Deramiocel heart-derived cellular therapy in advanced Duchenne muscular dystrophy (HOPE-3): a phase 3, randomised, double-blind, placebo-controlled trial

Craig M McDonald, Chet Villa, Jonathan H Soslow, Kati Maharry, Nathaniel Hogan, Michael Binks, Kevin C Berth, Kristi A Elliott, Michael Taylor, Kan N Hor, James Signorovich, Erik K Henricson, Han C Phan, Susan Apkon, Partha S Ghosh, Cuixia Tian, Aravindhan Veerapandiyan, Leigh Ramos-Platt, Katheryn Gambetta, Saunder M Bernes, Arun S Varadhachary, Susan T Iannaccone, Chamindra G Laverty, Seth J Perlman, Nancy E Bass, Kathryn Mosher, Russell J Butterfield, Katherine D Mathews, Rebecca J Scharf, Edward C Smith, Jane Anne Emerson, Eugenio Mercuri, Mark S Awadalla, Linda Marbán, Eduardo Marbán, William Alton, Margot Amalachandran, Pallavi Anand, Martha Arellano-Garcia, Scott Batchelor, Kaitlin Batley, RJ Billena, Kelsey Bloom, Meghan Bochnak, Kelly Bonarrigo, Alyssa Boudreau, Catherine Braun, Madeline Brown, Michelle Brown, Laura Brown, Zurisadai Gonzalez Castillo, Srinivas K. Chatitanya, Jeremy Chimienti, Sarah Chinander, Basil Darras, Jonathan Dayan, Amelia Decker, Karen Dhillon, Melissa Dixon, Angela Edmondson, Erik Ellsworth, Reza Farid, Cynthia Ferrante, Ashlee Folkes, Danielle Forrest, Jessica Getz, Matthew Ginsberg, Steven Giompoletti, Antonia Goelz, Courtney Goldsbury, Erica Goude, Courtney Grotski, Kristen Haigh, Wendy Haley, Clara Chow Haws, Shana Hayes, Leslie Hayes, Alicia Henriquez, Melissa Hicks-Wittman, Katie Hoffman, Margaret Hudspeth, Elizabeth Huett, Nazia Husain, Anna Jesus, Kelli Johnson, Hannah Johnson, Darcy Johnson, Rebecca Jorne, Nanette Joyce, Laura Juel, Anneliese Juhasz, Lynea Kaethler, Brenda Kashi, Amber Kellogg, Carolyn Kelly, Kristina Kelly, Tate M. Keough, Rachel Kim, Van Kim Ma, Madelyn Knight, Erica Knoll, Michelle Kraemer, Nancy Kuntz, Regina Laine, Katie Laubscher, Holly Lawrence, Sarah Lehman, Sarah Liber, Michelle Loftus, Amanda Lopez, Elizabeth Maczek, Anne Marie, Chelsea Masterson, Melissa McIntyre, Richa Mehta, Jon David Menteer, Chandra L. Miller, Julie Miner, Sarah Moldt, Lindsay Moore, Meghan F. Moore-Burk, Elaine Most, Adriane Mueller, Susan Murphy, Emily Murray, Diane Mwonga, Kalie Nakata, Leslie Nelson, Bella Nguyen, Alina Nicorici, Dana O'Rourke, Jaclyn Omura, Sarah Oswald, Lindsay Pare, Eunice Park, Amy Pasternak, Ankita Patel, Sean Patino, Kellen Peter, Han Phan, Maria Pinkham, Kallie Platt, Patricia Plumb, Stephanie Poelker, Tara Pratt, Erika Pyzik, Shelley R.H., Tammy Ramm, Lisa Reebals, Rebecca Rehborg, Lucy Reid, Markus Renno, Melissa Rentfrow, Kristy Riddle, Marissa Robertson, Christa Rocco, Sean Romeo, Ian Rossman, Irina Rybalsky, Dimah N Saade, Lindsay Sanchez, Russell Saneto, Catherine Schaefer, Jessica Schwieterman, Parissa Shayesteh, Renata Shih, Alexandria Silver, Andrew Skalsky, Lynette Slovensky, Mariah Stechschulte, Vikki Stefans, Prasanth Surampudi, Julie Tan, Emmanuelle Tiongson, Richard Torres, Melanie Valle, Lauren Vanderwerf, Leslie Vogel, Luke Waymire, Lisa Williams, Amelia Wilson, Deniece Winston, Michele Yang, Isabel Yank, Danielle N. Zimmerman, Alexandar Zygmunt

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DOI: 10.1016/s0140-6736(26)01385-1
Published: 2026-08
Container: The Lancet
Publisher: Elsevier BV
Open access: unknown

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BibTeX

@article{allodium:10.1016/s0140-6736-26-01385-1,
  title = {Deramiocel heart-derived cellular therapy in advanced Duchenne muscular dystrophy (HOPE-3): a phase 3, randomised, double-blind, placebo-controlled trial},
  author = {Craig M McDonald and Chet Villa and Jonathan H Soslow and Kati Maharry and Nathaniel Hogan and Michael Binks and Kevin C Berth and Kristi A Elliott and Michael Taylor and Kan N Hor and James Signorovich and Erik K Henricson and Han C Phan and Susan Apkon and Partha S Ghosh and Cuixia Tian and Aravindhan Veerapandiyan and Leigh Ramos-Platt and Katheryn Gambetta and Saunder M Bernes and Arun S Varadhachary and Susan T Iannaccone and Chamindra G Laverty and Seth J Perlman and Nancy E Bass and Kathryn Mosher and Russell J Butterfield and Katherine D Mathews and Rebecca J Scharf and Edward C Smith and Jane Anne Emerson and Eugenio Mercuri and Mark S Awadalla and Linda Marbán and Eduardo Marbán and William Alton and Margot Amalachandran and Pallavi Anand and Martha Arellano-Garcia and Scott Batchelor and Kaitlin Batley and RJ Billena and Kelsey Bloom and Meghan Bochnak and Kelly Bonarrigo and Alyssa Boudreau and Catherine Braun and Madeline Brown and Michelle Brown and Laura Brown and Zurisadai Gonzalez Castillo and Srinivas K. Chatitanya and Jeremy Chimienti and Sarah Chinander and Basil Darras and Jonathan Dayan and Amelia Decker and Karen Dhillon and Melissa Dixon and Angela Edmondson and Erik Ellsworth and Reza Farid and Cynthia Ferrante and Ashlee Folkes and Danielle Forrest and Jessica Getz and Matthew Ginsberg and Steven Giompoletti and Antonia Goelz and Courtney Goldsbury and Erica Goude and Courtney Grotski and Kristen Haigh and Wendy Haley and Clara Chow Haws and Shana Hayes and Leslie Hayes and Alicia Henriquez and Melissa Hicks-Wittman and Katie Hoffman and Margaret Hudspeth and Elizabeth Huett and Nazia Husain and Anna Jesus and Kelli Johnson and Hannah Johnson and Darcy Johnson and Rebecca Jorne and Nanette Joyce and Laura Juel and Anneliese Juhasz and Lynea Kaethler and Brenda Kashi and Amber Kellogg and Carolyn Kelly and Kristina Kelly and Tate M. Keough and Rachel Kim and Van Kim Ma and Madelyn Knight and Erica Knoll and Michelle Kraemer and Nancy Kuntz and Regina Laine and Katie Laubscher and Holly Lawrence and Sarah Lehman and Sarah Liber and Michelle Loftus and Amanda Lopez and Elizabeth Maczek and Anne Marie and Chelsea Masterson and Melissa McIntyre and Richa Mehta and Jon David Menteer and Chandra L. Miller and Julie Miner and Sarah Moldt and Lindsay Moore and Meghan F. Moore-Burk and Elaine Most and Adriane Mueller and Susan Murphy and Emily Murray and Diane Mwonga and Kalie Nakata and Leslie Nelson and Bella Nguyen and Alina Nicorici and Dana O'Rourke and Jaclyn Omura and Sarah Oswald and Lindsay Pare and Eunice Park and Amy Pasternak and Ankita Patel and Sean Patino and Kellen Peter and Han Phan and Maria Pinkham and Kallie Platt and Patricia Plumb and Stephanie Poelker and Tara Pratt and Erika Pyzik and Shelley R.H. and Tammy Ramm and Lisa Reebals and Rebecca Rehborg and Lucy Reid and Markus Renno and Melissa Rentfrow and Kristy Riddle and Marissa Robertson and Christa Rocco and Sean Romeo and Ian Rossman and Irina Rybalsky and Dimah N Saade and Lindsay Sanchez and Russell Saneto and Catherine Schaefer and Jessica Schwieterman and Parissa Shayesteh and Renata Shih and Alexandria Silver and Andrew Skalsky and Lynette Slovensky and Mariah Stechschulte and Vikki Stefans and Prasanth Surampudi and Julie Tan and Emmanuelle Tiongson and Richard Torres and Melanie Valle and Lauren Vanderwerf and Leslie Vogel and Luke Waymire and Lisa Williams and Amelia Wilson and Deniece Winston and Michele Yang and Isabel Yank and Danielle N. Zimmerman and Alexandar Zygmunt},
  year = {2026},
  journal = {The Lancet},
  doi = {10.1016/s0140-6736(26)01385-1},
  url = {https://doi.org/10.1016/s0140-6736(26)01385-1}
}

RIS

TY  - JOUR
TI  - Deramiocel heart-derived cellular therapy in advanced Duchenne muscular dystrophy (HOPE-3): a phase 3, randomised, double-blind, placebo-controlled trial
AU  - Craig M McDonald
AU  - Chet Villa
AU  - Jonathan H Soslow
AU  - Kati Maharry
AU  - Nathaniel Hogan
AU  - Michael Binks
AU  - Kevin C Berth
AU  - Kristi A Elliott
AU  - Michael Taylor
AU  - Kan N Hor
AU  - James Signorovich
AU  - Erik K Henricson
AU  - Han C Phan
AU  - Susan Apkon
AU  - Partha S Ghosh
AU  - Cuixia Tian
AU  - Aravindhan Veerapandiyan
AU  - Leigh Ramos-Platt
AU  - Katheryn Gambetta
AU  - Saunder M Bernes
AU  - Arun S Varadhachary
AU  - Susan T Iannaccone
AU  - Chamindra G Laverty
AU  - Seth J Perlman
AU  - Nancy E Bass
AU  - Kathryn Mosher
AU  - Russell J Butterfield
AU  - Katherine D Mathews
AU  - Rebecca J Scharf
AU  - Edward C Smith
AU  - Jane Anne Emerson
AU  - Eugenio Mercuri
AU  - Mark S Awadalla
AU  - Linda Marbán
AU  - Eduardo Marbán
AU  - William Alton
AU  - Margot Amalachandran
AU  - Pallavi Anand
AU  - Martha Arellano-Garcia
AU  - Scott Batchelor
AU  - Kaitlin Batley
AU  - RJ Billena
AU  - Kelsey Bloom
AU  - Meghan Bochnak
AU  - Kelly Bonarrigo
AU  - Alyssa Boudreau
AU  - Catherine Braun
AU  - Madeline Brown
AU  - Michelle Brown
AU  - Laura Brown
AU  - Zurisadai Gonzalez Castillo
AU  - Srinivas K. Chatitanya
AU  - Jeremy Chimienti
AU  - Sarah Chinander
AU  - Basil Darras
AU  - Jonathan Dayan
AU  - Amelia Decker
AU  - Karen Dhillon
AU  - Melissa Dixon
AU  - Angela Edmondson
AU  - Erik Ellsworth
AU  - Reza Farid
AU  - Cynthia Ferrante
AU  - Ashlee Folkes
AU  - Danielle Forrest
AU  - Jessica Getz
AU  - Matthew Ginsberg
AU  - Steven Giompoletti
AU  - Antonia Goelz
AU  - Courtney Goldsbury
AU  - Erica Goude
AU  - Courtney Grotski
AU  - Kristen Haigh
AU  - Wendy Haley
AU  - Clara Chow Haws
AU  - Shana Hayes
AU  - Leslie Hayes
AU  - Alicia Henriquez
AU  - Melissa Hicks-Wittman
AU  - Katie Hoffman
AU  - Margaret Hudspeth
AU  - Elizabeth Huett
AU  - Nazia Husain
AU  - Anna Jesus
AU  - Kelli Johnson
AU  - Hannah Johnson
AU  - Darcy Johnson
AU  - Rebecca Jorne
AU  - Nanette Joyce
AU  - Laura Juel
AU  - Anneliese Juhasz
AU  - Lynea Kaethler
AU  - Brenda Kashi
AU  - Amber Kellogg
AU  - Carolyn Kelly
AU  - Kristina Kelly
AU  - Tate M. Keough
AU  - Rachel Kim
AU  - Van Kim Ma
AU  - Madelyn Knight
AU  - Erica Knoll
AU  - Michelle Kraemer
AU  - Nancy Kuntz
AU  - Regina Laine
AU  - Katie Laubscher
AU  - Holly Lawrence
AU  - Sarah Lehman
AU  - Sarah Liber
AU  - Michelle Loftus
AU  - Amanda Lopez
AU  - Elizabeth Maczek
AU  - Anne Marie
AU  - Chelsea Masterson
AU  - Melissa McIntyre
AU  - Richa Mehta
AU  - Jon David Menteer
AU  - Chandra L. Miller
AU  - Julie Miner
AU  - Sarah Moldt
AU  - Lindsay Moore
AU  - Meghan F. Moore-Burk
AU  - Elaine Most
AU  - Adriane Mueller
AU  - Susan Murphy
AU  - Emily Murray
AU  - Diane Mwonga
AU  - Kalie Nakata
AU  - Leslie Nelson
AU  - Bella Nguyen
AU  - Alina Nicorici
AU  - Dana O'Rourke
AU  - Jaclyn Omura
AU  - Sarah Oswald
AU  - Lindsay Pare
AU  - Eunice Park
AU  - Amy Pasternak
AU  - Ankita Patel
AU  - Sean Patino
AU  - Kellen Peter
AU  - Han Phan
AU  - Maria Pinkham
AU  - Kallie Platt
AU  - Patricia Plumb
AU  - Stephanie Poelker
AU  - Tara Pratt
AU  - Erika Pyzik
AU  - Shelley R.H.
AU  - Tammy Ramm
AU  - Lisa Reebals
AU  - Rebecca Rehborg
AU  - Lucy Reid
AU  - Markus Renno
AU  - Melissa Rentfrow
AU  - Kristy Riddle
AU  - Marissa Robertson
AU  - Christa Rocco
AU  - Sean Romeo
AU  - Ian Rossman
AU  - Irina Rybalsky
AU  - Dimah N Saade
AU  - Lindsay Sanchez
AU  - Russell Saneto
AU  - Catherine Schaefer
AU  - Jessica Schwieterman
AU  - Parissa Shayesteh
AU  - Renata Shih
AU  - Alexandria Silver
AU  - Andrew Skalsky
AU  - Lynette Slovensky
AU  - Mariah Stechschulte
AU  - Vikki Stefans
AU  - Prasanth Surampudi
AU  - Julie Tan
AU  - Emmanuelle Tiongson
AU  - Richard Torres
AU  - Melanie Valle
AU  - Lauren Vanderwerf
AU  - Leslie Vogel
AU  - Luke Waymire
AU  - Lisa Williams
AU  - Amelia Wilson
AU  - Deniece Winston
AU  - Michele Yang
AU  - Isabel Yank
AU  - Danielle N. Zimmerman
AU  - Alexandar Zygmunt
PY  - 2026
JO  - The Lancet
DO  - 10.1016/s0140-6736(26)01385-1
UR  - https://doi.org/10.1016/s0140-6736(26)01385-1
ER  -

APA

McDonald, C. M., Villa, C., Soslow, J. H., Maharry, K., Hogan, N., Binks, M., Berth, K. C., Elliott, K. A., Taylor, M., Hor, K. N., Signorovich, J., Henricson, E. K., Phan, H. C., Apkon, S., Ghosh, P. S., Tian, C., Veerapandiyan, A., Ramos-Platt, L., Gambetta, K., Bernes, S. M., Varadhachary, A. S., Iannaccone, S. T., Laverty, C. G., Perlman, S. J., Bass, N. E., Mosher, K., Butterfield, R. J., Mathews, K. D., Scharf, R. J., Smith, E. C., Emerson, J. A., Mercuri, E., Awadalla, M. S., Marbán, L., Marbán, E., Alton, W., Amalachandran, M., Anand, P., Arellano-Garcia, M., Batchelor, S., Batley, K., Billena, R., Bloom, K., Bochnak, M., Bonarrigo, K., Boudreau, A., Braun, C., Brown, M., Brown, M., Brown, L., Castillo, Z. G., Chatitanya, S. K., Chimienti, J., Chinander, S., Darras, B., Dayan, J., Decker, A., Dhillon, K., Dixon, M., Edmondson, A., Ellsworth, E., Farid, R., Ferrante, C., Folkes, A., Forrest, D., Getz, J., Ginsberg, M., Giompoletti, S., Goelz, A., Goldsbury, C., Goude, E., Grotski, C., Haigh, K., Haley, W., Haws, C. C., Hayes, S., Hayes, L., Henriquez, A., Hicks-Wittman, M., Hoffman, K., Hudspeth, M., Huett, E., Husain, N., Jesus, A., Johnson, K., Johnson, H., Johnson, D., Jorne, R., Joyce, N., Juel, L., Juhasz, A., Kaethler, L., Kashi, B., Kellogg, A., Kelly, C., Kelly, K., Keough, T. M., Kim, R., Ma, V. K., Knight, M., Knoll, E., Kraemer, M., Kuntz, N., Laine, R., Laubscher, K., Lawrence, H., Lehman, S., Liber, S., Loftus, M., Lopez, A., Maczek, E., Marie, A., Masterson, C., McIntyre, M., Mehta, R., Menteer, J. D., Miller, C. L., Miner, J., Moldt, S., Moore, L., Moore-Burk, M. F., Most, E., Mueller, A., Murphy, S., Murray, E., Mwonga, D., Nakata, K., Nelson, L., Nguyen, B., Nicorici, A., O'Rourke, D., Omura, J., Oswald, S., Pare, L., Park, E., Pasternak, A., Patel, A., Patino, S., Peter, K., Phan, H., Pinkham, M., Platt, K., Plumb, P., Poelker, S., Pratt, T., Pyzik, E., R.H., S., Ramm, T., Reebals, L., Rehborg, R., Reid, L., Renno, M., Rentfrow, M., Riddle, K., Robertson, M., Rocco, C., Romeo, S., Rossman, I., Rybalsky, I., Saade, D. N., Sanchez, L., Saneto, R., Schaefer, C., Schwieterman, J., Shayesteh, P., Shih, R., Silver, A., Skalsky, A., Slovensky, L., Stechschulte, M., Stefans, V., Surampudi, P., Tan, J., Tiongson, E., Torres, R., Valle, M., Vanderwerf, L., Vogel, L., Waymire, L., Williams, L., Wilson, A., Winston, D., Yang, M., Yank, I., Zimmerman, D. N., & Zygmunt, A. (2026). Deramiocel heart-derived cellular therapy in advanced Duchenne muscular dystrophy (HOPE-3): a phase 3, randomised, double-blind, placebo-controlled trial. The Lancet. https://doi.org/10.1016/s0140-6736(26)01385-1

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