Efficacy of WRSs2, a live-attenuated Shigella sonnei vaccine, against shigellosis in a controlled human infection model in the USA: a phase 2, double-blind, randomised, placebo-controlled trial

Nadine Rouphael, Shahida Baqar, Michelle Dickey, Christina Quigley, Tena Pham, Josh Adams, Gaurav Kwatra, Sarah Bechnak, Veronica Smith, Erin M Scherer, Daniel S Graciaa, Jill El-Khorazaty, Jamie A Fraser, Susan Heard, Krista Cato, Jorge Mejia-Galvis, Shoshana Barnoy, Lakshmi Chandrasekharan, Chad K Porter, Akamol E Suvarnapunya, Malabi M Venkatesan, Robert W Frenck, Rebecca Brady, Carson Caldwell, Maegan Hampton, Monica McNeal, Grant Paulsen, Cassie Grimsley Ackerley, Jill Briggs, Matthew H. Collins, Daniel J. Gromer, Paulina A. Rebolledo, Hady Samaha, Jacob D. Sherman, Ralph Tanios, Jessica Traenkner, Zanthia Wiley, Lori Newman

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DOI: 10.1016/s1473-3099(26)00224-0
Published: 2026-06
Container: The Lancet Infectious Diseases
Publisher: Elsevier BV
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1016/s1473-3099-26-00224-0,
  title = {Efficacy of WRSs2, a live-attenuated Shigella sonnei vaccine, against shigellosis in a controlled human infection model in the USA: a phase 2, double-blind, randomised, placebo-controlled trial},
  author = {Nadine Rouphael and Shahida Baqar and Michelle Dickey and Christina Quigley and Tena Pham and Josh Adams and Gaurav Kwatra and Sarah Bechnak and Veronica Smith and Erin M Scherer and Daniel S Graciaa and Jill El-Khorazaty and Jamie A Fraser and Susan Heard and Krista Cato and Jorge Mejia-Galvis and Shoshana Barnoy and Lakshmi Chandrasekharan and Chad K Porter and Akamol E Suvarnapunya and Malabi M Venkatesan and Robert W Frenck and Rebecca Brady and Carson Caldwell and Maegan Hampton and Monica McNeal and Grant Paulsen and Cassie Grimsley Ackerley and Jill Briggs and Matthew H. Collins and Daniel J. Gromer and Paulina A. Rebolledo and Hady Samaha and Jacob D. Sherman and Ralph Tanios and Jessica Traenkner and Zanthia Wiley and Lori Newman},
  year = {2026},
  journal = {The Lancet Infectious Diseases},
  doi = {10.1016/s1473-3099(26)00224-0},
  url = {https://doi.org/10.1016/s1473-3099(26)00224-0}
}

RIS

TY  - JOUR
TI  - Efficacy of WRSs2, a live-attenuated Shigella sonnei vaccine, against shigellosis in a controlled human infection model in the USA: a phase 2, double-blind, randomised, placebo-controlled trial
AU  - Nadine Rouphael
AU  - Shahida Baqar
AU  - Michelle Dickey
AU  - Christina Quigley
AU  - Tena Pham
AU  - Josh Adams
AU  - Gaurav Kwatra
AU  - Sarah Bechnak
AU  - Veronica Smith
AU  - Erin M Scherer
AU  - Daniel S Graciaa
AU  - Jill El-Khorazaty
AU  - Jamie A Fraser
AU  - Susan Heard
AU  - Krista Cato
AU  - Jorge Mejia-Galvis
AU  - Shoshana Barnoy
AU  - Lakshmi Chandrasekharan
AU  - Chad K Porter
AU  - Akamol E Suvarnapunya
AU  - Malabi M Venkatesan
AU  - Robert W Frenck
AU  - Rebecca Brady
AU  - Carson Caldwell
AU  - Maegan Hampton
AU  - Monica McNeal
AU  - Grant Paulsen
AU  - Cassie Grimsley Ackerley
AU  - Jill Briggs
AU  - Matthew H. Collins
AU  - Daniel J. Gromer
AU  - Paulina A. Rebolledo
AU  - Hady Samaha
AU  - Jacob D. Sherman
AU  - Ralph Tanios
AU  - Jessica Traenkner
AU  - Zanthia Wiley
AU  - Lori Newman
PY  - 2026
JO  - The Lancet Infectious Diseases
DO  - 10.1016/s1473-3099(26)00224-0
UR  - https://doi.org/10.1016/s1473-3099(26)00224-0
ER  -

APA

Rouphael, N., Baqar, S., Dickey, M., Quigley, C., Pham, T., Adams, J., Kwatra, G., Bechnak, S., Smith, V., Scherer, E. M., Graciaa, D. S., El-Khorazaty, J., Fraser, J. A., Heard, S., Cato, K., Mejia-Galvis, J., Barnoy, S., Chandrasekharan, L., Porter, C. K., Suvarnapunya, A. E., Venkatesan, M. M., Frenck, R. W., Brady, R., Caldwell, C., Hampton, M., McNeal, M., Paulsen, G., Ackerley, C. G., Briggs, J., Collins, M. H., Gromer, D. J., Rebolledo, P. A., Samaha, H., Sherman, J. D., Tanios, R., Traenkner, J., Wiley, Z., & Newman, L. (2026). Efficacy of WRSs2, a live-attenuated Shigella sonnei vaccine, against shigellosis in a controlled human infection model in the USA: a phase 2, double-blind, randomised, placebo-controlled trial. The Lancet Infectious Diseases. https://doi.org/10.1016/s1473-3099(26)00224-0

Source records

crossref · retrieved 2026-09-26T03:58:01.813Z