Inhaled isoflurane for sedation of mechanically ventilated children in intensive care (IsoCOMFORT): a multicentre, randomised, active-control, assessor-masked, non-inferiority phase 3 trial

Jordi Miatello, Alba Palacios-Cuesta, Peter Radell, André Oberthuer, Stephen Playfor, Irene Amores-Hernández, Simon Barreault, Richard Biedermann, Maria Teresa Charlo Molina, Juan Encarnación Martínez, Benjamin Kuehne, Santiago Mencía, Maria Dolores Méndez, Christoph Menzel, Luc Morin, Lidia Oviedo, Jean-Eudes Piloquet, Magnus Falkenhav, Peter Sackey, Uwe Trieschmann, Pierre Tissieres, Ramy Charbel, Clémence Marais, Florent Baudin, Fleur Cour-Andlauer, Nicolas Joram, Julien Jegard, Michael Levy, Jerome Naudin, Maxence Fernandes, Ombeline Roignot, Joelle Beaudet, Sandrine De Sampaio, Yohan Soreze, Philippe Meyer, Francois Moreau, Ana Maria Llorente de la Fuente, Olga Ordóñez Sáez, Hugo Ahern, Rubén Ferreras, Carmen Román-Hernández, Guillermo Santos-Simarro, Rosa Maria Rodríguez Sánchez, Elisa Mérida Ales, Elia Sánchez Valederrábanos, Manuel Fernández Elías, Raquel Cieza, Alba Corchado, José Luis Unzueta-Roch, Cristina Yun Castilla, Raúl Montero Yéboles, Laura Díaz Rueda, Mónica Girona-Alarcon, Sara Bobillo-Pérez, Christoph Ulrichs, Mona Ströhlein, Hans Proquitté, René Höhn, Christoph Zürn, Monika Wolf, Anand Patil, Padmanabhan Ramnarayan

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DOI
10.1016/s2213-2600(25)00203-6
Published
2025-10
Container
The Lancet Respiratory Medicine
Publisher
Elsevier BV
Open access
unknown

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BibTeX

@article{allodium:10.1016/s2213-2600-25-00203-6,
  title = {Inhaled isoflurane for sedation of mechanically ventilated children in intensive care (IsoCOMFORT): a multicentre, randomised, active-control, assessor-masked, non-inferiority phase 3 trial},
  author = {Jordi Miatello and Alba Palacios-Cuesta and Peter Radell and André Oberthuer and Stephen Playfor and Irene Amores-Hernández and Simon Barreault and Richard Biedermann and Maria Teresa Charlo Molina and Juan Encarnación Martínez and Benjamin Kuehne and Santiago Mencía and Maria Dolores Méndez and Christoph Menzel and Luc Morin and Lidia Oviedo and Jean-Eudes Piloquet and Magnus Falkenhav and Peter Sackey and Uwe Trieschmann and Pierre Tissieres and Ramy Charbel and Clémence Marais and Florent Baudin and Fleur Cour-Andlauer and Nicolas Joram and Julien Jegard and Michael Levy and Jerome Naudin and Maxence Fernandes and Ombeline Roignot and Joelle Beaudet and Sandrine De Sampaio and Yohan Soreze and Philippe Meyer and Francois Moreau and Ana Maria Llorente de la Fuente and Olga Ordóñez Sáez and Hugo Ahern and Rubén Ferreras and Carmen Román-Hernández and Guillermo Santos-Simarro and Rosa Maria Rodríguez Sánchez and Elisa Mérida Ales and Elia Sánchez Valederrábanos and Manuel Fernández Elías and Raquel Cieza and Alba Corchado and José Luis Unzueta-Roch and Cristina Yun Castilla and Raúl Montero Yéboles and Laura Díaz Rueda and Mónica Girona-Alarcon and Sara Bobillo-Pérez and Christoph Ulrichs and Mona Ströhlein and Hans Proquitté and René Höhn and Christoph Zürn and Monika Wolf and Anand Patil and Padmanabhan Ramnarayan},
  year = {2025},
  journal = {The Lancet Respiratory Medicine},
  doi = {10.1016/s2213-2600(25)00203-6},
  url = {https://doi.org/10.1016/s2213-2600(25)00203-6}
}

RIS

TY  - JOUR
TI  - Inhaled isoflurane for sedation of mechanically ventilated children in intensive care (IsoCOMFORT): a multicentre, randomised, active-control, assessor-masked, non-inferiority phase 3 trial
AU  - Jordi Miatello
AU  - Alba Palacios-Cuesta
AU  - Peter Radell
AU  - André Oberthuer
AU  - Stephen Playfor
AU  - Irene Amores-Hernández
AU  - Simon Barreault
AU  - Richard Biedermann
AU  - Maria Teresa Charlo Molina
AU  - Juan Encarnación Martínez
AU  - Benjamin Kuehne
AU  - Santiago Mencía
AU  - Maria Dolores Méndez
AU  - Christoph Menzel
AU  - Luc Morin
AU  - Lidia Oviedo
AU  - Jean-Eudes Piloquet
AU  - Magnus Falkenhav
AU  - Peter Sackey
AU  - Uwe Trieschmann
AU  - Pierre Tissieres
AU  - Ramy Charbel
AU  - Clémence Marais
AU  - Florent Baudin
AU  - Fleur Cour-Andlauer
AU  - Nicolas Joram
AU  - Julien Jegard
AU  - Michael Levy
AU  - Jerome Naudin
AU  - Maxence Fernandes
AU  - Ombeline Roignot
AU  - Joelle Beaudet
AU  - Sandrine De Sampaio
AU  - Yohan Soreze
AU  - Philippe Meyer
AU  - Francois Moreau
AU  - Ana Maria Llorente de la Fuente
AU  - Olga Ordóñez Sáez
AU  - Hugo Ahern
AU  - Rubén Ferreras
AU  - Carmen Román-Hernández
AU  - Guillermo Santos-Simarro
AU  - Rosa Maria Rodríguez Sánchez
AU  - Elisa Mérida Ales
AU  - Elia Sánchez Valederrábanos
AU  - Manuel Fernández Elías
AU  - Raquel Cieza
AU  - Alba Corchado
AU  - José Luis Unzueta-Roch
AU  - Cristina Yun Castilla
AU  - Raúl Montero Yéboles
AU  - Laura Díaz Rueda
AU  - Mónica Girona-Alarcon
AU  - Sara Bobillo-Pérez
AU  - Christoph Ulrichs
AU  - Mona Ströhlein
AU  - Hans Proquitté
AU  - René Höhn
AU  - Christoph Zürn
AU  - Monika Wolf
AU  - Anand Patil
AU  - Padmanabhan Ramnarayan
PY  - 2025
JO  - The Lancet Respiratory Medicine
DO  - 10.1016/s2213-2600(25)00203-6
UR  - https://doi.org/10.1016/s2213-2600(25)00203-6
ER  - 

APA

Miatello, J., Palacios-Cuesta, A., Radell, P., Oberthuer, A., Playfor, S., Amores-Hernández, I., Barreault, S., Biedermann, R., Molina, M. T. C., Martínez, J. E., Kuehne, B., Mencía, S., Méndez, M. D., Menzel, C., Morin, L., Oviedo, L., Piloquet, J., Falkenhav, M., Sackey, P., Trieschmann, U., Tissieres, P., Charbel, R., Marais, C., Baudin, F., Cour-Andlauer, F., Joram, N., Jegard, J., Levy, M., Naudin, J., Fernandes, M., Roignot, O., Beaudet, J., Sampaio, S. D., Soreze, Y., Meyer, P., Moreau, F., Fuente, A. M. L. D. L., Sáez, O. O., Ahern, H., Ferreras, R., Román-Hernández, C., Santos-Simarro, G., Sánchez, R. M. R., Ales, E. M., Valederrábanos, E. S., Elías, M. F., Cieza, R., Corchado, A., Unzueta-Roch, J. L., Castilla, C. Y., Yéboles, R. M., Rueda, L. D., Girona-Alarcon, M., Bobillo-Pérez, S., Ulrichs, C., Ströhlein, M., Proquitté, H., Höhn, R., Zürn, C., Wolf, M., Patil, A., & Ramnarayan, P. (2025). Inhaled isoflurane for sedation of mechanically ventilated children in intensive care (IsoCOMFORT): a multicentre, randomised, active-control, assessor-masked, non-inferiority phase 3 trial. The Lancet Respiratory Medicine. https://doi.org/10.1016/s2213-2600(25)00203-6

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