Belzutifan plus lenvatinib versus cabozantinib in patients with previously treated advanced renal cell carcinoma (LITESPARK-011): an open-label, randomised, controlled, phase 3 trial

BibTeX

@article{allodium:10.1016/s0140-6736-26-01089-5,
  title = {Belzutifan plus lenvatinib versus cabozantinib in patients with previously treated advanced renal cell carcinoma (LITESPARK-011): an open-label, randomised, controlled, phase 3 trial},
  author = {Robert J Motzer and Ray McDermott and Se Hoon Park and Mauricio Burotto and Roberto Iacovelli and Elena Verzoni and Cristina Suárez and Masatoshi Eto and Hernan J Cutuli and Camillo Porta and Ray Manneh Kopp and Sylvie Rottey and Guillermo de Velasco and Begoña P Valderrama and Arun A Azad and Ugo De Giorgi and Michel Pavic and Piotr Tomczak and Robert Figlin and Hans M Westgeest and Annalisa Guida and Andrea Necchi and Fabio A Schutz and Britt B M Suelmann and John B A G Haanen and Sammy Shuai Yuan and Rodolfo F Perini and Ding Wang and Daniel Y C Heng and Manuela Schmidinger and Juan Pablo Sade and Ernesto Pablo Korbenfeld and Marcelo Daniel Tatangelo and Juan Ignacio Hernandez Moran and Hernan Javier Cutuli and Alejandro Dri and Babak Tamjid and Christopher Hocking and Arun Azad and Laurence Krieger and Ferdinand Luger and Clemens Mayr and Manuela Schmidinger and Dora Niedersuess-Beke and Johannes Meran and Martin Pichler and Thomas Bauernhofer and Sylvie Rottey and Benoit Beuselinck and Christine Gennigens and Nieves Martinez Chanza and Spyridon Sideris and Marco Gizzi and Jean-Pascal Machiels and Alan Arrieira Azambuja and Silvana Vale and Fabio A.B. Schutz and Silvio Correia Sales and Mahmoud Abdelsalam and Michel Pavic and Catherine Sperlich and Francisco Vera-Badillo and Daniel Heng and Christian Kollmannsberger and Naveen S. Basappa and Georg Arnold Bjarnason and Aly-Khan Lalani and Nicolas Marcoux and Dominick Bosse and Mauricio Burotto and Eduardo Yanez Ruiz and Ricardo Bruges and Martha Liliana Alarcon and Javier Cuello Lopez and Ray Manneh Kopp and Tomas Buchler and Jindrich Kopecky and Alexandr Poprach and Pavel Tolinger and Tomas Buchler and Katriina Jalkanen and Kaisa Leea Sunela and Krista Kankaanranta and Kalle Ensio Mattila and Vesa Valiaho and Sophie Abadie-Lacourtoisie and Frederic Rolland and Marine Gross-Goupil and Sabrina Falkowski and Ahmed Khalil and Christine Chevreau and Damien Pouessel and Loic Mourey and Jean-Christophe Eymard and Delphine Borchiellini and Philippe Barthelemy and Marinela Augustin and Andreas Becker and Severine Banek and Clara Humke and Markus Grabbert and Stefan Siemer and Julia Heinzelbecker and Peter Reichardt and Juliane Kuenzel and Florian Seseke and Thomas Steiner and Volker Perst and Matthias Saar and Jennifer Kranz and Sofia Shah and Ramona Stelmach and Stefanie Zschaebitz and Maria De Santis and Sofia Baka and Aristotelis Bamias and Angelos Koutras and Marinos Tsiatas and Flora Zagouri and Ray McDermott and John McCaffrey and Giuseppe Procopio and Elena Verzoni and Sergio Bracarda and Annalisa Guida and Camillo Porta and Elisa Biscaldi and Andrea Premoli and Sabrina Del Buono and Alketa Hamzaj and Consuelo Buttigliero and Armando Santoro and Ugo Federico Francesco De Giorgi and Cristian Lolli and Andrea Zivi and Andrea Necchi and Roberto Iacovelli and Nobuaki Matsubara and Yuji Miura and Koichi Suyama and Satoshi Anai and Makito Miyake and Makoto Sumitomo and Hideaki Miyake and Yuto Matsushita and Masatoshi Eto and Go Kimura and Noboru Nakaigawa and Hisashi Hasumi and Naoya Masumori and Yasuhisa Fujii and Kazutoshi Fujita and Ryuichi Mizuno and Mototsugu Oya and Taigo Kato and Yoshihiko Tomita and Kazutoshi Yamana and Naoto Kamiya and Tsunenori Kondo and Yasutomo Nakai and Akira Nagahara and Mutsushi Kawakita and Toshinari Yamasaki and John B.A.G. Haanen and Franchette van den Berkmortel and Marco Ben Polee and Paul Hamberg and Britt Berendine Maria Suelmann and Hans Westgeest and Astrid Van der Veldt and Danny Houtsma and Pawel Wiechno and Piotr Tomczak and Bogdan Zurawski and Marek Ziobro and Tudor Eliade Ciuleanu and Cristina Ligia Cebotaru and Michael Schenker and Igor Utyashev and Nikolay Keshishev and Aleksander Bystrov and Dmitry Vladislavovich Perlin and Andrey Vladimirovich Semenov and Anastasia Mochalova and Nikolay Viktorovich Kislov and Jae Lyun Lee and Se Hoon Park and Woo Kyun Bae and Oscar Reig Torras and Jose Pablo Maroto Rey and Aurea Molina Diaz and Begona Perez Valderrama and Javier Puente Vazquez and Jose Angel Arranz Arija and Cristina Suarez Rodriguez and Guillermo de Velasco Oria de Rueda and Richard Cathomas and Anja Lorch and Petros Tsantoulis and Ursula Vogl and Paul Nathan and Anand Sharma and Matthew Sephton and Gordon Urquhart and Poulam Patel and Naveed Sarwar and Mark Beresford and Sing Yu Moorcraft and Awais Jalil and Steven Ades and Carlos Alemany and Claud Grigg and Daniel Marcus Anderson and Michael Benjamin Atkins and Gary R. MacVicar and Bradley Carthon and Thomas Paul Bradley and Waddah Arafat and Sreenivasa Chandana and Robert Figlin and Arash Rezazadeh Kalebasty and Julio Hajdenberg and Daniel Landau and Hatem Hassanein and John Clark Henegan and Alan Tan and Thomas Christopher Westbrook and Mark D. Kochenderfer and Sandy Liu and Alexandra Drakaki and Robert Motzer and Suresh G. Nair and Petros Nikolinakos and Lindsay C. Overton and Joseph Maly and Mikhail Shtivelband and Eric A. Singer and Biren Saraiya and Przemyslaw Twardowski and Haris Zahoor and Zhentao Zhang and Brendan Connell and Scott Tykodi and Timothy Byun and Michael Roger Harrison and Pedro Barata and Brian Lewis and Benjamin Maughan},
  year = {2026},
  journal = {The Lancet},
  doi = {10.1016/s0140-6736(26)01089-5},
  url = {https://doi.org/10.1016/s0140-6736(26)01089-5}
}

RIS

TY  - JOUR
TI  - Belzutifan plus lenvatinib versus cabozantinib in patients with previously treated advanced renal cell carcinoma (LITESPARK-011): an open-label, randomised, controlled, phase 3 trial
AU  - Robert J Motzer
AU  - Ray McDermott
AU  - Se Hoon Park
AU  - Mauricio Burotto
AU  - Roberto Iacovelli
AU  - Elena Verzoni
AU  - Cristina Suárez
AU  - Masatoshi Eto
AU  - Hernan J Cutuli
AU  - Camillo Porta
AU  - Ray Manneh Kopp
AU  - Sylvie Rottey
AU  - Guillermo de Velasco
AU  - Begoña P Valderrama
AU  - Arun A Azad
AU  - Ugo De Giorgi
AU  - Michel Pavic
AU  - Piotr Tomczak
AU  - Robert Figlin
AU  - Hans M Westgeest
AU  - Annalisa Guida
AU  - Andrea Necchi
AU  - Fabio A Schutz
AU  - Britt B M Suelmann
AU  - John B A G Haanen
AU  - Sammy Shuai Yuan
AU  - Rodolfo F Perini
AU  - Ding Wang
AU  - Daniel Y C Heng
AU  - Manuela Schmidinger
AU  - Juan Pablo Sade
AU  - Ernesto Pablo Korbenfeld
AU  - Marcelo Daniel Tatangelo
AU  - Juan Ignacio Hernandez Moran
AU  - Hernan Javier Cutuli
AU  - Alejandro Dri
AU  - Babak Tamjid
AU  - Christopher Hocking
AU  - Arun Azad
AU  - Laurence Krieger
AU  - Ferdinand Luger
AU  - Clemens Mayr
AU  - Manuela Schmidinger
AU  - Dora Niedersuess-Beke
AU  - Johannes Meran
AU  - Martin Pichler
AU  - Thomas Bauernhofer
AU  - Sylvie Rottey
AU  - Benoit Beuselinck
AU  - Christine Gennigens
AU  - Nieves Martinez Chanza
AU  - Spyridon Sideris
AU  - Marco Gizzi
AU  - Jean-Pascal Machiels
AU  - Alan Arrieira Azambuja
AU  - Silvana Vale
AU  - Fabio A.B. Schutz
AU  - Silvio Correia Sales
AU  - Mahmoud Abdelsalam
AU  - Michel Pavic
AU  - Catherine Sperlich
AU  - Francisco Vera-Badillo
AU  - Daniel Heng
AU  - Christian Kollmannsberger
AU  - Naveen S. Basappa
AU  - Georg Arnold Bjarnason
AU  - Aly-Khan Lalani
AU  - Nicolas Marcoux
AU  - Dominick Bosse
AU  - Mauricio Burotto
AU  - Eduardo Yanez Ruiz
AU  - Ricardo Bruges
AU  - Martha Liliana Alarcon
AU  - Javier Cuello Lopez
AU  - Ray Manneh Kopp
AU  - Tomas Buchler
AU  - Jindrich Kopecky
AU  - Alexandr Poprach
AU  - Pavel Tolinger
AU  - Tomas Buchler
AU  - Katriina Jalkanen
AU  - Kaisa Leea Sunela
AU  - Krista Kankaanranta
AU  - Kalle Ensio Mattila
AU  - Vesa Valiaho
AU  - Sophie Abadie-Lacourtoisie
AU  - Frederic Rolland
AU  - Marine Gross-Goupil
AU  - Sabrina Falkowski
AU  - Ahmed Khalil
AU  - Christine Chevreau
AU  - Damien Pouessel
AU  - Loic Mourey
AU  - Jean-Christophe Eymard
AU  - Delphine Borchiellini
AU  - Philippe Barthelemy
AU  - Marinela Augustin
AU  - Andreas Becker
AU  - Severine Banek
AU  - Clara Humke
AU  - Markus Grabbert
AU  - Stefan Siemer
AU  - Julia Heinzelbecker
AU  - Peter Reichardt
AU  - Juliane Kuenzel
AU  - Florian Seseke
AU  - Thomas Steiner
AU  - Volker Perst
AU  - Matthias Saar
AU  - Jennifer Kranz
AU  - Sofia Shah
AU  - Ramona Stelmach
AU  - Stefanie Zschaebitz
AU  - Maria De Santis
AU  - Sofia Baka
AU  - Aristotelis Bamias
AU  - Angelos Koutras
AU  - Marinos Tsiatas
AU  - Flora Zagouri
AU  - Ray McDermott
AU  - John McCaffrey
AU  - Giuseppe Procopio
AU  - Elena Verzoni
AU  - Sergio Bracarda
AU  - Annalisa Guida
AU  - Camillo Porta
AU  - Elisa Biscaldi
AU  - Andrea Premoli
AU  - Sabrina Del Buono
AU  - Alketa Hamzaj
AU  - Consuelo Buttigliero
AU  - Armando Santoro
AU  - Ugo Federico Francesco De Giorgi
AU  - Cristian Lolli
AU  - Andrea Zivi
AU  - Andrea Necchi
AU  - Roberto Iacovelli
AU  - Nobuaki Matsubara
AU  - Yuji Miura
AU  - Koichi Suyama
AU  - Satoshi Anai
AU  - Makito Miyake
AU  - Makoto Sumitomo
AU  - Hideaki Miyake
AU  - Yuto Matsushita
AU  - Masatoshi Eto
AU  - Go Kimura
AU  - Noboru Nakaigawa
AU  - Hisashi Hasumi
AU  - Naoya Masumori
AU  - Yasuhisa Fujii
AU  - Kazutoshi Fujita
AU  - Ryuichi Mizuno
AU  - Mototsugu Oya
AU  - Taigo Kato
AU  - Yoshihiko Tomita
AU  - Kazutoshi Yamana
AU  - Naoto Kamiya
AU  - Tsunenori Kondo
AU  - Yasutomo Nakai
AU  - Akira Nagahara
AU  - Mutsushi Kawakita
AU  - Toshinari Yamasaki
AU  - John B.A.G. Haanen
AU  - Franchette van den Berkmortel
AU  - Marco Ben Polee
AU  - Paul Hamberg
AU  - Britt Berendine Maria Suelmann
AU  - Hans Westgeest
AU  - Astrid Van der Veldt
AU  - Danny Houtsma
AU  - Pawel Wiechno
AU  - Piotr Tomczak
AU  - Bogdan Zurawski
AU  - Marek Ziobro
AU  - Tudor Eliade Ciuleanu
AU  - Cristina Ligia Cebotaru
AU  - Michael Schenker
AU  - Igor Utyashev
AU  - Nikolay Keshishev
AU  - Aleksander Bystrov
AU  - Dmitry Vladislavovich Perlin
AU  - Andrey Vladimirovich Semenov
AU  - Anastasia Mochalova
AU  - Nikolay Viktorovich Kislov
AU  - Jae Lyun Lee
AU  - Se Hoon Park
AU  - Woo Kyun Bae
AU  - Oscar Reig Torras
AU  - Jose Pablo Maroto Rey
AU  - Aurea Molina Diaz
AU  - Begona Perez Valderrama
AU  - Javier Puente Vazquez
AU  - Jose Angel Arranz Arija
AU  - Cristina Suarez Rodriguez
AU  - Guillermo de Velasco Oria de Rueda
AU  - Richard Cathomas
AU  - Anja Lorch
AU  - Petros Tsantoulis
AU  - Ursula Vogl
AU  - Paul Nathan
AU  - Anand Sharma
AU  - Matthew Sephton
AU  - Gordon Urquhart
AU  - Poulam Patel
AU  - Naveed Sarwar
AU  - Mark Beresford
AU  - Sing Yu Moorcraft
AU  - Awais Jalil
AU  - Steven Ades
AU  - Carlos Alemany
AU  - Claud Grigg
AU  - Daniel Marcus Anderson
AU  - Michael Benjamin Atkins
AU  - Gary R. MacVicar
AU  - Bradley Carthon
AU  - Thomas Paul Bradley
AU  - Waddah Arafat
AU  - Sreenivasa Chandana
AU  - Robert Figlin
AU  - Arash Rezazadeh Kalebasty
AU  - Julio Hajdenberg
AU  - Daniel Landau
AU  - Hatem Hassanein
AU  - John Clark Henegan
AU  - Alan Tan
AU  - Thomas Christopher Westbrook
AU  - Mark D. Kochenderfer
AU  - Sandy Liu
AU  - Alexandra Drakaki
AU  - Robert Motzer
AU  - Suresh G. Nair
AU  - Petros Nikolinakos
AU  - Lindsay C. Overton
AU  - Joseph Maly
AU  - Mikhail Shtivelband
AU  - Eric A. Singer
AU  - Biren Saraiya
AU  - Przemyslaw Twardowski
AU  - Haris Zahoor
AU  - Zhentao Zhang
AU  - Brendan Connell
AU  - Scott Tykodi
AU  - Timothy Byun
AU  - Michael Roger Harrison
AU  - Pedro Barata
AU  - Brian Lewis
AU  - Benjamin Maughan
PY  - 2026
JO  - The Lancet
DO  - 10.1016/s0140-6736(26)01089-5
UR  - https://doi.org/10.1016/s0140-6736(26)01089-5
ER  - 

APA

Motzer, R. J., McDermott, R., Park, S. H., Burotto, M., Iacovelli, R., Verzoni, E., Suárez, C., Eto, M., Cutuli, H. J., Porta, C., Kopp, R. M., Rottey, S., Velasco, G. D., Valderrama, B. P., Azad, A. A., Giorgi, U. D., Pavic, M., Tomczak, P., Figlin, R., Westgeest, H. M., Guida, A., Necchi, A., Schutz, F. A., Suelmann, B. B. M., Haanen, J. B. A. G., Yuan, S. S., Perini, R. F., Wang, D., Heng, D. Y. C., Schmidinger, M., Sade, J. P., Korbenfeld, E. P., Tatangelo, M. D., Moran, J. I. H., Cutuli, H. J., Dri, A., Tamjid, B., Hocking, C., Azad, A., Krieger, L., Luger, F., Mayr, C., Schmidinger, M., Niedersuess-Beke, D., Meran, J., Pichler, M., Bauernhofer, T., Rottey, S., Beuselinck, B., Gennigens, C., Chanza, N. M., Sideris, S., Gizzi, M., Machiels, J., Azambuja, A. A., Vale, S., Schutz, F. A., Sales, S. C., Abdelsalam, M., Pavic, M., Sperlich, C., Vera-Badillo, F., Heng, D., Kollmannsberger, C., Basappa, N. S., Bjarnason, G. A., Lalani, A., Marcoux, N., Bosse, D., Burotto, M., Ruiz, E. Y., Bruges, R., Alarcon, M. L., Lopez, J. C., Kopp, R. M., Buchler, T., Kopecky, J., Poprach, A., Tolinger, P., Buchler, T., Jalkanen, K., Sunela, K. L., Kankaanranta, K., Mattila, K. E., Valiaho, V., Abadie-Lacourtoisie, S., Rolland, F., Gross-Goupil, M., Falkowski, S., Khalil, A., Chevreau, C., Pouessel, D., Mourey, L., Eymard, J., Borchiellini, D., Barthelemy, P., Augustin, M., Becker, A., Banek, S., Humke, C., Grabbert, M., Siemer, S., Heinzelbecker, J., Reichardt, P., Kuenzel, J., Seseke, F., Steiner, T., Perst, V., Saar, M., Kranz, J., Shah, S., Stelmach, R., Zschaebitz, S., Santis, M. D., Baka, S., Bamias, A., Koutras, A., Tsiatas, M., Zagouri, F., McDermott, R., McCaffrey, J., Procopio, G., Verzoni, E., Bracarda, S., Guida, A., Porta, C., Biscaldi, E., Premoli, A., Buono, S. D., Hamzaj, A., Buttigliero, C., Santoro, A., Giorgi, U. F. F. D., Lolli, C., Zivi, A., Necchi, A., Iacovelli, R., Matsubara, N., Miura, Y., Suyama, K., Anai, S., Miyake, M., Sumitomo, M., Miyake, H., Matsushita, Y., Eto, M., Kimura, G., Nakaigawa, N., Hasumi, H., Masumori, N., Fujii, Y., Fujita, K., Mizuno, R., Oya, M., Kato, T., Tomita, Y., Yamana, K., Kamiya, N., Kondo, T., Nakai, Y., Nagahara, A., Kawakita, M., Yamasaki, T., Haanen, J. B., Berkmortel, F. V. D., Polee, M. B., Hamberg, P., Suelmann, B. B. M., Westgeest, H., Veldt, A. V. D., Houtsma, D., Wiechno, P., Tomczak, P., Zurawski, B., Ziobro, M., Ciuleanu, T. E., Cebotaru, C. L., Schenker, M., Utyashev, I., Keshishev, N., Bystrov, A., Perlin, D. V., Semenov, A. V., Mochalova, A., Kislov, N. V., Lee, J. L., Park, S. H., Bae, W. K., Torras, O. R., Rey, J. P. M., Diaz, A. M., Valderrama, B. P., Vazquez, J. P., Arija, J. A. A., Rodriguez, C. S., Rueda, G. D. V. O. D., Cathomas, R., Lorch, A., Tsantoulis, P., Vogl, U., Nathan, P., Sharma, A., Sephton, M., Urquhart, G., Patel, P., Sarwar, N., Beresford, M., Moorcraft, S. Y., Jalil, A., Ades, S., Alemany, C., Grigg, C., Anderson, D. M., Atkins, M. B., MacVicar, G. R., Carthon, B., Bradley, T. P., Arafat, W., Chandana, S., Figlin, R., Kalebasty, A. R., Hajdenberg, J., Landau, D., Hassanein, H., Henegan, J. C., Tan, A., Westbrook, T. C., Kochenderfer, M. D., Liu, S., Drakaki, A., Motzer, R., Nair, S. G., Nikolinakos, P., Overton, L. C., Maly, J., Shtivelband, M., Singer, E. A., Saraiya, B., Twardowski, P., Zahoor, H., Zhang, Z., Connell, B., Tykodi, S., Byun, T., Harrison, M. R., Barata, P., Lewis, B., & Maughan, B. (2026). Belzutifan plus lenvatinib versus cabozantinib in patients with previously treated advanced renal cell carcinoma (LITESPARK-011): an open-label, randomised, controlled, phase 3 trial. The Lancet. https://doi.org/10.1016/s0140-6736(26)01089-5