Efficacy and safety of relacorilant for the treatment of patients with Cushing's syndrome (GRACE): a multicentre, phase 3, double-blind, placebo-controlled, randomised-withdrawal study

Rosario Pivonello, Giorgio Arnaldi, Richard J Auchus, Corin Badiu, Robert S Busch, Salvatore Cannavò, Ulrich Dischinger, Georgiana A Dobri, Diane M Donegan, Atanaska Elenkova, Pouneh K Fazeli, Richard A Feelders, Rogelio Garcia-Centeno, Aleksandra Gilis-Januszewska, Oksana Hamidi, Zeina C Hannoush, Atil Y Kargi, Harold J Miller, Aurelian-Emil Ranetti, Monica Recasens, Martin Reincke, Sergio Rovner, Roberto Salvatori, Julie Silverstein, Antonio Stigliano, Massimo Terzolo, Christina Wang, Kevin C J Yuen, Amanda Kesner-Hays, Austin L Hand, Iulia Cristina Tudor, Katherine A Araque, Andreas G Moraitis, Lisa Abbott, Amer Al-Karadsheh, Carmen Aresta, Giorgio Arnaldi, Richard J Auchus, Corin Badiu, Isabelle Bourdeau, Robert Busch, Salvatore Cannavò, Iwona Chmiel-Perzyńska, Ulrich Dischinger, Georgiana Dobri, Diane Donegan, Rivka Dresner-Pollak, Andjela Drincic, Honey E East, Atanaska Elenkova, Martin Fassnacht, Pouneh Fazeli, Richard A Feelders, Rogelio Garcia-Centeno, Eliza Geer, Aleksandra Gilis-Januszewska, Murray B Gordon, Yona Greenman, Oksana Hamidi, Zeina Hannoush, Anthony Heaney, Wenyu Huang, Syed A Imran, Andrea Isidori, Serge Jabbour, Atil Y Kargi, Daniel Katselnik, Alexandra Kautzky-Willer, Lawrence S Kirschner, Alice Levine, Jonea Lim, Francisco JT Maduerio, Marianna Martino, Joseph W Mathews, Harold Miller, Le Min, Dan Niculescu, Jean J Nya-Ngatchou, Jonathan Ownby, John C Parker, Antonio M Picó Alfonso, Rosario Pivonello, Cristina Preda, Aurelian-Emil Ranetti, Monica Recasens, Martin Reincke, Leszek Romanowski, Pnina Rotman-Pikielny, Sergio S Rovner, Isaac Sachmechi, Roberto Salvatori, Carla Scaroni, Ilan Shimon, Julie Silverstein, Alfonso Soto-Moreno, Antonio Stigliano, Massimo Terzolo, Christina Wang, Kevin CJ Yuen

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DOI: 10.1016/s2213-8587(25)00362-6
Published: 2026-04
Container: The Lancet Diabetes & Endocrinology
Publisher: Elsevier BV
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1016/s2213-8587-25-00362-6,
  title = {Efficacy and safety of relacorilant for the treatment of patients with Cushing's syndrome (GRACE): a multicentre, phase 3, double-blind, placebo-controlled, randomised-withdrawal study},
  author = {Rosario Pivonello and Giorgio Arnaldi and Richard J Auchus and Corin Badiu and Robert S Busch and Salvatore Cannavò and Ulrich Dischinger and Georgiana A Dobri and Diane M Donegan and Atanaska Elenkova and Pouneh K Fazeli and Richard A Feelders and Rogelio Garcia-Centeno and Aleksandra Gilis-Januszewska and Oksana Hamidi and Zeina C Hannoush and Atil Y Kargi and Harold J Miller and Aurelian-Emil Ranetti and Monica Recasens and Martin Reincke and Sergio Rovner and Roberto Salvatori and Julie Silverstein and Antonio Stigliano and Massimo Terzolo and Christina Wang and Kevin C J Yuen and Amanda Kesner-Hays and Austin L Hand and Iulia Cristina Tudor and Katherine A Araque and Andreas G Moraitis and Lisa Abbott and Amer Al-Karadsheh and Carmen Aresta and Giorgio Arnaldi and Richard J Auchus and Corin Badiu and Isabelle Bourdeau and Robert Busch and Salvatore Cannavò and Iwona Chmiel-Perzyńska and Ulrich Dischinger and Georgiana Dobri and Diane Donegan and Rivka Dresner-Pollak and Andjela Drincic and Honey E East and Atanaska Elenkova and Martin Fassnacht and Pouneh Fazeli and Richard A Feelders and Rogelio Garcia-Centeno and Eliza Geer and Aleksandra Gilis-Januszewska and Murray B Gordon and Yona Greenman and Oksana Hamidi and Zeina Hannoush and Anthony Heaney and Wenyu Huang and Syed A Imran and Andrea Isidori and Serge Jabbour and Atil Y Kargi and Daniel Katselnik and Alexandra Kautzky-Willer and Lawrence S Kirschner and Alice Levine and Jonea Lim and Francisco JT Maduerio and Marianna Martino and Joseph W Mathews and Harold Miller and Le Min and Dan Niculescu and Jean J Nya-Ngatchou and Jonathan Ownby and John C Parker and Antonio M Picó Alfonso and Rosario Pivonello and Cristina Preda and Aurelian-Emil Ranetti and Monica Recasens and Martin Reincke and Leszek Romanowski and Pnina Rotman-Pikielny and Sergio S Rovner and Isaac Sachmechi and Roberto Salvatori and Carla Scaroni and Ilan Shimon and Julie Silverstein and Alfonso Soto-Moreno and Antonio Stigliano and Massimo Terzolo and Christina Wang and Kevin CJ Yuen},
  year = {2026},
  journal = {The Lancet Diabetes \&amp; Endocrinology},
  doi = {10.1016/s2213-8587(25)00362-6},
  url = {https://doi.org/10.1016/s2213-8587(25)00362-6}
}

RIS

TY  - JOUR
TI  - Efficacy and safety of relacorilant for the treatment of patients with Cushing's syndrome (GRACE): a multicentre, phase 3, double-blind, placebo-controlled, randomised-withdrawal study
AU  - Rosario Pivonello
AU  - Giorgio Arnaldi
AU  - Richard J Auchus
AU  - Corin Badiu
AU  - Robert S Busch
AU  - Salvatore Cannavò
AU  - Ulrich Dischinger
AU  - Georgiana A Dobri
AU  - Diane M Donegan
AU  - Atanaska Elenkova
AU  - Pouneh K Fazeli
AU  - Richard A Feelders
AU  - Rogelio Garcia-Centeno
AU  - Aleksandra Gilis-Januszewska
AU  - Oksana Hamidi
AU  - Zeina C Hannoush
AU  - Atil Y Kargi
AU  - Harold J Miller
AU  - Aurelian-Emil Ranetti
AU  - Monica Recasens
AU  - Martin Reincke
AU  - Sergio Rovner
AU  - Roberto Salvatori
AU  - Julie Silverstein
AU  - Antonio Stigliano
AU  - Massimo Terzolo
AU  - Christina Wang
AU  - Kevin C J Yuen
AU  - Amanda Kesner-Hays
AU  - Austin L Hand
AU  - Iulia Cristina Tudor
AU  - Katherine A Araque
AU  - Andreas G Moraitis
AU  - Lisa Abbott
AU  - Amer Al-Karadsheh
AU  - Carmen Aresta
AU  - Giorgio Arnaldi
AU  - Richard J Auchus
AU  - Corin Badiu
AU  - Isabelle Bourdeau
AU  - Robert Busch
AU  - Salvatore Cannavò
AU  - Iwona Chmiel-Perzyńska
AU  - Ulrich Dischinger
AU  - Georgiana Dobri
AU  - Diane Donegan
AU  - Rivka Dresner-Pollak
AU  - Andjela Drincic
AU  - Honey E East
AU  - Atanaska Elenkova
AU  - Martin Fassnacht
AU  - Pouneh Fazeli
AU  - Richard A Feelders
AU  - Rogelio Garcia-Centeno
AU  - Eliza Geer
AU  - Aleksandra Gilis-Januszewska
AU  - Murray B Gordon
AU  - Yona Greenman
AU  - Oksana Hamidi
AU  - Zeina Hannoush
AU  - Anthony Heaney
AU  - Wenyu Huang
AU  - Syed A Imran
AU  - Andrea Isidori
AU  - Serge Jabbour
AU  - Atil Y Kargi
AU  - Daniel Katselnik
AU  - Alexandra Kautzky-Willer
AU  - Lawrence S Kirschner
AU  - Alice Levine
AU  - Jonea Lim
AU  - Francisco JT Maduerio
AU  - Marianna Martino
AU  - Joseph W Mathews
AU  - Harold Miller
AU  - Le Min
AU  - Dan Niculescu
AU  - Jean J Nya-Ngatchou
AU  - Jonathan Ownby
AU  - John C Parker
AU  - Antonio M Picó Alfonso
AU  - Rosario Pivonello
AU  - Cristina Preda
AU  - Aurelian-Emil Ranetti
AU  - Monica Recasens
AU  - Martin Reincke
AU  - Leszek Romanowski
AU  - Pnina Rotman-Pikielny
AU  - Sergio S Rovner
AU  - Isaac Sachmechi
AU  - Roberto Salvatori
AU  - Carla Scaroni
AU  - Ilan Shimon
AU  - Julie Silverstein
AU  - Alfonso Soto-Moreno
AU  - Antonio Stigliano
AU  - Massimo Terzolo
AU  - Christina Wang
AU  - Kevin CJ Yuen
PY  - 2026
JO  - The Lancet Diabetes &amp; Endocrinology
DO  - 10.1016/s2213-8587(25)00362-6
UR  - https://doi.org/10.1016/s2213-8587(25)00362-6
ER  -

APA

Pivonello, R., Arnaldi, G., Auchus, R. J., Badiu, C., Busch, R. S., Cannavò, S., Dischinger, U., Dobri, G. A., Donegan, D. M., Elenkova, A., Fazeli, P. K., Feelders, R. A., Garcia-Centeno, R., Gilis-Januszewska, A., Hamidi, O., Hannoush, Z. C., Kargi, A. Y., Miller, H. J., Ranetti, A., Recasens, M., Reincke, M., Rovner, S., Salvatori, R., Silverstein, J., Stigliano, A., Terzolo, M., Wang, C., Yuen, K. C. J., Kesner-Hays, A., Hand, A. L., Tudor, I. C., Araque, K. A., Moraitis, A. G., Abbott, L., Al-Karadsheh, A., Aresta, C., Arnaldi, G., Auchus, R. J., Badiu, C., Bourdeau, I., Busch, R., Cannavò, S., Chmiel-Perzyńska, I., Dischinger, U., Dobri, G., Donegan, D., Dresner-Pollak, R., Drincic, A., East, H. E., Elenkova, A., Fassnacht, M., Fazeli, P., Feelders, R. A., Garcia-Centeno, R., Geer, E., Gilis-Januszewska, A., Gordon, M. B., Greenman, Y., Hamidi, O., Hannoush, Z., Heaney, A., Huang, W., Imran, S. A., Isidori, A., Jabbour, S., Kargi, A. Y., Katselnik, D., Kautzky-Willer, A., Kirschner, L. S., Levine, A., Lim, J., Maduerio, F. J., Martino, M., Mathews, J. W., Miller, H., Min, L., Niculescu, D., Nya-Ngatchou, J. J., Ownby, J., Parker, J. C., Alfonso, A. M. P., Pivonello, R., Preda, C., Ranetti, A., Recasens, M., Reincke, M., Romanowski, L., Rotman-Pikielny, P., Rovner, S. S., Sachmechi, I., Salvatori, R., Scaroni, C., Shimon, I., Silverstein, J., Soto-Moreno, A., Stigliano, A., Terzolo, M., Wang, C., & Yuen, K. C. (2026). Efficacy and safety of relacorilant for the treatment of patients with Cushing's syndrome (GRACE): a multicentre, phase 3, double-blind, placebo-controlled, randomised-withdrawal study. The Lancet Diabetes & Endocrinology. https://doi.org/10.1016/s2213-8587(25)00362-6

Source records

crossref · retrieved 2026-09-27T00:45:35.067Z