaquin Sanchez Garcia and Ederson Roberto de Mattos and Patricia Walker and Jeong Ok Lee and Suguru Fukuhara and Yuko Mishima and Jie Jin and Zhengzi Qian and Russell Sterrett and Ronit Gurion and Natalia Rotter and David Belada and Katerina Kopeckova and Marek Trneny and Kamal Bouabdallah and Laure LeBras and Agathe Waultier and Stephanie Guidez and Pierre Feugier and Enrico Derenzini and Gloria Margiotta Casaluci and Blanca Sanchez Gonzalez and Javier Lopez Jiménez and Norma Gutierrez Gutierrez and Guillermo Rodriguez and Ana Carolina Caballero Gonzalez and Eva de Jongh and Wim Terpstra and Joost Vermaat and Tsai-Yun Chen and Hung-Lin Liu and Takayuki Ikezoe and Huijing Wu and Wenyu Li and Hongmei Jing and Adam Kittai and Catherine Diefenbach and Brad Hunter and Netanel Horowitz and Petra Pichler and Gabor Mikala and Andras Masszi and Lubos Drgona and Marie-Christine Ngirabacu and Ann Janssens and Romain Guieze and Eric Durot and Corinne Haioun and Johannes Duell and Enrico Schalk and Monica Tani and Ana Carla Oliveira Ramos and Raul Cordoba Mascunano and Carlos Grande Garcia and Adolfo de la Fuente and Michael Roost Clausen and Troels Thomsen and Ingemar Lagerlof and Inger Nijhof and Roderick Johnson and Danielle Leao Cordeiro de and Ricardo Bigni and Hock Choong Lai and Samar Issa and Dong-Yeop Shin and Cheng-Wei Chou and Hideki Goto and Takafumi Nakao and Caixia Li and Xiaolei Wei and Xudong Wei and Wenbin Qian and Shuo Ma and Vijayalakshmi Donthireddy and Catherine Diefenbach and Mark Fesler and Francisco Hernandez-Ilizaliturri and Moshe Levy and Abhijeet Kumar and Habte Yimer and David Berz and Fernando Cabanillas and Maya Koren Michowitz and Muhit Ozcan and Ozan Salim and Guray Saydam and Mehmet Turgut and Ozgur Mehtap and Mehmet Orhan Ayyildiz and Eirini Katodritou and Meletios-Athanasios Dimopoulos and Peter Rajnics and Vanessa Van Hende and Renaud Roufosse and Inge Vrelust and Nadine Morineau and Sylvain Choquet and Emmanuel Bachy and Julie Abraham and Frank Kroschinsky and Carmen Herling and Marco Ladetto and Potito Scalzulli and Andres Ferreri and Simone Ferrero and Stefan Hohaus and Stefan Kallert and Berit Johansson and Rinske Boersma and Eduard Libourel and Clara Klerk and Matthew Wilson and Rebecca Auer and Shankaranarayana Paneesha and Toby Eyre and David Lewis and Robert Ayto and Wendy Osborne and Luciana Andrea Guanchiale and Hun Chuah and Anita Shetty and Chan Cheah and Allanah Kilfoyle and Won Seog Kim and Ho-Jin Shin and Tomoaki Fujisaki and Takahiro Kumode and Kenji Ishitsuka and Junichiro Yuda and Hisayuki Yokoyama and Koji Kato and Toshio Kitawaki and Tadakazu Kondo and Youko Suehiro and Yoshiaki Ogawa and Hideyuki Nakazawa and Akihiro Tomita and Hirotoshi Kamata and Xun Lai and Yuerong Shuang and Guangxun Gao and Lihong Liu and Haiyan Yang and XiNan Cen},
  year = {2026},
  journal = {The Lancet},
  doi = {10.1016/s0140-6736(25)02360-8},
  url = {https://doi.org/10.1016/s0140-6736(25)02360-8}
}

RIS

TY  - JOUR
TI  - Epcoritamab, lenalidomide, and rituximab versus lenalidomide and rituximab for relapsed or refractory follicular lymphoma (EPCORE FL-1): a global, open-label, randomised, phase 3 trial
AU  - Lorenzo Falchi
AU  - Marcel Nijland
AU  - Huiqiang Huang
AU  - Kim M Linton
AU  - John F Seymour
AU  - Rong Tao
AU  - Michal Kwiatek
AU  - Abel Costa
AU  - Theodoros P Vassilakopoulos
AU  - Richard Greil
AU  - Ana Jiménez-Ubieto
AU  - Shane A Gangatharan
AU  - Ohad Benjamini
AU  - Catherine Thieblemont
AU  - Alessandra Tucci
AU  - Anna Elinder-Camburn
AU  - Arpad Illes
AU  - Jan Novak
AU  - Miguel A Pavlovsky
AU  - Andrew McDonald
AU  - Dok Hyun Yoon
AU  - Dai Maruyama
AU  - Gauri Sunkersett
AU  - Jian P Mei
AU  - Nabanita Mukherjee
AU  - Feng Zhu
AU  - Abualbishr Alshreef
AU  - Elena Favaro
AU  - Franck Morschhauser
AU  - Panagiotis Tsirigotis
AU  - Juliana Pereira
AU  - Sonia Gonzalez de Villambrosia
AU  - Jayr Schmidt Filho
AU  - Irit Avivi
AU  - Wojciech Jurczak
AU  - Olivier Casasnovas
AU  - Juan Miguel Bergua Burgues
AU  - Jianzhen Shen
AU  - Neta Goldschmidt
AU  - Maria Bouzani
AU  - Zsolt Nagy
AU  - Loic Ysebaert
AU  - Roch Houot
AU  - Benoit Tessoulin
AU  - Gandhi Laurent Damaj
AU  - Umberto Vitolo
AU  - Juan Manuel Sancho
AU  - Vinay Vanguru
AU  - Su-Peng Yeh
AU  - Xiaojing Yan
AU  - Ashley Freeman
AU  - Jean-Francois Larouche
AU  - Szabolcs Modok
AU  - Caterina Patti
AU  - Joaquin Sanchez Garcia
AU  - Ederson Roberto de Mattos
AU  - Patricia Walker
AU  - Jeong Ok Lee
AU  - Suguru Fukuhara
AU  - Yuko Mishima
AU  - Jie Jin
AU  - Zhengzi Qian
AU  - Russell Sterrett
AU  - Ronit Gurion
AU  - Natalia Rotter
AU  - David Belada
AU  - Katerina Kopeckova
AU  - Marek Trneny
AU  - Kamal Bouabdallah
AU  - Laure LeBras
AU  - Agathe Waultier
AU  - Stephanie Guidez
AU  - Pierre Feugier
AU  - Enrico Derenzini
AU  - Gloria Margiotta Casaluci
AU  - Blanca Sanchez Gonzalez
AU  - Javier Lopez Jiménez
AU  - Norma Gutierrez Gutierrez
AU  - Guillermo Rodriguez
AU  - Ana Carolina Caballero Gonzalez
AU  - Eva de Jongh
AU  - Wim Terpstra
AU  - Joost Vermaat
AU  - Tsai-Yun Chen
AU  - Hung-Lin Liu
AU  - Takayuki Ikezoe
AU  - Huijing Wu
AU  - Wenyu Li
AU  - Hongmei Jing
AU  - Adam Kittai
AU  - Catherine Diefenbach
AU  - Brad Hunter
AU  - Netanel Horowitz
AU  - Petra Pichler
AU  - Gabor Mikala
AU  - Andras Masszi
AU  - Lubos Drgona
AU  - Marie-Christine Ngirabacu
AU  - Ann Janssens
AU  - Romain Guieze
AU  - Eric Durot
AU  - Corinne Haioun
AU  - Johannes Duell
AU  - Enrico Schalk
AU  - Monica Tani
AU  - Ana Carla Oliveira Ramos
AU  - Raul Cordoba Mascunano
AU  - Carlos Grande Garcia
AU  - Adolfo de la Fuente
AU  - Michael Roost Clausen
AU  - Troels Thomsen
AU  - Ingemar Lagerlof
AU  - Inger Nijhof
AU  - Roderick Johnson
AU  - Danielle Leao Cordeiro de
AU  - Ricardo Bigni
AU  - Hock Choong Lai
AU  - Samar Issa
AU  - Dong-Yeop Shin
AU  - Cheng-Wei Chou
AU  - Hideki Goto
AU  - Takafumi Nakao
AU  - Caixia Li
AU  - Xiaolei Wei
AU  - Xudong Wei
AU  - Wenbin Qian
AU  - Shuo Ma
AU  - Vijayalakshmi Donthireddy
AU  - Catherine Diefenbach
AU  - Mark Fesler
AU  - Francisco Hernandez-Ilizaliturri
AU  - Moshe Levy
AU  - Abhijeet Kumar
AU  - Habte Yimer
AU  - David Berz
AU  - Fernando Cabanillas
AU  - Maya Koren Michowitz
AU  - Muhit Ozcan
AU  - Ozan Salim
AU  - Guray Saydam
AU  - Mehmet Turgut
AU  - Ozgur Mehtap
AU  - Mehmet Orhan Ayyildiz
AU  - Eirini Katodritou
AU  - Meletios-Athanasios Dimopoulos
AU  - Peter Rajnics
AU  - Vanessa Van Hende
AU  - Renaud Roufosse
AU  - Inge Vrelust
AU  - Nadine Morineau
AU  - Sylvain Choquet
AU  - Emmanuel Bachy
AU  - Julie Abraham
AU  - Frank Kroschinsky
AU  - Carmen Herling
AU  - Marco Ladetto
AU  - Potito Scalzulli
AU  - Andres Ferreri
AU  - Simone Ferrero
AU  - Stefan Hohaus
AU  - Stefan Kallert
AU  - Berit Johansson
AU  - Rinske Boersma
AU  - Eduard Libourel
AU  - Clara Klerk
AU  - Matthew Wilson
AU  - Rebecca Auer
AU  - Shankaranarayana Paneesha
AU  - Toby Eyre
AU  - David Lewis
AU  - Robert Ayto
AU  - Wendy Osborne
AU  - Luciana Andrea Guanchiale
AU  - Hun Chuah
AU  - Anita Shetty
AU  - Chan Cheah
AU  - Allanah Kilfoyle
AU  - Won Seog Kim
AU  - Ho-Jin Shin
AU  - Tomoaki Fujisaki
AU  - Takahiro Kumode
AU  - Kenji Ishitsuka
AU  - Junichiro Yuda
AU  - Hisayuki Yokoyama
AU  - Koji Kato
AU  - Toshio Kitawaki
AU  - Tadakazu Kondo
AU  - Youko Suehiro
AU  - Yoshiaki Ogawa
AU  - Hideyuki Nakazawa
AU  - Akihiro Tomita
AU  - Hirotoshi Kamata
AU  - Xun Lai
AU  - Yuerong Shuang
AU  - Guangxun Gao
AU  - Lihong Liu
AU  - Haiyan Yang
AU  - XiNan Cen
PY  - 2026
JO  - The Lancet
DO  - 10.1016/s0140-6736(25)02360-8
UR  - https://doi.org/10.1016/s0140-6736(25)02360-8
ER  -

APA

Falchi, L., Nijland, M., Huang, H., Linton, K. M., Seymour, J. F., Tao, R., Kwiatek, M., Costa, A., Vassilakopoulos, T. P., Greil, R., Jiménez-Ubieto, A., Gangatharan, S. A., Benjamini, O., Thieblemont, C., Tucci, A., Elinder-Camburn, A., Illes, A., Novak, J., Pavlovsky, M. A., McDonald, A., Yoon, D. H., Maruyama, D., Sunkersett, G., Mei, J. P., Mukherjee, N., Zhu, F., Alshreef, A., Favaro, E., Morschhauser, F., Tsirigotis, P., Pereira, J., Villambrosia, S. G. D., Filho, J. S., Avivi, I., Jurczak, W., Casasnovas, O., Burgues, J. M. B., Shen, J., Goldschmidt, N., Bouzani, M., Nagy, Z., Ysebaert, L., Houot, R., Tessoulin, B., Damaj, G. L., Vitolo, U., Sancho, J. M., Vanguru, V., Yeh, S., Yan, X., Freeman, A., Larouche, J., Modok, S., Patti, C., Garcia, J. S., Mattos, E. R. D., Walker, P., Lee, J. O., Fukuhara, S., Mishima, Y., Jin, J., Qian, Z., Sterrett, R., Gurion, R., Rotter, N., Belada, D., Kopeckova, K., Trneny, M., Bouabdallah, K., LeBras, L., Waultier, A., Guidez, S., Feugier, P., Derenzini, E., Casaluci, G. M., Gonzalez, B. S., Jiménez, J. L., Gutierrez, N. G., Rodriguez, G., Gonzalez, A. C. C., Jongh, E. D., Terpstra, W., Vermaat, J., Chen, T., Liu, H., Ikezoe, T., Wu, H., Li, W., Jing, H., Kittai, A., Diefenbach, C., Hunter, B., Horowitz, N., Pichler, P., Mikala, G., Masszi, A., Drgona, L., Ngirabacu, M., Janssens, A., Guieze, R., Durot, E., Haioun, C., Duell, J., Schalk, E., Tani, M., Ramos, A. C. O., Mascunano, R. C., Garcia, C. G., Fuente, A. D. L., Clausen, M. R., Thomsen, T., Lagerlof, I., Nijhof, I., Johnson, R., de, D. L. C., Bigni, R., Lai, H. C., Issa, S., Shin, D., Chou, C., Goto, H., Nakao, T., Li, C., Wei, X., Wei, X., Qian, W., Ma, S., Donthireddy, V., Diefenbach, C., Fesler, M., Hernandez-Ilizaliturri, F., Levy, M., Kumar, A., Yimer, H., Berz, D., Cabanillas, F., Michowitz, M. K., Ozcan, M., Salim, O., Saydam, G., Turgut, M., Mehtap, O., Ayyildiz, M. O., Katodritou, E., Dimopoulos, M., Rajnics, P., Hende, V. V., Roufosse, R., Vrelust, I., Morineau, N., Choquet, S., Bachy, E., Abraham, J., Kroschinsky, F., Herling, C., Ladetto, M., Scalzulli, P., Ferreri, A., Ferrero, S., Hohaus, S., Kallert, S., Johansson, B., Boersma, R., Libourel, E., Klerk, C., Wilson, M., Auer, R., Paneesha, S., Eyre, T., Lewis, D., Ayto, R., Osborne, W., Guanchiale, L. A., Chuah, H., Shetty, A., Cheah, C., Kilfoyle, A., Kim, W. S., Shin, H., Fujisaki, T., Kumode, T., Ishitsuka, K., Yuda, J., Yokoyama, H., Kato, K., Kitawaki, T., Kondo, T., Suehiro, Y., Ogawa, Y., Nakazawa, H., Tomita, A., Kamata, H., Lai, X., Shuang, Y., Gao, G., Liu, L., Yang, H., & Cen, X. (2026). Epcoritamab, lenalidomide, and rituximab versus lenalidomide and rituximab for relapsed or refractory follicular lymphoma (EPCORE FL-1): a global, open-label, randomised, phase 3 trial. The Lancet. https://doi.org/10.1016/s0140-6736(25)02360-8

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crossref · retrieved 2026-09-27T03:46:52.325Z