Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial

Emil Lou, Modassir S Choudhry, Timothy K Starr, Timothy D Folsom, Jason Bell, Blaine Rathmann, Anthony P DeFeo, Jihyun Kim, Nicholas Slipek, Zhaohui Jin, Darin Sumstad, Christopher A Klebanoff, Katherine Ladner, Akshat Sarkari, R Scott McIvor, Thomas A Murray, Jeffrey S Miller, Madhuri Rao, Eric Jensen, Jacob Ankeny, Mahmoud A Khalifa, Anil Chauhan, Benjamin Spilseth, Ajay Dixit, Paolo P Provenzano, Wenjing Pan, Daniel Weber, Miranda Byrne-Steele, Tom Henley, David H McKenna, Matthew J Johnson, Beau R Webber, Branden S Moriarity

Open source

DOI: 10.1016/s1470-2045(25)00083-x
Published: 2025-05
Container: The Lancet Oncology
Publisher: Elsevier BV
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1016/s1470-2045-25-00083-x,
  title = {Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial},
  author = {Emil Lou and Modassir S Choudhry and Timothy K Starr and Timothy D Folsom and Jason Bell and Blaine Rathmann and Anthony P DeFeo and Jihyun Kim and Nicholas Slipek and Zhaohui Jin and Darin Sumstad and Christopher A Klebanoff and Katherine Ladner and Akshat Sarkari and R Scott McIvor and Thomas A Murray and Jeffrey S Miller and Madhuri Rao and Eric Jensen and Jacob Ankeny and Mahmoud A Khalifa and Anil Chauhan and Benjamin Spilseth and Ajay Dixit and Paolo P Provenzano and Wenjing Pan and Daniel Weber and Miranda Byrne-Steele and Tom Henley and David H McKenna and Matthew J Johnson and Beau R Webber and Branden S Moriarity},
  year = {2025},
  journal = {The Lancet Oncology},
  doi = {10.1016/s1470-2045(25)00083-x},
  url = {https://doi.org/10.1016/s1470-2045(25)00083-x}
}

RIS

TY  - JOUR
TI  - Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial
AU  - Emil Lou
AU  - Modassir S Choudhry
AU  - Timothy K Starr
AU  - Timothy D Folsom
AU  - Jason Bell
AU  - Blaine Rathmann
AU  - Anthony P DeFeo
AU  - Jihyun Kim
AU  - Nicholas Slipek
AU  - Zhaohui Jin
AU  - Darin Sumstad
AU  - Christopher A Klebanoff
AU  - Katherine Ladner
AU  - Akshat Sarkari
AU  - R Scott McIvor
AU  - Thomas A Murray
AU  - Jeffrey S Miller
AU  - Madhuri Rao
AU  - Eric Jensen
AU  - Jacob Ankeny
AU  - Mahmoud A Khalifa
AU  - Anil Chauhan
AU  - Benjamin Spilseth
AU  - Ajay Dixit
AU  - Paolo P Provenzano
AU  - Wenjing Pan
AU  - Daniel Weber
AU  - Miranda Byrne-Steele
AU  - Tom Henley
AU  - David H McKenna
AU  - Matthew J Johnson
AU  - Beau R Webber
AU  - Branden S Moriarity
PY  - 2025
JO  - The Lancet Oncology
DO  - 10.1016/s1470-2045(25)00083-x
UR  - https://doi.org/10.1016/s1470-2045(25)00083-x
ER  -

APA

Lou, E., Choudhry, M. S., Starr, T. K., Folsom, T. D., Bell, J., Rathmann, B., DeFeo, A. P., Kim, J., Slipek, N., Jin, Z., Sumstad, D., Klebanoff, C. A., Ladner, K., Sarkari, A., McIvor, R. S., Murray, T. A., Miller, J. S., Rao, M., Jensen, E., Ankeny, J., Khalifa, M. A., Chauhan, A., Spilseth, B., Dixit, A., Provenzano, P. P., Pan, W., Weber, D., Byrne-Steele, M., Henley, T., McKenna, D. H., Johnson, M. J., Webber, B. R., & Moriarity, B. S. (2025). Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial. The Lancet Oncology. https://doi.org/10.1016/s1470-2045(25)00083-x

Source records

crossref · retrieved 2026-09-27T06:02:07.257Z