Pembrolizumab plus weekly paclitaxel in platinum-resistant recurrent ovarian cancer (ENGOT-ov65/KEYNOTE-B96): a multicentre, randomised, double-blind, phase 3 study

Nicoletta Colombo, Emese Zsiros, Gabriella Parma, Eliana Rulli, Alexandra Sebastianelli, Mariusz Bidzinski, Carlos Gallardo, Emad Matanes, Kosei Hasegawa, Fatih Kose, Manuel Magallanes-Maciel, Rebecca A Herbertson, Sumitra Ananda, Judith R Kroep, Andreia Cristina de Melo, Philip R Debruyne, Jae-Weon Kim, Jalid Sehouli, Marc-Edy Pierre, Sakari Hietanen, Claudio Zamagni, Xin Lu, Bradley J Monk, Robert L Coleman, Xuan Peng, Karin Yamada, Agata M Bogusz, Thibault De La Motte Rouge, Xiaohua Wu, Sumitra Ananda, Jeffrey Goh, Andrew Dean, Bo Gao, Philip Debruyne, Laura Polastro, Hannelore Denys, Thais Baert, Maite Schurmann, Graziela Zibetti Dal Molin, Ruffo Freitas-Junior, Andreia Cristina de Melo, Andrea Juliana Gomes, Lilian Barros, Anagha Gurjal, Leathia Fiorino, Alexandra Sebastianelli, Suzanne Fortin, Susie Lau, Andrew Robinson, Lucy Gilbert, Jennifer Brown Broderick, Allan Covens, Prafull Ghatage, Carlos Gallardo, Felipe Rey Gonzalez, Claudio Painemal, Eva Garcia, Pablo Rodriguez, Eduardo Yanez Ruiz, Carlos Romero Sanchez, Carolina Ibanez, Sihai Liao, Zhengzheng Chen, Hong Zheng, Lingya Pan, Xiaohua Wu, An Lin, Jieqing Zhang, Genhai Zhu, Li Wang, Yi Huang, Jie Tang, Siyuan Zeng, Yuzhen Guo, Xiumin Li, Huaijun Zhou, Xin Lu, Qingshui Li, Yu Wang, Weiguo Lv, Hongqin Zhao, Songling Zhang, Yuan Jing Hu, Ke Wang, Guiling Li, Rutie Yin, Yu Zhang, Hongying Yang, Yang Shen, Yifeng Wang, Rafael Vallejo Rodrigues, Pedro Ramos Guette, Tomas Sanchez, Indira Hernandez, Andres Fernando Arenas Arias, Charlotte Haslund, Sakari Hietanen, Emmanuel Guardiola, Thibault de la Motte Rouge, Florence Joly-Lobbedez, Laurence Venat, Laura Deiana, Alain Lortholary, Diana Bello Roufai, Gerhard Gebauer, Mustafa Deryal, Jalid Sehouli, Lucia Otten, Pauline Wimberger, Tanja Fehm, Peter Fasching, Bahriye Aktas, Marina Wirtz, Karen Cadoo, Gil Bar-Sela, Salomon Stemmer, Emed Matanes, Ora Rosengarten, Jacob Korach, Mihai Meirovitz, Tamar Safra, Giulia Carlo Stella, Germana Tognon, Francesco Raspagliesi, Claudio Zamagni, Gabriella Maria Parma, Annamaria Ferrero, Stefania Canova, Shiro Suzuki, Mayu Yunokawa, Tomoka Usami, Hidemichi Watari, Tsukasa Baba, Shin Nishio, Kazuki Sudo, Kenichi Harano, Kazuhiro Takehara, Noriyuki Katsumata, Shoji Kamiura, Kosei Hasegawa, Nobutaka Takahashi, Shin Wha Lee, Jae Hoon Kim, Jae-Weon Kim, EunJi Nam, Roberto Ivan Romero Diaz, Manuel Magallanes Maciel, Yamil Lopez Chuken, David Cantu de Leon, Juan Ceja Garcia, Ingrid Boere, Judith Kroep, Petronella Ottevanger, Inge Baas, Michelle Wilson, Anne Marie Hansson, Beata Mackowiak-Matejczyk, Rafal Tarnawski, Mariusz Bidzinski, Marcin Misiek, Anna Danska-Bidzinska, Pawel Knapp, Radoslaw Madry, Dagmara Klasa-Mazurkiewicz, Valeriya Saevets, Alexandra Tyulyandina, Aleksander Bystrov, Pavel Skopin, Elena Pashkova, Yuksel Urun, Huseyin Akilli, Fatih Kose, Haci Mehmet Turk, Ganim Khatib, Pinar Gursoy, Tevfik Bese, Mesut Yilmaz, Christine Parkinson, Rebecca Herbertson, Iain McNeish, Joey Wood, Michelle Ferguson, John McGrane, Emma Hudson, Sarah Moon, Timothy Lestingi, Raza Khan, June Hou, Angeles Secord, Mark Genesen, Lyndsay Willmott, Christina Annunziata, Deena Graham, Kristin Anderson, Panayotis Ledakis, Kimberly Resnick, Robert Wenham, Steven McCure, Janelle Fauci, Michael Koontz, Anya Menzies, Christopher Darus, Emese Zsiros, Rachel Bramblet, Maria Bell, Beverly Long, Michael Callahan, Kristi McIntyre, Christine Lee, Michael Ulm, Merry Markham, Susan Zweizig, Alexander Olawaiye, Destin Black, Alessandro Santin

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DOI: 10.1016/s0140-6736(26)00602-1
Published: 2026-04
Container: The Lancet
Publisher: Elsevier BV
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BibTeX

@article{allodium:10.1016/s0140-6736-26-00602-1,
  title = {Pembrolizumab plus weekly paclitaxel in platinum-resistant recurrent ovarian cancer (ENGOT-ov65/KEYNOTE-B96): a multicentre, randomised, double-blind, phase 3 study},
  author = {Nicoletta Colombo and Emese Zsiros and Gabriella Parma and Eliana Rulli and Alexandra Sebastianelli and Mariusz Bidzinski and Carlos Gallardo and Emad Matanes and Kosei Hasegawa and Fatih Kose and Manuel Magallanes-Maciel and Rebecca A Herbertson and Sumitra Ananda and Judith R Kroep and Andreia Cristina de Melo and Philip R Debruyne and Jae-Weon Kim and Jalid Sehouli and Marc-Edy Pierre and Sakari Hietanen and Claudio Zamagni and Xin Lu and Bradley J Monk and Robert L Coleman and Xuan Peng and Karin Yamada and Agata M Bogusz and Thibault De La Motte Rouge and Xiaohua Wu and Sumitra Ananda and Jeffrey Goh and Andrew Dean and Bo Gao and Philip Debruyne and Laura Polastro and Hannelore Denys and Thais Baert and Maite Schurmann and Graziela Zibetti Dal Molin and Ruffo Freitas-Junior and Andreia Cristina de Melo and Andrea Juliana Gomes and Lilian Barros and Anagha Gurjal and Leathia Fiorino and Alexandra Sebastianelli and Suzanne Fortin and Susie Lau and Andrew Robinson and Lucy Gilbert and Jennifer Brown Broderick and Allan Covens and Prafull Ghatage and Carlos Gallardo and Felipe Rey Gonzalez and Claudio Painemal and Eva Garcia and Pablo Rodriguez and Eduardo Yanez Ruiz and Carlos Romero Sanchez and Carolina Ibanez and Sihai Liao and Zhengzheng Chen and Hong Zheng and Lingya Pan and Xiaohua Wu and An Lin and Jieqing Zhang and Genhai Zhu and Li Wang and Yi Huang and Jie Tang and Siyuan Zeng and Yuzhen Guo and Xiumin Li and Huaijun Zhou and Xin Lu and Qingshui Li and Yu Wang and Weiguo Lv and Hongqin Zhao and Songling Zhang and Yuan Jing Hu and Ke Wang and Guiling Li and Rutie Yin and Yu Zhang and Hongying Yang and Yang Shen and Yifeng Wang and Rafael Vallejo Rodrigues and Pedro Ramos Guette and Tomas Sanchez and Indira Hernandez and Andres Fernando Arenas Arias and Charlotte Haslund and Sakari Hietanen and Emmanuel Guardiola and Thibault de la Motte Rouge and Florence Joly-Lobbedez and Laurence Venat and Laura Deiana and Alain Lortholary and Diana Bello Roufai and Gerhard Gebauer and Mustafa Deryal and Jalid Sehouli and Lucia Otten and Pauline Wimberger and Tanja Fehm and Peter Fasching and Bahriye Aktas and Marina Wirtz and Karen Cadoo and Gil Bar-Sela and Salomon Stemmer and Emed Matanes and Ora Rosengarten and Jacob Korach and Mihai Meirovitz and Tamar Safra and Giulia Carlo Stella and Germana Tognon and Francesco Raspagliesi and Claudio Zamagni and Gabriella Maria Parma and Annamaria Ferrero and Stefania Canova and Shiro Suzuki and Mayu Yunokawa and Tomoka Usami and Hidemichi Watari and Tsukasa Baba and Shin Nishio and Kazuki Sudo and Kenichi Harano and Kazuhiro Takehara and Noriyuki Katsumata and Shoji Kamiura and Kosei Hasegawa and Nobutaka Takahashi and Shin Wha Lee and Jae Hoon Kim and Jae-Weon Kim and EunJi Nam and Roberto Ivan Romero Diaz and Manuel Magallanes Maciel and Yamil Lopez Chuken and David Cantu de Leon and Juan Ceja Garcia and Ingrid Boere and Judith Kroep and Petronella Ottevanger and Inge Baas and Michelle Wilson and Anne Marie Hansson and Beata Mackowiak-Matejczyk and Rafal Tarnawski and Mariusz Bidzinski and Marcin Misiek and Anna Danska-Bidzinska and Pawel Knapp and Radoslaw Madry and Dagmara Klasa-Mazurkiewicz and Valeriya Saevets and Alexandra Tyulyandina and Aleksander Bystrov and Pavel Skopin and Elena Pashkova and Yuksel Urun and Huseyin Akilli and Fatih Kose and Haci Mehmet Turk and Ganim Khatib and Pinar Gursoy and Tevfik Bese and Mesut Yilmaz and Christine Parkinson and Rebecca Herbertson and Iain McNeish and Joey Wood and Michelle Ferguson and John McGrane and Emma Hudson and Sarah Moon and Timothy Lestingi and Raza Khan and June Hou and Angeles Secord and Mark Genesen and Lyndsay Willmott and Christina Annunziata and Deena Graham and Kristin Anderson and Panayotis Ledakis and Kimberly Resnick and Robert Wenham and Steven McCure and Janelle Fauci and Michael Koontz and Anya Menzies and Christopher Darus and Emese Zsiros and Rachel Bramblet and Maria Bell and Beverly Long and Michael Callahan and Kristi McIntyre and Christine Lee and Michael Ulm and Merry Markham and Susan Zweizig and Alexander Olawaiye and Destin Black and Alessandro Santin},
  year = {2026},
  journal = {The Lancet},
  doi = {10.1016/s0140-6736(26)00602-1},
  url = {https://doi.org/10.1016/s0140-6736(26)00602-1}
}

RIS

TY  - JOUR
TI  - Pembrolizumab plus weekly paclitaxel in platinum-resistant recurrent ovarian cancer (ENGOT-ov65/KEYNOTE-B96): a multicentre, randomised, double-blind, phase 3 study
AU  - Nicoletta Colombo
AU  - Emese Zsiros
AU  - Gabriella Parma
AU  - Eliana Rulli
AU  - Alexandra Sebastianelli
AU  - Mariusz Bidzinski
AU  - Carlos Gallardo
AU  - Emad Matanes
AU  - Kosei Hasegawa
AU  - Fatih Kose
AU  - Manuel Magallanes-Maciel
AU  - Rebecca A Herbertson
AU  - Sumitra Ananda
AU  - Judith R Kroep
AU  - Andreia Cristina de Melo
AU  - Philip R Debruyne
AU  - Jae-Weon Kim
AU  - Jalid Sehouli
AU  - Marc-Edy Pierre
AU  - Sakari Hietanen
AU  - Claudio Zamagni
AU  - Xin Lu
AU  - Bradley J Monk
AU  - Robert L Coleman
AU  - Xuan Peng
AU  - Karin Yamada
AU  - Agata M Bogusz
AU  - Thibault De La Motte Rouge
AU  - Xiaohua Wu
AU  - Sumitra Ananda
AU  - Jeffrey Goh
AU  - Andrew Dean
AU  - Bo Gao
AU  - Philip Debruyne
AU  - Laura Polastro
AU  - Hannelore Denys
AU  - Thais Baert
AU  - Maite Schurmann
AU  - Graziela Zibetti Dal Molin
AU  - Ruffo Freitas-Junior
AU  - Andreia Cristina de Melo
AU  - Andrea Juliana Gomes
AU  - Lilian Barros
AU  - Anagha Gurjal
AU  - Leathia Fiorino
AU  - Alexandra Sebastianelli
AU  - Suzanne Fortin
AU  - Susie Lau
AU  - Andrew Robinson
AU  - Lucy Gilbert
AU  - Jennifer Brown Broderick
AU  - Allan Covens
AU  - Prafull Ghatage
AU  - Carlos Gallardo
AU  - Felipe Rey Gonzalez
AU  - Claudio Painemal
AU  - Eva Garcia
AU  - Pablo Rodriguez
AU  - Eduardo Yanez Ruiz
AU  - Carlos Romero Sanchez
AU  - Carolina Ibanez
AU  - Sihai Liao
AU  - Zhengzheng Chen
AU  - Hong Zheng
AU  - Lingya Pan
AU  - Xiaohua Wu
AU  - An Lin
AU  - Jieqing Zhang
AU  - Genhai Zhu
AU  - Li Wang
AU  - Yi Huang
AU  - Jie Tang
AU  - Siyuan Zeng
AU  - Yuzhen Guo
AU  - Xiumin Li
AU  - Huaijun Zhou
AU  - Xin Lu
AU  - Qingshui Li
AU  - Yu Wang
AU  - Weiguo Lv
AU  - Hongqin Zhao
AU  - Songling Zhang
AU  - Yuan Jing Hu
AU  - Ke Wang
AU  - Guiling Li
AU  - Rutie Yin
AU  - Yu Zhang
AU  - Hongying Yang
AU  - Yang Shen
AU  - Yifeng Wang
AU  - Rafael Vallejo Rodrigues
AU  - Pedro Ramos Guette
AU  - Tomas Sanchez
AU  - Indira Hernandez
AU  - Andres Fernando Arenas Arias
AU  - Charlotte Haslund
AU  - Sakari Hietanen
AU  - Emmanuel Guardiola
AU  - Thibault de la Motte Rouge
AU  - Florence Joly-Lobbedez
AU  - Laurence Venat
AU  - Laura Deiana
AU  - Alain Lortholary
AU  - Diana Bello Roufai
AU  - Gerhard Gebauer
AU  - Mustafa Deryal
AU  - Jalid Sehouli
AU  - Lucia Otten
AU  - Pauline Wimberger
AU  - Tanja Fehm
AU  - Peter Fasching
AU  - Bahriye Aktas
AU  - Marina Wirtz
AU  - Karen Cadoo
AU  - Gil Bar-Sela
AU  - Salomon Stemmer
AU  - Emed Matanes
AU  - Ora Rosengarten
AU  - Jacob Korach
AU  - Mihai Meirovitz
AU  - Tamar Safra
AU  - Giulia Carlo Stella
AU  - Germana Tognon
AU  - Francesco Raspagliesi
AU  - Claudio Zamagni
AU  - Gabriella Maria Parma
AU  - Annamaria Ferrero
AU  - Stefania Canova
AU  - Shiro Suzuki
AU  - Mayu Yunokawa
AU  - Tomoka Usami
AU  - Hidemichi Watari
AU  - Tsukasa Baba
AU  - Shin Nishio
AU  - Kazuki Sudo
AU  - Kenichi Harano
AU  - Kazuhiro Takehara
AU  - Noriyuki Katsumata
AU  - Shoji Kamiura
AU  - Kosei Hasegawa
AU  - Nobutaka Takahashi
AU  - Shin Wha Lee
AU  - Jae Hoon Kim
AU  - Jae-Weon Kim
AU  - EunJi Nam
AU  - Roberto Ivan Romero Diaz
AU  - Manuel Magallanes Maciel
AU  - Yamil Lopez Chuken
AU  - David Cantu de Leon
AU  - Juan Ceja Garcia
AU  - Ingrid Boere
AU  - Judith Kroep
AU  - Petronella Ottevanger
AU  - Inge Baas
AU  - Michelle Wilson
AU  - Anne Marie Hansson
AU  - Beata Mackowiak-Matejczyk
AU  - Rafal Tarnawski
AU  - Mariusz Bidzinski
AU  - Marcin Misiek
AU  - Anna Danska-Bidzinska
AU  - Pawel Knapp
AU  - Radoslaw Madry
AU  - Dagmara Klasa-Mazurkiewicz
AU  - Valeriya Saevets
AU  - Alexandra Tyulyandina
AU  - Aleksander Bystrov
AU  - Pavel Skopin
AU  - Elena Pashkova
AU  - Yuksel Urun
AU  - Huseyin Akilli
AU  - Fatih Kose
AU  - Haci Mehmet Turk
AU  - Ganim Khatib
AU  - Pinar Gursoy
AU  - Tevfik Bese
AU  - Mesut Yilmaz
AU  - Christine Parkinson
AU  - Rebecca Herbertson
AU  - Iain McNeish
AU  - Joey Wood
AU  - Michelle Ferguson
AU  - John McGrane
AU  - Emma Hudson
AU  - Sarah Moon
AU  - Timothy Lestingi
AU  - Raza Khan
AU  - June Hou
AU  - Angeles Secord
AU  - Mark Genesen
AU  - Lyndsay Willmott
AU  - Christina Annunziata
AU  - Deena Graham
AU  - Kristin Anderson
AU  - Panayotis Ledakis
AU  - Kimberly Resnick
AU  - Robert Wenham
AU  - Steven McCure
AU  - Janelle Fauci
AU  - Michael Koontz
AU  - Anya Menzies
AU  - Christopher Darus
AU  - Emese Zsiros
AU  - Rachel Bramblet
AU  - Maria Bell
AU  - Beverly Long
AU  - Michael Callahan
AU  - Kristi McIntyre
AU  - Christine Lee
AU  - Michael Ulm
AU  - Merry Markham
AU  - Susan Zweizig
AU  - Alexander Olawaiye
AU  - Destin Black
AU  - Alessandro Santin
PY  - 2026
JO  - The Lancet
DO  - 10.1016/s0140-6736(26)00602-1
UR  - https://doi.org/10.1016/s0140-6736(26)00602-1
ER  -

APA

Colombo, N., Zsiros, E., Parma, G., Rulli, E., Sebastianelli, A., Bidzinski, M., Gallardo, C., Matanes, E., Hasegawa, K., Kose, F., Magallanes-Maciel, M., Herbertson, R. A., Ananda, S., Kroep, J. R., Melo, A. C. D., Debruyne, P. R., Kim, J., Sehouli, J., Pierre, M., Hietanen, S., Zamagni, C., Lu, X., Monk, B. J., Coleman, R. L., Peng, X., Yamada, K., Bogusz, A. M., Rouge, T. D. L. M., Wu, X., Ananda, S., Goh, J., Dean, A., Gao, B., Debruyne, P., Polastro, L., Denys, H., Baert, T., Schurmann, M., Molin, G. Z. D., Freitas-Junior, R., Melo, A. C. D., Gomes, A. J., Barros, L., Gurjal, A., Fiorino, L., Sebastianelli, A., Fortin, S., Lau, S., Robinson, A., Gilbert, L., Broderick, J. B., Covens, A., Ghatage, P., Gallardo, C., Gonzalez, F. R., Painemal, C., Garcia, E., Rodriguez, P., Ruiz, E. Y., Sanchez, C. R., Ibanez, C., Liao, S., Chen, Z., Zheng, H., Pan, L., Wu, X., Lin, A., Zhang, J., Zhu, G., Wang, L., Huang, Y., Tang, J., Zeng, S., Guo, Y., Li, X., Zhou, H., Lu, X., Li, Q., Wang, Y., Lv, W., Zhao, H., Zhang, S., Hu, Y. J., Wang, K., Li, G., Yin, R., Zhang, Y., Yang, H., Shen, Y., Wang, Y., Rodrigues, R. V., Guette, P. R., Sanchez, T., Hernandez, I., Arias, A. F. A., Haslund, C., Hietanen, S., Guardiola, E., Rouge, T. D. L. M., Joly-Lobbedez, F., Venat, L., Deiana, L., Lortholary, A., Roufai, D. B., Gebauer, G., Deryal, M., Sehouli, J., Otten, L., Wimberger, P., Fehm, T., Fasching, P., Aktas, B., Wirtz, M., Cadoo, K., Bar-Sela, G., Stemmer, S., Matanes, E., Rosengarten, O., Korach, J., Meirovitz, M., Safra, T., Stella, G. C., Tognon, G., Raspagliesi, F., Zamagni, C., Parma, G. M., Ferrero, A., Canova, S., Suzuki, S., Yunokawa, M., Usami, T., Watari, H., Baba, T., Nishio, S., Sudo, K., Harano, K., Takehara, K., Katsumata, N., Kamiura, S., Hasegawa, K., Takahashi, N., Lee, S. W., Kim, J. H., Kim, J., Nam, E., Diaz, R. I. R., Maciel, M. M., Chuken, Y. L., Leon, D. C. D., Garcia, J. C., Boere, I., Kroep, J., Ottevanger, P., Baas, I., Wilson, M., Hansson, A. M., Mackowiak-Matejczyk, B., Tarnawski, R., Bidzinski, M., Misiek, M., Danska-Bidzinska, A., Knapp, P., Madry, R., Klasa-Mazurkiewicz, D., Saevets, V., Tyulyandina, A., Bystrov, A., Skopin, P., Pashkova, E., Urun, Y., Akilli, H., Kose, F., Turk, H. M., Khatib, G., Gursoy, P., Bese, T., Yilmaz, M., Parkinson, C., Herbertson, R., McNeish, I., Wood, J., Ferguson, M., McGrane, J., Hudson, E., Moon, S., Lestingi, T., Khan, R., Hou, J., Secord, A., Genesen, M., Willmott, L., Annunziata, C., Graham, D., Anderson, K., Ledakis, P., Resnick, K., Wenham, R., McCure, S., Fauci, J., Koontz, M., Menzies, A., Darus, C., Zsiros, E., Bramblet, R., Bell, M., Long, B., Callahan, M., McIntyre, K., Lee, C., Ulm, M., Markham, M., Zweizig, S., Olawaiye, A., Black, D., & Santin, A. (2026). Pembrolizumab plus weekly paclitaxel in platinum-resistant recurrent ovarian cancer (ENGOT-ov65/KEYNOTE-B96): a multicentre, randomised, double-blind, phase 3 study. The Lancet. https://doi.org/10.1016/s0140-6736(26)00602-1

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crossref · retrieved 2026-11-10T13:49:25.947Z