Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial

Biree Andemariam, Kevin H M Kuo, Farjah H Algahtani, Salam Al Kindi, Kenneth I Ataga, Pablo Bartolucci, Andrew Campbell, Raffaella Colombatti, Alexander K Glaros, Kaoutar Hafraoui, Modupe Idowu, Seethal A Jacob, Clarisse L C Lobo, Obiageli E Nnodu, Lucas Otieno, Wally R Smith, Swee Lay Thein, Eduard J van Beers, Sarah Gheuens, Brooke Hensley, Abdulafeez Oluyadi, Kareem Osman, Asif Pathan, Spurthi Patil, Tao Song, Amber M Yates, Ahmar U Zaidi, Caterina Minniti, Miguel R Abboud

Open source

DOI: 10.1016/s0140-6736(26)01480-7
Published: 2026-10
Container: The Lancet
Publisher: Elsevier BV
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1016/s0140-6736-26-01480-7,
  title = {Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial},
  author = {Biree Andemariam and Kevin H M Kuo and Farjah H Algahtani and Salam Al Kindi and Kenneth I Ataga and Pablo Bartolucci and Andrew Campbell and Raffaella Colombatti and Alexander K Glaros and Kaoutar Hafraoui and Modupe Idowu and Seethal A Jacob and Clarisse L C Lobo and Obiageli E Nnodu and Lucas Otieno and Wally R Smith and Swee Lay Thein and Eduard J van Beers and Sarah Gheuens and Brooke Hensley and Abdulafeez Oluyadi and Kareem Osman and Asif Pathan and Spurthi Patil and Tao Song and Amber M Yates and Ahmar U Zaidi and Caterina Minniti and Miguel R Abboud},
  year = {2026},
  journal = {The Lancet},
  doi = {10.1016/s0140-6736(26)01480-7},
  url = {https://doi.org/10.1016/s0140-6736(26)01480-7}
}

RIS

TY  - JOUR
TI  - Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial
AU  - Biree Andemariam
AU  - Kevin H M Kuo
AU  - Farjah H Algahtani
AU  - Salam Al Kindi
AU  - Kenneth I Ataga
AU  - Pablo Bartolucci
AU  - Andrew Campbell
AU  - Raffaella Colombatti
AU  - Alexander K Glaros
AU  - Kaoutar Hafraoui
AU  - Modupe Idowu
AU  - Seethal A Jacob
AU  - Clarisse L C Lobo
AU  - Obiageli E Nnodu
AU  - Lucas Otieno
AU  - Wally R Smith
AU  - Swee Lay Thein
AU  - Eduard J van Beers
AU  - Sarah Gheuens
AU  - Brooke Hensley
AU  - Abdulafeez Oluyadi
AU  - Kareem Osman
AU  - Asif Pathan
AU  - Spurthi Patil
AU  - Tao Song
AU  - Amber M Yates
AU  - Ahmar U Zaidi
AU  - Caterina Minniti
AU  - Miguel R Abboud
PY  - 2026
JO  - The Lancet
DO  - 10.1016/s0140-6736(26)01480-7
UR  - https://doi.org/10.1016/s0140-6736(26)01480-7
ER  -

APA

Andemariam, B., Kuo, K. H. M., Algahtani, F. H., Kindi, S. A., Ataga, K. I., Bartolucci, P., Campbell, A., Colombatti, R., Glaros, A. K., Hafraoui, K., Idowu, M., Jacob, S. A., Lobo, C. L. C., Nnodu, O. E., Otieno, L., Smith, W. R., Thein, S. L., Beers, E. J. V., Gheuens, S., Hensley, B., Oluyadi, A., Osman, K., Pathan, A., Patil, S., Song, T., Yates, A. M., Zaidi, A. U., Minniti, C., & Abboud, M. R. (2026). Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial. The Lancet. https://doi.org/10.1016/s0140-6736(26)01480-7

Source records

crossref · retrieved 2026-11-10T20:07:56.503Z