Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK
- DOI
- 10.1016/s2213-2600(21)00013-8
- Published
- 2021-07
- Container
- The Lancet Respiratory Medicine
- Publisher
- Elsevier BV
- Open access
- unknown
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BibTeX
@article{allodium:10.1016/s2213-2600-21-00013-8,
title = {Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK},
author = {Chloe I Bloom and Thomas M Drake and Annemarie B Docherty and Brian J Lipworth and Sebastian L Johnston and Jonathan S Nguyen-Van-Tam and Gail Carson and Jake Dunning and Ewen M Harrison and J Kenneth Baillie and Malcolm G Semple and Paul Cullinan and Peter J M Openshaw and Beatrice Alex and Benjamin Bach and Wendy S Barclay and Debby Bogaert and Meera Chand and Graham S Cooke and Ana da Filipe and Tom Fletcher and Christoper A Green and Ewen M Harrison and Julian A Hiscox and Antonia Ying Ho and Peter W Horby and Samreen Ijaz and Saye Khoo and Paul Klenerman and Andrew Law and Wei Shen Lim and Alexander J Mentzer and Laura Merson and Alison M Meynert and Mahdad Noursadeghi and Shona C Moore and Massimo Palmarini and William A Paxton and Georgios Pollakis and Nicholas Price and Andrew Rambaut and David L Robertson and Clark D Russell and Vanessa Sancho-Shimizu and Janet T Scott and Thushan de Silva and Louise Sigfrid and Tom Solomon and Shiranee Sriskandan and David Stuart and Charlotte Summers and Richard S Tedder and Emma C Thomson and AA Roger Thompson and Ryan S Thwaites and Lance CW Turtle and Maria Zambon and Hayley Hardwick and Chloe Donohue and Ruth Lyons and Fiona Griffiths and Wilna Oosthuyzen and Lisa Norman and Riinu Pius and Cameron J Fairfield and Stephen R Knight and Kenneth A Mclean and Derek Murphy and Catherine A Shaw and Jo Dalton and Michelle Girvan and Egle Saviciute and Stephanie Roberts and Janet Harrison and Laura Marsh and Marie Connor and Sophie Halpin and Clare Jackson and Carrol Gamble and Gary Leeming and Andrew Law and Murray Wham and Sara Clohisey and Ross Hendry and James Scott-Brown and William Greenhalf and Victoria Shaw and Sara McDonald and Seán Keating and Katie A. Ahmed and Jane A Armstrong and Milton Ashworth and Innocent G Asiimwe and Siddharth Bakshi and Samantha L Barlow and Laura Booth and Benjamin Brennan and Katie Bullock and Benjamin WA Catterall and Jordan J Clark and Emily A Clarke and Sarah Cole and Louise Cooper and Helen Cox and Christopher Davis and Oslem Dincarslan and Chris Dunn and Philip Dyer and Angela Elliott and Anthony Evans and Lorna Finch and Lewis WS Fisher and Terry Foster and Isabel Garcia-Dorival and William Greenhalf and Philip Gunning and Catherine Hartley and Rebecca L Jensen and Christopher B Jones and Trevor R Jones and Shadia Khandaker and Katharine King and Robyn T. Kiy and Chrysa Koukorava and Annette Lake and Suzannah Lant and Diane Latawiec and Lara Lavelle-Langham and Daniella Lefteri and Lauren Lett and Lucia A Livoti and Maria Mancini and Sarah McDonald and Laurence McEvoy and John McLauchlan and Soeren Metelmann and Nahida S Miah and Joanna Middleton and Joyce Mitchell and Shona C Moore and Ellen G Murphy and Rebekah Penrice-Randal and Jack Pilgrim and Tessa Prince and Will Reynolds and P. Matthew Ridley and Debby Sales and Victoria E Shaw and Rebecca K Shears and Benjamin Small and Krishanthi S Subramaniam and Agnieska Szemiel and Aislynn Taggart and Jolanta Tanianis-Hughes and Jordan Thomas and Erwan Trochu and Libby van Tonder and Eve Wilcock and J. Eunice Zhang and Lisa Flaherty and Nicole Maziere and Emily Cass and Alejandra Doce Carracedo and Nicola Carlucci and Anthony Holmes and Hannah Massey and Kayode Adeniji and Daniel Agranoff and Ken Agwuh and Dhiraj Ail and Ana Alegria and Brian Angus and Abdul Ashish and Dougal Atkinson and Shahedal Bari and Gavin Barlow and Stella Barnass and Nicholas Barrett and Christopher Bassford and David Baxter and Michael Beadsworth and Jolanta Bernatoniene and John Berridge and Nicola Best and Pieter Bothma and David Brealey and Robin Brittain-Long and Naomi Bulteel and Tom Burden and Andrew Burtenshaw and Vikki Caruth and David Chadwick and Duncan Chambler and Nigel Chee and Jenny Child and Srikanth Chukkambotla and Tom Clark and Paul Collini and Catherine Cosgrove and Jason Cupitt and Maria-Teresa Cutino-Moguel and Paul Dark and Chris Dawson and Samir Dervisevic and Phil Donnison and Sam Douthwaite and Ingrid DuRand and Ahilanadan Dushianthan and Tristan Dyer and Cariad Evans and Chi Eziefula and Chrisopher Fegan and Adam Finn and Duncan Fullerton and Sanjeev Garg and Sanjeev Garg and Atul Garg and Effrossyni Gkrania-Klotsas and Jo Godden and Arthur Goldsmith and Clive Graham and Elaine Hardy and Stuart Hartshorn and Daniel Harvey and Peter Havalda and Daniel B Hawcutt and Maria Hobrok and Luke Hodgson and Anil Hormis and Michael Jacobs and Susan Jain and Paul Jennings and Agilan Kaliappan and Vidya Kasipandian and Stephen Kegg and Michael Kelsey and Jason Kendall and Caroline Kerrison and Ian Kerslake and Oliver Koch and Gouri Koduri and George Koshy and Shondipon Laha and Steven Laird and Susan Larkin and Tamas Leiner and Patrick Lillie and James Limb and Vanessa Linnett and Jeff Little and Michael MacMahon and Emily MacNaughton and Ravish Mankregod and Huw Masson and Elijah Matovu and Katherine McCullough and Ruth McEwen and Manjula Meda and Gary Mills and Jane Minton and Mariyam Mirfenderesky and Kavya Mohandas and Quen Mok and James Moon and Elinoor Moore and Patrick Morgan and Craig Morris and Katherine Mortimore and Samuel Moses and Mbiye Mpenge and Rohinton Mulla and Michael Murphy and Megan Nagel and Thapas Nagarajan and Mark Nelson and Igor Otahal and Mark Pais and Selva Panchatsharam and Hassan Paraiso and Brij Patel and Natalie Pattison and Justin Pepperell and Mark Peters and Mandeep Phull and Stefania Pintus and Jagtur Pooni and Frank Post and David Price and Rachel Prout and Nikolas Rae and Henrik Reschreiter and Tim Reynolds and Neil Richardson and Mark Roberts and Devender Roberts and Alistair Rose and Guy Rousseau and Brendan Ryan and Taranprit Saluja and Aarti Shah and Prad Shanmuga and Anil Sharma and Anna Shawcross and Jeremy Sizer and Manu Shankar-Hari and Richard Smith and Catherine Snelson and Nick Spittle and Nikki Staines and Tom Stambach and Richard Stewart and Pradeep Subudhi and Tamas Szakmany and Kate Tatham and Jo Thomas and Chris Thompson and Robert Thompson and Ascanio Tridente and Darell Tupper-Carey and Mary Twagira and Andrew Ustianowski and Nick Vallotton and Lisa Vincent-Smith and Shico Visuvanathan and Alan Vuylsteke and Sam Waddy and Rachel Wake and Andrew Walden and Ingeborg Welters and Tony Whitehouse and Paul Whittaker and Ashley Whittington and Meme Wijesinghe and Martin Williams and Lawrence Wilson and Sarah Wilson and Stephen Winchester and Martin Wiselka and Adam Wolverson and Daniel G Wooton and Andrew Workman and Bryan Yates and Peter Young},
year = {2021},
journal = {The Lancet Respiratory Medicine},
doi = {10.1016/s2213-2600(21)00013-8},
url = {https://doi.org/10.1016/s2213-2600(21)00013-8}
}RIS
TY - JOUR TI - Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK AU - Chloe I Bloom AU - Thomas M Drake AU - Annemarie B Docherty AU - Brian J Lipworth AU - Sebastian L Johnston AU - Jonathan S Nguyen-Van-Tam AU - Gail Carson AU - Jake Dunning AU - Ewen M Harrison AU - J Kenneth Baillie AU - Malcolm G Semple AU - Paul Cullinan AU - Peter J M Openshaw AU - Beatrice Alex AU - Benjamin Bach AU - Wendy S Barclay AU - Debby Bogaert AU - Meera Chand AU - Graham S Cooke AU - Ana da Filipe AU - Tom Fletcher AU - Christoper A Green AU - Ewen M Harrison AU - Julian A Hiscox AU - Antonia Ying Ho AU - Peter W Horby AU - Samreen Ijaz AU - Saye Khoo AU - Paul Klenerman AU - Andrew Law AU - Wei Shen Lim AU - Alexander J Mentzer AU - Laura Merson AU - Alison M Meynert AU - Mahdad Noursadeghi AU - Shona C Moore AU - Massimo Palmarini AU - William A Paxton AU - Georgios Pollakis AU - Nicholas Price AU - Andrew Rambaut AU - David L Robertson AU - Clark D Russell AU - Vanessa Sancho-Shimizu AU - Janet T Scott AU - Thushan de Silva AU - Louise Sigfrid AU - Tom Solomon AU - Shiranee Sriskandan AU - David Stuart AU - Charlotte Summers AU - Richard S Tedder AU - Emma C Thomson AU - AA Roger Thompson AU - Ryan S Thwaites AU - Lance CW Turtle AU - Maria Zambon AU - Hayley Hardwick AU - Chloe Donohue AU - Ruth Lyons AU - Fiona Griffiths AU - Wilna Oosthuyzen AU - Lisa Norman AU - Riinu Pius AU - Cameron J Fairfield AU - Stephen R Knight AU - Kenneth A Mclean AU - Derek Murphy AU - Catherine A Shaw AU - Jo Dalton AU - Michelle Girvan AU - Egle Saviciute AU - Stephanie Roberts AU - Janet Harrison AU - Laura Marsh AU - Marie Connor AU - Sophie Halpin AU - Clare Jackson AU - Carrol Gamble AU - Gary Leeming AU - Andrew Law AU - Murray Wham AU - Sara Clohisey AU - Ross Hendry AU - James Scott-Brown AU - William Greenhalf AU - Victoria Shaw AU - Sara McDonald AU - Seán Keating AU - Katie A. Ahmed AU - Jane A Armstrong AU - Milton Ashworth AU - Innocent G Asiimwe AU - Siddharth Bakshi AU - Samantha L Barlow AU - Laura Booth AU - Benjamin Brennan AU - Katie Bullock AU - Benjamin WA Catterall AU - Jordan J Clark AU - Emily A Clarke AU - Sarah Cole AU - Louise Cooper AU - Helen Cox AU - Christopher Davis AU - Oslem Dincarslan AU - Chris Dunn AU - Philip Dyer AU - Angela Elliott AU - Anthony Evans AU - Lorna Finch AU - Lewis WS Fisher AU - Terry Foster AU - Isabel Garcia-Dorival AU - William Greenhalf AU - Philip Gunning AU - Catherine Hartley AU - Rebecca L Jensen AU - Christopher B Jones AU - Trevor R Jones AU - Shadia Khandaker AU - Katharine King AU - Robyn T. Kiy AU - Chrysa Koukorava AU - Annette Lake AU - Suzannah Lant AU - Diane Latawiec AU - Lara Lavelle-Langham AU - Daniella Lefteri AU - Lauren Lett AU - Lucia A Livoti AU - Maria Mancini AU - Sarah McDonald AU - Laurence McEvoy AU - John McLauchlan AU - Soeren Metelmann AU - Nahida S Miah AU - Joanna Middleton AU - Joyce Mitchell AU - Shona C Moore AU - Ellen G Murphy AU - Rebekah Penrice-Randal AU - Jack Pilgrim AU - Tessa Prince AU - Will Reynolds AU - P. Matthew Ridley AU - Debby Sales AU - Victoria E Shaw AU - Rebecca K Shears AU - Benjamin Small AU - Krishanthi S Subramaniam AU - Agnieska Szemiel AU - Aislynn Taggart AU - Jolanta Tanianis-Hughes AU - Jordan Thomas AU - Erwan Trochu AU - Libby van Tonder AU - Eve Wilcock AU - J. Eunice Zhang AU - Lisa Flaherty AU - Nicole Maziere AU - Emily Cass AU - Alejandra Doce Carracedo AU - Nicola Carlucci AU - Anthony Holmes AU - Hannah Massey AU - Kayode Adeniji AU - Daniel Agranoff AU - Ken Agwuh AU - Dhiraj Ail AU - Ana Alegria AU - Brian Angus AU - Abdul Ashish AU - Dougal Atkinson AU - Shahedal Bari AU - Gavin Barlow AU - Stella Barnass AU - Nicholas Barrett AU - Christopher Bassford AU - David Baxter AU - Michael Beadsworth AU - Jolanta Bernatoniene AU - John Berridge AU - Nicola Best AU - Pieter Bothma AU - David Brealey AU - Robin Brittain-Long AU - Naomi Bulteel AU - Tom Burden AU - Andrew Burtenshaw AU - Vikki Caruth AU - David Chadwick AU - Duncan Chambler AU - Nigel Chee AU - Jenny Child AU - Srikanth Chukkambotla AU - Tom Clark AU - Paul Collini AU - Catherine Cosgrove AU - Jason Cupitt AU - Maria-Teresa Cutino-Moguel AU - Paul Dark AU - Chris Dawson AU - Samir Dervisevic AU - Phil Donnison AU - Sam Douthwaite AU - Ingrid DuRand AU - Ahilanadan Dushianthan AU - Tristan Dyer AU - Cariad Evans AU - Chi Eziefula AU - Chrisopher Fegan AU - Adam Finn AU - Duncan Fullerton AU - Sanjeev Garg AU - Sanjeev Garg AU - Atul Garg AU - Effrossyni Gkrania-Klotsas AU - Jo Godden AU - Arthur Goldsmith AU - Clive Graham AU - Elaine Hardy AU - Stuart Hartshorn AU - Daniel Harvey AU - Peter Havalda AU - Daniel B Hawcutt AU - Maria Hobrok AU - Luke Hodgson AU - Anil Hormis AU - Michael Jacobs AU - Susan Jain AU - Paul Jennings AU - Agilan Kaliappan AU - Vidya Kasipandian AU - Stephen Kegg AU - Michael Kelsey AU - Jason Kendall AU - Caroline Kerrison AU - Ian Kerslake AU - Oliver Koch AU - Gouri Koduri AU - George Koshy AU - Shondipon Laha AU - Steven Laird AU - Susan Larkin AU - Tamas Leiner AU - Patrick Lillie AU - James Limb AU - Vanessa Linnett AU - Jeff Little AU - Michael MacMahon AU - Emily MacNaughton AU - Ravish Mankregod AU - Huw Masson AU - Elijah Matovu AU - Katherine McCullough AU - Ruth McEwen AU - Manjula Meda AU - Gary Mills AU - Jane Minton AU - Mariyam Mirfenderesky AU - Kavya Mohandas AU - Quen Mok AU - James Moon AU - Elinoor Moore AU - Patrick Morgan AU - Craig Morris AU - Katherine Mortimore AU - Samuel Moses AU - Mbiye Mpenge AU - Rohinton Mulla AU - Michael Murphy AU - Megan Nagel AU - Thapas Nagarajan AU - Mark Nelson AU - Igor Otahal AU - Mark Pais AU - Selva Panchatsharam AU - Hassan Paraiso AU - Brij Patel AU - Natalie Pattison AU - Justin Pepperell AU - Mark Peters AU - Mandeep Phull AU - Stefania Pintus AU - Jagtur Pooni AU - Frank Post AU - David Price AU - Rachel Prout AU - Nikolas Rae AU - Henrik Reschreiter AU - Tim Reynolds AU - Neil Richardson AU - Mark Roberts AU - Devender Roberts AU - Alistair Rose AU - Guy Rousseau AU - Brendan Ryan AU - Taranprit Saluja AU - Aarti Shah AU - Prad Shanmuga AU - Anil Sharma AU - Anna Shawcross AU - Jeremy Sizer AU - Manu Shankar-Hari AU - Richard Smith AU - Catherine Snelson AU - Nick Spittle AU - Nikki Staines AU - Tom Stambach AU - Richard Stewart AU - Pradeep Subudhi AU - Tamas Szakmany AU - Kate Tatham AU - Jo Thomas AU - Chris Thompson AU - Robert Thompson AU - Ascanio Tridente AU - Darell Tupper-Carey AU - Mary Twagira AU - Andrew Ustianowski AU - Nick Vallotton AU - Lisa Vincent-Smith AU - Shico Visuvanathan AU - Alan Vuylsteke AU - Sam Waddy AU - Rachel Wake AU - Andrew Walden AU - Ingeborg Welters AU - Tony Whitehouse AU - Paul Whittaker AU - Ashley Whittington AU - Meme Wijesinghe AU - Martin Williams AU - Lawrence Wilson AU - Sarah Wilson AU - Stephen Winchester AU - Martin Wiselka AU - Adam Wolverson AU - Daniel G Wooton AU - Andrew Workman AU - Bryan Yates AU - Peter Young PY - 2021 JO - The Lancet Respiratory Medicine DO - 10.1016/s2213-2600(21)00013-8 UR - https://doi.org/10.1016/s2213-2600(21)00013-8 ER -
APA
Bloom, C. I., Drake, T. M., Docherty, A. B., Lipworth, B. J., Johnston, S. L., Nguyen-Van-Tam, J. S., Carson, G., Dunning, J., Harrison, E. M., Baillie, J. K., Semple, M. G., Cullinan, P., Openshaw, P. J. M., Alex, B., Bach, B., Barclay, W. S., Bogaert, D., Chand, M., Cooke, G. S., Filipe, A. D., Fletcher, T., Green, C. A., Harrison, E. M., Hiscox, J. A., Ho, A. Y., Horby, P. W., Ijaz, S., Khoo, S., Klenerman, P., Law, A., Lim, W. S., Mentzer, A. J., Merson, L., Meynert, A. M., Noursadeghi, M., Moore, S. C., Palmarini, M., Paxton, W. A., Pollakis, G., Price, N., Rambaut, A., Robertson, D. L., Russell, C. D., Sancho-Shimizu, V., Scott, J. T., Silva, T. D., Sigfrid, L., Solomon, T., Sriskandan, S., Stuart, D., Summers, C., Tedder, R. S., Thomson, E. C., Thompson, A. R., Thwaites, R. S., Turtle, L. C., Zambon, M., Hardwick, H., Donohue, C., Lyons, R., Griffiths, F., Oosthuyzen, W., Norman, L., Pius, R., Fairfield, C. J., Knight, S. R., Mclean, K. A., Murphy, D., Shaw, C. A., Dalton, J., Girvan, M., Saviciute, E., Roberts, S., Harrison, J., Marsh, L., Connor, M., Halpin, S., Jackson, C., Gamble, C., Leeming, G., Law, A., Wham, M., Clohisey, S., Hendry, R., Scott-Brown, J., Greenhalf, W., Shaw, V., McDonald, S., Keating, S., Ahmed, K. A., Armstrong, J. A., Ashworth, M., Asiimwe, I. G., Bakshi, S., Barlow, S. L., Booth, L., Brennan, B., Bullock, K., Catterall, B. W., Clark, J. J., Clarke, E. A., Cole, S., Cooper, L., Cox, H., Davis, C., Dincarslan, O., Dunn, C., Dyer, P., Elliott, A., Evans, A., Finch, L., Fisher, L. W., Foster, T., Garcia-Dorival, I., Greenhalf, W., Gunning, P., Hartley, C., Jensen, R. L., Jones, C. B., Jones, T. R., Khandaker, S., King, K., Kiy, R. T., Koukorava, C., Lake, A., Lant, S., Latawiec, D., Lavelle-Langham, L., Lefteri, D., Lett, L., Livoti, L. A., Mancini, M., McDonald, S., McEvoy, L., McLauchlan, J., Metelmann, S., Miah, N. S., Middleton, J., Mitchell, J., Moore, S. C., Murphy, E. G., Penrice-Randal, R., Pilgrim, J., Prince, T., Reynolds, W., Ridley, P. M., Sales, D., Shaw, V. E., Shears, R. K., Small, B., Subramaniam, K. S., Szemiel, A., Taggart, A., Tanianis-Hughes, J., Thomas, J., Trochu, E., Tonder, L. V., Wilcock, E., Zhang, J. E., Flaherty, L., Maziere, N., Cass, E., Carracedo, A. D., Carlucci, N., Holmes, A., Massey, H., Adeniji, K., Agranoff, D., Agwuh, K., Ail, D., Alegria, A., Angus, B., Ashish, A., Atkinson, D., Bari, S., Barlow, G., Barnass, S., Barrett, N., Bassford, C., Baxter, D., Beadsworth, M., Bernatoniene, J., Berridge, J., Best, N., Bothma, P., Brealey, D., Brittain-Long, R., Bulteel, N., Burden, T., Burtenshaw, A., Caruth, V., Chadwick, D., Chambler, D., Chee, N., Child, J., Chukkambotla, S., Clark, T., Collini, P., Cosgrove, C., Cupitt, J., Cutino-Moguel, M., Dark, P., Dawson, C., Dervisevic, S., Donnison, P., Douthwaite, S., DuRand, I., Dushianthan, A., Dyer, T., Evans, C., Eziefula, C., Fegan, C., Finn, A., Fullerton, D., Garg, S., Garg, S., Garg, A., Gkrania-Klotsas, E., Godden, J., Goldsmith, A., Graham, C., Hardy, E., Hartshorn, S., Harvey, D., Havalda, P., Hawcutt, D. B., Hobrok, M., Hodgson, L., Hormis, A., Jacobs, M., Jain, S., Jennings, P., Kaliappan, A., Kasipandian, V., Kegg, S., Kelsey, M., Kendall, J., Kerrison, C., Kerslake, I., Koch, O., Koduri, G., Koshy, G., Laha, S., Laird, S., Larkin, S., Leiner, T., Lillie, P., Limb, J., Linnett, V., Little, J., MacMahon, M., MacNaughton, E., Mankregod, R., Masson, H., Matovu, E., McCullough, K., McEwen, R., Meda, M., Mills, G., Minton, J., Mirfenderesky, M., Mohandas, K., Mok, Q., Moon, J., Moore, E., Morgan, P., Morris, C., Mortimore, K., Moses, S., Mpenge, M., Mulla, R., Murphy, M., Nagel, M., Nagarajan, T., Nelson, M., Otahal, I., Pais, M., Panchatsharam, S., Paraiso, H., Patel, B., Pattison, N., Pepperell, J., Peters, M., Phull, M., Pintus, S., Pooni, J., Post, F., Price, D., Prout, R., Rae, N., Reschreiter, H., Reynolds, T., Richardson, N., Roberts, M., Roberts, D., Rose, A., Rousseau, G., Ryan, B., Saluja, T., Shah, A., Shanmuga, P., Sharma, A., Shawcross, A., Sizer, J., Shankar-Hari, M., Smith, R., Snelson, C., Spittle, N., Staines, N., Stambach, T., Stewart, R., Subudhi, P., Szakmany, T., Tatham, K., Thomas, J., Thompson, C., Thompson, R., Tridente, A., Tupper-Carey, D., Twagira, M., Ustianowski, A., Vallotton, N., Vincent-Smith, L., Visuvanathan, S., Vuylsteke, A., Waddy, S., Wake, R., Walden, A., Welters, I., Whitehouse, T., Whittaker, P., Whittington, A., Wijesinghe, M., Williams, M., Wilson, L., Wilson, S., Winchester, S., Wiselka, M., Wolverson, A., Wooton, D. G., Workman, A., Yates, B., & Young, P. (2021). Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. The Lancet Respiratory Medicine. https://doi.org/10.1016/s2213-2600(21)00013-8
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