Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

Marion Moseby-Knappe, Helena Levin, Susann Ullén, Henrik Zetterberg, Kaj Blennow, Alice Lagebrant, Josef Dankiewicz, Janus C Jakobsen, Gisela Lilja, Alistair D Nichol, Glenn Eastwood, Kate Ainscough, Matthew J C Thomas, Anders M Grejs, Thomas R Keeble, Christian Rylander, Joachim Düring, Matt P Wise, Jan Hovdenes, Christian Storm, Ola Borgquist, Alain Cariou, Nicolas Deye, Jean-Baptiste Lascarrou, Jonathan Bannard-Smith, Johan Undén, Philippe Vignon, Stéphane Legriel, Ondřej Šmíd, David Pogson, Jiri Karasek, Peter J McGuigan, Michael Joannidis, Hans Kirkegaard, Jeremy Bewley, Steffen Christensen, Maria Rita Maccaroni, Anna Valerianova, Andreas Lundin, Anna Lybeck, Christoph Leithner, Filip Varhaník, Katie Sweet, Andrew Walden, Hans Friberg, Tobias Cronberg, Niklas Nielsen, Jan Belohlávek, Ronny Beer, Frank Hartig, Raimund Helbok, Sebastian Klein, Andreas Peer, Michal Otáhal, Marek Flaksa, David Kemlink, Jan Malík, Jan Rulíšek, Michal Šíranec, Zdenek Stach, Petra Zavadilova, Anne Adolfsson, Anna Bjärnroos, Kajsa Jönsson, Susann Schrey, Erik Westhall, Frida Antonsson, Git Bergman, Jörgen Gamroth, Maria Meirik, Zoe Garland, Lisa Grimmer, Bethany Gumbrill, Lucy Howie, Zoe Garland, Rebekah Johnson, Chloe Searles, Agnieszka Skorko, Victoria Taylor, Deborah Peripoorani, Peter Juhl-Olsen, Ida Katrine Thomsen, Lisa Gregersen Østergaard, Julien Charpentier, Pierre Dupland, Arianne Gavaud, Pierre Jaubert, Mathieu Jozwiak, Nathalie Marin, Jean-Paul Mira, Frederic Pene, Guillaume Savary, Bruno Megarbane, Pierre Mora, Katarina Rudolfsson, Helena Sandberg, Martin Thorsson, Kristin Savolainen, Maria Hansbo, Malin Helliksson, Björne Nödtveidt, Johan Sanner, Victoria Sem, Gill Adams, Rajesh K Aggarwal, Jo-Anne Cartwright, Steven Church, Gerald J Clesham, Denise Webster, John R Davies, Kelly Farrell, Reto Gamma, Laetitia Sutterlin, Isabelle Malissin, Nicolas Peron, Karim Jaffal, Hélène Migueres, Aymen Mrad, Caroline Grant, Foued El Gharbi, Sebastian Voicu, Hugo Bellut, Guillaume Lacave, Marine Paul, Carole Ouisse, Thomas Daix, Camilla Sund Lindquist, Stefan Persson, Ida Berglund, Eric Bergström, Cathrine Törnqvist, Ingela Östman, Jade Cole, Helen Hill, Michelle Davies, Jane Harding, Rohan Jagathesan, Alamgir Kabir, Paul A Kelly, Lauren Kittridge, Arnaud Desachy, Marco Mion, Naveen Nain, Raghunath Nalgirkar, Bruno Evrard, Bruno Francois, Anne-Laure Fedou, Marine Goudelin, Jens Nee, Roman Desta Lindgren, Elisabeth Myhrman, Birgitta Ryding, Patrik Martner, Louise Martinell, Simon Schmidbauer, Tim Schröder, Åse Rasmussen, Andreas Espinoza, Kristin Wisløff-Aase, Simon Jakobsson, Sven Olav Løstegaard, Ingrid Eiving, Marita Ahlqvist, Rhys Davies, Jenny Brooks, Angharad Williams, Jacqueline Curtain, Emma Thomas, Stephen Fernandez, Matt Morgan, Oscar Lundberg, Mattias Bergström, Julie Highfield, Eve Cocks, Gyanesh Namjoshi, Stacey Pepper, Emily Redman, Nicholas M Robinson, Jeremy Sayer, Amanda Solesbury, Kare H Tang, Sali Urovi, Kunal Waghmare, Ingrid Didriksson, Patrik Johnsson, Marina Larsson, Stefan Hau-Olsson, Petrea Frid, Fredrik Buchwald, Lydia Pennant, Sofia Rose, Stephen Haffey, Aisling O'Neill, Kathryn Ward, Anna Chillingworth, Julie Cloake, Libby Cole, Hilary Galvin, Noel Watson, Teresa Webber, Parminder Bhuie, Nicola Jacques, Zoe Daly, Steve Rose, Rachael Quayle, Anila Sukumaran

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DOI
10.1016/s2213-2600(25)00363-7
Published
2026-03
Container
The Lancet Respiratory Medicine
Publisher
Elsevier BV
Open access
unknown

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BibTeX

@article{allodium:10.1016/s2213-2600-25-00363-7,
  title = {Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial},
  author = {Marion Moseby-Knappe and Helena Levin and Susann Ullén and Henrik Zetterberg and Kaj Blennow and Alice Lagebrant and Josef Dankiewicz and Janus C Jakobsen and Gisela Lilja and Alistair D Nichol and Glenn Eastwood and Kate Ainscough and Matthew J C Thomas and Anders M Grejs and Thomas R Keeble and Christian Rylander and Joachim Düring and Matt P Wise and Jan Hovdenes and Christian Storm and Ola Borgquist and Alain Cariou and Nicolas Deye and Jean-Baptiste Lascarrou and Jonathan Bannard-Smith and Johan Undén and Philippe Vignon and Stéphane Legriel and Ondřej Šmíd and David Pogson and Jiri Karasek and Peter J McGuigan and Michael Joannidis and Hans Kirkegaard and Jeremy Bewley and Steffen Christensen and Maria Rita Maccaroni and Anna Valerianova and Andreas Lundin and Anna Lybeck and Christoph Leithner and Filip Varhaník and Katie Sweet and Andrew Walden and Hans Friberg and Tobias Cronberg and Niklas Nielsen and Jan Belohlávek and Ronny Beer and Frank Hartig and Raimund Helbok and Sebastian Klein and Andreas Peer and Michal Otáhal and Marek Flaksa and David Kemlink and Jan Malík and Jan Rulíšek and Michal Šíranec and Zdenek Stach and Petra Zavadilova and Anne Adolfsson and Anna Bjärnroos and Kajsa Jönsson and Susann Schrey and Erik Westhall and Frida Antonsson and Git Bergman and Jörgen Gamroth and Maria Meirik and Zoe Garland and Lisa Grimmer and Bethany Gumbrill and Lucy Howie and Zoe Garland and Rebekah Johnson and Chloe Searles and Agnieszka Skorko and Victoria Taylor and Deborah Peripoorani and Peter Juhl-Olsen and Ida Katrine Thomsen and Lisa Gregersen Østergaard and Julien Charpentier and Pierre Dupland and Arianne Gavaud and Pierre Jaubert and Mathieu Jozwiak and Nathalie Marin and Jean-Paul Mira and Frederic Pene and Guillaume Savary and Bruno Megarbane and Pierre Mora and Katarina Rudolfsson and Helena Sandberg and Martin Thorsson and Kristin Savolainen and Maria Hansbo and Malin Helliksson and Björne Nödtveidt and Johan Sanner and Victoria Sem and Gill Adams and Rajesh K Aggarwal and Jo-Anne Cartwright and Steven Church and Gerald J Clesham and Denise Webster and John R Davies and Kelly Farrell and Reto Gamma and Laetitia Sutterlin and Isabelle Malissin and Nicolas Peron and Karim Jaffal and Hélène Migueres and Aymen Mrad and Caroline Grant and Foued El Gharbi and Sebastian Voicu and Hugo Bellut and Guillaume Lacave and Marine Paul and Carole Ouisse and Thomas Daix and Camilla Sund Lindquist and Stefan Persson and Ida Berglund and Eric Bergström and Cathrine Törnqvist and Ingela Östman and Jade Cole and Helen Hill and Michelle Davies and Jane Harding and Rohan Jagathesan and Alamgir Kabir and Paul A Kelly and Lauren Kittridge and Arnaud Desachy and Marco Mion and Naveen Nain and Raghunath Nalgirkar and Bruno Evrard and Bruno Francois and Anne-Laure Fedou and Marine Goudelin and Jens Nee and Roman Desta Lindgren and Elisabeth Myhrman and Birgitta Ryding and Patrik Martner and Louise Martinell and Simon Schmidbauer and Tim Schröder and Åse Rasmussen and Andreas Espinoza and Kristin Wisløff-Aase and Simon Jakobsson and Sven Olav Løstegaard and Ingrid Eiving and Marita Ahlqvist and Rhys Davies and Jenny Brooks and Angharad Williams and Jacqueline Curtain and Emma Thomas and Stephen Fernandez and Matt Morgan and Oscar Lundberg and Mattias Bergström and Julie Highfield and Eve Cocks and Gyanesh Namjoshi and Stacey Pepper and Emily Redman and Nicholas M Robinson and Jeremy Sayer and Amanda Solesbury and Kare H Tang and Sali Urovi and Kunal Waghmare and Ingrid Didriksson and Patrik Johnsson and Marina Larsson and Stefan Hau-Olsson and Petrea Frid and Fredrik Buchwald and Lydia Pennant and Sofia Rose and Stephen Haffey and Aisling O'Neill and Kathryn Ward and Anna Chillingworth and Julie Cloake and Libby Cole and Hilary Galvin and Noel Watson and Teresa Webber and Parminder Bhuie and Nicola Jacques and Zoe Daly and Steve Rose and Rachael Quayle and Anila Sukumaran},
  year = {2026},
  journal = {The Lancet Respiratory Medicine},
  doi = {10.1016/s2213-2600(25)00363-7},
  url = {https://doi.org/10.1016/s2213-2600(25)00363-7}
}

RIS

TY  - JOUR
TI  - Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
AU  - Marion Moseby-Knappe
AU  - Helena Levin
AU  - Susann Ullén
AU  - Henrik Zetterberg
AU  - Kaj Blennow
AU  - Alice Lagebrant
AU  - Josef Dankiewicz
AU  - Janus C Jakobsen
AU  - Gisela Lilja
AU  - Alistair D Nichol
AU  - Glenn Eastwood
AU  - Kate Ainscough
AU  - Matthew J C Thomas
AU  - Anders M Grejs
AU  - Thomas R Keeble
AU  - Christian Rylander
AU  - Joachim Düring
AU  - Matt P Wise
AU  - Jan Hovdenes
AU  - Christian Storm
AU  - Ola Borgquist
AU  - Alain Cariou
AU  - Nicolas Deye
AU  - Jean-Baptiste Lascarrou
AU  - Jonathan Bannard-Smith
AU  - Johan Undén
AU  - Philippe Vignon
AU  - Stéphane Legriel
AU  - Ondřej Šmíd
AU  - David Pogson
AU  - Jiri Karasek
AU  - Peter J McGuigan
AU  - Michael Joannidis
AU  - Hans Kirkegaard
AU  - Jeremy Bewley
AU  - Steffen Christensen
AU  - Maria Rita Maccaroni
AU  - Anna Valerianova
AU  - Andreas Lundin
AU  - Anna Lybeck
AU  - Christoph Leithner
AU  - Filip Varhaník
AU  - Katie Sweet
AU  - Andrew Walden
AU  - Hans Friberg
AU  - Tobias Cronberg
AU  - Niklas Nielsen
AU  - Jan Belohlávek
AU  - Ronny Beer
AU  - Frank Hartig
AU  - Raimund Helbok
AU  - Sebastian Klein
AU  - Andreas Peer
AU  - Michal Otáhal
AU  - Marek Flaksa
AU  - David Kemlink
AU  - Jan Malík
AU  - Jan Rulíšek
AU  - Michal Šíranec
AU  - Zdenek Stach
AU  - Petra Zavadilova
AU  - Anne Adolfsson
AU  - Anna Bjärnroos
AU  - Kajsa Jönsson
AU  - Susann Schrey
AU  - Erik Westhall
AU  - Frida Antonsson
AU  - Git Bergman
AU  - Jörgen Gamroth
AU  - Maria Meirik
AU  - Zoe Garland
AU  - Lisa Grimmer
AU  - Bethany Gumbrill
AU  - Lucy Howie
AU  - Zoe Garland
AU  - Rebekah Johnson
AU  - Chloe Searles
AU  - Agnieszka Skorko
AU  - Victoria Taylor
AU  - Deborah Peripoorani
AU  - Peter Juhl-Olsen
AU  - Ida Katrine Thomsen
AU  - Lisa Gregersen Østergaard
AU  - Julien Charpentier
AU  - Pierre Dupland
AU  - Arianne Gavaud
AU  - Pierre Jaubert
AU  - Mathieu Jozwiak
AU  - Nathalie Marin
AU  - Jean-Paul Mira
AU  - Frederic Pene
AU  - Guillaume Savary
AU  - Bruno Megarbane
AU  - Pierre Mora
AU  - Katarina Rudolfsson
AU  - Helena Sandberg
AU  - Martin Thorsson
AU  - Kristin Savolainen
AU  - Maria Hansbo
AU  - Malin Helliksson
AU  - Björne Nödtveidt
AU  - Johan Sanner
AU  - Victoria Sem
AU  - Gill Adams
AU  - Rajesh K Aggarwal
AU  - Jo-Anne Cartwright
AU  - Steven Church
AU  - Gerald J Clesham
AU  - Denise Webster
AU  - John R Davies
AU  - Kelly Farrell
AU  - Reto Gamma
AU  - Laetitia Sutterlin
AU  - Isabelle Malissin
AU  - Nicolas Peron
AU  - Karim Jaffal
AU  - Hélène Migueres
AU  - Aymen Mrad
AU  - Caroline Grant
AU  - Foued El Gharbi
AU  - Sebastian Voicu
AU  - Hugo Bellut
AU  - Guillaume Lacave
AU  - Marine Paul
AU  - Carole Ouisse
AU  - Thomas Daix
AU  - Camilla Sund Lindquist
AU  - Stefan Persson
AU  - Ida Berglund
AU  - Eric Bergström
AU  - Cathrine Törnqvist
AU  - Ingela Östman
AU  - Jade Cole
AU  - Helen Hill
AU  - Michelle Davies
AU  - Jane Harding
AU  - Rohan Jagathesan
AU  - Alamgir Kabir
AU  - Paul A Kelly
AU  - Lauren Kittridge
AU  - Arnaud Desachy
AU  - Marco Mion
AU  - Naveen Nain
AU  - Raghunath Nalgirkar
AU  - Bruno Evrard
AU  - Bruno Francois
AU  - Anne-Laure Fedou
AU  - Marine Goudelin
AU  - Jens Nee
AU  - Roman Desta Lindgren
AU  - Elisabeth Myhrman
AU  - Birgitta Ryding
AU  - Patrik Martner
AU  - Louise Martinell
AU  - Simon Schmidbauer
AU  - Tim Schröder
AU  - Åse Rasmussen
AU  - Andreas Espinoza
AU  - Kristin Wisløff-Aase
AU  - Simon Jakobsson
AU  - Sven Olav Løstegaard
AU  - Ingrid Eiving
AU  - Marita Ahlqvist
AU  - Rhys Davies
AU  - Jenny Brooks
AU  - Angharad Williams
AU  - Jacqueline Curtain
AU  - Emma Thomas
AU  - Stephen Fernandez
AU  - Matt Morgan
AU  - Oscar Lundberg
AU  - Mattias Bergström
AU  - Julie Highfield
AU  - Eve Cocks
AU  - Gyanesh Namjoshi
AU  - Stacey Pepper
AU  - Emily Redman
AU  - Nicholas M Robinson
AU  - Jeremy Sayer
AU  - Amanda Solesbury
AU  - Kare H Tang
AU  - Sali Urovi
AU  - Kunal Waghmare
AU  - Ingrid Didriksson
AU  - Patrik Johnsson
AU  - Marina Larsson
AU  - Stefan Hau-Olsson
AU  - Petrea Frid
AU  - Fredrik Buchwald
AU  - Lydia Pennant
AU  - Sofia Rose
AU  - Stephen Haffey
AU  - Aisling O'Neill
AU  - Kathryn Ward
AU  - Anna Chillingworth
AU  - Julie Cloake
AU  - Libby Cole
AU  - Hilary Galvin
AU  - Noel Watson
AU  - Teresa Webber
AU  - Parminder Bhuie
AU  - Nicola Jacques
AU  - Zoe Daly
AU  - Steve Rose
AU  - Rachael Quayle
AU  - Anila Sukumaran
PY  - 2026
JO  - The Lancet Respiratory Medicine
DO  - 10.1016/s2213-2600(25)00363-7
UR  - https://doi.org/10.1016/s2213-2600(25)00363-7
ER  - 

APA

Moseby-Knappe, M., Levin, H., Ullén, S., Zetterberg, H., Blennow, K., Lagebrant, A., Dankiewicz, J., Jakobsen, J. C., Lilja, G., Nichol, A. D., Eastwood, G., Ainscough, K., Thomas, M. J. C., Grejs, A. M., Keeble, T. R., Rylander, C., Düring, J., Wise, M. P., Hovdenes, J., Storm, C., Borgquist, O., Cariou, A., Deye, N., Lascarrou, J., Bannard-Smith, J., Undén, J., Vignon, P., Legriel, S., Šmíd, O., Pogson, D., Karasek, J., McGuigan, P. J., Joannidis, M., Kirkegaard, H., Bewley, J., Christensen, S., Maccaroni, M. R., Valerianova, A., Lundin, A., Lybeck, A., Leithner, C., Varhaník, F., Sweet, K., Walden, A., Friberg, H., Cronberg, T., Nielsen, N., Belohlávek, J., Beer, R., Hartig, F., Helbok, R., Klein, S., Peer, A., Otáhal, M., Flaksa, M., Kemlink, D., Malík, J., Rulíšek, J., Šíranec, M., Stach, Z., Zavadilova, P., Adolfsson, A., Bjärnroos, A., Jönsson, K., Schrey, S., Westhall, E., Antonsson, F., Bergman, G., Gamroth, J., Meirik, M., Garland, Z., Grimmer, L., Gumbrill, B., Howie, L., Garland, Z., Johnson, R., Searles, C., Skorko, A., Taylor, V., Peripoorani, D., Juhl-Olsen, P., Thomsen, I. K., Østergaard, L. G., Charpentier, J., Dupland, P., Gavaud, A., Jaubert, P., Jozwiak, M., Marin, N., Mira, J., Pene, F., Savary, G., Megarbane, B., Mora, P., Rudolfsson, K., Sandberg, H., Thorsson, M., Savolainen, K., Hansbo, M., Helliksson, M., Nödtveidt, B., Sanner, J., Sem, V., Adams, G., Aggarwal, R. K., Cartwright, J., Church, S., Clesham, G. J., Webster, D., Davies, J. R., Farrell, K., Gamma, R., Sutterlin, L., Malissin, I., Peron, N., Jaffal, K., Migueres, H., Mrad, A., Grant, C., Gharbi, F. E., Voicu, S., Bellut, H., Lacave, G., Paul, M., Ouisse, C., Daix, T., Lindquist, C. S., Persson, S., Berglund, I., Bergström, E., Törnqvist, C., Östman, I., Cole, J., Hill, H., Davies, M., Harding, J., Jagathesan, R., Kabir, A., Kelly, P. A., Kittridge, L., Desachy, A., Mion, M., Nain, N., Nalgirkar, R., Evrard, B., Francois, B., Fedou, A., Goudelin, M., Nee, J., Lindgren, R. D., Myhrman, E., Ryding, B., Martner, P., Martinell, L., Schmidbauer, S., Schröder, T., Rasmussen, Å., Espinoza, A., Wisløff-Aase, K., Jakobsson, S., Løstegaard, S. O., Eiving, I., Ahlqvist, M., Davies, R., Brooks, J., Williams, A., Curtain, J., Thomas, E., Fernandez, S., Morgan, M., Lundberg, O., Bergström, M., Highfield, J., Cocks, E., Namjoshi, G., Pepper, S., Redman, E., Robinson, N. M., Sayer, J., Solesbury, A., Tang, K. H., Urovi, S., Waghmare, K., Didriksson, I., Johnsson, P., Larsson, M., Hau-Olsson, S., Frid, P., Buchwald, F., Pennant, L., Rose, S., Haffey, S., O'Neill, A., Ward, K., Chillingworth, A., Cloake, J., Cole, L., Galvin, H., Watson, N., Webber, T., Bhuie, P., Jacques, N., Daly, Z., Rose, S., Quayle, R., & Sukumaran, A. (2026). Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial. The Lancet Respiratory Medicine. https://doi.org/10.1016/s2213-2600(25)00363-7

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