Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial

Dave Singh, Christopher E Brightling, Klaus F Rabe, MeiLan K Han, Stephanie A Christenson, M Bradley Drummond, Alberto Papi, Ian D Pavord, Nestor A Molfino, Gun Almqvist, Ales Kotalik, Åsa Hellqvist, Monika Gołąbek, Navreet S Sindhwani, Sandhia S Ponnarambil, Jasmin Belle-Isle, Jerome Nadeau, William Killorn, Bruno Francoeur, Emilie Millaire, Bonavuth Pek, Murdo Ferguson, Francois Maltais, Kieran Killian, Giuseppe Mazza, Lyle Melenka, Brandie Walker, Celine Bergeron, John FitzGerald, Ulla Møller Weinreich, Elisabeth Bendstrup, Celeste Porsbjerg, Charlotte Ulrik, Ingrid Titlestad, Christian Meyer, Ole Hilberg, Francis Couturaud, Claire Andrejak, Arnaud Bourdin, Gilles Devouassoux, Jean-Louis Pepin, Pascal Chanez, Arnaud Cavailles, Andreas Eich, Andrea Ludwig-Sengpiel, Henrik Watz, Thomas Schultz, Amir Bar-Shai, Ori Wand, Yochai Adir, Neville Berkman, Gershon Fink, David Shitrit, Gabriel Izbicki, Yael Raviv, Pascal Wielders, Martijn Goosens, Roxane Heller-Baan, Johannes in't Veen, Frank Custers, Yeon-Mok Oh, YongChul Lee, Jaeyeol Kim, Kwang-Ha Yoo, Jung-Won Park, Sang Haak Lee, Joong Hyun Ahn, Sook Young Lee, Jin Woo Kim, Kwan Ho Lee, Luis Mateos Caballero, Elsa Naval Sendra, David Ramos Barbón, José Luis Velasco Garrido, Bernardino Alcázar Navarrete, Dinesh Saralaya, Michael Crooks, Pallav Shah, Rekha Chaudhuri, Anthony de Soyza, Monica Nordstrom, Akshay Dwarakanath, Steven Weinstein, David Pham, John Mitchell, Selwyn Spangenthal, Sever Surdulescu, Michael Denenberg, Sady Alpizar, David Maybee, Timothy Moriarty, Faisal Fakih, Richard Beasley, Marvin Heuer, Amit Patel, Jeffrey Dorf, Rafael Martinez, Shahrukh Kureishy, Ryan Klein, Mitzie Hewitt, Jeremy Cole, Emory Robinette, Edward Cordasco, Robert Garver, Gerard Criner, Frank Sciurba, Edward Kerwin, Gregg Lucksinger, John Delgado, David Russian, Geoffrey Chupp

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DOI
10.1016/s2213-2600(24)00324-2
Published
2025-01
Container
The Lancet Respiratory Medicine
Publisher
Elsevier BV
Open access
unknown

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BibTeX

@article{allodium:10.1016/s2213-2600-24-00324-2,
  title = {Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial},
  author = {Dave Singh and Christopher E Brightling and Klaus F Rabe and MeiLan K Han and Stephanie A Christenson and M Bradley Drummond and Alberto Papi and Ian D Pavord and Nestor A Molfino and Gun Almqvist and Ales Kotalik and Åsa Hellqvist and Monika Gołąbek and Navreet S Sindhwani and Sandhia S Ponnarambil and Jasmin Belle-Isle and Jerome Nadeau and William Killorn and Bruno Francoeur and Emilie Millaire and Bonavuth Pek and Murdo Ferguson and Francois Maltais and Kieran Killian and Giuseppe Mazza and Lyle Melenka and Brandie Walker and Celine Bergeron and John FitzGerald and Ulla Møller Weinreich and Elisabeth Bendstrup and Celeste Porsbjerg and Charlotte Ulrik and Ingrid Titlestad and Christian Meyer and Ole Hilberg and Francis Couturaud and Claire Andrejak and Arnaud Bourdin and Gilles Devouassoux and Jean-Louis Pepin and Pascal Chanez and Arnaud Cavailles and Andreas Eich and Andrea Ludwig-Sengpiel and Henrik Watz and Thomas Schultz and Amir Bar-Shai and Ori Wand and Yochai Adir and Neville Berkman and Gershon Fink and David Shitrit and Gabriel Izbicki and Yael Raviv and Pascal Wielders and Martijn Goosens and Roxane Heller-Baan and Johannes in't Veen and Frank Custers and Yeon-Mok Oh and YongChul Lee and Jaeyeol Kim and Kwang-Ha Yoo and Jung-Won Park and Sang Haak Lee and Joong Hyun Ahn and Sook Young Lee and Jin Woo Kim and Kwan Ho Lee and Luis Mateos Caballero and Elsa Naval Sendra and David Ramos Barbón and José Luis Velasco Garrido and Bernardino Alcázar Navarrete and Dinesh Saralaya and Michael Crooks and Pallav Shah and Rekha Chaudhuri and Anthony de Soyza and Monica Nordstrom and Akshay Dwarakanath and Steven Weinstein and David Pham and John Mitchell and Selwyn Spangenthal and Sever Surdulescu and Michael Denenberg and Sady Alpizar and David Maybee and Timothy Moriarty and Faisal Fakih and Richard Beasley and Marvin Heuer and Amit Patel and Jeffrey Dorf and Rafael Martinez and Shahrukh Kureishy and Ryan Klein and Mitzie Hewitt and Jeremy Cole and Emory Robinette and Edward Cordasco and Robert Garver and Gerard Criner and Frank Sciurba and Edward Kerwin and Gregg Lucksinger and John Delgado and David Russian and Geoffrey Chupp},
  year = {2025},
  journal = {The Lancet Respiratory Medicine},
  doi = {10.1016/s2213-2600(24)00324-2},
  url = {https://doi.org/10.1016/s2213-2600(24)00324-2}
}

RIS

TY  - JOUR
TI  - Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial
AU  - Dave Singh
AU  - Christopher E Brightling
AU  - Klaus F Rabe
AU  - MeiLan K Han
AU  - Stephanie A Christenson
AU  - M Bradley Drummond
AU  - Alberto Papi
AU  - Ian D Pavord
AU  - Nestor A Molfino
AU  - Gun Almqvist
AU  - Ales Kotalik
AU  - Åsa Hellqvist
AU  - Monika Gołąbek
AU  - Navreet S Sindhwani
AU  - Sandhia S Ponnarambil
AU  - Jasmin Belle-Isle
AU  - Jerome Nadeau
AU  - William Killorn
AU  - Bruno Francoeur
AU  - Emilie Millaire
AU  - Bonavuth Pek
AU  - Murdo Ferguson
AU  - Francois Maltais
AU  - Kieran Killian
AU  - Giuseppe Mazza
AU  - Lyle Melenka
AU  - Brandie Walker
AU  - Celine Bergeron
AU  - John FitzGerald
AU  - Ulla Møller Weinreich
AU  - Elisabeth Bendstrup
AU  - Celeste Porsbjerg
AU  - Charlotte Ulrik
AU  - Ingrid Titlestad
AU  - Christian Meyer
AU  - Ole Hilberg
AU  - Francis Couturaud
AU  - Claire Andrejak
AU  - Arnaud Bourdin
AU  - Gilles Devouassoux
AU  - Jean-Louis Pepin
AU  - Pascal Chanez
AU  - Arnaud Cavailles
AU  - Andreas Eich
AU  - Andrea Ludwig-Sengpiel
AU  - Henrik Watz
AU  - Thomas Schultz
AU  - Amir Bar-Shai
AU  - Ori Wand
AU  - Yochai Adir
AU  - Neville Berkman
AU  - Gershon Fink
AU  - David Shitrit
AU  - Gabriel Izbicki
AU  - Yael Raviv
AU  - Pascal Wielders
AU  - Martijn Goosens
AU  - Roxane Heller-Baan
AU  - Johannes in't Veen
AU  - Frank Custers
AU  - Yeon-Mok Oh
AU  - YongChul Lee
AU  - Jaeyeol Kim
AU  - Kwang-Ha Yoo
AU  - Jung-Won Park
AU  - Sang Haak Lee
AU  - Joong Hyun Ahn
AU  - Sook Young Lee
AU  - Jin Woo Kim
AU  - Kwan Ho Lee
AU  - Luis Mateos Caballero
AU  - Elsa Naval Sendra
AU  - David Ramos Barbón
AU  - José Luis Velasco Garrido
AU  - Bernardino Alcázar Navarrete
AU  - Dinesh Saralaya
AU  - Michael Crooks
AU  - Pallav Shah
AU  - Rekha Chaudhuri
AU  - Anthony de Soyza
AU  - Monica Nordstrom
AU  - Akshay Dwarakanath
AU  - Steven Weinstein
AU  - David Pham
AU  - John Mitchell
AU  - Selwyn Spangenthal
AU  - Sever Surdulescu
AU  - Michael Denenberg
AU  - Sady Alpizar
AU  - David Maybee
AU  - Timothy Moriarty
AU  - Faisal Fakih
AU  - Richard Beasley
AU  - Marvin Heuer
AU  - Amit Patel
AU  - Jeffrey Dorf
AU  - Rafael Martinez
AU  - Shahrukh Kureishy
AU  - Ryan Klein
AU  - Mitzie Hewitt
AU  - Jeremy Cole
AU  - Emory Robinette
AU  - Edward Cordasco
AU  - Robert Garver
AU  - Gerard Criner
AU  - Frank Sciurba
AU  - Edward Kerwin
AU  - Gregg Lucksinger
AU  - John Delgado
AU  - David Russian
AU  - Geoffrey Chupp
PY  - 2025
JO  - The Lancet Respiratory Medicine
DO  - 10.1016/s2213-2600(24)00324-2
UR  - https://doi.org/10.1016/s2213-2600(24)00324-2
ER  - 

APA

Singh, D., Brightling, C. E., Rabe, K. F., Han, M. K., Christenson, S. A., Drummond, M. B., Papi, A., Pavord, I. D., Molfino, N. A., Almqvist, G., Kotalik, A., Hellqvist, Å., Gołąbek, M., Sindhwani, N. S., Ponnarambil, S. S., Belle-Isle, J., Nadeau, J., Killorn, W., Francoeur, B., Millaire, E., Pek, B., Ferguson, M., Maltais, F., Killian, K., Mazza, G., Melenka, L., Walker, B., Bergeron, C., FitzGerald, J., Weinreich, U. M., Bendstrup, E., Porsbjerg, C., Ulrik, C., Titlestad, I., Meyer, C., Hilberg, O., Couturaud, F., Andrejak, C., Bourdin, A., Devouassoux, G., Pepin, J., Chanez, P., Cavailles, A., Eich, A., Ludwig-Sengpiel, A., Watz, H., Schultz, T., Bar-Shai, A., Wand, O., Adir, Y., Berkman, N., Fink, G., Shitrit, D., Izbicki, G., Raviv, Y., Wielders, P., Goosens, M., Heller-Baan, R., Veen, J. I., Custers, F., Oh, Y., Lee, Y., Kim, J., Yoo, K., Park, J., Lee, S. H., Ahn, J. H., Lee, S. Y., Kim, J. W., Lee, K. H., Caballero, L. M., Sendra, E. N., Barbón, D. R., Garrido, J. L. V., Navarrete, B. A., Saralaya, D., Crooks, M., Shah, P., Chaudhuri, R., Soyza, A. D., Nordstrom, M., Dwarakanath, A., Weinstein, S., Pham, D., Mitchell, J., Spangenthal, S., Surdulescu, S., Denenberg, M., Alpizar, S., Maybee, D., Moriarty, T., Fakih, F., Beasley, R., Heuer, M., Patel, A., Dorf, J., Martinez, R., Kureishy, S., Klein, R., Hewitt, M., Cole, J., Robinette, E., Cordasco, E., Garver, R., Criner, G., Sciurba, F., Kerwin, E., Lucksinger, G., Delgado, J., Russian, D., & Chupp, G. (2025). Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial. The Lancet Respiratory Medicine. https://doi.org/10.1016/s2213-2600(24)00324-2

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