Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial

Alberto J Espay, Fabrizio Stocchi, Rajesh Pahwa, Alberto Albanese, Aaron Ellenbogen, Joaquim J Ferreira, Nir Giladi, Tanya Gurevich, Sharon Hassin-Baer, Jorge Hernandez-Vara, Stuart H Isaacson, Karl Kieburtz, Peter A LeWitt, Lydia Lopez-Manzanares, C Warren Olanow, Werner Poewe, Harini Sarva, Tami Yardeni, Liat Adar, Laurence Salin, Nelson Lopes, Nissim Sasson, Ryan Case, Olivier Rascol, Mitra Afshari, Fernando Alonso-Frech, Alexander Amelin, David Arkadir, Samih Badarny, Ernest Balaguer Martinez, Marek Balaz, Marta Blazuez Estrada, Andrzej Bogucki, James Boyd, Laura Buyan Dent, Camille Carroll, Giovanni Castelnovo, Martinez Castrillo, K Ray Chaudhuri, Jeffrey Cooney, Anne-Gaëlle Corbillé, Esther Cubo Delgado, Teodor Danaila, Rob De Bie, Joy Antonelle De Marcaida, Maria Francesca De Pandis, Sophie Dethy, Rohit Dhall, Ruth Djaldetti, John Duda, Franck Durif, Borrue Fernandez, Yeva Fernandez, Stephen Flitman, Eric Freyre Alvarez, Caroline Giordana, John Goudreau, Francisco Grandas Perez, Robert A Hauser, David Houghton, Robert Hutchman, Arnaldo Isa, Jorge Juncos, Sulada Kanchana, Iryna Karaban, Gabriela Klodowska-Duda, Norbert Kovacs, Dariusz Koziorowski, Jaime Kulisevsky Bojarski, Rajeev Kumar, Kore Liow, Vered Livneh, Juan Lopez Lozano, Lan Luo, Nataliya Lytvynenko, Irene Malaty, Roberto Marconi, Ana Raquel Marques, Irene Martinez Torres, Aashoo Mentreddi, Pablo Mir Rivera, Francesca Morgante, Sergii Moskovko, Stephen Mullin, Marshall Nash, Yuliya Neryanova, Marco Onofrj, Jill Ostrem, Claudio Pacchetti, Neepa Patel, Nicola Pavese, Clelia Pellicano, Manuela Pilleri, Dimitry Pokhabov, Gonzalo Revuelta, Ana Margarida Rodrigues, Ramon Rodriguez, Monika Rudzinska, Nighat Sarwar, Julie Schwartzbard, Laura Scorr, Binit Shah, Matej Skorvanek, John Slevin, Tatyana Slobodin, Gianfranco Spalletta, Alessandro Stefani, Lynn Struck, Michele Tagliati, Yen Tai, Danette Taylor, Alessandro Tessitore, Astrid Thomas, Winona Tse, Peter Valkovic, Leo Verhagen, Elena Vostrikova, Benjamin Walter, David Weisman, Gilad Yahalom, Zuleykha Zalyalova, Katerina Zarubova, Irina Zhukova

Open source

DOI: 10.1016/s1474-4422(24)00052-8
Published: 2024-05
Container: The Lancet Neurology
Publisher: Elsevier BV
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1016/s1474-4422-24-00052-8,
  title = {Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial},
  author = {Alberto J Espay and Fabrizio Stocchi and Rajesh Pahwa and Alberto Albanese and Aaron Ellenbogen and Joaquim J Ferreira and Nir Giladi and Tanya Gurevich and Sharon Hassin-Baer and Jorge Hernandez-Vara and Stuart H Isaacson and Karl Kieburtz and Peter A LeWitt and Lydia Lopez-Manzanares and C Warren Olanow and Werner Poewe and Harini Sarva and Tami Yardeni and Liat Adar and Laurence Salin and Nelson Lopes and Nissim Sasson and Ryan Case and Olivier Rascol and Mitra Afshari and Fernando Alonso-Frech and Alexander Amelin and David Arkadir and Samih Badarny and Ernest Balaguer Martinez and Marek Balaz and Marta Blazuez Estrada and Andrzej Bogucki and James Boyd and Laura Buyan Dent and Camille Carroll and Giovanni Castelnovo and Martinez Castrillo and K Ray Chaudhuri and Jeffrey Cooney and Anne-Gaëlle Corbillé and Esther Cubo Delgado and Teodor Danaila and Rob De Bie and Joy Antonelle De Marcaida and Maria Francesca De Pandis and Sophie Dethy and Rohit Dhall and Ruth Djaldetti and John Duda and Franck Durif and Borrue Fernandez and Yeva Fernandez and Stephen Flitman and Eric Freyre Alvarez and Caroline Giordana and John Goudreau and Francisco Grandas Perez and Robert A Hauser and David Houghton and Robert Hutchman and Arnaldo Isa and Jorge Juncos and Sulada Kanchana and Iryna Karaban and Gabriela Klodowska-Duda and Norbert Kovacs and Dariusz Koziorowski and Jaime Kulisevsky Bojarski and Rajeev Kumar and Kore Liow and Vered Livneh and Juan Lopez Lozano and Lan Luo and Nataliya Lytvynenko and Irene Malaty and Roberto Marconi and Ana Raquel Marques and Irene Martinez Torres and Aashoo Mentreddi and Pablo Mir Rivera and Francesca Morgante and Sergii Moskovko and Stephen Mullin and Marshall Nash and Yuliya Neryanova and Marco Onofrj and Jill Ostrem and Claudio Pacchetti and Neepa Patel and Nicola Pavese and Clelia Pellicano and Manuela Pilleri and Dimitry Pokhabov and Gonzalo Revuelta and Ana Margarida Rodrigues and Ramon Rodriguez and Monika Rudzinska and Nighat Sarwar and Julie Schwartzbard and Laura Scorr and Binit Shah and Matej Skorvanek and John Slevin and Tatyana Slobodin and Gianfranco Spalletta and Alessandro Stefani and Lynn Struck and Michele Tagliati and Yen Tai and Danette Taylor and Alessandro Tessitore and Astrid Thomas and Winona Tse and Peter Valkovic and Leo Verhagen and Elena Vostrikova and Benjamin Walter and David Weisman and Gilad Yahalom and Zuleykha Zalyalova and Katerina Zarubova and Irina Zhukova},
  year = {2024},
  journal = {The Lancet Neurology},
  doi = {10.1016/s1474-4422(24)00052-8},
  url = {https://doi.org/10.1016/s1474-4422(24)00052-8}
}

RIS

TY  - JOUR
TI  - Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial
AU  - Alberto J Espay
AU  - Fabrizio Stocchi
AU  - Rajesh Pahwa
AU  - Alberto Albanese
AU  - Aaron Ellenbogen
AU  - Joaquim J Ferreira
AU  - Nir Giladi
AU  - Tanya Gurevich
AU  - Sharon Hassin-Baer
AU  - Jorge Hernandez-Vara
AU  - Stuart H Isaacson
AU  - Karl Kieburtz
AU  - Peter A LeWitt
AU  - Lydia Lopez-Manzanares
AU  - C Warren Olanow
AU  - Werner Poewe
AU  - Harini Sarva
AU  - Tami Yardeni
AU  - Liat Adar
AU  - Laurence Salin
AU  - Nelson Lopes
AU  - Nissim Sasson
AU  - Ryan Case
AU  - Olivier Rascol
AU  - Mitra Afshari
AU  - Fernando Alonso-Frech
AU  - Alexander Amelin
AU  - David Arkadir
AU  - Samih Badarny
AU  - Ernest Balaguer Martinez
AU  - Marek Balaz
AU  - Marta Blazuez Estrada
AU  - Andrzej Bogucki
AU  - James Boyd
AU  - Laura Buyan Dent
AU  - Camille Carroll
AU  - Giovanni Castelnovo
AU  - Martinez Castrillo
AU  - K Ray Chaudhuri
AU  - Jeffrey Cooney
AU  - Anne-Gaëlle Corbillé
AU  - Esther Cubo Delgado
AU  - Teodor Danaila
AU  - Rob De Bie
AU  - Joy Antonelle De Marcaida
AU  - Maria Francesca De Pandis
AU  - Sophie Dethy
AU  - Rohit Dhall
AU  - Ruth Djaldetti
AU  - John Duda
AU  - Franck Durif
AU  - Borrue Fernandez
AU  - Yeva Fernandez
AU  - Stephen Flitman
AU  - Eric Freyre Alvarez
AU  - Caroline Giordana
AU  - John Goudreau
AU  - Francisco Grandas Perez
AU  - Robert A Hauser
AU  - David Houghton
AU  - Robert Hutchman
AU  - Arnaldo Isa
AU  - Jorge Juncos
AU  - Sulada Kanchana
AU  - Iryna Karaban
AU  - Gabriela Klodowska-Duda
AU  - Norbert Kovacs
AU  - Dariusz Koziorowski
AU  - Jaime Kulisevsky Bojarski
AU  - Rajeev Kumar
AU  - Kore Liow
AU  - Vered Livneh
AU  - Juan Lopez Lozano
AU  - Lan Luo
AU  - Nataliya Lytvynenko
AU  - Irene Malaty
AU  - Roberto Marconi
AU  - Ana Raquel Marques
AU  - Irene Martinez Torres
AU  - Aashoo Mentreddi
AU  - Pablo Mir Rivera
AU  - Francesca Morgante
AU  - Sergii Moskovko
AU  - Stephen Mullin
AU  - Marshall Nash
AU  - Yuliya Neryanova
AU  - Marco Onofrj
AU  - Jill Ostrem
AU  - Claudio Pacchetti
AU  - Neepa Patel
AU  - Nicola Pavese
AU  - Clelia Pellicano
AU  - Manuela Pilleri
AU  - Dimitry Pokhabov
AU  - Gonzalo Revuelta
AU  - Ana Margarida Rodrigues
AU  - Ramon Rodriguez
AU  - Monika Rudzinska
AU  - Nighat Sarwar
AU  - Julie Schwartzbard
AU  - Laura Scorr
AU  - Binit Shah
AU  - Matej Skorvanek
AU  - John Slevin
AU  - Tatyana Slobodin
AU  - Gianfranco Spalletta
AU  - Alessandro Stefani
AU  - Lynn Struck
AU  - Michele Tagliati
AU  - Yen Tai
AU  - Danette Taylor
AU  - Alessandro Tessitore
AU  - Astrid Thomas
AU  - Winona Tse
AU  - Peter Valkovic
AU  - Leo Verhagen
AU  - Elena Vostrikova
AU  - Benjamin Walter
AU  - David Weisman
AU  - Gilad Yahalom
AU  - Zuleykha Zalyalova
AU  - Katerina Zarubova
AU  - Irina Zhukova
PY  - 2024
JO  - The Lancet Neurology
DO  - 10.1016/s1474-4422(24)00052-8
UR  - https://doi.org/10.1016/s1474-4422(24)00052-8
ER  -

APA

Espay, A. J., Stocchi, F., Pahwa, R., Albanese, A., Ellenbogen, A., Ferreira, J. J., Giladi, N., Gurevich, T., Hassin-Baer, S., Hernandez-Vara, J., Isaacson, S. H., Kieburtz, K., LeWitt, P. A., Lopez-Manzanares, L., Olanow, C. W., Poewe, W., Sarva, H., Yardeni, T., Adar, L., Salin, L., Lopes, N., Sasson, N., Case, R., Rascol, O., Afshari, M., Alonso-Frech, F., Amelin, A., Arkadir, D., Badarny, S., Martinez, E. B., Balaz, M., Estrada, M. B., Bogucki, A., Boyd, J., Dent, L. B., Carroll, C., Castelnovo, G., Castrillo, M., Chaudhuri, K. R., Cooney, J., Corbillé, A., Delgado, E. C., Danaila, T., Bie, R. D., Marcaida, J. A. D., Pandis, M. F. D., Dethy, S., Dhall, R., Djaldetti, R., Duda, J., Durif, F., Fernandez, B., Fernandez, Y., Flitman, S., Alvarez, E. F., Giordana, C., Goudreau, J., Perez, F. G., Hauser, R. A., Houghton, D., Hutchman, R., Isa, A., Juncos, J., Kanchana, S., Karaban, I., Klodowska-Duda, G., Kovacs, N., Koziorowski, D., Bojarski, J. K., Kumar, R., Liow, K., Livneh, V., Lozano, J. L., Luo, L., Lytvynenko, N., Malaty, I., Marconi, R., Marques, A. R., Torres, I. M., Mentreddi, A., Rivera, P. M., Morgante, F., Moskovko, S., Mullin, S., Nash, M., Neryanova, Y., Onofrj, M., Ostrem, J., Pacchetti, C., Patel, N., Pavese, N., Pellicano, C., Pilleri, M., Pokhabov, D., Revuelta, G., Rodrigues, A. M., Rodriguez, R., Rudzinska, M., Sarwar, N., Schwartzbard, J., Scorr, L., Shah, B., Skorvanek, M., Slevin, J., Slobodin, T., Spalletta, G., Stefani, A., Struck, L., Tagliati, M., Tai, Y., Taylor, D., Tessitore, A., Thomas, A., Tse, W., Valkovic, P., Verhagen, L., Vostrikova, E., Walter, B., Weisman, D., Yahalom, G., Zalyalova, Z., Zarubova, K., & Zhukova, I. (2024). Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(24)00052-8

Source records

crossref · retrieved 2026-09-27T08:18:28.059Z