Effect of baxdrostat on ambulatory blood pressure in patients with resistant hypertension (Bax24): a phase 3, randomised, double-blind, placebo-controlled trial

Michel Azizi, Jenifer M Brown, Jamie P Dwyer, John M Flack, Erica S W Jones, Raisa Kurlyandskaya, Hongjian Li, Filip Birve, Aina S Lihn, Shira Perl, Markus P Schlaich, Hirotaka Shibata, Ji-Guang Wang, Bryan Williams, Cesar Zaidman, Sonia Sassone, Miguel Cuenca, Diego Arakaki, Mariano Chahin, María Andrea Steinacher, Fredy Ferre Pacora, Juan Loureyro, Jun Yang, Markus Schlaich, Tine De Backer, Hans T Kindt, Philippe Delmotte, Blagovest Stoimenov, Kiril Dzhomanov, Krassimir Cvetkov, Dimitar Raev, Stefan Naydenov, Shivinder Jolly, John Vyselaar, Luis Noronha, Daniel Gaudet, Amritanshu Pandey, Jennifer Ringrose, Yves Robitaille, Jiri Vesely, Jiri Krupicka, Ladislav Busak, Jitka Pruchova, Wolfgang Jungmair, Sebastian Cremer, Markus van der Giet, Stephan Schirmer, Spasija Parizova, Michael Doumas, George Stergiou, Konstantinos Tsioufis, Zoltán Miklós Járai, András Vorobcsuk, Tibor Kiss, Gizella Pap, András Csaba Nagy, Attila Farkas, Desmond Samuel, Mohd Faiz Faizul Fauzi, Mohamad Muslim Jamian, Louie Tirador, Gabriel Jocson, Marek Rajzer, Andrzej Januszewicz, Andrzej Tykarski, Michał Hoffmann, Jan Zbigniew Peruga, Edyta Zbroch, Piotr Sobieraj, Abdulmajid Mukhtar, Talal AlJabbary, Lubomir Antalik, Jan Fedacko, Peter Fulop, Lesley Burgess, Gulam Latiff, Julián Segura de la Morena, José Antonio García Donaire, Miguel Camafort Babkowski, Alejandro de la Sierra, Javier Sobrino Martínez, Anna Oliveras Serrano, Fernando Martinez, Manuel Gorostidi Pérez, Francisco Fuentes Jimenez, Chern-En Chiang, Kang-Ling Wang, Yen-Wen Wu, I-Chang Hsieh, Praew Kotruchin, Yongkasem Vorasettakarnkij, Weranuj Roubsanthisuk, Prin Vathesatogkit, Krit Leemasawat, Hilmi Erdem Sumbul, Özge Turgay Yıldırım, Cagri Yayla, Ozkan Gungor, Ismail Kocyigit, Auditi Naziat, Manish Saxena, Gordon Irvine, Andrew Hill, Amardeep Heer, David Wingfield, Sam Davies, John Jackson, Philip Lewis, David Bernard, Minesh Rajpal, Christopher Romero, Kianoosh Kaveh, Mario Guillen, Lorena Lewy-Alterbaum, Vanna Gold, Travis Taylor, Justin Arambasick, John Ducker, Rekha John, Eric Kirk, Manuel Montero, Nauman Shahid, George Thomas, Gary Sirken, David Guzman, Hai Nguyen, Dung Pham, Hai Nguyen, Hien Nguyen, Thao Dinh, Yen Nguyen

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DOI
10.1016/s0140-6736(25)02549-8
Published
2026-03
Container
The Lancet
Publisher
Elsevier BV
Open access
unknown

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@article{allodium:10.1016/s0140-6736-25-02549-8,
  title = {Effect of baxdrostat on ambulatory blood pressure in patients with resistant hypertension (Bax24): a phase 3, randomised, double-blind, placebo-controlled trial},
  author = {Michel Azizi and Jenifer M Brown and Jamie P Dwyer and John M Flack and Erica S W Jones and Raisa Kurlyandskaya and Hongjian Li and Filip Birve and Aina S Lihn and Shira Perl and Markus P Schlaich and Hirotaka Shibata and Ji-Guang Wang and Bryan Williams and Cesar Zaidman and Sonia Sassone and Miguel Cuenca and Diego Arakaki and Mariano Chahin and María Andrea Steinacher and Fredy Ferre Pacora and Juan Loureyro and Jun Yang and Markus Schlaich and Tine De Backer and Hans T Kindt and Philippe Delmotte and Blagovest Stoimenov and Kiril Dzhomanov and Krassimir Cvetkov and Dimitar Raev and Stefan Naydenov and Shivinder Jolly and John Vyselaar and Luis Noronha and Daniel Gaudet and Amritanshu Pandey and Jennifer Ringrose and Yves Robitaille and Jiri Vesely and Jiri Krupicka and Ladislav Busak and Jitka Pruchova and Wolfgang Jungmair and Sebastian Cremer and Markus van der Giet and Stephan Schirmer and Spasija Parizova and Michael Doumas and George Stergiou and Konstantinos Tsioufis and Zoltán Miklós Járai and András Vorobcsuk and Tibor Kiss and Gizella Pap and András Csaba Nagy and Attila Farkas and Desmond Samuel and Mohd Faiz Faizul Fauzi and Mohamad Muslim Jamian and Louie Tirador and Gabriel Jocson and Marek Rajzer and Andrzej Januszewicz and Andrzej Tykarski and Michał Hoffmann and Jan Zbigniew Peruga and Edyta Zbroch and Piotr Sobieraj and Abdulmajid Mukhtar and Talal AlJabbary and Lubomir Antalik and Jan Fedacko and Peter Fulop and Lesley Burgess and Gulam Latiff and Julián Segura de la Morena and José Antonio García Donaire and Miguel Camafort Babkowski and Alejandro de la Sierra and Javier Sobrino Martínez and Anna Oliveras Serrano and Fernando Martinez and Manuel Gorostidi Pérez and Francisco Fuentes Jimenez and Chern-En Chiang and Kang-Ling Wang and Yen-Wen Wu and I-Chang Hsieh and Praew Kotruchin and Yongkasem Vorasettakarnkij and Weranuj Roubsanthisuk and Prin Vathesatogkit and Krit Leemasawat and Hilmi Erdem Sumbul and Özge Turgay Yıldırım and Cagri Yayla and Ozkan Gungor and Ismail Kocyigit and Auditi Naziat and Manish Saxena and Gordon Irvine and Andrew Hill and Amardeep Heer and David Wingfield and Sam Davies and John Jackson and Philip Lewis and David Bernard and Minesh Rajpal and Christopher Romero and Kianoosh Kaveh and Mario Guillen and Lorena Lewy-Alterbaum and Vanna Gold and Travis Taylor and Justin Arambasick and John Ducker and Rekha John and Eric Kirk and Manuel Montero and Nauman Shahid and George Thomas and Gary Sirken and David Guzman and Hai Nguyen and Dung Pham and Hai Nguyen and Hien Nguyen and Thao Dinh and Yen Nguyen},
  year = {2026},
  journal = {The Lancet},
  doi = {10.1016/s0140-6736(25)02549-8},
  url = {https://doi.org/10.1016/s0140-6736(25)02549-8}
}

RIS

TY  - JOUR
TI  - Effect of baxdrostat on ambulatory blood pressure in patients with resistant hypertension (Bax24): a phase 3, randomised, double-blind, placebo-controlled trial
AU  - Michel Azizi
AU  - Jenifer M Brown
AU  - Jamie P Dwyer
AU  - John M Flack
AU  - Erica S W Jones
AU  - Raisa Kurlyandskaya
AU  - Hongjian Li
AU  - Filip Birve
AU  - Aina S Lihn
AU  - Shira Perl
AU  - Markus P Schlaich
AU  - Hirotaka Shibata
AU  - Ji-Guang Wang
AU  - Bryan Williams
AU  - Cesar Zaidman
AU  - Sonia Sassone
AU  - Miguel Cuenca
AU  - Diego Arakaki
AU  - Mariano Chahin
AU  - María Andrea Steinacher
AU  - Fredy Ferre Pacora
AU  - Juan Loureyro
AU  - Jun Yang
AU  - Markus Schlaich
AU  - Tine De Backer
AU  - Hans T Kindt
AU  - Philippe Delmotte
AU  - Blagovest Stoimenov
AU  - Kiril Dzhomanov
AU  - Krassimir Cvetkov
AU  - Dimitar Raev
AU  - Stefan Naydenov
AU  - Shivinder Jolly
AU  - John Vyselaar
AU  - Luis Noronha
AU  - Daniel Gaudet
AU  - Amritanshu Pandey
AU  - Jennifer Ringrose
AU  - Yves Robitaille
AU  - Jiri Vesely
AU  - Jiri Krupicka
AU  - Ladislav Busak
AU  - Jitka Pruchova
AU  - Wolfgang Jungmair
AU  - Sebastian Cremer
AU  - Markus van der Giet
AU  - Stephan Schirmer
AU  - Spasija Parizova
AU  - Michael Doumas
AU  - George Stergiou
AU  - Konstantinos Tsioufis
AU  - Zoltán Miklós Járai
AU  - András Vorobcsuk
AU  - Tibor Kiss
AU  - Gizella Pap
AU  - András Csaba Nagy
AU  - Attila Farkas
AU  - Desmond Samuel
AU  - Mohd Faiz Faizul Fauzi
AU  - Mohamad Muslim Jamian
AU  - Louie Tirador
AU  - Gabriel Jocson
AU  - Marek Rajzer
AU  - Andrzej Januszewicz
AU  - Andrzej Tykarski
AU  - Michał Hoffmann
AU  - Jan Zbigniew Peruga
AU  - Edyta Zbroch
AU  - Piotr Sobieraj
AU  - Abdulmajid Mukhtar
AU  - Talal AlJabbary
AU  - Lubomir Antalik
AU  - Jan Fedacko
AU  - Peter Fulop
AU  - Lesley Burgess
AU  - Gulam Latiff
AU  - Julián Segura de la Morena
AU  - José Antonio García Donaire
AU  - Miguel Camafort Babkowski
AU  - Alejandro de la Sierra
AU  - Javier Sobrino Martínez
AU  - Anna Oliveras Serrano
AU  - Fernando Martinez
AU  - Manuel Gorostidi Pérez
AU  - Francisco Fuentes Jimenez
AU  - Chern-En Chiang
AU  - Kang-Ling Wang
AU  - Yen-Wen Wu
AU  - I-Chang Hsieh
AU  - Praew Kotruchin
AU  - Yongkasem Vorasettakarnkij
AU  - Weranuj Roubsanthisuk
AU  - Prin Vathesatogkit
AU  - Krit Leemasawat
AU  - Hilmi Erdem Sumbul
AU  - Özge Turgay Yıldırım
AU  - Cagri Yayla
AU  - Ozkan Gungor
AU  - Ismail Kocyigit
AU  - Auditi Naziat
AU  - Manish Saxena
AU  - Gordon Irvine
AU  - Andrew Hill
AU  - Amardeep Heer
AU  - David Wingfield
AU  - Sam Davies
AU  - John Jackson
AU  - Philip Lewis
AU  - David Bernard
AU  - Minesh Rajpal
AU  - Christopher Romero
AU  - Kianoosh Kaveh
AU  - Mario Guillen
AU  - Lorena Lewy-Alterbaum
AU  - Vanna Gold
AU  - Travis Taylor
AU  - Justin Arambasick
AU  - John Ducker
AU  - Rekha John
AU  - Eric Kirk
AU  - Manuel Montero
AU  - Nauman Shahid
AU  - George Thomas
AU  - Gary Sirken
AU  - David Guzman
AU  - Hai Nguyen
AU  - Dung Pham
AU  - Hai Nguyen
AU  - Hien Nguyen
AU  - Thao Dinh
AU  - Yen Nguyen
PY  - 2026
JO  - The Lancet
DO  - 10.1016/s0140-6736(25)02549-8
UR  - https://doi.org/10.1016/s0140-6736(25)02549-8
ER  -

APA

Azizi, M., Brown, J. M., Dwyer, J. P., Flack, J. M., Jones, E. S. W., Kurlyandskaya, R., Li, H., Birve, F., Lihn, A. S., Perl, S., Schlaich, M. P., Shibata, H., Wang, J., Williams, B., Zaidman, C., Sassone, S., Cuenca, M., Arakaki, D., Chahin, M., Steinacher, M. A., Pacora, F. F., Loureyro, J., Yang, J., Schlaich, M., Backer, T. D., Kindt, H. T., Delmotte, P., Stoimenov, B., Dzhomanov, K., Cvetkov, K., Raev, D., Naydenov, S., Jolly, S., Vyselaar, J., Noronha, L., Gaudet, D., Pandey, A., Ringrose, J., Robitaille, Y., Vesely, J., Krupicka, J., Busak, L., Pruchova, J., Jungmair, W., Cremer, S., Giet, M. V. D., Schirmer, S., Parizova, S., Doumas, M., Stergiou, G., Tsioufis, K., Járai, Z. M., Vorobcsuk, A., Kiss, T., Pap, G., Nagy, A. C., Farkas, A., Samuel, D., Fauzi, M. F. F., Jamian, M. M., Tirador, L., Jocson, G., Rajzer, M., Januszewicz, A., Tykarski, A., Hoffmann, M., Peruga, J. Z., Zbroch, E., Sobieraj, P., Mukhtar, A., AlJabbary, T., Antalik, L., Fedacko, J., Fulop, P., Burgess, L., Latiff, G., Morena, J. S. D. L., Donaire, J. A. G., Babkowski, M. C., Sierra, A. D. L., Martínez, J. S., Serrano, A. O., Martinez, F., Pérez, M. G., Jimenez, F. F., Chiang, C., Wang, K., Wu, Y., Hsieh, I., Kotruchin, P., Vorasettakarnkij, Y., Roubsanthisuk, W., Vathesatogkit, P., Leemasawat, K., Sumbul, H. E., Yıldırım, Ö. T., Yayla, C., Gungor, O., Kocyigit, I., Naziat, A., Saxena, M., Irvine, G., Hill, A., Heer, A., Wingfield, D., Davies, S., Jackson, J., Lewis, P., Bernard, D., Rajpal, M., Romero, C., Kaveh, K., Guillen, M., Lewy-Alterbaum, L., Gold, V., Taylor, T., Arambasick, J., Ducker, J., John, R., Kirk, E., Montero, M., Shahid, N., Thomas, G., Sirken, G., Guzman, D., Nguyen, H., Pham, D., Nguyen, H., Nguyen, H., Dinh, T., & Nguyen, Y. (2026). Effect of baxdrostat on ambulatory blood pressure in patients with resistant hypertension (Bax24): a phase 3, randomised, double-blind, placebo-controlled trial. The Lancet. https://doi.org/10.1016/s0140-6736(25)02549-8

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