Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial

Joseph P Broderick, Andrew M Naidech, Jordan J Elm, Kazunori Toyoda, Dar Dowlatshahi, Andrew M Demchuk, Pooja Khatri, Thorsten Steiner, Philip M Bath, Heinrich J Audebert, Achala Vagal, Sohei Yoshimura, Stephan A Mayer, Lily L Wang, Noor Sabagha, J D Mocco, Carlos Molina, Richard Aviv, Emily Stinson, Syed A Quadri, Janice Carrozzella, Thien Huynh, Anh Phan, Jonathan Beall, Iris Davis, Nobuyuki Sakai, Tsuyoshi Ohta, Michiko Yokosawa, Takayuki Hara, Navdeep Sangha, Kenichi Morita, Ming Yin Dominc Tse, Christopher D Streib, Fumio Miyashita, Yolanda Silva, Yoshinari Nagakane, Tudor Gheorghiu, Chung-Huan Sun, Teruyuki Hirano, Sven Poli, Tsuyoshi Izumo, Mayumi Fukuda-Doi, Masafumi Ihara, Masatoshi Koga, Brian Buck, Kyle B Walsh, Ilana Spokoyny, James C Grotta, Joseph Broderick, James Grotta, Andrew Naidech, Jordan Elm, Kazunori Toyoda, Andrew Demchuk, Dar Dowlatshahi, Carlos Molina, Thorsten Steiner, Philip Bath, Heinrich Audebert, Jay Mocco, Pooja Khatri, Achala Vagal, Richard Aviv, Stephan Mayer, Scott Janis, Sohei Yoshimura, Syed Quadri, Emily Stinson, Noor Sabagha, Lily Wang, Janice Carrozzella, Thien Huynh, Anh Phan, Jonathan Beall, Iris Davis, Nobuyuki Sakai, Tsuyoshi Ohta, Michiko Yokosawa, Takayuki Hara, Navdeep Sangha, Kenichi Morita, Ming Yin Dominic Tse, Christopher Streib, Fumio Miyashita, Yolanda Silva, Yoshinari Nagakane, Tudor Gheorghiu, Chung-Huan Sun, Teruyuki Hirano, Sven Poli, Tsuyoshi Izumo, Mayumi Fukuda-Doi, Masafumi Ihara, Masatoshi Koga, Brian Buck, Kyle Walsh, Ilana Spokoyny, Digvijaya Navalkele, Toshiyuki Fujinaka, Joan Marti Fabregas, William Hicks, Toshiichi Watanabe, Yusuke Yakushiji, Pere Cardona Portela, Mouhammad Jumaa, Amit Kansara, Christian Nolte, Alexandra Muccilli, Raisa Martinez, Alejandro Bustamante Rangel, Hauke Schneider, Takahiro Kuwashiro, Brett Meyer, Ashkan Shoamanesh, Laura Gioia, Elizabeth Liptrap, Pierre Borczuk, Nina Gentile, Supreet Kaur, Harish Shownkeen, Jason Mathew, Jan Purrucker, Shigeru Fujimoto, Erika Marulanda-Londono, Mustapha Ezzeddine, Fernanda Carvalho Poyraz, May Nour, Anna Khanna, Lauren Ng, Peter Panagos, Jason Appleton, Bernd Kallmuenzer, Houman Khosravani, Ramesh Grandhi, Peter Vajda, Vineeta Singh, Jay Shah, Sanjeev Sivakumar, Laura Zimmerman, Errol Gordon, Robert Jackson, Michael Brogan, Dennis Rivet, Parneet Grewal, Yousef Hannawi, Ali Mansour, Babak Jahromi, Brian Silver, Eugene Scharf, Nishita Singh, Indira Natarajan, Francisco Purroy

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DOI: 10.1016/s0140-6736(26)00097-8
Published: 2026-02
Container: The Lancet
Publisher: Elsevier BV
Open access: unknown

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BibTeX

@article{allodium:10.1016/s0140-6736-26-00097-8,
  title = {Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial},
  author = {Joseph P Broderick and Andrew M Naidech and Jordan J Elm and Kazunori Toyoda and Dar Dowlatshahi and Andrew M Demchuk and Pooja Khatri and Thorsten Steiner and Philip M Bath and Heinrich J Audebert and Achala Vagal and Sohei Yoshimura and Stephan A Mayer and Lily L Wang and Noor Sabagha and J D Mocco and Carlos Molina and Richard Aviv and Emily Stinson and Syed A Quadri and Janice Carrozzella and Thien Huynh and Anh Phan and Jonathan Beall and Iris Davis and Nobuyuki Sakai and Tsuyoshi Ohta and Michiko Yokosawa and Takayuki Hara and Navdeep Sangha and Kenichi Morita and Ming Yin Dominc Tse and Christopher D Streib and Fumio Miyashita and Yolanda Silva and Yoshinari Nagakane and Tudor Gheorghiu and Chung-Huan Sun and Teruyuki Hirano and Sven Poli and Tsuyoshi Izumo and Mayumi Fukuda-Doi and Masafumi Ihara and Masatoshi Koga and Brian Buck and Kyle B Walsh and Ilana Spokoyny and James C Grotta and Joseph Broderick and James Grotta and Andrew Naidech and Jordan Elm and Kazunori Toyoda and Andrew Demchuk and Dar Dowlatshahi and Carlos Molina and Thorsten Steiner and Philip Bath and Heinrich Audebert and Jay Mocco and Pooja Khatri and Achala Vagal and Richard Aviv and Stephan Mayer and Scott Janis and Sohei Yoshimura and Syed Quadri and Emily Stinson and Noor Sabagha and Lily Wang and Janice Carrozzella and Thien Huynh and Anh Phan and Jonathan Beall and Iris Davis and Nobuyuki Sakai and Tsuyoshi Ohta and Michiko Yokosawa and Takayuki Hara and Navdeep Sangha and Kenichi Morita and Ming Yin Dominic Tse and Christopher Streib and Fumio Miyashita and Yolanda Silva and Yoshinari Nagakane and Tudor Gheorghiu and Chung-Huan Sun and Teruyuki Hirano and Sven Poli and Tsuyoshi Izumo and Mayumi Fukuda-Doi and Masafumi Ihara and Masatoshi Koga and Brian Buck and Kyle Walsh and Ilana Spokoyny and Digvijaya Navalkele and Toshiyuki Fujinaka and Joan Marti Fabregas and William Hicks and Toshiichi Watanabe and Yusuke Yakushiji and Pere Cardona Portela and Mouhammad Jumaa and Amit Kansara and Christian Nolte and Alexandra Muccilli and Raisa Martinez and Alejandro Bustamante Rangel and Hauke Schneider and Takahiro Kuwashiro and Brett Meyer and Ashkan Shoamanesh and Laura Gioia and Elizabeth Liptrap and Pierre Borczuk and Nina Gentile and Supreet Kaur and Harish Shownkeen and Jason Mathew and Jan Purrucker and Shigeru Fujimoto and Erika Marulanda-Londono and Mustapha Ezzeddine and Fernanda Carvalho Poyraz and May Nour and Anna Khanna and Lauren Ng and Peter Panagos and Jason Appleton and Bernd Kallmuenzer and Houman Khosravani and Ramesh Grandhi and Peter Vajda and Vineeta Singh and Jay Shah and Sanjeev Sivakumar and Laura Zimmerman and Errol Gordon and Robert Jackson and Michael Brogan and Dennis Rivet and Parneet Grewal and Yousef Hannawi and Ali Mansour and Babak Jahromi and Brian Silver and Eugene Scharf and Nishita Singh and Indira Natarajan and Francisco Purroy},
  year = {2026},
  journal = {The Lancet},
  doi = {10.1016/s0140-6736(26)00097-8},
  url = {https://doi.org/10.1016/s0140-6736(26)00097-8}
}

RIS

TY  - JOUR
TI  - Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial
AU  - Joseph P Broderick
AU  - Andrew M Naidech
AU  - Jordan J Elm
AU  - Kazunori Toyoda
AU  - Dar Dowlatshahi
AU  - Andrew M Demchuk
AU  - Pooja Khatri
AU  - Thorsten Steiner
AU  - Philip M Bath
AU  - Heinrich J Audebert
AU  - Achala Vagal
AU  - Sohei Yoshimura
AU  - Stephan A Mayer
AU  - Lily L Wang
AU  - Noor Sabagha
AU  - J D Mocco
AU  - Carlos Molina
AU  - Richard Aviv
AU  - Emily Stinson
AU  - Syed A Quadri
AU  - Janice Carrozzella
AU  - Thien Huynh
AU  - Anh Phan
AU  - Jonathan Beall
AU  - Iris Davis
AU  - Nobuyuki Sakai
AU  - Tsuyoshi Ohta
AU  - Michiko Yokosawa
AU  - Takayuki Hara
AU  - Navdeep Sangha
AU  - Kenichi Morita
AU  - Ming Yin Dominc Tse
AU  - Christopher D Streib
AU  - Fumio Miyashita
AU  - Yolanda Silva
AU  - Yoshinari Nagakane
AU  - Tudor Gheorghiu
AU  - Chung-Huan Sun
AU  - Teruyuki Hirano
AU  - Sven Poli
AU  - Tsuyoshi Izumo
AU  - Mayumi Fukuda-Doi
AU  - Masafumi Ihara
AU  - Masatoshi Koga
AU  - Brian Buck
AU  - Kyle B Walsh
AU  - Ilana Spokoyny
AU  - James C Grotta
AU  - Joseph Broderick
AU  - James Grotta
AU  - Andrew Naidech
AU  - Jordan Elm
AU  - Kazunori Toyoda
AU  - Andrew Demchuk
AU  - Dar Dowlatshahi
AU  - Carlos Molina
AU  - Thorsten Steiner
AU  - Philip Bath
AU  - Heinrich Audebert
AU  - Jay Mocco
AU  - Pooja Khatri
AU  - Achala Vagal
AU  - Richard Aviv
AU  - Stephan Mayer
AU  - Scott Janis
AU  - Sohei Yoshimura
AU  - Syed Quadri
AU  - Emily Stinson
AU  - Noor Sabagha
AU  - Lily Wang
AU  - Janice Carrozzella
AU  - Thien Huynh
AU  - Anh Phan
AU  - Jonathan Beall
AU  - Iris Davis
AU  - Nobuyuki Sakai
AU  - Tsuyoshi Ohta
AU  - Michiko Yokosawa
AU  - Takayuki Hara
AU  - Navdeep Sangha
AU  - Kenichi Morita
AU  - Ming Yin Dominic Tse
AU  - Christopher Streib
AU  - Fumio Miyashita
AU  - Yolanda Silva
AU  - Yoshinari Nagakane
AU  - Tudor Gheorghiu
AU  - Chung-Huan Sun
AU  - Teruyuki Hirano
AU  - Sven Poli
AU  - Tsuyoshi Izumo
AU  - Mayumi Fukuda-Doi
AU  - Masafumi Ihara
AU  - Masatoshi Koga
AU  - Brian Buck
AU  - Kyle Walsh
AU  - Ilana Spokoyny
AU  - Digvijaya Navalkele
AU  - Toshiyuki Fujinaka
AU  - Joan Marti Fabregas
AU  - William Hicks
AU  - Toshiichi Watanabe
AU  - Yusuke Yakushiji
AU  - Pere Cardona Portela
AU  - Mouhammad Jumaa
AU  - Amit Kansara
AU  - Christian Nolte
AU  - Alexandra Muccilli
AU  - Raisa Martinez
AU  - Alejandro Bustamante Rangel
AU  - Hauke Schneider
AU  - Takahiro Kuwashiro
AU  - Brett Meyer
AU  - Ashkan Shoamanesh
AU  - Laura Gioia
AU  - Elizabeth Liptrap
AU  - Pierre Borczuk
AU  - Nina Gentile
AU  - Supreet Kaur
AU  - Harish Shownkeen
AU  - Jason Mathew
AU  - Jan Purrucker
AU  - Shigeru Fujimoto
AU  - Erika Marulanda-Londono
AU  - Mustapha Ezzeddine
AU  - Fernanda Carvalho Poyraz
AU  - May Nour
AU  - Anna Khanna
AU  - Lauren Ng
AU  - Peter Panagos
AU  - Jason Appleton
AU  - Bernd Kallmuenzer
AU  - Houman Khosravani
AU  - Ramesh Grandhi
AU  - Peter Vajda
AU  - Vineeta Singh
AU  - Jay Shah
AU  - Sanjeev Sivakumar
AU  - Laura Zimmerman
AU  - Errol Gordon
AU  - Robert Jackson
AU  - Michael Brogan
AU  - Dennis Rivet
AU  - Parneet Grewal
AU  - Yousef Hannawi
AU  - Ali Mansour
AU  - Babak Jahromi
AU  - Brian Silver
AU  - Eugene Scharf
AU  - Nishita Singh
AU  - Indira Natarajan
AU  - Francisco Purroy
PY  - 2026
JO  - The Lancet
DO  - 10.1016/s0140-6736(26)00097-8
UR  - https://doi.org/10.1016/s0140-6736(26)00097-8
ER  -

APA

Broderick, J. P., Naidech, A. M., Elm, J. J., Toyoda, K., Dowlatshahi, D., Demchuk, A. M., Khatri, P., Steiner, T., Bath, P. M., Audebert, H. J., Vagal, A., Yoshimura, S., Mayer, S. A., Wang, L. L., Sabagha, N., Mocco, J. D., Molina, C., Aviv, R., Stinson, E., Quadri, S. A., Carrozzella, J., Huynh, T., Phan, A., Beall, J., Davis, I., Sakai, N., Ohta, T., Yokosawa, M., Hara, T., Sangha, N., Morita, K., Tse, M. Y. D., Streib, C. D., Miyashita, F., Silva, Y., Nagakane, Y., Gheorghiu, T., Sun, C., Hirano, T., Poli, S., Izumo, T., Fukuda-Doi, M., Ihara, M., Koga, M., Buck, B., Walsh, K. B., Spokoyny, I., Grotta, J. C., Broderick, J., Grotta, J., Naidech, A., Elm, J., Toyoda, K., Demchuk, A., Dowlatshahi, D., Molina, C., Steiner, T., Bath, P., Audebert, H., Mocco, J., Khatri, P., Vagal, A., Aviv, R., Mayer, S., Janis, S., Yoshimura, S., Quadri, S., Stinson, E., Sabagha, N., Wang, L., Carrozzella, J., Huynh, T., Phan, A., Beall, J., Davis, I., Sakai, N., Ohta, T., Yokosawa, M., Hara, T., Sangha, N., Morita, K., Tse, M. Y. D., Streib, C., Miyashita, F., Silva, Y., Nagakane, Y., Gheorghiu, T., Sun, C., Hirano, T., Poli, S., Izumo, T., Fukuda-Doi, M., Ihara, M., Koga, M., Buck, B., Walsh, K., Spokoyny, I., Navalkele, D., Fujinaka, T., Fabregas, J. M., Hicks, W., Watanabe, T., Yakushiji, Y., Portela, P. C., Jumaa, M., Kansara, A., Nolte, C., Muccilli, A., Martinez, R., Rangel, A. B., Schneider, H., Kuwashiro, T., Meyer, B., Shoamanesh, A., Gioia, L., Liptrap, E., Borczuk, P., Gentile, N., Kaur, S., Shownkeen, H., Mathew, J., Purrucker, J., Fujimoto, S., Marulanda-Londono, E., Ezzeddine, M., Poyraz, F. C., Nour, M., Khanna, A., Ng, L., Panagos, P., Appleton, J., Kallmuenzer, B., Khosravani, H., Grandhi, R., Vajda, P., Singh, V., Shah, J., Sivakumar, S., Zimmerman, L., Gordon, E., Jackson, R., Brogan, M., Rivet, D., Grewal, P., Hannawi, Y., Mansour, A., Jahromi, B., Silver, B., Scharf, E., Singh, N., Natarajan, I., & Purroy, F. (2026). Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. The Lancet. https://doi.org/10.1016/s0140-6736(26)00097-8

Source records

crossref · retrieved 2026-09-25T16:51:00.208Z