Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial

Erik H A Michels, Pierre-François Dequin, Joe M Butler, Antoine Guillon, Bruno Evrard, Fleur P Paling, Tom D Y Reijnders, Alex R Schuurman, Tjitske S R van Engelen, Xanthe Brands, Bastiaan W Haak, Lieuwe D J Bos, Carolyn Leroux, Evangelos J Giamarellos-Bourboulis, Jaap Stoker, Jan M Prins, Daniël R Faber, Renée A Douma, Timothy E Sweeney, Surbhi Malhotra-Kumar, Jan A J W Kluytmans, Brendon P Scicluna, Olaf L Cremer, Michael Matthay, Carolyn Calfee, W Joost Wiersinga, Hessel Peters-Sengers, Tom van der Poll

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DOI
10.1016/s2213-2600(25)00429-1
Published
2026-04
Container
The Lancet Respiratory Medicine
Publisher
Elsevier BV
Open access
unknown

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BibTeX

@article{allodium:10.1016/s2213-2600-25-00429-1,
  title = {Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial},
  author = {Erik H A Michels and Pierre-François Dequin and Joe M Butler and Antoine Guillon and Bruno Evrard and Fleur P Paling and Tom D Y Reijnders and Alex R Schuurman and Tjitske S R van Engelen and Xanthe Brands and Bastiaan W Haak and Lieuwe D J Bos and Carolyn Leroux and Evangelos J Giamarellos-Bourboulis and Jaap Stoker and Jan M Prins and Daniël R Faber and Renée A Douma and Timothy E Sweeney and Surbhi Malhotra-Kumar and Jan A J W Kluytmans and Brendon P Scicluna and Olaf L Cremer and Michael Matthay and Carolyn Calfee and W Joost Wiersinga and Hessel Peters-Sengers and Tom van der Poll},
  year = {2026},
  journal = {The Lancet Respiratory Medicine},
  doi = {10.1016/s2213-2600(25)00429-1},
  url = {https://doi.org/10.1016/s2213-2600(25)00429-1}
}

RIS

TY  - JOUR
TI  - Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial
AU  - Erik H A Michels
AU  - Pierre-François Dequin
AU  - Joe M Butler
AU  - Antoine Guillon
AU  - Bruno Evrard
AU  - Fleur P Paling
AU  - Tom D Y Reijnders
AU  - Alex R Schuurman
AU  - Tjitske S R van Engelen
AU  - Xanthe Brands
AU  - Bastiaan W Haak
AU  - Lieuwe D J Bos
AU  - Carolyn Leroux
AU  - Evangelos J Giamarellos-Bourboulis
AU  - Jaap Stoker
AU  - Jan M Prins
AU  - Daniël R Faber
AU  - Renée A Douma
AU  - Timothy E Sweeney
AU  - Surbhi Malhotra-Kumar
AU  - Jan A J W Kluytmans
AU  - Brendon P Scicluna
AU  - Olaf L Cremer
AU  - Michael Matthay
AU  - Carolyn Calfee
AU  - W Joost Wiersinga
AU  - Hessel Peters-Sengers
AU  - Tom van der Poll
PY  - 2026
JO  - The Lancet Respiratory Medicine
DO  - 10.1016/s2213-2600(25)00429-1
UR  - https://doi.org/10.1016/s2213-2600(25)00429-1
ER  -

APA

Michels, E. H. A., Dequin, P., Butler, J. M., Guillon, A., Evrard, B., Paling, F. P., Reijnders, T. D. Y., Schuurman, A. R., Engelen, T. S. R. V., Brands, X., Haak, B. W., Bos, L. D. J., Leroux, C., Giamarellos-Bourboulis, E. J., Stoker, J., Prins, J. M., Faber, D. R., Douma, R. A., Sweeney, T. E., Malhotra-Kumar, S., Kluytmans, J. A. J. W., Scicluna, B. P., Cremer, O. L., Matthay, M., Calfee, C., Wiersinga, W. J., Peters-Sengers, H., & Poll, T. V. D. (2026). Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial. The Lancet Respiratory Medicine. https://doi.org/10.1016/s2213-2600(25)00429-1

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