Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, randomised, controlled, superiority trial

Cinta Moraleda, Alfredo Tagarro, Sara Domínguez-Rodríguez, Victor Musiime, Hilda Mujuru, Chishala Chabala, Tisungane Mvalo, Pui-Ying Iroh-Tam, Justina Bramugy, Lola Madrid, Jahit Sacarlal, Alfeu Passanduca, Muhammad Sidat, Uneisse Cassia, Hellen Tukamuhebwa Aanyu, Abner Tagoola, Constantine Mutata, Bwendo Nduna, Chimwemwe Chawinga, Lughano Ghambi, Matthew Bates, Sheila Fernández-Luis, Amir Seni, Merunissa Gafur, Damalie Nalwanga, Denis Nansera, Mutsa Bwakura-Dangarembizi, Natasha Namuziya, Franklyn Nkongho Egbe, John Tembo, Álvaro Ballesteros, Raoul Moh, Lilit Manukyan, David Lora, Olivier Marcy, Tom G Jacobs, David Burger, Quique Bassat, Valeriane Leroy, Alessandra Nardone, W Chris Buck, Pablo Rojo, Sónia Martins, Elias Manjate, Kajal Chhanganlal, Celda Mavume, Belinda Macmillian, Aurora Mucarengua, Adelina Manheche, Teresa Gatoma, Edson Arcanjo, Atija Salimo, Laize Beca, Raul Atibo, Hélio Brande, Rito Eleutério, Marizelina Chaves, Armando Saíde, Stella Langa, Natália Nipaco, Luzidina Martins, Mércia Nhaca, Sara Machava, Anastância Chirindza, Dalila Rego, Sílvia Chaúque, Dália Machel, Anélsio Cossa, Alínia Pedro, Andrew Kiggwe, Judith Beinomugisha, Agnes Alungat, Nancy Lajara Mark, Joseph Ssessanga, Josam Thembo Mwesige, Sharafat Nkinzi, Kenneth Muwanguzi, John Paul Lubega, Sophie Mutesi, Aminah Nalunkuuma, Elizabeth Najjingo, Bashirah Mbabazi, Godfrey Musoro, Moses Chitsamatanga, Ennie Chidziva, Misheck Phiri, Stuart Chitongo, Shepherd Mudzingwa, Joy Chimanzi, Ruth Nhema, Shirley Mutsai, Makhosonke Ndlovu, Columbus Moyo, Nathalie Mudzimurema, Trust Mukanganiki, Pia Ngwaru, Tsitsi Ngwenzi, Sibusisiwe Weza, Hazel Patricia Munyama, Veronica Mulenga, Perfect Shankalala, Idah Zulu, Kelvin Zimba, Helen Mhango, Chalwe Chibuye, Juliet Namwinwa, Terence Chipoya, Bwalya Simunyola, Tina Simwanga, Eustace Mwango, Sharon Kunda, Muleya Inambao, Salome Chitondo, Wyclef Mumba, Endreen Mankunshe, Barbara Halende, Kajimalwendo Mumba, Mangani Zulu, Davies Sondashi, Henry Musukwa, Caren Kabanda, Kwitaka Muluzi, Elizabeth Nkosi, Rufaro Mtolongo, Eddah Kafasiyanji, James Kaphatika, Ganizani Chilewani, Simon Nicholas, John Ndaferenkhande, Emmie Mbale, Bright Lipenga, James Nyirenda, Joyce Macheso, Sizwa Dziko, Maika Bangali, Sophie Desmonde, Dimitri Kambou

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DOI: 10.1016/s0140-6736(26)00754-3
Published: 2026-07
Container: The Lancet
Publisher: Elsevier BV
Open access: unknown

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BibTeX

@article{allodium:10.1016/s0140-6736-26-00754-3,
  title = {Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, randomised, controlled, superiority trial},
  author = {Cinta Moraleda and Alfredo Tagarro and Sara Domínguez-Rodríguez and Victor Musiime and Hilda Mujuru and Chishala Chabala and Tisungane Mvalo and Pui-Ying Iroh-Tam and Justina Bramugy and Lola Madrid and Jahit Sacarlal and Alfeu Passanduca and Muhammad Sidat and Uneisse Cassia and Hellen Tukamuhebwa Aanyu and Abner Tagoola and Constantine Mutata and Bwendo Nduna and Chimwemwe Chawinga and Lughano Ghambi and Matthew Bates and Sheila Fernández-Luis and Amir Seni and Merunissa Gafur and Damalie Nalwanga and Denis Nansera and Mutsa Bwakura-Dangarembizi and Natasha Namuziya and Franklyn Nkongho Egbe and John Tembo and Álvaro Ballesteros and Raoul Moh and Lilit Manukyan and David Lora and Olivier Marcy and Tom G Jacobs and David Burger and Quique Bassat and Valeriane Leroy and Alessandra Nardone and W Chris Buck and Pablo Rojo and Sónia Martins and Elias Manjate and Kajal Chhanganlal and Celda Mavume and Belinda Macmillian and Aurora Mucarengua and Adelina Manheche and Teresa Gatoma and Edson Arcanjo and Atija Salimo and Laize Beca and Raul Atibo and Hélio Brande and Rito Eleutério and Marizelina Chaves and Armando Saíde and Stella Langa and Natália Nipaco and Luzidina Martins and Mércia Nhaca and Sara Machava and Anastância Chirindza and Dalila Rego and Sílvia Chaúque and Dália Machel and Anélsio Cossa and Alínia Pedro and Andrew Kiggwe and Judith Beinomugisha and Agnes Alungat and Nancy Lajara Mark and Joseph Ssessanga and Josam Thembo Mwesige and Sharafat Nkinzi and Kenneth Muwanguzi and John Paul Lubega and Sophie Mutesi and Aminah Nalunkuuma and Elizabeth Najjingo and Bashirah Mbabazi and Godfrey Musoro and Moses Chitsamatanga and Ennie Chidziva and Misheck Phiri and Stuart Chitongo and Shepherd Mudzingwa and Joy Chimanzi and Ruth Nhema and Shirley Mutsai and Makhosonke Ndlovu and Columbus Moyo and Nathalie Mudzimurema and Trust Mukanganiki and Pia Ngwaru and Tsitsi Ngwenzi and Sibusisiwe Weza and Hazel Patricia Munyama and Veronica Mulenga and Perfect Shankalala and Idah Zulu and Kelvin Zimba and Helen Mhango and Chalwe Chibuye and Juliet Namwinwa and Terence Chipoya and Bwalya Simunyola and Tina Simwanga and Eustace Mwango and Sharon Kunda and Muleya Inambao and Salome Chitondo and Wyclef Mumba and Endreen Mankunshe and Barbara Halende and Kajimalwendo Mumba and Mangani Zulu and Davies Sondashi and Henry Musukwa and Caren Kabanda and Kwitaka Muluzi and Elizabeth Nkosi and Rufaro Mtolongo and Eddah Kafasiyanji and James Kaphatika and Ganizani Chilewani and Simon Nicholas and John Ndaferenkhande and Emmie Mbale and Bright Lipenga and James Nyirenda and Joyce Macheso and Sizwa Dziko and Maika Bangali and Sophie Desmonde and Dimitri Kambou},
  year = {2026},
  journal = {The Lancet},
  doi = {10.1016/s0140-6736(26)00754-3},
  url = {https://doi.org/10.1016/s0140-6736(26)00754-3}
}

RIS

TY  - JOUR
TI  - Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, randomised, controlled, superiority trial
AU  - Cinta Moraleda
AU  - Alfredo Tagarro
AU  - Sara Domínguez-Rodríguez
AU  - Victor Musiime
AU  - Hilda Mujuru
AU  - Chishala Chabala
AU  - Tisungane Mvalo
AU  - Pui-Ying Iroh-Tam
AU  - Justina Bramugy
AU  - Lola Madrid
AU  - Jahit Sacarlal
AU  - Alfeu Passanduca
AU  - Muhammad Sidat
AU  - Uneisse Cassia
AU  - Hellen Tukamuhebwa Aanyu
AU  - Abner Tagoola
AU  - Constantine Mutata
AU  - Bwendo Nduna
AU  - Chimwemwe Chawinga
AU  - Lughano Ghambi
AU  - Matthew Bates
AU  - Sheila Fernández-Luis
AU  - Amir Seni
AU  - Merunissa Gafur
AU  - Damalie Nalwanga
AU  - Denis Nansera
AU  - Mutsa Bwakura-Dangarembizi
AU  - Natasha Namuziya
AU  - Franklyn Nkongho Egbe
AU  - John Tembo
AU  - Álvaro Ballesteros
AU  - Raoul Moh
AU  - Lilit Manukyan
AU  - David Lora
AU  - Olivier Marcy
AU  - Tom G Jacobs
AU  - David Burger
AU  - Quique Bassat
AU  - Valeriane Leroy
AU  - Alessandra Nardone
AU  - W Chris Buck
AU  - Pablo Rojo
AU  - Sónia Martins
AU  - Elias Manjate
AU  - Kajal Chhanganlal
AU  - Celda Mavume
AU  - Belinda Macmillian
AU  - Aurora Mucarengua
AU  - Adelina Manheche
AU  - Teresa Gatoma
AU  - Edson Arcanjo
AU  - Atija Salimo
AU  - Laize Beca
AU  - Raul Atibo
AU  - Hélio Brande
AU  - Rito Eleutério
AU  - Marizelina Chaves
AU  - Armando Saíde
AU  - Stella Langa
AU  - Natália Nipaco
AU  - Luzidina Martins
AU  - Mércia Nhaca
AU  - Sara Machava
AU  - Anastância Chirindza
AU  - Dalila Rego
AU  - Sílvia Chaúque
AU  - Dália Machel
AU  - Anélsio Cossa
AU  - Alínia Pedro
AU  - Andrew Kiggwe
AU  - Judith Beinomugisha
AU  - Agnes Alungat
AU  - Nancy Lajara Mark
AU  - Joseph Ssessanga
AU  - Josam Thembo Mwesige
AU  - Sharafat Nkinzi
AU  - Kenneth Muwanguzi
AU  - John Paul Lubega
AU  - Sophie Mutesi
AU  - Aminah Nalunkuuma
AU  - Elizabeth Najjingo
AU  - Bashirah Mbabazi
AU  - Godfrey Musoro
AU  - Moses Chitsamatanga
AU  - Ennie Chidziva
AU  - Misheck Phiri
AU  - Stuart Chitongo
AU  - Shepherd Mudzingwa
AU  - Joy Chimanzi
AU  - Ruth Nhema
AU  - Shirley Mutsai
AU  - Makhosonke Ndlovu
AU  - Columbus Moyo
AU  - Nathalie Mudzimurema
AU  - Trust Mukanganiki
AU  - Pia Ngwaru
AU  - Tsitsi Ngwenzi
AU  - Sibusisiwe Weza
AU  - Hazel Patricia Munyama
AU  - Veronica Mulenga
AU  - Perfect Shankalala
AU  - Idah Zulu
AU  - Kelvin Zimba
AU  - Helen Mhango
AU  - Chalwe Chibuye
AU  - Juliet Namwinwa
AU  - Terence Chipoya
AU  - Bwalya Simunyola
AU  - Tina Simwanga
AU  - Eustace Mwango
AU  - Sharon Kunda
AU  - Muleya Inambao
AU  - Salome Chitondo
AU  - Wyclef Mumba
AU  - Endreen Mankunshe
AU  - Barbara Halende
AU  - Kajimalwendo Mumba
AU  - Mangani Zulu
AU  - Davies Sondashi
AU  - Henry Musukwa
AU  - Caren Kabanda
AU  - Kwitaka Muluzi
AU  - Elizabeth Nkosi
AU  - Rufaro Mtolongo
AU  - Eddah Kafasiyanji
AU  - James Kaphatika
AU  - Ganizani Chilewani
AU  - Simon Nicholas
AU  - John Ndaferenkhande
AU  - Emmie Mbale
AU  - Bright Lipenga
AU  - James Nyirenda
AU  - Joyce Macheso
AU  - Sizwa Dziko
AU  - Maika Bangali
AU  - Sophie Desmonde
AU  - Dimitri Kambou
PY  - 2026
JO  - The Lancet
DO  - 10.1016/s0140-6736(26)00754-3
UR  - https://doi.org/10.1016/s0140-6736(26)00754-3
ER  -

APA

Moraleda, C., Tagarro, A., Domínguez-Rodríguez, S., Musiime, V., Mujuru, H., Chabala, C., Mvalo, T., Iroh-Tam, P., Bramugy, J., Madrid, L., Sacarlal, J., Passanduca, A., Sidat, M., Cassia, U., Aanyu, H. T., Tagoola, A., Mutata, C., Nduna, B., Chawinga, C., Ghambi, L., Bates, M., Fernández-Luis, S., Seni, A., Gafur, M., Nalwanga, D., Nansera, D., Bwakura-Dangarembizi, M., Namuziya, N., Egbe, F. N., Tembo, J., Ballesteros, Á., Moh, R., Manukyan, L., Lora, D., Marcy, O., Jacobs, T. G., Burger, D., Bassat, Q., Leroy, V., Nardone, A., Buck, W. C., Rojo, P., Martins, S., Manjate, E., Chhanganlal, K., Mavume, C., Macmillian, B., Mucarengua, A., Manheche, A., Gatoma, T., Arcanjo, E., Salimo, A., Beca, L., Atibo, R., Brande, H., Eleutério, R., Chaves, M., Saíde, A., Langa, S., Nipaco, N., Martins, L., Nhaca, M., Machava, S., Chirindza, A., Rego, D., Chaúque, S., Machel, D., Cossa, A., Pedro, A., Kiggwe, A., Beinomugisha, J., Alungat, A., Mark, N. L., Ssessanga, J., Mwesige, J. T., Nkinzi, S., Muwanguzi, K., Lubega, J. P., Mutesi, S., Nalunkuuma, A., Najjingo, E., Mbabazi, B., Musoro, G., Chitsamatanga, M., Chidziva, E., Phiri, M., Chitongo, S., Mudzingwa, S., Chimanzi, J., Nhema, R., Mutsai, S., Ndlovu, M., Moyo, C., Mudzimurema, N., Mukanganiki, T., Ngwaru, P., Ngwenzi, T., Weza, S., Munyama, H. P., Mulenga, V., Shankalala, P., Zulu, I., Zimba, K., Mhango, H., Chibuye, C., Namwinwa, J., Chipoya, T., Simunyola, B., Simwanga, T., Mwango, E., Kunda, S., Inambao, M., Chitondo, S., Mumba, W., Mankunshe, E., Halende, B., Mumba, K., Zulu, M., Sondashi, D., Musukwa, H., Kabanda, C., Muluzi, K., Nkosi, E., Mtolongo, R., Kafasiyanji, E., Kaphatika, J., Chilewani, G., Nicholas, S., Ndaferenkhande, J., Mbale, E., Lipenga, B., Nyirenda, J., Macheso, J., Dziko, S., Bangali, M., Desmonde, S., & Kambou, D. (2026). Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, randomised, controlled, superiority trial. The Lancet. https://doi.org/10.1016/s0140-6736(26)00754-3

Source records

crossref · retrieved 2026-09-25T20:26:45.857Z